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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cardiac muscle hypertrophy
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Accession:GO:0010611 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.



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regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmcd1 LIM and cysteine-rich domains 1 involved_in ISO (PMID:20026769) RGD PMID:20026769 NCBI chr 4:145,393,153...145,452,049 JBrowse link
negative regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp10 bone morphogenetic protein 10 involved_in IEA
ISO
GO_REF:0000107
(PMID:16798733)
Ensembl
RGD
PMID:16798733 GO_REF:0000107 NCBI chr 4:119,872,066...119,877,694 JBrowse link
G Cav3 caveolin 3 involved_in
acts_upstream_of_or_within
ISO (PMID:12847114)
MGI:2180558 (PMID:18552160)
RGD PMID:12847114 PMID:18552160 NCBI chr 4:147,137,993...147,153,967 JBrowse link
G Fbxo32 F-box protein 32 involved_in IMP PMID:24117217 BHF-UCL PMID:24117217 RGD:11079185 NCBI chr 7:91,620,925...91,654,491 JBrowse link
G Gata5 GATA binding protein 5 involved_in ISO (PMID:21633169) RGD PMID:21633169 NCBI chr 3:187,796,140...187,804,327 JBrowse link
G Gdf1 growth differentiation factor 1 IMP RGD PMID:24275554 RGD:11252017 NCBI chr16:19,131,271...19,146,480 JBrowse link
G Glrx3 glutaredoxin 3 involved_in ISO (PMID:18258855) RGD PMID:18258855 NCBI chr 1:192,241,707...192,272,012 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta acts_upstream_of_or_within ISO (PMID:11782539) RGD PMID:11782539 NCBI chr11:76,004,502...76,154,665 JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 involved_in IGI
IMP
PMID:24657879 BHF-UCL PMID:24657879 PMID:24657879 RGD:11344938, RGD:11344938 NCBI chr17:19,983,217...20,163,598 JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:28679649 RGD:329955564 NCBI chr 1:79,956,380...79,974,354 JBrowse link
G Mir1 microRNA 1 involved_in ISO (PMID:19933931) RGD PMID:19933931 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mir1a-1 microRNA 1a-1 involved_in ISO (PMID:19933931) RGD PMID:19933931 NCBI chr 3:167,487,117...167,487,201 JBrowse link
G Mlip muscular LMNA-interacting protein involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:22343712)
UniProt
RGD
PMID:22343712 GO_REF:0000024 NCBI chr 8:77,935,087...78,204,725 JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:26491108) RGD PMID:26491108 NCBI chr 3:29,676,040...29,721,613 JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in ISO (PMID:15130891) RGD PMID:15130891 NCBI chr12:33,844,609...33,862,265 JBrowse link
G Rgs2 regulator of G-protein signaling 2 involved_in ISO (PMID:19127022) RGD PMID:19127022 NCBI chr13:58,350,063...58,352,666 JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:16151019)
Ensembl
RGD
PMID:16151019 GO_REF:0000107 NCBI chr18:69,518,988...69,549,684 JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IMP PMID:30980393 UniProt PMID:30980393 RGD:401901224 NCBI chr10:14,850,765...14,853,046 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A involved_in ISO UniProtKB:P25119 (PMID:26491108) RGD PMID:26491108 NCBI chr 4:159,837,119...159,849,817 JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in ISO UniProtKB:P25118 (PMID:26491108) RGD PMID:26491108 NCBI chr 5:157,070,642...157,104,216 JBrowse link
G Trim63 tripartite motif containing 63 involved_in IMP PMID:24117217 BHF-UCL PMID:24117217 RGD:11079185 NCBI chr 5:146,533,492...146,547,332 JBrowse link
negative regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:19287093) RGD PMID:19287093 NCBI chr13:47,708,157...47,807,389 JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA RGD PMID:19204184 RGD:9685562 NCBI chr 5:166,606,841...166,620,124 JBrowse link
G Foxo1 forkhead box O1 involved_in IMP PMID:26436652 UniProt PMID:26436652 RGD:13210548 NCBI chr 2:138,462,974...138,541,420 JBrowse link
