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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cell fate commitment
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Accession:GO:0010453 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

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regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936697:1,054,237...1,061,468
Ensembl chrNW_004936697:1,056,636...1,061,468 		JBrowse link
G Gdf3 growth differentiation factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004937847:8,179...16,783
Ensembl chrNW_004937847:7,456...16,783 		JBrowse link
G Pax7 paired box 7 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:5,045,284...5,131,859
Ensembl chrNW_004936474:5,045,284...5,131,859 		JBrowse link
G Znf157 zinc finger protein 157 acts_upstream_of_or_within ISO (PMID:22588720) MGI PMID:22588720 NCBI chrNW_004936502:13,127,503...13,158,443
Ensembl chrNW_004936502:13,127,563...13,158,962 		JBrowse link
negative regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glis1 GLIS family zinc finger 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936522:7,376,850...7,571,818
Ensembl chrNW_004936522:7,375,994...7,571,828 		JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936892:181,834...187,691
Ensembl chrNW_004936892:181,834...187,691 		JBrowse link
G Nkx6-2 NK6 homeobox 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:19,024,106...19,025,387
Ensembl chrNW_004936486:19,024,263...19,025,390 		JBrowse link
G Sostdc1 sclerostin domain containing 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936546:2,976,045...2,980,487
Ensembl chrNW_004936546:2,975,606...2,980,514 		JBrowse link
G Spdef SAM pointed domain containing ETS transcription factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:24,563,591...24,571,739
Ensembl chrNW_004936476:24,563,591...24,570,692 		JBrowse link
negative regulation of cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936711:640,002...642,580
Ensembl chrNW_004936711:639,905...642,622 		JBrowse link
negative regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfi1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO (PMID:16230531) MGI PMID:16230531 NCBI chrNW_004936537:6,610,565...6,618,509
Ensembl chrNW_004936537:6,610,565...6,618,450 		JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd7 frizzled class receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936726:1,256,684...1,275,324
Ensembl chrNW_004936726:1,256,678...1,275,467 		JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:15,533,264...15,534,576
Ensembl chrNW_004936483:15,533,522...15,534,576 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936787:307,290...309,963
Ensembl chrNW_004936787:306,941...310,166 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:15,533,264...15,534,576
Ensembl chrNW_004936483:15,533,522...15,534,576 		JBrowse link
G Sfrp2 secreted frizzled related protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936576:604,174...612,440
Ensembl chrNW_004936576:604,069...613,021 		JBrowse link
negative regulation of retinal cone cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casz1 castor zinc finger 1 acts_upstream_of_or_within ISO (PMID:25654255) MGI PMID:25654255 NCBI chrNW_004936623:4,478,421...4,503,207
Ensembl chrNW_004936623:4,467,837...4,494,390 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak3 Janus kinase 3 acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:20696842) Ensembl
UniProt		 PMID:20696842 GO_REF:0000107 NCBI chrNW_004936596:3,212,593...3,224,426
Ensembl chrNW_004936596:3,212,593...3,224,048 		JBrowse link
G Lgals1 galectin 1 acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:24752896) Ensembl
UniProt		 PMID:24752896 GO_REF:0000107 NCBI chrNW_004936492:3,407,704...3,411,197
Ensembl chrNW_004936492:3,407,049...3,411,222 		JBrowse link
G LOC101954799 signal transducer and activator of transcription 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:17,095,047...17,115,945
Ensembl chrNW_004936490:17,095,954...17,114,866 		JBrowse link
G Loxl3 lysyl oxidase like 3 involved_in IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chrNW_004936556:745,798...765,926
Ensembl chrNW_004936556:745,798...765,918 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:13,546,405...13,558,635
Ensembl chrNW_004936490:13,546,292...13,558,635 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:14,499,495...14,508,074
Ensembl chrNW_004936481:14,499,577...14,508,017 		JBrowse link
