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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cell fate commitment
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Accession:GO:0010453 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

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regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:18823971) UniProt PMID:18823971 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303 		JBrowse link
G Gdf3 growth differentiation factor 3 involved_in ISO (PMID:18823971) UniProt PMID:18823971 NCBI chrNW_004955413:6,493,734...6,516,315 JBrowse link
G Pax7 paired box 7 acts_upstream_of_or_within ISO (PMID:23070814) MGI PMID:23070814 NCBI chrNW_004955527:474,450...573,869
Ensembl chrNW_004955527:474,403...574,689 		JBrowse link
G Znf157 zinc finger protein 157 acts_upstream_of_or_within ISO (PMID:22588720) MGI PMID:22588720 NCBI chrNW_004955516:692,871...727,103
Ensembl chrNW_004955516:692,871...727,103 		JBrowse link
negative regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glis1 GLIS family zinc finger 1 involved_in ISO (PMID:30544251) UniProt PMID:30544251 NCBI chrNW_004955464:5,495,528...5,680,114
Ensembl chrNW_004955464:5,496,031...5,681,011 		JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within ISO (PMID:16801560) MGI PMID:16801560 NCBI chrNW_004955413:6,561,323...6,565,770
Ensembl chrNW_004955413:6,562,275...6,565,463 		JBrowse link
G Nkx6-2 NK6 homeobox 2 acts_upstream_of_or_within ISO (PMID:11567614) MGI PMID:11567614 NCBI chrNW_004955477:10,386,033...10,387,423
Ensembl chrNW_004955477:10,386,033...10,387,423 		JBrowse link
G Sostdc1 sclerostin domain containing 1 acts_upstream_of_or_within ISO (PMID:22509524) MGI PMID:22509524 NCBI chrNW_004955410:19,657,805...19,662,121
Ensembl chrNW_004955410:19,657,029...19,662,131 		JBrowse link
G Spdef SAM pointed domain containing ETS transcription factor acts_upstream_of_or_within ISO (PMID:19759516) MGI PMID:19759516 NCBI chrNW_004955437:2,667,499...2,679,940
Ensembl chrNW_004955437:2,666,105...2,680,061 		JBrowse link
negative regulation of cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 acts_upstream_of_or_within ISO (PMID:11425898) MGI PMID:11425898 NCBI chrNW_004955420:14,565,921...14,568,447
Ensembl chrNW_004955420:14,564,283...14,568,447 		JBrowse link
negative regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfi1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO (PMID:16230531) MGI PMID:16230531 NCBI chrNW_004955423:2,024,084...2,032,530
Ensembl chrNW_004955423:2,022,417...2,033,149 		JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd7 frizzled class receptor 7 involved_in ISO (PMID:18681827) BHF-UCL PMID:18681827 NCBI chrNW_004955457:12,729,277...12,733,057
Ensembl chrNW_004955457:12,731,279...12,732,979 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) BHF-UCL PMID:20559569 NCBI chrNW_004955425:7,353,964...7,357,599 JBrowse link
G Sfrp2 secreted frizzled related protein 2 acts_upstream_of_or_within ISO (PMID:17462603) MGI PMID:17462603 NCBI chrNW_004955471:8,103,937...8,112,596
Ensembl chrNW_004955471:8,103,783...8,112,321 		JBrowse link
negative regulation of retinal cone cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casz1 castor zinc finger 1 acts_upstream_of_or_within ISO (PMID:25654255) MGI PMID:25654255 NCBI chrNW_004955486:2,923,239...2,975,835
Ensembl chrNW_004955486:2,923,234...2,974,486 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 CD69 molecule involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004955413:5,579,037...5,586,238
Ensembl chrNW_004955413:5,579,072...5,587,491 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (PMID:20696842) UniProt PMID:20696842 NCBI chrNW_004955524:3,399,895...3,412,018
Ensembl chrNW_004955524:3,401,642...3,411,643 		JBrowse link
G Lgals1 galectin 1 involved_in ISO (PMID:24752896) UniProt PMID:24752896 NCBI chrNW_004955413:24,072,086...24,075,452
Ensembl chrNW_004955413:24,072,086...24,075,452 		JBrowse link
G Loxl3 lysyl oxidase like 3 involved_in ISO (PMID:28065600) UniProt PMID:28065600 NCBI chrNW_004955424:11,236,415...11,255,801
Ensembl chrNW_004955424:11,236,836...11,259,570 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A involved_in ISO (PMID:20696842) UniProt PMID:20696842 NCBI chrNW_004955451:16,305,363...16,319,219
Ensembl chrNW_004955451:16,305,363...16,318,534 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) UniProt PMID:21151104 NCBI chrNW_004955451:13,315,237...13,317,888
Ensembl chrNW_004955451:13,315,859...13,325,937 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) UniProt PMID:24107315 NCBI chrNW_004955406:13,391,162...13,402,479 JBrowse link
positive regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx6-2 NK6 homeobox 2 acts_upstream_of_or_within ISO (PMID:11567614) MGI PMID:11567614 NCBI chrNW_004955477:10,386,033...10,387,423
