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ONTOLOGY REPORT - ANNOTATIONS

Term:microtubule severing ATPase activity
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Accession:GO:0008568 term browser browse the term
Definition:Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.
Comment:See also the cellular component term 'katanin complex ; GO:0008352'.
Synonyms:exact_synonym: ATP phosphohydrolase (tubulin-dimerizing)
 narrow_synonym: katanin activity
 xref: EC:5.6.1.1;   MetaCyc:3.6.4.3-RXN;   Reactome:R-HSA-9668419 "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites"


show annotations for term's descendants           Sort by:
microtubule severing ATPase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fign fidgetin, microtubule severing factor enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:48,637,510...48,760,772
Ensembl chr 3:48,642,496...48,760,787 		JBrowse link
G Fignl1 fidgetin-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455 		JBrowse link
G Katna1 katanin catalytic subunit A1 enables IEA
ISO		 GO_REF:0000003
(PMID:10751153)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:10751153 GO_REF:0000003 GO_REF:0000107 NCBI chr 1:2,202,501...2,244,132
Ensembl chr 1:2,202,490...2,244,131 		JBrowse link
G Katnal1 katanin catalytic subunit A1 like 1 enables ISO
ISS		 (PMID:26929214)
GO_REF:0000024
(PMID:22654668)		 RGD
UniProt		 PMID:22654668 PMID:26929214 GO_REF:0000024 NCBI chr12:6,094,663...6,156,114
Ensembl chr12:6,102,836...6,157,553 		JBrowse link
G Katnal2 katanin catalytic subunit A1 like 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:70,531,759...70,607,886
Ensembl chr18:70,531,754...70,608,082 		JBrowse link
G Spast spastin enables IEA
ISS
ISO		 GO_REF:0000003
GO_REF:0000024
(PMID:15716377), (PMID:16219033), (PMID:17389232), (PMID:23745751), (PMID:26875866)
GO_REF:0000104		 UniProt
RGD		 PMID:15716377 PMID:16219033 PMID:17389232 PMID:23745751 PMID:26875866 GO_REF:0000003 GO_REF:0000024 GO_REF:0000104 NCBI chr 6:21,055,349...21,106,586
Ensembl chr 6:21,055,349...21,107,954 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20736
    ATP-dependent activity 628
      microtubule severing ATPase activity 6
Path 2
Term Annotations click to browse term
  molecular_function 20736
    catalytic activity 6109
      catalytic activity, acting on a protein 2507
        microtubule severing ATPase activity 6
paths to the root