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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, classical pathway
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Accession:GO:0006958 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
Synonyms:exact_synonym: complement cascade, classical pathway
 xref: Reactome:R-HSA-173623 "Classical antibody-mediated complement activation"


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complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07006691.1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 1:228,016,498...228,043,066 JBrowse link
G C1qa complement C1q A chain involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:29449492)
GO_REF:0000043
MGI:2158701 (PMID:11901193)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:11901193 PMID:29449492 GO_REF:0000043 GO_REF:0000107 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain involved_in ISO
IEA		 (PMID:29449492)
GO_REF:0000043		 RGD
UniProt		 PMID:29449492 GO_REF:0000043 NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qbp complement C1q binding protein involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA		 (PMID:29449492)
GO_REF:0000043
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:29449492 GO_REF:0000043 GO_REF:0000107 NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C1r complement C1r involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:157,412,692...157,423,484 		JBrowse link
G C1rl complement C1r subcomponent like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:159,080,495...159,097,066
Ensembl chr 4:157,394,200...157,410,134 		JBrowse link
G C1s complement C1s involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C2 complement C2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3 complement C3 involved_in TAS
IEA		 GO_REF:0000043 UniProt
RGD		 PMID:16996480 GO_REF:0000043, RGD:1600605 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4a complement C4A involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:4,010,306...4,024,707
Ensembl chr20:4,005,731...4,020,080 		JBrowse link
G C4b complement C4B involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G C4bpa complement component 4 binding protein, alpha involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C5l1 complement C5 like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:38,799,165...38,818,443
Ensembl chr 3:18,404,899...18,420,054 		JBrowse link
G C6 complement C6 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cfb complement factor B involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfi complement factor I involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Crp C-reactive protein IMP RGD PMID:16367929 RGD:1580273 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G ENSRNOG00000065917 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 6:132,469,837...132,473,735 JBrowse link
G ENSRNOG00000070986 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 6:132,341,443...132,343,215 JBrowse link
G Igg-2a gamma-2a immunoglobulin heavy chain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Igh-6 immunoglobulin heavy chain 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Ighg1 immunoglobulin heavy constant gamma 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:6952213)		 GO_Central
RGD		 PMID:6952213 GO_REF:0000033 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
G Mbl1 mannose binding lectin 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr16:17,063,232...17,069,271
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mbl2 mannose binding lectin 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:237,429,873...237,465,567 JBrowse link
G Serping1 serpin family G member 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpa complement component 4 binding protein, alpha involved_in ISO
IEA
IBA		 (PMID:22333221)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:22333221 GO_REF:0000033 GO_REF:0000107 NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in ISO
IEA		 (PMID:22333221)
GO_REF:0000107		 RGD
Ensembl		 PMID:22333221 GO_REF:0000107 NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G Cd46 CD46 molecule involved_in ISO
IBA		 (PMID:9029106)
GO_REF:0000033		 RGD
GO_Central		 PMID:9029106 GO_REF:0000033 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cd46l1 CD46 molecule like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:34,538,996...34,539,997
Ensembl chr20:33,996,224...33,997,432 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:109,207,034...109,244,980
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) RGD PMID:23482636 NCBI chr13:96,982,867...97,109,419
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
G Zp3r zona pellucida 3 receptor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:44,572,283...44,617,101
Ensembl chr13:42,020,018...42,064,812 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:30548312) RGD PMID:30548312 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO MGI:2387405 (PMID:9892684) RGD PMID:9892684 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    immune system process 3132
      immune effector process 847
        complement activation 66
          complement activation, classical pathway 40
            negative regulation of complement activation, classical pathway 8
            positive regulation of complement activation, classical pathway 1
            regulation of complement activation, classical pathway + 10
Path 2
Term Annotations click to browse term
  biological_process 20567
    biological regulation 13841
      regulation of biological process 13403
        positive regulation of biological process 6770
          positive regulation of immune system process 1208
            positive regulation of immune response 834
              activation of immune response 599
                complement activation 66
                  complement activation, classical pathway 40
                    negative regulation of complement activation, classical pathway 8
                    positive regulation of complement activation, classical pathway 1
                    regulation of complement activation, classical pathway + 10
paths to the root