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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity
 xref: Reactome:R-HSA-166658 "Complement cascade"


show annotations for term's descendants           Sort by:
complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1r complement C1r involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:157,412,692...157,423,484 		JBrowse link
G C1s complement C1s involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C2 complement C2 involved_in ISO
IEA
IBA		 (PMID:19302245)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033		 RGD
Ensembl
InterPro
GO_Central		 PMID:19302245 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3 complement C3 acts_upstream_of_or_within
involved_in		 IDA
IEA
ISO
IBA		 GO_REF:0000107
GO_REF:0000002
(PMID:18947875), (PMID:25284781)
GO_REF:0000033
(PMID:19302245)		 Ensembl
InterPro
RGD
GO_Central		 PMID:18947875 PMID:19302245 PMID:25284781 PMID:20712003 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:5129529 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4a complement C4A involved_in
acts_upstream_of_or_within		 TAS
IEA
ISO
IBA		 GO_REF:0000002
(PMID:1438267), (PMID:8133084)
GO_REF:0000033
UniProtKB:P0C0L5 (PMID:19302245)		 InterPro
RGD
GO_Central		 PMID:1438267 PMID:8133084 PMID:19302245 PMID:11773063 GO_REF:0000002 GO_REF:0000033, RGD:1302926 NCBI chr20:4,010,306...4,024,707
Ensembl chr20:4,005,731...4,020,080 		JBrowse link
G C4b complement C4B involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 UniProtKB:P0C0L4|UniProtKB:P0C0L5 (PMID:19302245)
GO_REF:0000002
MGI:1889070 (PMID:12421924)
GO_REF:0000033		 RGD
InterPro
GO_Central		 PMID:12421924 PMID:19302245 GO_REF:0000002 GO_REF:0000033 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G C5l1 complement C5 like 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:38,799,165...38,818,443
Ensembl chr 3:18,404,899...18,420,054 		JBrowse link
G C6 complement C6 involved_in ISO
IEA
IBA		 (PMID:2808363)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:2808363 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C8a complement C8 alpha chain acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (PMID:12413696)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:12413696 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C8g complement C8 gamma chain involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:28,718,648...28,720,232
Ensembl chr 3:8,305,920...8,323,495 		JBrowse link
G C9 complement C9 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cfb complement factor B involved_in IDA
IEA
IBA		 GO_REF:0000107
GO_REF:0000002
GO_REF:0000033		 Ensembl
InterPro
GO_Central
RGD		 PMID:6906329 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:2311339 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within
involved_in		 IEP
ISO
IBA		 (PMID:15574507), (PMID:17517971), (PMID:17921253), (PMID:19411110), (PMID:19541934), (PMID:20675597), (PMID:20702729), (PMID:28057640)
GO_REF:0000033
(PMID:24835392)		 RGD
GO_Central		 PMID:15574507 PMID:17517971 PMID:17921253 PMID:19411110 PMID:19541934 More... GO_REF:0000033, RGD:1599888 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cfhr1 complement factor H-related 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:53,946,298...53,961,282
Ensembl chr13:51,369,211...51,410,592 		JBrowse link
G Cfhr2 complement factor H-related 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:53,726,553...53,798,225
Ensembl chr13:51,175,841...51,247,495 		JBrowse link
G Cfhr2l1 complement factor H-related 2-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:53,813,350...53,847,482
Ensembl chr13:51,262,633...51,296,723 		JBrowse link
G Cfhr4 complement factor H-related 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:53,973,301...54,042,179
Ensembl chr13:51,422,592...51,491,502 		JBrowse link
G Cfi complement factor I involved_in ISO (PMID:18202746) RGD PMID:18202746 NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISO (PMID:23954398) RGD PMID:23954398 NCBI chr 6:50,952,357...50,984,845
Ensembl chr 6:45,223,980...45,271,145 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO (PMID:20675597) RGD PMID:20675597 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G ENSRNOG00000066867 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr13:51,363,065...51,384,561 JBrowse link
G Lcn12 lipocalin 12 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:28,710,557...28,713,537
Ensembl chr 3:8,305,920...8,323,495 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in NAS
IEA		 GO_REF:0000002 InterPro
RGD		 PMID:12847554 GO_REF:0000002, RGD:633273 NCBI chr11:90,839,081...90,909,922
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in NAS
IEA		 GO_REF:0000002 InterPro
RGD		 PMID:10586086 GO_REF:0000002, RGD:633276 NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H acts_upstream_of_or_within ISO (PMID:20813971) RGD PMID:20813971 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C5l1 complement C5 like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:38,799,165...38,818,443
Ensembl chr 3:18,404,899...18,420,054 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cfb complement factor B acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1861129 (PMID:27564415), (PMID:9238044)
GO_REF:0000043		 RGD
UniProt		 PMID:9238044 PMID:27564415 GO_REF:0000043 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfd complement factor D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:27564415)
GO_REF:0000107
