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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, alternative pathway
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Accession:GO:0006957 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Synonyms:exact_synonym: complement cascade, alternative pathway
 xref: Reactome:R-HSA-173736 "Alternative complement activation"

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complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624862:3,234,826...3,288,574
Ensembl chrNW_004624862:3,232,463...3,288,640 		JBrowse link
G C8b complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624862:3,187,573...3,224,895
Ensembl chrNW_004624862:3,187,120...3,225,751 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624759:15,534,743...15,623,767
Ensembl chrNW_004624759:15,534,660...15,624,381 		JBrowse link
G Cfb complement factor B involved_in
acts_upstream_of_or_within 		IEA
ISO 		(PMID:9238044)
(PMID:27564415) 		UniProt
MGI		 PMID:9238044 PMID:27564415 GO_REF:0000043 NCBI chrNW_004624754:24,310,344...24,316,482
Ensembl chrNW_004624754:24,310,247...24,317,366 		JBrowse link
G Cfd complement factor D acts_upstream_of_or_within ISO (PMID:27564415) MGI PMID:27564415 NCBI chrNW_004624828:7,714,926...7,717,139
Ensembl chrNW_004624828:7,711,537...7,717,337 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within_negative_effect ISO (PMID:19828624)
(PMID:27564415) 		MGI PMID:19828624 PMID:27564415 NCBI chrNW_004624798:3,332,549...3,414,435 JBrowse link
G Cfp complement factor properdin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624978:180,352...194,467
Ensembl chrNW_004624978:184,286...190,970 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect 		ISO (PMID:11981823)
(PMID:19828624) 		ARUK-UCL
MGI		 PMID:11981823 PMID:19828624 NCBI chrNW_004624807:4,149,472...4,179,269
Ensembl chrNW_004624807:4,152,230...4,179,211 		JBrowse link
G LOC101710080 complement C5-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:14,200,770...14,240,865 JBrowse link
G LOC101710435 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:14,296,904...14,396,585
Ensembl chrNW_004624760:14,296,967...14,396,188 		JBrowse link
G LOC101723821 complement C5-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:14,243,406...14,292,627 JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004624807:4,040,639...4,074,631 JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624835:5,531,507...5,600,181
Ensembl chrNW_004624835:5,531,472...5,599,922 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO (PMID:17051150) UniProt PMID:17051150 NCBI chrNW_004624898:1,268,998...1,288,756
Ensembl chrNW_004624898:1,268,886...1,289,180 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) ComplexPortal PMID:20378178 PMID:28671664 NCBI chrNW_004624798:3,332,549...3,414,435 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17647
    immune system process 2290
      immune response 1438
        innate immune response 733
          complement activation, alternative pathway 15
            negative regulation of complement activation, alternative pathway 3
            positive regulation of complement activation, alternative pathway 0
            regulation of complement activation, alternative pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 17647
    biological regulation 11839
      regulation of biological process 11484
        positive regulation of biological process 6138
          positive regulation of response to stimulus 2298
            positive regulation of immune response 676
              activation of immune response 500
                complement activation 44
                  complement activation, alternative pathway 15
                    negative regulation of complement activation, alternative pathway 3
                    positive regulation of complement activation, alternative pathway 0
                    regulation of complement activation, alternative pathway + 4
paths to the root