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ONTOLOGY REPORT - ANNOTATIONS

Term:tRNA methyltransferase activity
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Accession:GO:0008175 term browser browse the term
Definition:Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.
Synonyms:xref: reactome:R-HSA-6782879 "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6782881 "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6782890 "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6783473 "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)";   reactome:R-HSA-6786500 "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34";   reactome:R-HSA-6786567 "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine"


show annotations for term's descendants           Sort by:
tRNA methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh8 alkB homolog 8, tRNA methyltransferase enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 6:6,121,402...6,198,226
Ensembl chr 6:378,100...452,165 		JBrowse link
G Bcdin3d BCDIN3 domain containing RNA methyltransferase enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:28119416), (PMID:31919512)		 UniProt
Ensembl
RGD		 PMID:28119416 PMID:31919512 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:132,484,404...132,488,998
Ensembl chr 7:130,605,541...130,610,115 		JBrowse link
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000104
GO_REF:0000002		 GO_Central
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr  X:14,243,684...14,256,555
Ensembl chr  X:14,244,050...14,252,030 		JBrowse link
G Lcmt2 leucine carboxyl methyltransferase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:108,099,960...108,102,084
Ensembl chr 3:108,099,961...108,102,084 		JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 enables ISO (PMID:16424344)
MGI:3695409 (PMID:16424344)		 RGD PMID:16424344 NCBI chr17:81,510,740...81,554,036
Ensembl chr17:76,610,543...76,645,439 		JBrowse link
G Trmt12 tRNA methyltransferase 12 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:90,417,846...90,419,472
Ensembl chr 7:90,417,862...90,419,867 		JBrowse link
G Trmt13 tRNA methyltransferase 13 homolog enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:204,533,630...204,547,711
Ensembl chr 2:204,533,632...204,546,843 		JBrowse link
G Trmt5 tRNA methyltransferase 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:91,963,558...91,987,660
Ensembl chr 6:91,943,724...91,987,555 		JBrowse link
G Trmt9b tRNA methyltransferase 9B (putative) enables ISO
IEA		 (PMID:23381944)
GO_REF:0000117		 RGD
UniProt		 PMID:23381944 GO_REF:0000117 NCBI chr16:62,439,625...62,495,526
Ensembl chr16:55,743,018...55,792,144 		JBrowse link
G Tyw3 tRNA-yW synthesizing protein 3 homolog enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:243,529,912...243,552,043
Ensembl chr 2:243,529,946...243,552,039 		JBrowse link
tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh8 alkB homolog 8, tRNA methyltransferase enables IBA
ISO		 GO_REF:0000033
(PMID:20583019)		 GO_Central
RGD		 PMID:20583019 GO_REF:0000033 NCBI chr 6:6,121,402...6,198,226
Ensembl chr 6:378,100...452,165 		JBrowse link
G Trmt9b tRNA methyltransferase 9B (putative) enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:62,439,625...62,495,526
Ensembl chr16:55,743,018...55,792,144 		JBrowse link
tRNA (adenine(58)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt61a tRNA methyltransferase 61A enables IEA GO_REF:0000116
GO_REF:0000002
GO_REF:0000003		 RHEA
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr 6:130,737,230...130,743,251
Ensembl chr 6:130,737,219...130,743,243 		JBrowse link
tRNA (adenine(9)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt10c tRNA methyltransferase 10C, mitochondrial RNase P subunit enables ISO
