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ONTOLOGY REPORT - ANNOTATIONS

Term:translational attenuation
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Accession:GO:0009386 term browser browse the term
Definition:Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.


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translational attenuation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trap1 TNF receptor-associated protein 1 involved_in ISO
IEA 		(PMID:24113185)
GO_REF:0000107 		RGD
Ensembl		 PMID:24113185 GO_REF:0000107 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        macromolecule metabolic process 9981
          protein metabolic process 5185
            regulation of protein metabolic process 1968
              regulation of translation 483
                translational attenuation 1
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        regulation of cellular process 13032
          regulation of metabolic process 6776
            regulation of biosynthetic process 5581
              regulation of macromolecule biosynthetic process 5373
                regulation of gene expression 5256
                  post-transcriptional regulation of gene expression 766
                    regulation of translation 483
                      translational attenuation 1
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