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ONTOLOGY REPORT - ANNOTATIONS

Term:microtubule nucleation
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Accession:GO:0007020 term browser browse the term
Definition:The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).
Synonyms:xref: Wikipedia:Microtubule_nucleation


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microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC125920.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr19:54,975,097...54,975,705 JBrowse link
G Akap9 A-kinase anchoring protein 9 involved_in ISO
IBA		 (PMID:19242490)
GO_REF:0000033		 RGD
GO_Central		 PMID:19242490 GO_REF:0000033 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606 		JBrowse link
G Ccdc57 coiled-coil domain containing 57 involved_in ISO
IBA		 (PMID:32402286)
GO_REF:0000033		 RGD
GO_Central		 PMID:32402286 GO_REF:0000033 NCBI chr10:106,092,784...106,196,405
Ensembl chr10:106,092,947...106,196,077 		JBrowse link
G Ccdc66 coiled-coil domain containing 66 involved_in IEA
ISO		 GO_REF:0000107
(PMID:35849559)		 Ensembl
RGD		 PMID:35849559 GO_REF:0000107 NCBI chr16:2,668,810...2,700,717
Ensembl chr16:2,662,131...2,694,023 		JBrowse link
G Clasp1 cytoplasmic linker associated protein 1 involved_in ISO (PMID:17543864) RGD PMID:17543864 NCBI chr13:32,046,362...32,267,954
Ensembl chr13:29,493,596...29,715,146 		JBrowse link
G Clasp2 cytoplasmic linker associated protein 2 involved_in ISO
ISS		 (PMID:17543864)
GO_REF:0000024		 RGD
UniProt		 PMID:17543864 GO_REF:0000024 NCBI chr 8:122,555,532...122,736,934
Ensembl chr 8:113,677,284...113,858,731 		JBrowse link
G Csnk1d casein kinase 1, delta acts_upstream_of_or_within ISO (PMID:24648492) RGD PMID:24648492 NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614 		JBrowse link
G Golga2 golgin A2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19242490), (PMID:26165940)		 UniProt
RGD		 PMID:19242490 PMID:26165940 GO_REF:0000024 NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279 		JBrowse link
G Haus2 HAUS augmin like complex subunit 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:107,553,146...107,565,982
Ensembl chr 3:107,553,161...107,565,157 		JBrowse link
G Haus2-ps1 HAUS augmin like complex subunit 2, pseudogene 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:54,975,001...54,975,705
Ensembl chr19:54,975,097...54,975,705 		JBrowse link
G Nde1 nudE neurodevelopment protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
(PMID:11163258)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:11163258 GO_REF:0000033 GO_REF:0000107 NCBI chr10:839,788...883,946
Ensembl chr10:839,788...883,869 		JBrowse link
G Ndel1 nudE neurodevelopment protein 1-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:54,001,435...54,080,909
Ensembl chr10:53,516,491...53,570,907 		JBrowse link
G Nedd1 NEDD1 gamma-tubulin ring complex targeting factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:27,233,050...27,274,486
Ensembl chr 7:27,233,316...27,274,486 		JBrowse link
G Pcnt pericentrin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:12,190,597...12,278,723
Ensembl chr20:12,191,648...12,278,710 		JBrowse link
G Slain1 SLAIN motif family, member 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:80,482,818...80,542,461
Ensembl chr15:80,482,367...80,542,350 		JBrowse link
G Slain2 SLAIN motif family, member 2 involved_in ISO
IBA		 (PMID:21646404)
GO_REF:0000033		 RGD
GO_Central		 PMID:21646404 GO_REF:0000033 NCBI chr14:35,236,034...35,314,186
Ensembl chr14:35,236,041...35,304,678 		JBrowse link
G Ssna1 SS nuclear autoantigen 1 involved_in ISO (PMID:34970964) RGD PMID:34970964 NCBI chr 3:28,483,107...28,484,571
Ensembl chr 3:8,084,974...8,086,356 		JBrowse link
G Tpx2 TPX2, microtubule nucleation factor involved_in ISO (PMID:26414402) RGD PMID:26414402 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468 		JBrowse link
G Tubg1 tubulin, gamma 1 involved_in TAS
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:10470852 GO_REF:0000033, RGD:634415 NCBI chr10:86,052,845...86,059,436
Ensembl chr10:86,052,743...86,059,433 		JBrowse link
G Tubg2 tubulin, gamma 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:86,091,205...86,108,053
Ensembl chr10:86,091,188...86,097,580 		JBrowse link
G Tubgcp2 tubulin gamma complex component 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:194,791,113...194,817,807
Ensembl chr 1:194,792,142...194,817,619 		JBrowse link
G Tubgcp3 tubulin gamma complex component 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:76,851,859...76,912,499
Ensembl chr16:76,851,810...76,912,499 		JBrowse link
G Tubgcp4 tubulin gamma complex component 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:108,141,081...108,172,207
Ensembl chr 3:108,141,625...108,169,437 		JBrowse link
G Tubgcp5 tubulin gamma complex component 5 involved_in ISO
IBA		 (PMID:11694571)
GO_REF:0000033		 RGD
GO_Central		 PMID:11694571 GO_REF:0000033 NCBI chr 1:106,636,526...106,672,175
Ensembl chr 1:106,636,526...106,672,175 		JBrowse link
G Tubgcp6 tubulin gamma complex component 6 involved_in ISO
IBA		 (PMID:11694571)
GO_REF:0000033		 RGD
GO_Central		 PMID:11694571 GO_REF:0000033 NCBI chr 7:120,177,686...120,198,986