G Lmna lamin A/C involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:26436652)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:26436652 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:176,237,564...176,265,301 JBrowse link
G Mlip muscular LMNA-interacting protein involved_in ISO (PMID:26359501), (PMID:26436652) RGD PMID:26359501 PMID:26436652 NCBI chr 8:77,935,087...78,204,725 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of_or_within IDA PMID:29695452 BHF-UCL PMID:29695452 RGD:150521636 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Smad3 SMAD family member 3 involved_in IGI PMID:27038547 BHF-UCL PMID:27038547 RGD:11535100 NCBI chr 8:64,126,829...64,236,960 JBrowse link
negative regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap1 A-kinase anchoring protein 1 IMP RGD PMID:19358331 RGD:2312604 NCBI chr10:74,118,232...74,151,366 JBrowse link
G Cav3 caveolin 3 IMP RGD PMID:21170593 RGD:6784534 NCBI chr 4:147,137,993...147,153,967 JBrowse link
G Ctdp1 CTD phosphatase subunit 1 IMP RGD PMID:22569295 RGD:9686371 NCBI chr18:73,854,277...73,916,232 JBrowse link
G Foxp1 forkhead box P1 IMP RGD PMID:26333362 RGD:11561912 NCBI chr 4:133,117,346...133,808,647 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase IMP RGD PMID:24190878 RGD:10449133 NCBI chr  X:157,352,364...157,372,144 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in IEA
ISO
GO_REF:0000107
(PMID:20516643)
Ensembl
RGD
PMID:20516643 GO_REF:0000107 NCBI chr 1:89,943,669...89,953,514 JBrowse link
G Mir451a microRNA 451a IMP RGD PMID:25209900 RGD:11558015 NCBI chr10:62,961,520...62,961,591 JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IMP RGD PMID:22082674 RGD:11533929 NCBI chr 1:161,522,399...161,637,623 JBrowse link
G Pi16 peptidase inhibitor 16 acts_upstream_of_or_within ISO (PMID:17909105) RGD PMID:17909105 NCBI chr20:7,376,073...7,385,386 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IMP RGD PMID:22198280 RGD:5687133 NCBI chr 7:118,712,261...118,780,723 JBrowse link
G Rbm10 RNA binding motif protein 10 IMP RGD PMID:30257214 RGD:151667449 NCBI chr  X:1,540,399...1,572,571 JBrowse link
G Rgs2 regulator of G-protein signaling 2 IMP RGD PMID:16380388 RGD:13524577 NCBI chr13:58,350,063...58,352,666 JBrowse link
G Rgs4 regulator of G-protein signaling 4 IDA RGD PMID:9918533 RGD:7207376 NCBI chr13:81,936,775...81,943,103 JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 IMP RGD PMID:25022898 RGD:13464131 NCBI chr11:56,847,837...56,886,302 JBrowse link
G Yy1 YY1 transcription factor IMP RGD PMID:18632988 RGD:9588273 NCBI chr 6:133,471,615...133,500,875 JBrowse link
G Zfp418 zinc finger protein 418 acts_upstream_of_or_within ISO (PMID:29065170) RGD PMID:29065170 NCBI chr 1:66,581,406...66,594,247 JBrowse link
positive regulation of cardiac muscle hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 IMP RGD PMID:29466442 RGD:329337358 NCBI chr13:77,747,752...77,833,952 JBrowse link
G Adk adenosine kinase IMP RGD PMID:21335462 RGD:6482642 NCBI chr15:2,912,543...3,295,745 JBrowse link
G Adra1a adrenoceptor alpha 1A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:27994061)
Ensembl
RGD
PMID:27994061 GO_REF:0000107 NCBI chr15:45,005,648...45,111,416 JBrowse link
G Agt angiotensinogen involved_in IDA PMID:8348686 BHF-UCL PMID:8348686 RGD:8553767 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Becn1 beclin 1 acts_upstream_of_or_within ISO MGI:2683833 (PMID:27994061) RGD PMID:27994061 NCBI chr10:86,731,649...86,747,002 JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO
IEA
IMP
(PMID:17921333)
GO_REF:0000107
RGD
Ensembl
PMID:17921333 PMID:17921333 GO_REF:0000107, RGD:2302083 NCBI chr 4:119,872,066...119,877,694 JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta involved_in ISO
ISS
(PMID:17179159)
GO_REF:0000024
RGD
UniProt
PMID:17179159 GO_REF:0000024 NCBI chr 2:217,698,324...217,961,898 JBrowse link
