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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cell fate commitment
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Accession:GO:0010453 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


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regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752 		JBrowse link
G GDF3 growth differentiation factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:7,813,288...7,819,418
Ensembl chr12:7,972,907...7,979,815 		JBrowse link
G PAX7 paired box 7 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:17,589,513...17,707,442
Ensembl chr 1:18,639,641...18,756,952 		JBrowse link
G ZNF157 zinc finger protein 157 acts_upstream_of_or_within ISO (PMID:22588720) MGI PMID:22588720 NCBI chr  X:39,802,953...39,852,227
Ensembl chr  X:47,699,782...47,746,867 		JBrowse link
negative regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLIS1 GLIS family zinc finger 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:52,778,438...53,015,050
Ensembl chr 1:54,376,866...54,610,255 		JBrowse link
G NANOG Nanog homeobox acts_upstream_of_or_within ISO (PMID:16801560) MGI PMID:16801560 NCBI chr12:7,913,037...7,919,715 JBrowse link
G NKX6-2 NK6 homeobox 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr10:133,682,456...133,683,445 JBrowse link
G SOSTDC1 sclerostin domain containing 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:17,193,531...17,229,769
Ensembl chr 7:16,443,703...16,448,076
Ensembl chr 7:16,443,703...16,448,076 		JBrowse link
G SPDEF SAM pointed domain containing ETS transcription factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr 6:35,202,983...35,209,639 JBrowse link
negative regulation of cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HES1 hes family bHLH transcription factor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:191,432,513...191,435,387
Ensembl chr 3:201,749,044...201,754,257 		JBrowse link
negative regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GFI1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO (PMID:16230531) MGI PMID:16230531 NCBI chr 1:95,139,171...95,151,054
Ensembl chr 1:93,876,245...93,883,528 		JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FZD7 frizzled class receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:89,290,929...89,294,873
Ensembl chr2B:207,439,942...207,446,283 		JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:68,440,626...68,441,935
Ensembl chr15:87,645,768...87,647,210 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:48,950,704...48,953,815
Ensembl chr10:51,084,027...51,089,776 		JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:68,440,626...68,441,935
Ensembl chr15:87,645,768...87,647,210 		JBrowse link
G SFRP2 secreted frizzled related protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:146,123,075...146,131,543
Ensembl chr 4:157,944,733...157,953,258 		JBrowse link
negative regulation of retinal cone cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASZ1 castor zinc finger 1 acts_upstream_of_or_within ISO (PMID:25654255) MGI PMID:25654255 NCBI chr 1:9,396,936...9,557,100
Ensembl chr 1:10,622,519...10,677,091 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD69 CD69 molecule acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:24752896) Ensembl
UniProt		 PMID:24752896 GO_REF:0000107 NCBI chr12:9,800,446...9,808,874
Ensembl chr12:10,049,668...10,058,094 		JBrowse link
G JAK3 Janus kinase 3 acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:20696842) Ensembl
UniProt		 PMID:20696842 GO_REF:0000107 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G LGALS1 galectin 1 acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:24752896) Ensembl
UniProt		 PMID:24752896 GO_REF:0000107 NCBI chr22:18,593,154...18,597,432
Ensembl chr22:36,426,228...36,430,356 		JBrowse link
G LOC100988550 signal transducer and activator of transcription 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,005,025...15,029,110
Ensembl chr17:15,228,465...15,251,783 		JBrowse link
G LOXL3 lysyl oxidase like 3 involved_in IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chr2A:74,598,870...74,622,502
Ensembl chr2A:76,105,957...76,128,495 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (PMID:24107315) UniProt PMID:24107315
positive regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NKX6-2 NK6 homeobox 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr10:133,682,456...133,683,445 JBrowse link
G SPDEF SAM pointed domain containing ETS transcription factor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr 6:35,202,983...35,209,639 JBrowse link
positive regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF2 fibroblast growth factor 2 acts_upstream_of_or_within ISO (PMID:18635606) MGI PMID:18635606 NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942 		JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO (PMID:16230531) MGI PMID:16230531 NCBI chr 1:95,139,171...95,151,054
Ensembl chr 1:93,876,245...93,883,528 		JBrowse link
G PAX6 paired box 6 ISO RGD PMID:11880342 RGD:729590 NCBI chr11:31,753,190...31,782,225
Ensembl chr11:31,641,813...31,664,474 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT3A Wnt family member 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:203,409,294...203,463,214
Ensembl chr 1:208,628,706...208,674,469 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD2 bromodomain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:32,538,130...32,550,823
Ensembl chr 6:33,657,648...33,666,031 		JBrowse link
G BRD4 bromodomain containing 4 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chr19:14,768,239...14,805,770
Ensembl chr19:15,754,930...15,789,600 		JBrowse link
G EP300 EP300 lysine acetyltransferase acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:28262505) Ensembl
UniProt		 PMID:28262505 GO_REF:0000107 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:32,575,321...32,576,856
Ensembl chr12:32,828,902...32,830,617 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358 		JBrowse link
regulation of cardiac cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOX17 SRY-box transcription factor 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:50,883,088...50,885,542
Ensembl chr 8:48,257,287...48,259,808 		JBrowse link
regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LMO4 LIM domain only 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:119,848,323...119,867,007
Ensembl chr 1:88,698,962...88,718,760 		JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:48,950,704...48,953,815
Ensembl chr10:51,084,027...51,089,776 		JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESRP1 epithelial splicing regulatory protein 1 involved_in ISO (PMID:29107558) UniProt PMID:29107558 NCBI chr 8:91,261,488...91,327,990
Ensembl chr 8:93,203,198...93,530,653 		JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1A bone morphogenetic protein receptor type 1A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:83,185,040...83,353,239
Ensembl chr10:86,837,469...86,912,912 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:37,713,133...37,773,098
Ensembl chr 8:34,890,147...34,948,904 		JBrowse link
regulation of neural crest cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1A bone morphogenetic protein receptor type 1A NOT|involved_in ISO (PMID:15073157) BHF-UCL PMID:15073157 NCBI chr10:83,185,040...83,353,239
Ensembl chr10:86,837,469...86,912,912 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19472
    developmental process 6808
      regulation of developmental process 2626
        regulation of cell fate commitment 36
          negative regulation of cell fate commitment + 19
          positive regulation of cell fate commitment + 11
          regulation of R7 cell fate commitment + 0
          regulation of T-helper 17 cell lineage commitment + 12
          regulation of cell fate specification + 13
          regulation of retinal cone cell fate commitment + 1
          regulation of retinal rod cell fate commitment + 0
          regulation of venous endothelial cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 19472
    developmental process 6808
      cellular developmental process 4621
        cell differentiation 4620
          cell fate commitment 295
            regulation of cell fate commitment 36
              negative regulation of cell fate commitment + 19
              positive regulation of cell fate commitment + 11
              regulation of R7 cell fate commitment + 0
              regulation of T-helper 17 cell lineage commitment + 12
              regulation of cell fate specification + 13
              regulation of retinal cone cell fate commitment + 1
              regulation of retinal rod cell fate commitment + 0
              regulation of venous endothelial cell fate commitment + 0
paths to the root