Ensembl chr 7:120,177,686...120,199,011 		JBrowse link
astral microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpap centrosome assembly and centriole elongation protein acts_upstream_of_or_within ISO (PMID:11003675) RGD PMID:11003675 NCBI chr15:30,627,206...30,690,384
Ensembl chr15:30,627,224...30,686,791 		JBrowse link
centrosome-templated microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cep192 centrosomal protein 192 involved_in ISO (PMID:17980596) RGD PMID:17980596 NCBI chr18:61,373,937...61,458,405
Ensembl chr18:61,332,158...61,458,379 		JBrowse link
G Nin ninein involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:15784680)		 GO_Central
RGD		 PMID:15784680 GO_REF:0000033 NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639 		JBrowse link
microtubule nucleation by interphase microtubule organizing center term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mzt1 mitotic spindle organizing protein 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:75,787,281...75,797,589
Ensembl chr15:75,786,994...75,797,589 		JBrowse link
microtubule nucleation by microtubule organizing center term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tppp tubulin polymerization promoting protein involved_in ISO
IEA
ISS		 (PMID:31522887)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:31522887 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:29,257,111...29,281,134
Ensembl chr 1:29,261,255...29,281,134 		JBrowse link
negative regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef7 Rho guanine nucleotide exchange factor 7 involved_in ISS
ISO		 GO_REF:0000024
(PMID:27012601)		 UniProt
RGD		 PMID:27012601 GO_REF:0000024 NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697 		JBrowse link
positive regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckap5 cytoskeleton associated protein 5 involved_in ISO (PMID:26414402) RGD PMID:26414402 NCBI chr 3:97,946,966...98,049,050
Ensembl chr 3:77,491,276...77,593,264 		JBrowse link
G Dctn1 dynactin subunit 1 involved_in ISO
ISS
IEA		 (PMID:23874158)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:23874158 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:117,228,722...117,261,528
Ensembl chr 4:115,661,638...115,703,815 		JBrowse link
G Git1 GIT ArfGAP 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:27012601)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:27012601 GO_REF:0000024 GO_REF:0000107 NCBI chr10:62,342,082...62,356,379
Ensembl chr10:62,342,299...62,356,373 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO
ISS		 (PMID:27137183)
GO_REF:0000024		 RGD
UniProt		 PMID:27137183 GO_REF:0000024 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISS
ISO		 GO_REF:0000024
(PMID:27137183)		 UniProt
RGD		 PMID:27137183 GO_REF:0000024 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Mecp2 methyl CpG binding protein 2 involved_in ISO (PMID:25527496) RGD PMID:25527496 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 involved_in ISO
ISS		 (PMID:27012601)
GO_REF:0000024		 RGD
UniProt		 PMID:27012601 GO_REF:0000024 NCBI chr 1:161,522,399...161,637,623
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein involved_in ISO (PMID:29162697) RGD PMID:29162697 NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379 		JBrowse link
regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eml2 EMAP like 2 involved_in ISO
IEA
ISS		 (PMID:11694528)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:11694528 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341 		JBrowse link
G Nme7 NME/NM23 family member 7 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24807905)		 Ensembl
RGD		 PMID:24807905 GO_REF:0000107 NCBI chr13:79,190,462...79,319,890
Ensembl chr13:76,657,367...76,786,765 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      microtubule-based process 1082
        microtubule cytoskeleton organization 713
          microtubule nucleation 41
            chromatin-templated microtubule nucleation 0
            microtubule nucleation by microtubule organizing center + 5
            mitotic spindle-templated microtubule nucleation 0
            negative regulation of microtubule nucleation 1
            positive regulation of microtubule nucleation + 8
            regulation of microtubule nucleation + 11
Path 2
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      cellular component organization or biogenesis 7196
        cellular component organization 6911
          organelle organization 3697
            cytoskeleton organization 1586
              microtubule cytoskeleton organization 713
                microtubule polymerization or depolymerization 153
                  microtubule polymerization 99
                    microtubule nucleation 41
                      chromatin-templated microtubule nucleation 0
                      microtubule nucleation by microtubule organizing center + 5
                      mitotic spindle-templated microtubule nucleation 0
                      negative regulation of microtubule nucleation 1
                      positive regulation of microtubule nucleation + 8
                      regulation of microtubule nucleation + 11
paths to the root