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ONTOLOGY REPORT - ANNOTATIONS

Term:sodium:potassium:chloride symporter activity
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Accession:GO:0008511 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).
Synonyms:xref: RHEA:72395;   Reactome:R-HSA-5623588 "Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol";   reactome:R-HSA-426086 "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol"


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sodium:potassium:chloride symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a1 solute carrier family 12 member 1 enables IDA
ISO
IBA
IEA		 (PMID:21321328)
GO_REF:0000033
(PMID:11790783)
GO_REF:0000117		 RGD
GO_Central
UniProt		 PMID:11790783 PMID:21321328 PMID:16291577 GO_REF:0000033 GO_REF:0000117, RGD:1624189 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 enables IMP
ISO
IBA		 (PMID:33597714)
GO_REF:0000033		 RGD
GO_Central		 PMID:33597714 PMID:12556450 GO_REF:0000033, RGD:1580435 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21087
    transporter activity 1269
      transmembrane transporter activity 1162
        monoatomic ion transmembrane transporter activity 770
          monoatomic cation transmembrane transporter activity 651
            solute:monoatomic cation symporter activity 117
              solute:sodium symporter activity 85
                potassium:sodium symporter activity 3
                  sodium:potassium:chloride symporter activity 3
Path 2
Term Annotations click to browse term
  molecular_function 21087
    transporter activity 1269
      transmembrane transporter activity 1162
        active transmembrane transporter activity 449
          secondary active transmembrane transporter activity 293
            symporter activity 143
              solute:monoatomic cation symporter activity 117
                monoatomic anion:monoatomic cation symporter activity 26
                  chloride:monoatomic cation symporter activity 23
                    sodium:chloride symporter activity 17
                      sodium:potassium:chloride symporter activity 3
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