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ONTOLOGY REPORT - ANNOTATIONS

Term:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity
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Accession:GO:0008425 term browser browse the term
Definition:Catalysis of the reaction: a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+.
Comment:Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
Synonyms:exact_synonym: 2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity;   2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity;   coenzyme Q biosynthesis methyltransferase activity;   coenzyme Q biosynthetic process methyltransferase activity
 broad_synonym: ubiquinone biosynthesis methyltransferase activity;   ubiquinone biosynthetic process methyltransferase activity
 xref: EC:2.1.1.201;   RHEA:28286;   Reactome:R-HSA-2162188 "COQ5 methylates MDMQ10H2"

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2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COQ5 coenzyme Q5, methyltransferase enables IEA UniProt
RHEA
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Ensembl		 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 NCBI chr11:115,858,488...115,882,184
Ensembl chr11:115,856,817...115,882,181 		JBrowse link
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  molecular_function 19851
    catalytic activity 6522
      transferase activity 2491
        transferase activity, transferring one-carbon groups 211
          methyltransferase activity 199
            C-methyltransferase activity 6
              2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity 1
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