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ONTOLOGY REPORT - ANNOTATIONS


Term:protein catabolic process in the vacuole
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Accession:GO:0007039 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases.
Synonyms:related_synonym: vacuolar protein breakdown;   vacuolar protein catabolic process;   vacuolar protein catabolism;   vacuolar protein degradation



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protein catabolic process in the vacuole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within ISO MGI:1856973 (PMID:23704209) RGD PMID:23704209 NCBI chr 1:210,556,270...210,568,021 JBrowse link
lysosomal protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap5z1 adaptor related protein complex 5 subunit zeta 1 acts_upstream_of_or_within ISO MGI:4460281 (PMID:30930081) RGD PMID:30930081 NCBI chr12:12,093,834...12,109,043 JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr 9:36,650,384...36,654,348 JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (PMID:10527801), (PMID:17855597) RGD PMID:10527801 PMID:17855597 NCBI chr 1:181,156,071...181,169,458 JBrowse link
G Cst7 cystatin F involved_in ISO (PMID:15752368), (PMID:22365146) RGD PMID:15752368 PMID:22365146 NCBI chr 3:139,396,830...139,405,557 JBrowse link
G Ctsh cathepsin H involved_in ISO (PMID:15752368) RGD PMID:15752368 NCBI chr 8:99,488,756...99,507,639 JBrowse link
G Dpp7 dipeptidylpeptidase 7 acts_upstream_of_or_within ISO (PMID:28728022) RGD PMID:28728022 NCBI chr 3:28,563,240...28,567,492 JBrowse link
G Grn granulin precursor acts_upstream_of_or_within ISO MGI:3762618 (PMID:28728022) RGD PMID:28728022 NCBI chr10:87,387,672...87,393,777 JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in ISO
ISS
IEA
(PMID:24880125)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:24880125 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:122,038,734...122,087,745 JBrowse link
G Mfsd8 major facilitator superfamily domain containing 8 acts_upstream_of_or_within ISO (PMID:27654426) RGD PMID:27654426 NCBI chr 2:123,822,042...123,847,808 JBrowse link
G Mgat3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase acts_upstream_of ISO MGI:1857830 (PMID:25592972), (PMID:26467158) RGD PMID:25592972 PMID:26467158 NCBI chr 7:111,708,353...111,761,825 JBrowse link
G Psap prosaposin acts_upstream_of_or_within ISO (PMID:12813057) RGD PMID:12813057 NCBI chr20:28,756,951...28,783,422 JBrowse link
G Slc17a9 solute carrier family 17 member 9 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:24962569)
Ensembl
RGD
PMID:24962569 GO_REF:0000107 NCBI chr 3:188,211,106...188,233,553 JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within ISO MGI:5319917 (PMID:28728022) RGD PMID:28728022 NCBI chr 4:41,328,125...41,347,315 JBrowse link
G Tmem199 transmembrane protein 199 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:28296633)
UniProt
Ensembl
RGD
PMID:28296633 GO_REF:0000024 GO_REF:0000107 NCBI chr10:63,402,493...63,407,065 JBrowse link
G Tpp1 tripeptidyl peptidase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:28728022)
Ensembl
RGD
PMID:28728022 GO_REF:0000107 NCBI chr 1:160,097,984...160,104,108 JBrowse link
G Vps13a vacuolar protein sorting 13 homolog A involved_in ISO (PMID:30709847) RGD PMID:30709847 NCBI chr 1:223,328,784...223,555,500 JBrowse link
negative regulation of lysosomal protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Laptm4b lysosomal protein transmembrane 4 beta involved_in ISO
IEA
ISS
(PMID:25588945)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:25588945 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:65,434,525...65,477,386 JBrowse link
G Mgat3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase acts_upstream_of_or_within ISS
ISO
GO_REF:0000024
MGI:1857830 (PMID:25592972), (PMID:26467158)
UniProt
RGD
PMID:25592972 PMID:26467158 GO_REF:0000024 NCBI chr 7:111,708,353...111,761,825 JBrowse link
G Usp8 ubiquitin specific peptidase 8 involved_in ISO (PMID:27444016) RGD PMID:27444016 NCBI chr 3:113,962,136...114,009,683 JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (PMID:26203154) RGD PMID:26203154 NCBI chr19:21,765,771...21,801,620 JBrowse link
positive regulation of lysosomal protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldlr low density lipoprotein receptor involved_in IEA
ISO
GO_REF:0000107
(PMID:22383525)
Ensembl
RGD
PMID:22383525 GO_REF:0000107 NCBI chr 8:20,270,020...20,292,981 JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO
IEA
(PMID:23152628)
GO_REF:0000107
RGD
Ensembl
PMID:23152628 GO_REF:0000107 NCBI chr 7:65,265,639...65,346,196 JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in ISO (PMID:9228033) RGD PMID:9228033 NCBI chr 3:54,189,305...54,346,769 JBrowse link
G Marchf2 membrane associated ring-CH-type finger 2 involved_in ISO
IEA
(PMID:29573664)
GO_REF:0000107
RGD
Ensembl
PMID:29573664 GO_REF:0000107 NCBI chr 7:14,480,605...14,507,821 JBrowse link
positive regulation of protein catabolic process in the vacuole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISO
IEA
(PMID:25635054)
GO_REF:0000107
RGD
Ensembl
PMID:25635054 GO_REF:0000107 NCBI chr 1:207,665,274...207,681,094 JBrowse link
regulation of lysosomal protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO UniProtKB:Q9CTG6 (PMID:23499937), (PMID:24334770)
(PMID:24334770)
RGD PMID:23499937 PMID:24334770 NCBI chr 5:153,292,722...153,312,143 JBrowse link
G Mfsd8 major facilitator superfamily domain containing 8 acts_upstream_of_or_within ISO (PMID:29514215) RGD PMID:29514215 NCBI chr 2:123,822,042...123,847,808 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      metabolic process 12157
        catabolic process 2918
          macromolecule catabolic process 1678
            protein catabolic process 1194
              protein catabolic process in the vacuole 26
                lysosomal protein catabolic process + 24
                negative regulation of protein catabolic process in the vacuole + 4
                positive regulation of protein catabolic process in the vacuole + 5
                regulation of protein catabolic process in the vacuole + 11
paths to the root