Ensembl chrNW_004955477:10,386,033...10,387,423 		JBrowse link
G Spdef SAM pointed domain containing ETS transcription factor acts_upstream_of_or_within ISO (PMID:19759516) MGI PMID:19759516 NCBI chrNW_004955437:2,667,499...2,679,940
Ensembl chrNW_004955437:2,666,105...2,680,061 		JBrowse link
positive regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 acts_upstream_of_or_within ISO (PMID:18635606) MGI PMID:18635606 NCBI chrNW_004955428:17,840,554...17,894,779
Ensembl chrNW_004955428:17,840,628...17,894,773 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO (PMID:16230531) MGI PMID:16230531 NCBI chrNW_004955423:2,024,084...2,032,530
Ensembl chrNW_004955423:2,022,417...2,033,149 		JBrowse link
G Pax6 paired box 6 ISO RGD PMID:11880342 RGD:729590 NCBI chrNW_004955476:10,058,979...10,074,668
Ensembl chrNW_004955476:10,058,961...10,074,162 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:20559569) BHF-UCL PMID:20559569 NCBI chrNW_004955581:351,375...382,541
Ensembl chrNW_004955581:350,889...382,541 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004955437:1,584,890...1,592,486
Ensembl chrNW_004955437:1,584,479...1,592,826 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004955495:7,959,033...7,989,216
Ensembl chrNW_004955495:7,957,510...7,988,498 		JBrowse link
G Ep300 EP300 lysine acetyltransferase involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004955413:26,647,553...26,727,875
Ensembl chrNW_004955413:26,648,339...26,727,933 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:19501566) BHF-UCL PMID:19501566 NCBI chrNW_004955458:3,946,964...3,949,180
Ensembl chrNW_004955458:3,947,803...3,949,312 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase involved_in ISO (PMID:36171294) UniProt PMID:36171294 NCBI chrNW_004955420:14,927,490...15,007,082
Ensembl chrNW_004955420:14,923,575...15,007,081 		JBrowse link
regulation of cardiac cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox17 SRY-box transcription factor 17 involved_in ISO (PMID:17360443) BHF-UCL PMID:17360443 NCBI chrNW_004955454:13,689,403...13,690,019 JBrowse link
regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmo4 LIM domain only 4 acts_upstream_of_or_within ISO (PMID:19323994) MGI PMID:19323994 NCBI chrNW_004955423:6,849,542...6,865,928
Ensembl chrNW_004955423:6,849,555...6,866,137 		JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) BHF-UCL PMID:20559569 NCBI chrNW_004955425:7,353,964...7,357,599 JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esrp1 epithelial splicing regulatory protein 1 involved_in ISO (PMID:29107558) UniProt PMID:29107558 NCBI chrNW_004955417:10,813,831...10,881,238
Ensembl chrNW_004955417:10,813,593...10,882,921 		JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO (PMID:16943278) MGI PMID:16943278 NCBI chrNW_004955510:5,812,571...5,936,312
Ensembl chrNW_004955510:5,905,008...5,936,312 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO (PMID:16943278) MGI PMID:16943278 NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111 		JBrowse link
regulation of neural crest cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A NOT|involved_in ISO (PMID:15073157) BHF-UCL PMID:15073157 NCBI chrNW_004955510:5,812,571...5,936,312
Ensembl chrNW_004955510:5,905,008...5,936,312 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12722
    developmental process 6017
      regulation of developmental process 2389
        regulation of cell fate commitment 35
          negative regulation of cell fate commitment + 18
          positive regulation of cell fate commitment + 11
          regulation of R7 cell fate commitment + 0
          regulation of T-helper 17 cell lineage commitment + 12
          regulation of cell fate specification + 12
          regulation of retinal cone cell fate commitment + 1
          regulation of retinal rod cell fate commitment + 0
          regulation of venous endothelial cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 12722
    developmental process 6017
      cellular developmental process 3996
        cell differentiation 3995
          cell fate commitment 251
            regulation of cell fate commitment 35
              negative regulation of cell fate commitment + 18
              positive regulation of cell fate commitment + 11
              regulation of R7 cell fate commitment + 0
              regulation of T-helper 17 cell lineage commitment + 12
              regulation of cell fate specification + 12
              regulation of retinal cone cell fate commitment + 1
              regulation of retinal rod cell fate commitment + 0
              regulation of venous endothelial cell fate commitment + 0
paths to the root