G Cdk9 cyclin-dependent kinase 9 IMP RGD PMID:20081228 RGD:9698419 NCBI chr 3:36,394,168...36,399,016 JBrowse link
G Ece1 endothelin converting enzyme 1 IMP RGD PMID:20099522 RGD:7243873 NCBI chr 5:155,361,031...155,462,723 JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:12847114) RGD PMID:12847114 NCBI chr17:22,660,799...22,666,687 JBrowse link
G Gsn gelsolin IMP RGD PMID:24505034 RGD:329333013 NCBI chr 3:38,982,605...39,035,849 JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in ISO
IEA
UniProtKB:P63328|UniProtKB:Q02078 (PMID:24161931)
GO_REF:0000107
RGD
Ensembl
PMID:24161931 GO_REF:0000107 NCBI chr16:37,928,145...37,931,488 JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO (PMID:19654000), (PMID:19933931) RGD PMID:19654000 PMID:19933931 NCBI chr 7:24,169,608...24,249,446 JBrowse link
G Mef2a myocyte enhancer factor 2a involved_in ISO
IEA
UniProtKB:P61296 (PMID:24161931)
GO_REF:0000107
RGD
Ensembl
PMID:24161931 GO_REF:0000107 NCBI chr 1:120,847,874...120,982,488 JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in IMP PMID:19654000 UniProt PMID:19654000 RGD:5131609 NCBI chr 2:15,708,732...15,871,639 JBrowse link
G Mrtfa myocardin related transcription factor A IMP RGD PMID:21280178 RGD:529389387 NCBI chr 7:112,544,305...112,714,418 JBrowse link
G Mtpn myotrophin involved_in ISO
IMP
(PMID:10329199)
PMID:18693253
RGD PMID:10329199 PMID:18693253 RGD:8553542 NCBI chr 4:64,159,273...64,186,686 JBrowse link
G Myocd myocardin IMP RGD PMID:21280178 RGD:529389387 NCBI chr10:50,332,356...50,426,819 JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 involved_in IMP PMID:30980393 UniProt PMID:30980393 RGD:401901224 NCBI chr19:50,870,464...50,944,992 JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 involved_in IMP PMID:25625556 UniProt PMID:25625556 RGD:10054073 NCBI chr 5:67,157,141...67,198,287 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in IMP PMID:25625556 UniProt PMID:25625556 RGD:10054073 NCBI chr13:94,839,484...94,871,295 JBrowse link
G Pde5a phosphodiesterase 5A involved_in IEA
ISO
GO_REF:0000107
(PMID:19127022)
Ensembl
RGD
PMID:19127022 GO_REF:0000107 NCBI chr 2:210,858,515...211,003,480 JBrowse link
G Pde9a phosphodiesterase 9A involved_in ISS
ISO
GO_REF:0000024
(PMID:25799991)
UniProt
RGD
PMID:25799991 GO_REF:0000024 NCBI chr20:9,469,809...9,562,949 JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO RNAcentral:URS0000021B51_10090|UniProtKB:P61296 (PMID:24161931), (PMID:24657879) RGD PMID:24161931 PMID:24657879 NCBI chr 2:227,839,058...228,113,560 JBrowse link
G Prkca protein kinase C, alpha involved_in IDA PMID:11864993 UniProt PMID:11864993 RGD:8554603 NCBI chr10:93,388,991...93,787,617 JBrowse link
G Ptk2 protein tyrosine kinase 2 acts_upstream_of_or_within ISO (PMID:27994061) RGD PMID:27994061 NCBI chr 7:107,015,730...107,220,865 JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:28679962)
Ensembl
RGD
PMID:28679962 GO_REF:0000107 NCBI chr18:1,387,360...1,509,218 JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in IMP
ISO
PMID:28679962
(PMID:28679962)
RGD PMID:28679962 PMID:28679962 RGD:13601991 NCBI chr 6:45,407,823...45,502,773 JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO (PMID:21359875) RGD PMID:21359875 NCBI chr 5:145,576,341...145,629,630 JBrowse link
G Twf1 twinfilin actin-binding protein 1 involved_in ISO (PMID:20571053) RGD PMID:20571053 NCBI chr 7:127,595,210...127,607,821 JBrowse link
positive regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in ISO (PMID:19287093) RGD PMID:19287093 NCBI chr 2:227,839,058...228,113,560 JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 involved_in ISO (PMID:19287093) RGD PMID:19287093 NCBI chr 2:119,481,313...119,619,333 JBrowse link
positive regulation of cell growth involved in cardiac muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:18194989 RGD:5129139 NCBI chr 1:265,777,103...265,780,114 JBrowse link
