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ONTOLOGY REPORT - ANNOTATIONS


Term:epidermal growth factor catabolic process
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Accession:GO:0007174 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor.
Comment:This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'.
Synonyms:exact_synonym: EGF breakdown;   EGF catabolism;   epidermal growth factor breakdown;   epidermal growth factor catabolism
 related_synonym: EGF receptor ligand processing;   epidermal growth factor ligand processing;   intracellular EGF processing;   receptor-mediated EGF processing



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epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:18272684)
(PMID:16282324)
RGD PMID:16282324 PMID:18272684 NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:120,461,963...120,506,889
JBrowse link
G Snx5 sorting nexin 5 IDA RGD PMID:16487940 RGD:13508623 NCBI chr 3:152,075,258...152,094,508
Ensembl chr 3:131,621,880...131,641,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      metabolic process 12160
        catabolic process 2919
          macromolecule catabolic process 1678
            protein catabolic process 1199
              epidermal growth factor catabolic process 2
Path 2
Term Annotations click to browse term
  biological_process 20536
    biological regulation 13822
      regulation of biological process 13376
        regulation of cellular process 13014
          signal transduction 7251
            cell surface receptor signaling pathway 2882
              enzyme-linked receptor protein signaling pathway 1062
                cell surface receptor protein tyrosine kinase signaling pathway 671
                  ERBB signaling pathway 177
                    regulation of ERBB signaling pathway 77
                      negative regulation of ERBB signaling pathway 35
                        negative regulation of epidermal growth factor receptor signaling pathway 32
                          epidermal growth factor catabolic process 2
paths to the root