IEA		 (PMID:23042678)
GO_REF:0000003
GO_REF:0000116
GO_REF:0000107		 RGD
UniProt
RHEA
Ensembl		 PMID:23042678 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr11:44,584,388...44,589,466
Ensembl chr11:44,584,113...44,589,568 		JBrowse link
tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 enables ISO
IEA		 (PMID:25404562), (PMID:26310293), (PMID:36720500)
GO_REF:0000116
GO_REF:0000107
GO_REF:0000003
GO_REF:0000117		 RGD
RHEA
Ensembl
UniProt		 PMID:25404562 PMID:26310293 PMID:36720500 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 NCBI chr  X:14,243,684...14,256,555
Ensembl chr  X:14,244,050...14,252,030 		JBrowse link
tRNA (cytidine-3-)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl2 methyltransferase like 2 enables ISO
IEA
IBA		 (PMID:28655767), (PMID:34268557)
GO_REF:0000107
GO_REF:0000033
MGI:5903740 (PMID:28655767)		 RGD
Ensembl
GO_Central		 PMID:28655767 PMID:34268557 GO_REF:0000033 GO_REF:0000107 NCBI chr10:90,095,527...90,109,354
Ensembl chr10:90,095,527...90,119,528 		JBrowse link
G Mettl6 methyltransferase 6, tRNA N3-cytidine enables ISO
IEA		 (PMID:32923617), (PMID:34268557), (PMID:34862464), (PMID:34922197)
GO_REF:0000107
MGI:5903741 (PMID:28655767)		 RGD
Ensembl		 PMID:28655767 PMID:32923617 PMID:34268557 PMID:34862464 PMID:34922197 GO_REF:0000107 NCBI chr16:6,683,820...6,699,013
Ensembl chr16:6,583,465...6,698,975 		JBrowse link
G Mettl8 methyltransferase 8, tRNA N3-cytidine enables ISO
IBA		 (PMID:34774131), (PMID:35017528)
GO_REF:0000033		 RGD
GO_Central		 PMID:34774131 PMID:35017528 GO_REF:0000033 NCBI chr 3:55,731,453...55,863,652
Ensembl chr 3:55,770,167...55,863,676 		JBrowse link
tRNA (cytidine-5-)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsun2 NOP2/Sun RNA methyltransferase 2 enables ISO
IEA
IBA		 (PMID:17071714), (PMID:31287866), (PMID:34556860)
GO_REF:0000107
GO_REF:0000002
(PMID:22885326), (PMID:23871666), (PMID:31276587), (PMID:31287866)
GO_REF:0000033		 RGD
Ensembl
InterPro
GO_Central		 PMID:17071714 PMID:22885326 PMID:23871666 PMID:31276587 PMID:31287866 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:35,490,583...35,514,839
Ensembl chr 1:33,662,139...33,685,862 		JBrowse link
G Nsun3 NOP2/Sun RNA methyltransferase 3 enables ISO (PMID:27214402), (PMID:27356879), (PMID:27497299) RGD PMID:27214402 PMID:27356879 PMID:27497299 NCBI chr11:37,490,832...37,575,607
Ensembl chr11:37,490,838...37,568,543 		JBrowse link
G Nsun6 NOP2/Sun RNA methyltransferase 6 enables ISO
IEA		 (PMID:26160102), (PMID:27703015), (PMID:28531330), (PMID:37226891)
GO_REF:0000107		 RGD
Ensembl		 PMID:26160102 PMID:27703015 PMID:28531330 PMID:37226891 GO_REF:0000107 NCBI chr17:77,912,374...77,955,694
Ensembl chr17:77,912,377...77,950,006 		JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 enables ISS
ISO		 GO_REF:0000024
(PMID:22885326), (PMID:26271101)
(PMID:16424344), (PMID:18567810)		 UniProt
RGD		 PMID:16424344 PMID:18567810 PMID:22885326 PMID:26271101 GO_REF:0000024 NCBI chr17:81,510,740...81,554,036
Ensembl chr17:76,610,543...76,645,439 		JBrowse link
tRNA (guanine(10)-N2)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt11 tRNA methyltransferase 11 homolog enables IEA
ISO
ISS		 GO_REF:0000002
GO_REF:0000116
(PMID:37283053)
GO_REF:0000024		 InterPro
RHEA
RGD
UniProt		 PMID:37283053 GO_REF:0000002 GO_REF:0000024 GO_REF:0000116 NCBI chr 1:27,054,437...27,109,765
Ensembl chr 1:27,054,420...27,201,610 		JBrowse link
tRNA (guanine(18)-2'-O)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tarbp1 TAR (HIV-1) RNA binding protein 1 enables IEA
ISO		 GO_REF:0000107
(PMID:38867004)		 Ensembl
RGD		 PMID:38867004 GO_REF:0000107 NCBI chr19:54,398,268...54,449,293
