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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cell fate commitment
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Accession:GO:0010453 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


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regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:18823971)		 Ensembl
CAFA
RGD		 PMID:18823971 GO_REF:0000024 GO_REF:0000107 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Gdf3 growth differentiation factor 3 involved_in ISO (PMID:18823971) RGD PMID:18823971 NCBI chr 4:157,503,547...157,507,923
Ensembl chr 4:155,830,909...155,835,937 		JBrowse link
G Pax7 paired box 7 acts_upstream_of_or_within ISO MGI:1857831|MGI:3047633 (PMID:23070814) RGD PMID:23070814 NCBI chr 5:157,279,623...157,381,188
Ensembl chr 5:151,999,092...152,097,979 		JBrowse link
G Zfp157 zinc finger protein 157 acts_upstream_of_or_within ISO MGI:4124834 (PMID:22588720) RGD PMID:22588720 NCBI chr12:21,356,253...21,393,006
Ensembl chr12:16,248,230...16,270,698 		JBrowse link
negative regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glis1 GLIS family zinc finger 1 involved_in ISO (PMID:30544251) RGD PMID:30544251 NCBI chr 5:127,450,934...127,640,929
Ensembl chr 5:122,222,128...122,412,141 		JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within ISO MGI:109452 (PMID:16801560) RGD PMID:16801560 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Nkx6-2 NK6 homeobox 2 acts_upstream_of_or_within ISO MGI:2651850 (PMID:11567614) RGD PMID:11567614 NCBI chr 1:203,811,582...203,813,122
Ensembl chr 1:194,381,975...194,383,515 		JBrowse link
G Sostdc1 sclerostin domain containing 1 acts_upstream_of_or_within ISO MGI:3604658 (PMID:22509524) RGD PMID:22509524 NCBI chr 6:53,051,336...53,055,510
Ensembl chr 6:53,051,354...53,055,579 		JBrowse link
G Spdef SAM pointed domain containing ets transcription factor acts_upstream_of_or_within ISO MGI:4398888 (PMID:19759516) RGD PMID:19759516 NCBI chr20:5,773,236...5,787,685
Ensembl chr20:5,771,441...5,785,893 		JBrowse link
negative regulation of cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2149672 (PMID:11425898)		 Ensembl
RGD		 PMID:11425898 GO_REF:0000107 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
negative regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfi1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO MGI:2449921 (PMID:16230531) RGD PMID:16230531 NCBI chr14:2,185,489...2,204,191
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd7 frizzled class receptor 7 involved_in ISO (PMID:18681827) RGD PMID:18681827 NCBI chr 9:68,425,538...68,428,357
Ensembl chr 9:60,930,875...60,935,781 		JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (PMID:18593560) RGD PMID:18593560 NCBI chr 1:143,147,671...143,149,189
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (PMID:18593560) RGD PMID:18593560 NCBI chr 1:143,147,671...143,149,189
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:98956 (PMID:17462603) RGD PMID:17462603 NCBI chr 2:171,387,536...171,395,081
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
negative regulation of retinal cone cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casz1 castor zinc finger 1 acts_upstream_of_or_within ISO MGI:3052661|MGI:4841554 (PMID:25654255) RGD PMID:25654255 NCBI chr 5:164,527,083...164,677,037
Ensembl chr 5:159,243,995...159,393,400 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule involved_in ISO (PMID:24752896) RGD PMID:24752896 NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO
IEA		 (PMID:20696842)
GO_REF:0000107		 RGD
Ensembl		 PMID:20696842 GO_REF:0000107 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lgals1 galectin 1 involved_in ISO
IEA		 (PMID:24752896)
GO_REF:0000107		 RGD
Ensembl		 PMID:24752896 GO_REF:0000107 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Loxl3 lysyl oxidase-like 3 involved_in ISO (PMID:28065600) RGD PMID:28065600 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A involved_in ISO
IEA		 (PMID:20696842)
GO_REF:0000107		 RGD
Ensembl		 PMID:20696842 GO_REF:0000107 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (PMID:21151104) RGD PMID:21151104 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (PMID:24107315) RGD PMID:24107315 NCBI chr13:76,366,790...76,440,673
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
positive regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx6-2 NK6 homeobox 2 acts_upstream_of_or_within ISO MGI:2651850 (PMID:11567614) RGD PMID:11567614 NCBI chr 1:203,811,582...203,813,122
Ensembl chr 1:194,381,975...194,383,515 		JBrowse link
G Spdef SAM pointed domain containing ets transcription factor acts_upstream_of_or_within ISO MGI:4398888 (PMID:19759516) RGD PMID:19759516 NCBI chr20:5,773,236...5,787,685
Ensembl chr20:5,771,441...5,785,893 		JBrowse link
positive regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 acts_upstream_of_or_within ISO (PMID:18635606) RGD PMID:18635606 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO MGI:2449921 (PMID:16230531) RGD PMID:16230531 NCBI chr14:2,185,489...2,204,191
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
G Pax6 paired box 6 IMP RGD PMID:11880342 RGD:729590 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:28262505)		 UniProt
RGD		 PMID:28262505 GO_REF:0000024 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IBA
ISO		 GO_REF:0000033
(PMID:19501566)		 GO_Central
RGD		 PMID:19501566 GO_REF:0000033 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:36171294)		 UniProt
Ensembl
RGD		 PMID:36171294 GO_REF:0000024 GO_REF:0000107 NCBI chr11:84,612,943...84,690,025
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
regulation of cardiac cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox17 SRY-box transcription factor 17 involved_in ISO (PMID:17360443) RGD PMID:17360443 NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmo4 LIM domain only 4 acts_upstream_of_or_within ISO MGI:3664560 (PMID:19323994) RGD PMID:19323994 NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880 		JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esrp1 epithelial splicing regulatory protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29107558)		 UniProt
RGD		 PMID:29107558 GO_REF:0000024 NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062 		JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO MGI:95522 (PMID:16943278) RGD PMID:16943278 NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO MGI:1338938 (PMID:16943278) RGD PMID:16943278 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
regulation of neural crest cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A NOT|involved_in ISO (PMID:15073157) RGD PMID:15073157 NCBI chr16:9,740,751...9,786,861
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    developmental process 7109
      regulation of developmental process 2775
        regulation of cell fate commitment 36
          negative regulation of cell fate commitment + 19
          positive regulation of cell fate commitment + 11
          regulation of R7 cell fate commitment + 0
          regulation of T-helper 17 cell lineage commitment + 12
          regulation of cell fate specification + 13
          regulation of retinal cone cell fate commitment + 1
          regulation of retinal rod cell fate commitment + 0
          regulation of venous endothelial cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 20536
    developmental process 7109
      cellular developmental process 4812
        cell differentiation 4811
          cell fate commitment 290
            regulation of cell fate commitment 36
              negative regulation of cell fate commitment + 19
              positive regulation of cell fate commitment + 11
              regulation of R7 cell fate commitment + 0
              regulation of T-helper 17 cell lineage commitment + 12
              regulation of cell fate specification + 13
              regulation of retinal cone cell fate commitment + 1
              regulation of retinal rod cell fate commitment + 0
              regulation of venous endothelial cell fate commitment + 0
paths to the root