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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation, alternative pathway
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Accession:GO:0006957 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Synonyms:exact_synonym: complement cascade, alternative pathway
 xref: Reactome:R-HSA-173736 "Alternative complement activation"


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complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C5l1 complement C5 like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,401,716...18,420,064
Ensembl chr 3:18,404,899...18,420,054 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cfb complement factor B acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1861129 (PMID:27564415), (PMID:9238044)
GO_REF:0000043		 RGD
UniProt		 PMID:9238044 PMID:27564415 GO_REF:0000043 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfd complement factor D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:27564415)
GO_REF:0000043
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:27564415 GO_REF:0000043 GO_REF:0000107 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within
acts_upstream_of_or_within_negative_effect		 ISO (PMID:27564415)
(PMID:19828624)		 RGD PMID:19828624 PMID:27564415 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cfp complement factor properdin involved_in ISO
IEA		 MGI:3774548 (PMID:18292556)
GO_REF:0000107		 RGD
Ensembl		 PMID:18292556 GO_REF:0000107 NCBI chr  X:3,715,551...3,721,113
Ensembl chr  X:1,161,979...1,167,573 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect		 ISO (PMID:11981823)
(PMID:19828624)		 RGD PMID:11981823 PMID:19828624 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) RGD PMID:9029106 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) RGD PMID:23482636 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO
IBA		 UniProtKB:P01024 (PMID:17051150)
GO_REF:0000033		 RGD
GO_Central		 PMID:17051150 GO_REF:0000033 NCBI chr  X:61,144,926...61,170,212
Ensembl chr  X:61,144,928...61,170,212 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) RGD PMID:20378178 PMID:28671664 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    immune system process 3130
      immune response 2236
        innate immune response 1025
          complement activation, alternative pathway 14
            negative regulation of complement activation, alternative pathway 3
            positive regulation of complement activation, alternative pathway 0
            regulation of complement activation, alternative pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        positive regulation of biological process 6766
          positive regulation of response to stimulus 2577
            positive regulation of immune response 833
              activation of immune response 598
                complement activation 66
                  complement activation, alternative pathway 14
                    negative regulation of complement activation, alternative pathway 3
                    positive regulation of complement activation, alternative pathway 0
                    regulation of complement activation, alternative pathway + 4
paths to the root