Ensembl chr19:54,398,253...54,449,261 		JBrowse link
tRNA (guanine(26)-N2)-dimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt1 tRNA methyltransferase 1 enables IEA
ISO		 GO_REF:0000003
(PMID:10982862), (PMID:28784718), (PMID:31898845), (PMID:37204604), (PMID:39786990)
GO_REF:0000116
GO_REF:0000104
GO_REF:0000107		 UniProt
RGD
RHEA
Ensembl		 PMID:10982862 PMID:28784718 PMID:31898845 PMID:37204604 PMID:39786990 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 NCBI chr19:40,361,583...40,374,971
Ensembl chr19:23,456,756...23,466,956 		JBrowse link
tRNA (guanine(37)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt5 tRNA methyltransferase 5 enables IEA GO_REF:0000116
GO_REF:0000002
GO_REF:0000104
GO_REF:0000003		 RHEA
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000116 NCBI chr 6:91,963,558...91,987,660
Ensembl chr 6:91,943,724...91,987,555 		JBrowse link
tRNA (guanine(46)-N7)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl1 methyltransferase 1, tRNA methylguanosine enables ISO
IEA
IBA		 (PMID:12403464), (PMID:15861136), (PMID:36599982), (PMID:36599985), (PMID:37369656)
GO_REF:0000002
GO_REF:0000003
GO_REF:0000104
GO_REF:0000107
GO_REF:0000033		 RGD
InterPro
UniProt
Ensembl
GO_Central		 PMID:12403464 PMID:15861136 PMID:36599982 PMID:36599985 PMID:37369656 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 7:64,750,189...64,754,531
Ensembl chr 7:62,864,853...62,869,202 		JBrowse link
tRNA (guanine(6)-N2)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thumpd3 THUMP domain containing 3 enables ISO
IEA		 (PMID:34669960), (PMID:37283053)
GO_REF:0000107		 RGD
Ensembl		 PMID:34669960 PMID:37283053 GO_REF:0000107 NCBI chr 4:146,185,422...146,209,802
Ensembl chr 4:146,185,503...146,211,246 		JBrowse link
tRNA (guanine(7)-N2)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thumpd3 THUMP domain containing 3 enables ISO
IEA		 (PMID:34669960)
GO_REF:0000107		 RGD
Ensembl		 PMID:34669960 GO_REF:0000107 NCBI chr 4:146,185,422...146,209,802
Ensembl chr 4:146,185,503...146,211,246 		JBrowse link
tRNA (guanine) methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 enables ISO
IEA		 (PMID:32558197)
GO_REF:0000107		 RGD
Ensembl		 PMID:32558197 GO_REF:0000107 NCBI chr  X:14,243,684...14,256,555
Ensembl chr  X:14,244,050...14,252,030 		JBrowse link
G Tarbp1 TAR (HIV-1) RNA binding protein 1 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr19:54,398,268...54,449,293
Ensembl chr19:54,398,253...54,449,261 		JBrowse link
G Thumpd2 THUMP domain containing 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:13,924,742...13,976,657
Ensembl chr 6:13,924,765...13,976,657 		JBrowse link
G Thumpd3 THUMP domain containing 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:146,185,422...146,209,802
Ensembl chr 4:146,185,503...146,211,246 		JBrowse link
G Trmt1 tRNA methyltransferase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:40,361,583...40,374,971
Ensembl chr19:23,456,756...23,466,956 		JBrowse link
G Trmt11 tRNA methyltransferase 11 homolog enables IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:27,054,437...27,109,765
Ensembl chr 1:27,054,420...27,201,610 		JBrowse link
G Trmt1l tRNA methyltransferase 1-like enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:63,510,097...63,543,268
Ensembl chr13:63,510,204...63,543,266 		JBrowse link
tRNA (guanosine(9)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt10a tRNA methyltransferase 10A enables IEA
ISO		 GO_REF:0000003
GO_REF:0000116
(PMID:23042678), (PMID:32392304)
GO_REF:0000107		 UniProt
RHEA
RGD
Ensembl		 PMID:23042678 PMID:32392304 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr 2:226,669,445...226,684,166
Ensembl chr 2:226,669,832...226,684,151 		JBrowse link
G Trmt10b tRNA methyltransferase 10B enables IEA