positive regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx6-2 NK6 homeobox 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:19,024,106...19,025,387
Ensembl chrNW_004936486:19,024,263...19,025,390 		JBrowse link
G Spdef SAM pointed domain containing ETS transcription factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:24,563,591...24,571,739
Ensembl chrNW_004936476:24,563,591...24,570,692 		JBrowse link
positive regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afg2a AAA ATPase AFG2A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936662:1,957,364...2,207,410
Ensembl chrNW_004936662:1,886,176...1,929,097
Ensembl chrNW_004936662:1,886,176...1,929,097 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO (PMID:16230531) MGI PMID:16230531 NCBI chrNW_004936537:6,610,565...6,618,509
Ensembl chrNW_004936537:6,610,565...6,618,450 		JBrowse link
G Pax6 paired box 6 ISO RGD PMID:11880342 RGD:729590 NCBI chrNW_004936533:5,952,529...5,980,889
Ensembl chrNW_004936533:5,957,971...5,982,075 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936864:150,742...179,205
Ensembl chrNW_004936864:150,732...192,423 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:25,807,179...25,818,914
Ensembl chrNW_004936476:25,807,163...25,818,899 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004936596:5,176,682...5,246,102
Ensembl chrNW_004936596:5,177,147...5,246,518 		JBrowse link
G Ep300 EP300 lysine acetyltransferase acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:28262505) Ensembl
UniProt		 PMID:28262505 GO_REF:0000107 NCBI chrNW_004936492:696,982...778,132
Ensembl chrNW_004936492:696,960...778,138 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936646:743,630...745,998
Ensembl chrNW_004936646:743,688...745,836 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936711:1,027,531...1,113,796
Ensembl chrNW_004936711:1,032,935...1,106,847 		JBrowse link
regulation of cardiac cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox17 SRY-box transcription factor 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:1,248,582...1,251,406
Ensembl chrNW_004936496:1,248,577...1,251,430 		JBrowse link
regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmo4 LIM domain only 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936732:1,541,511...1,557,845
Ensembl chrNW_004936732:1,541,515...1,555,735 		JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936787:307,290...309,963
Ensembl chrNW_004936787:306,941...310,166 		JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esrp1 epithelial splicing regulatory protein 1 involved_in ISO (PMID:29107558) UniProt PMID:29107558 NCBI chrNW_004936544:7,633,266...7,690,624
Ensembl chrNW_004936544:7,633,071...7,691,655 		JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936804:52,435...115,289
Ensembl chrNW_004936804:48,947...115,412 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936710:1,760,365...1,815,269
Ensembl chrNW_004936710:1,760,089...1,815,508 		JBrowse link
regulation of neural crest cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A NOT|involved_in ISO (PMID:15073157) BHF-UCL PMID:15073157 NCBI chrNW_004936804:52,435...115,289
Ensembl chrNW_004936804:48,947...115,412 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17733
    developmental process 6580
      regulation of developmental process 2529
        regulation of cell fate commitment 35
          negative regulation of cell fate commitment + 18
          positive regulation of cell fate commitment + 11
          regulation of R7 cell fate commitment + 0
          regulation of T-helper 17 cell lineage commitment + 11
          regulation of cell fate specification + 13
          regulation of retinal cone cell fate commitment + 1
          regulation of retinal rod cell fate commitment + 0
          regulation of venous endothelial cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 17733
    developmental process 6580
      cellular developmental process 4463
        cell differentiation 4462
          cell fate commitment 290
            regulation of cell fate commitment 35
              negative regulation of cell fate commitment + 18
              positive regulation of cell fate commitment + 11
              regulation of R7 cell fate commitment + 0
              regulation of T-helper 17 cell lineage commitment + 11
              regulation of cell fate specification + 13
              regulation of retinal cone cell fate commitment + 1
              regulation of retinal rod cell fate commitment + 0
              regulation of venous endothelial cell fate commitment + 0
paths to the root