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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, alternative pathway
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Accession:GO:0006957 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Synonyms:exact_synonym: complement cascade, alternative pathway
 xref: Reactome:R-HSA-173736 "Alternative complement activation"


show annotations for term's descendants           Sort by:
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761 		JBrowse link
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chr11:73,953,727...74,029,919
Ensembl chr11:73,953,727...74,029,851 		JBrowse link
G C8B complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:52,535,359...52,574,872
Ensembl chr 5:52,532,481...52,574,182 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:69,660,861...69,719,793
Ensembl chr 4:69,660,907...69,719,562 		JBrowse link
G CFB complement factor B involved_in
acts_upstream_of_or_within 		IEA
ISO 		(PMID:9238044)
(PMID:27564415) 		UniProt
MGI		 PMID:9238044 PMID:27564415 GO_REF:0000043 NCBI chr12:1,400,143...1,406,267 JBrowse link
G CFD complement factor D acts_upstream_of_or_within ISO (PMID:27564415) MGI PMID:27564415 NCBI chr20:57,785,297...57,787,773
Ensembl chr20:57,657,154...57,787,713 		JBrowse link
G CFH complement factor H acts_upstream_of_or_within_negative_effect ISO (PMID:19828624)
(PMID:27564415) 		MGI PMID:19828624 PMID:27564415 NCBI chr38:2,878,677...2,956,226 JBrowse link
G CFP complement factor properdin involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:41,245,868...41,252,194
Ensembl chr  X:41,245,905...41,251,623 		JBrowse link
G LOC484960 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:50,993,122...51,019,645 JBrowse link
G LOC490269 complement receptor type 2 involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chr 7:6,456,238...6,480,672 JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC490269 complement receptor type 2 involved_in ISO (PMID:10531307) UniProt PMID:10531307 NCBI chr 7:6,456,238...6,480,672 JBrowse link
G LOC609365 CD46 molecule, complement regulatory protein-like involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chr 7:6,602,762...6,646,561 JBrowse link
G SUSD4 sushi domain containing 4 involved_in ISO (PMID:23482636) UniProt PMID:23482636 NCBI chr38:23,640,882...23,685,288
Ensembl chr38:23,639,616...23,685,304 		JBrowse link
G VSIG4 V-set and immunoglobulin domain containing 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:50,839,979...50,881,684
Ensembl chr  X:50,803,330...50,881,618 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) ComplexPortal PMID:20378178 PMID:28671664 NCBI chr38:2,878,677...2,956,226 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22130
    immune system process 2648
      immune response 1728
        innate immune response 934
          complement activation, alternative pathway 13
            negative regulation of complement activation, alternative pathway 4
            positive regulation of complement activation, alternative pathway 0
            regulation of complement activation, alternative pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 22130
    biological regulation 12559
      regulation of biological process 12177
        positive regulation of biological process 6621
          positive regulation of response to stimulus 2499
            positive regulation of immune response 755
              activation of immune response 556
                complement activation 51
                  complement activation, alternative pathway 13
                    negative regulation of complement activation, alternative pathway 4
                    positive regulation of complement activation, alternative pathway 0
                    regulation of complement activation, alternative pathway + 5
paths to the root