ISO		 GO_REF:0000107
GO_REF:0000116
GO_REF:0000003
(PMID:23042678)		 Ensembl
RHEA
UniProt
RGD		 PMID:23042678 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr 5:64,344,491...64,368,175
Ensembl chr 5:59,548,869...59,572,526 		JBrowse link
G Trmt10c tRNA methyltransferase 10C, mitochondrial RNase P subunit enables ISO
IEA		 (PMID:23042678)
GO_REF:0000003
GO_REF:0000116
GO_REF:0000107		 RGD
UniProt
RHEA
Ensembl		 PMID:23042678 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr11:44,584,388...44,589,466
Ensembl chr11:44,584,113...44,589,568 		JBrowse link
tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmo tRNA methyltransferase O enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000116
(PMID:25063302)		 UniProt
RHEA
RGD		 PMID:25063302 GO_REF:0000024 GO_REF:0000116 NCBI chr 5:60,663,106...60,676,423
Ensembl chr 5:60,667,864...60,676,423 		JBrowse link
tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt2a tRNA methyltransferase 2 homolog A enables ISO
IEA		 (PMID:31361898), (PMID:33799331)
GO_REF:0000107		 RGD
Ensembl		 PMID:31361898 PMID:33799331 GO_REF:0000107 NCBI chr11:96,241,998...96,246,719
Ensembl chr11:82,737,689...82,742,336 		JBrowse link
G Trmt2b tRNA methyltransferase 2 homolog B enables ISO (PMID:31948311)
(PMID:31736397)		 RGD PMID:31736397 PMID:31948311 NCBI chr  X:101,716,656...101,777,105 JBrowse link
tRNA (uridine) methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh8 alkB homolog 8, tRNA methyltransferase enables ISO (PMID:20308323)
(PMID:20123966)		 RGD PMID:20123966 PMID:20308323 NCBI chr 6:6,121,402...6,198,226
Ensembl chr 6:378,100...452,165 		JBrowse link
G Trmt44 tRNA methyltransferase 44 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000104		 GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000104 NCBI chr14:79,399,943...79,424,761
Ensembl chr14:75,182,029...75,200,147 		JBrowse link
tRNA 2'-O-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftsj1 FtsJ RNA 2'-O-methyltransferase 1 enables ISO (PMID:25404562), (PMID:26310293) RGD PMID:25404562 PMID:26310293 NCBI chr  X:14,243,684...14,256,555
Ensembl chr  X:14,244,050...14,252,030 		JBrowse link
G Trmt13 tRNA methyltransferase 13 homolog enables IEA GO_REF:0000104
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr 2:204,533,630...204,547,711
Ensembl chr 2:204,533,632...204,546,843 		JBrowse link
tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt44 tRNA methyltransferase 44 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:79,399,943...79,424,761
Ensembl chr14:75,182,029...75,200,147 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      catalytic activity, acting on a nucleic acid 651
        catalytic activity, acting on RNA 411
          RNA methyltransferase activity 64
            tRNA methyltransferase activity 31
              tRNA (adenine) methyltransferase activity + 3
              tRNA (cytidine) methyltransferase activity + 8
              tRNA (guanine) methyltransferase activity + 12
              tRNA (uridine) methyltransferase activity + 5
              tRNA 2'-O-methyltransferase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 21100
    catalytic activity 6213
      transferase activity 2476
        transferase activity, transferring one-carbon groups 215
          methyltransferase activity 204
            RNA methyltransferase activity 64
              tRNA methyltransferase activity 31
                tRNA (adenine) methyltransferase activity + 3
                tRNA (cytidine) methyltransferase activity + 8
                tRNA (guanine) methyltransferase activity + 12
                tRNA (uridine) methyltransferase activity + 5
                tRNA 2'-O-methyltransferase activity 2
paths to the root