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ONTOLOGY REPORT - ANNOTATIONS

Term:synaptic transmission, cholinergic
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Accession:GO:0007271 term browser browse the term
Definition:The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IMP RGD PMID:15297571 RGD:1625662 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Anxa9 annexin A9 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 acts_upstream_of_or_within ISO MGI:1888740 (PMID:10944224) RGD PMID:10944224 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit acts_upstream_of_or_within TAS
IEA
ISO 		GO_REF:0000107
MGI:3774038 (PMID:18077337) 		Ensembl
RGD		 PMID:18077337 PMID:12117536 GO_REF:0000107, RGD:632442 NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476 		JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit involved_in
acts_upstream_of_or_within 		IEA
ISO
IBA 		GO_REF:0000108
MGI:2155602 (PMID:16162937)
GO_REF:0000033 		GOC
RGD
GO_Central		 PMID:16162937 GO_REF:0000033 GO_REF:0000108 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit involved_in
acts_upstream_of_or_within 		IMP
ISO
IDA
ISS
IBA 		(PMID:17132685), (PMID:27698419), (PMID:29720657), (PMID:38454578)
PMID:9882698
PMID:22593584
GO_REF:0000024
MGI:2158758 (PMID:11226318), (PMID:11906696)
GO_REF:0000033 		RGD
UniProt
GO_Central		 PMID:11226318 PMID:11906696 PMID:17132685 PMID:27698419 PMID:29720657 More... GO_REF:0000024 GO_REF:0000033, RGD:1358635, RGD:596936194, RGD:596936208 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit involved_in IEA
IBA 		GO_REF:0000108
GO_REF:0000033 		GOC
GO_Central		 GO_REF:0000033 GO_REF:0000108 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit acts_upstream_of_or_within
involved_in 		IMP
IEA
IDA
ISO 		GO_REF:0000107
PMID:17510177
UniProtKB:P05067 (PMID:20164328)
MGI:1888407 (PMID:9364063) 		Ensembl
RGD		 PMID:9364063 PMID:20164328 PMID:15044058 PMID:17510177 GO_REF:0000107, RGD:1600975, RGD:596936198 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit involved_in ISO
IEA 		(PMID:8872460)
GO_REF:0000107 		RGD
Ensembl		 PMID:8872460 GO_REF:0000107 NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit involved_in IMP
ISO
ISS 		(PMID:17132685), (PMID:27698419), (PMID:29720657), (PMID:38454578)
GO_REF:0000024 		RGD
UniProt		 PMID:17132685 PMID:27698419 PMID:29720657 PMID:38454578 PMID:12754307 GO_REF:0000024, RGD:1358637 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:87,862,417...87,870,833
Ensembl chr 9:87,862,407...87,870,833 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:55,331,211...55,339,923
Ensembl chr10:55,331,212...55,335,530 		JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 9:87,878,085...87,884,193
Ensembl chr 9:87,878,085...87,914,482 		JBrowse link
G Dmd dystrophin acts_upstream_of_positive_effect ISO
IEA 		MGI:1856328 (PMID:9334395)
GO_REF:0000107 		RGD
Ensembl		 PMID:9334395 GO_REF:0000107 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Lynx1 Ly6/neurotoxin 1 acts_upstream_of_or_within ISO (PMID:19246390) RGD PMID:19246390 NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023 		JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 acts_upstream_of_or_within ISO (PMID:19246390) RGD PMID:19246390 NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493 		JBrowse link
G Rapsn receptor-associated protein of the synapse acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		UniProtKB:Q9GZZ6 (PMID:18420419)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:18420419 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:77,015,073...77,024,378
Ensembl chr 3:76,983,471...77,024,373 		JBrowse link
G Ric3 RIC3 acetylcholine receptor chaperone acts_upstream_of_or_within
involved_in 		IGI
IBA 		PMID:18420419
GO_REF:0000033 		GO_Central PMID:18420419 GO_REF:0000033, RGD:2317082 NCBI chr 1:163,030,621...163,086,583
Ensembl chr 1:163,032,158...163,086,519 		JBrowse link
G Slc5a7 solute carrier family 5 member 7 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
MGI:3045463 (PMID:15173594), (PMID:16162937) 		GO_Central
Ensembl
RGD		 PMID:15173594 PMID:16162937 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258 		JBrowse link
negative regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr6 5-hydroxytryptamine receptor 6 IMP RGD PMID:16987217 RGD:2317005 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912 		JBrowse link
positive regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IMP phrenic nerve terminals in the presence of adenosine transport inhibitor deoxycoformycin RGD PMID:12679375 RGD:1625693 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C IMP RGD PMID:15266551 RGD:1625007 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 involved_in ISS
ISO 		GO_REF:0000024
(PMID:19635813) 		UniProt
RGD		 PMID:19635813 GO_REF:0000024 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Tacr2 tachykinin receptor 2 IMP RGD PMID:12747940 RGD:5147477 NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446 		JBrowse link
positive regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma IDA RGD PMID:1900518 RGD:2311499 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Lama2 laminin subunit alpha 2 acts_upstream_of_or_within ISO
IEA 		MGI:1856026 (PMID:8568931)
GO_REF:0000107 		RGD
Ensembl		 PMID:8568931 GO_REF:0000107 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530 		JBrowse link
G Musk muscle associated receptor tyrosine kinase IMP RGD PMID:16870737 RGD:2317092 NCBI chr 5:73,058,427...73,169,696
Ensembl chr 5:73,058,121...73,171,932 		JBrowse link
G Nalcn sodium leak channel, non-selective involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:100,398,583...100,741,243
Ensembl chr15:100,398,615...100,741,001 		JBrowse link
G Ngfr nerve growth factor receptor IMP medial septum and diagonal band of Broca (MS-DBB) neurons stimulated by NGF RGD PMID:18256260 RGD:5508750 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Tac1 tachykinin, precursor 1 IDA RGD PMID:17949415 RGD:2304335 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:17949415 RGD:2304335 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:15944374 RGD:2306844 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237 		JBrowse link
regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209|MGI:2181384 (PMID:10686170), (PMID:12624181) RGD PMID:10686170 PMID:12624181 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit acts_upstream_of_or_within ISO MGI:2155602 (PMID:16162937) RGD PMID:16162937 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) RGD PMID:19332541 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cell communication 7907
        cell-cell signaling 1491
          synaptic signaling 1011
            trans-synaptic signaling 967
              anterograde trans-synaptic signaling 959
                chemical synaptic transmission 959
                  synaptic transmission, cholinergic 38
                    acetylcholine catabolic process in synaptic cleft 0
                    acetylcholine secretion, neurotransmission + 7
                    negative regulation of synaptic transmission, cholinergic + 1
                    positive regulation of synaptic transmission, cholinergic + 12
                    regulation of synaptic transmission, cholinergic + 16
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        signaling 7874
          cell-cell signaling 1491
            synaptic signaling 1011
              trans-synaptic signaling 967
                anterograde trans-synaptic signaling 959
                  chemical synaptic transmission 959
                    synaptic transmission, cholinergic 38
                      acetylcholine catabolic process in synaptic cleft 0
                      acetylcholine secretion, neurotransmission + 7
                      negative regulation of synaptic transmission, cholinergic + 1
                      positive regulation of synaptic transmission, cholinergic + 12
                      regulation of synaptic transmission, cholinergic + 16
paths to the root