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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, alternative pathway
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Accession:GO:0006957 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Synonyms:exact_synonym: complement cascade, alternative pathway
 xref: Reactome:R-HSA-173736 "Alternative complement activation"

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complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936487:9,391,774...9,474,168
Ensembl chrNW_004936487:9,391,804...9,474,159 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936522:4,686,306...4,745,175
Ensembl chrNW_004936522:4,686,081...4,745,175 		JBrowse link
G C8b complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936522:4,638,111...4,673,388
Ensembl chrNW_004936522:4,644,047...4,673,615 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936518:2,947,956...2,994,892
Ensembl chrNW_004936518:2,958,995...2,994,880 		JBrowse link
G Cfb complement factor B involved_in
acts_upstream_of_or_within 		IEA
ISO 		(PMID:27564415)
(PMID:9238044) 		UniProt
MGI		 PMID:9238044 PMID:27564415 GO_REF:0000043 NCBI chrNW_004936727:1,595,872...1,602,274
Ensembl chrNW_004936727:1,595,499...1,602,215 		JBrowse link
G Cfd complement factor D acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:350,925...352,732
Ensembl chrNW_004936588:350,921...355,582 		JBrowse link
G Cfp complement factor properdin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936502:13,391,613...13,398,723
Ensembl chrNW_004936502:13,391,535...13,397,440 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect 		ISO (PMID:11981823)
(PMID:19828624) 		ARUK-UCL
MGI		 PMID:11981823 PMID:19828624 NCBI chrNW_004936557:5,246,770...5,256,608 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004936557:5,136,784...5,175,543 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:10531307) UniProt PMID:10531307 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936526:488,604...615,265
Ensembl chrNW_004936526:485,348...615,265 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936635:2,167,633...2,191,725
Ensembl chrNW_004936635:2,167,617...2,191,740 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17413
    immune system process 2310
      immune response 1463
        innate immune response 745
          complement activation, alternative pathway 12
            negative regulation of complement activation, alternative pathway 4
            positive regulation of complement activation, alternative pathway 0
            regulation of complement activation, alternative pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 17413
    biological regulation 11396
      regulation of biological process 11032
        positive regulation of biological process 6175
          positive regulation of response to stimulus 2338
            positive regulation of immune response 701
              activation of immune response 515
                complement activation 45
                  complement activation, alternative pathway 12
                    negative regulation of complement activation, alternative pathway 4
                    positive regulation of complement activation, alternative pathway 0
                    regulation of complement activation, alternative pathway + 4
paths to the root