G Akap6 A-kinase anchoring protein 6 IMP
IDA
RGD PMID:21550986 PMID:16306226 RGD:6902940, RGD:2312613 NCBI chr 6:75,919,350...76,359,667 JBrowse link
G Ccn4 cellular communication network factor 4 IMP RGD PMID:21376054 RGD:5129173 NCBI chr 7:100,534,578...100,566,287 JBrowse link
G Ddx39b DExD-box helicase 39B IMP RGD PMID:20116367 RGD:10401141 NCBI chr20:3,547,702...3,585,064 JBrowse link
G Edn1 endothelin 1 involved_in ISO RNAcentral:URS000006FDD4_9606|RNAcentral:URS000013D17D_9606 (PMID:24117217) RGD PMID:24117217 NCBI chr17:22,660,799...22,666,687 JBrowse link
G Ep300 E1A binding protein p300 IMP RGD PMID:12724418 RGD:2312280 NCBI chr 7:114,987,857...115,058,652 JBrowse link
G Fdps farnesyl diphosphate synthase IMP RGD PMID:19716825 RGD:2316294 NCBI chr 2:176,795,192...176,804,816 JBrowse link
G Hamp hepcidin antimicrobial peptide IMP RGD PMID:24424338 RGD:11041632 NCBI chr 1:95,298,332...95,300,271 JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA
RNAcentral:URS000006FDD4_9606|RNAcentral:URS000013D17D_9606 (PMID:24117217)
GO_REF:0000107
RGD
Ensembl
PMID:24117217 GO_REF:0000107 NCBI chr 7:24,169,608...24,249,446 JBrowse link
G Mir19a microRNA 19a involved_in ISO UniProtKB:P05019 (PMID:24117217) RGD PMID:24117217 NCBI chr15:92,180,912...92,180,993 JBrowse link
G Mir19b1 microRNA 19b-1 involved_in ISO UniProtKB:P05019 (PMID:24117217) RGD PMID:24117217 NCBI chr15:92,181,214...92,181,300 JBrowse link
G Mir19b2 microRNA 19b-2 involved_in ISO UniProtKB:P05019 (PMID:24117217) RGD PMID:24117217 NCBI chr  X:132,422,072...132,422,167 JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:21318349 PMID:21933187 RGD:10040977, RGD:10040978 NCBI chr 5:164,167,985...164,277,438 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IMP RGD PMID:22989630 RGD:7174736 NCBI chr18:31,522,783...31,644,508 JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 IMP RGD PMID:23261455 RGD:13514044 NCBI chr15:26,494,722...26,517,893 JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 IMP RGD PMID:23487407 RGD:8693424 NCBI chr 8:27,465,538...27,477,016 JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:25281201 RGD:13514043 NCBI chr20:25,305,953...25,328,000 JBrowse link
G Slc25a4 solute carrier family 25 member 4 IDA RGD PMID:21325829 RGD:9681466 NCBI chr16:46,072,935...46,076,730 JBrowse link
G Trip10 thyroid hormone receptor interactor 10 IMP RGD PMID:23915320 RGD:11535145 NCBI chr 9:2,219,695...2,234,771 JBrowse link
regulation of cardiac muscle hypertrophy in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-CoA carboxylase beta IMP RGD PMID:31709908 RGD:329901803 NCBI chr12:48,026,394...48,138,214 JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO
IEA
(PMID:17921333)
GO_REF:0000107
RGD
Ensembl
PMID:17921333 GO_REF:0000107 NCBI chr 4:119,872,066...119,877,694 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    response to stimulus 11012
      muscle adaptation 158
        regulation of muscle adaptation 125
          regulation of cardiac muscle hypertrophy 89
            negative regulation of cardiac muscle hypertrophy + 40
            positive regulation of cardiac muscle hypertrophy + 48
            regulation of cardiac muscle hypertrophy in response to stress + 11
Path 2
Term Annotations click to browse term
  biological_process 20534
    multicellular organismal process 8969
      system process 3558
        muscle system process 485
          muscle hypertrophy 136
            striated muscle hypertrophy 134
              cardiac muscle hypertrophy 130
                regulation of cardiac muscle hypertrophy 89
                  negative regulation of cardiac muscle hypertrophy + 40
                  positive regulation of cardiac muscle hypertrophy + 48
                  regulation of cardiac muscle hypertrophy in response to stress + 11
paths to the root