GO_REF:0000043		 RGD
Ensembl
UniProt		 PMID:27564415 GO_REF:0000043 GO_REF:0000107 NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:9,813,150...9,815,053 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within
acts_upstream_of_or_within_negative_effect		 ISO (PMID:27564415)
(PMID:19828624)		 RGD PMID:19828624 PMID:27564415 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cfp complement factor properdin involved_in ISO
IEA		 MGI:3774548 (PMID:18292556)
GO_REF:0000107		 RGD
Ensembl		 PMID:18292556 GO_REF:0000107 NCBI chr  X:3,715,551...3,721,113
Ensembl chr  X:1,161,979...1,167,573 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect		 ISO (PMID:11981823)
(PMID:19828624)		 RGD PMID:11981823 PMID:19828624 NCBI chr13:109,207,034...109,244,980
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07006691.1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 1:228,016,498...228,043,066 JBrowse link
G C1qa complement C1q A chain involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:29449492)
GO_REF:0000043
MGI:2158701 (PMID:11901193)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:11901193 PMID:29449492 GO_REF:0000043 GO_REF:0000107 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain involved_in ISO
IEA		 (PMID:29449492)
GO_REF:0000043		 RGD
UniProt		 PMID:29449492 GO_REF:0000043 NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qbp complement C1q binding protein involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G C1qc complement C1q C chain involved_in ISO
IEA		 (PMID:29449492)
GO_REF:0000043
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:29449492 GO_REF:0000043 GO_REF:0000107 NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C1r complement C1r involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:157,412,692...157,423,484 		JBrowse link
G C1rl complement C1r subcomponent like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:159,080,495...159,097,066
Ensembl chr 4:157,394,200...157,410,134 		JBrowse link
G C1s complement C1s involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C2 complement C2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3 complement C3 involved_in TAS
IEA		 GO_REF:0000043 UniProt
RGD		 PMID:16996480 GO_REF:0000043, RGD:1600605 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4a complement C4A involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:4,010,306...4,024,707
Ensembl chr20:4,005,731...4,020,080 		JBrowse link
G C4b complement C4B involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G C4bpa complement component 4 binding protein, alpha involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C5l1 complement C5 like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:38,799,165...38,818,443
Ensembl chr 3:18,404,899...18,420,054 		JBrowse link
G C6 complement C6 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cfb complement factor B involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfi complement factor I involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:221,062,206...221,104,790
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Crp C-reactive protein IMP RGD PMID:16367929 RGD:1580273 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G ENSRNOG00000065917 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 6:132,469,837...132,473,735 JBrowse link
G ENSRNOG00000070986 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 6:132,341,443...132,343,215 JBrowse link
G Igg-2a gamma-2a immunoglobulin heavy chain involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Igh-6 immunoglobulin heavy chain 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Ighg1 immunoglobulin heavy constant gamma 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:6952213)		 GO_Central
RGD		 PMID:6952213 GO_REF:0000033 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
G Mbl1 mannose binding lectin 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr16:17,063,232...17,069,271
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mbl2 mannose binding lectin 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:237,429,873...237,465,567 JBrowse link
G Serping1 serpin family G member 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07006691.1 involved_in
acts_upstream_of_or_within		 IEA GO_REF:0000043
GO_REF:0000107		 UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 Ensembl chr 1:228,016,498...228,043,066 JBrowse link
G Cd69 Cd69 molecule TAS RGD PMID:11034393 PMID:15506986 RGD:1354527, RGD:1354528 NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Colec10 collectin subfamily member 10 involved_in ISO
IEA		 (PMID:24174618)
GO_REF:0000107		 RGD
Ensembl		 PMID:24174618 GO_REF:0000107 NCBI chr 7:87,634,686...87,695,465
Ensembl chr 7:85,744,895...85,805,675 		JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISO (PMID:24174618), (PMID:25912189) RGD PMID:24174618 PMID:25912189 NCBI chr 6:50,952,357...50,984,845
Ensembl chr 6:45,223,980...45,271,145 		JBrowse link
G Fcna ficolin A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:28,844,036...28,847,441
Ensembl chr 3:8,445,907...8,449,105 		JBrowse link
G Fcnb ficolin B involved_in ISO
IEA
IBA		 (PMID:16116205)
GO_REF:0000043
GO_REF:0000107
GO_REF:0000033		 RGD
UniProt
Ensembl
GO_Central		 PMID:16116205 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 3:31,791,750...31,800,188
Ensembl chr 3:11,393,739...11,402,151 		JBrowse link
G Krt1 keratin 1 involved_in ISO
IEA		 UniProtKB:P11226 (PMID:11549596)
GO_REF:0000107		 RGD
Ensembl		 PMID:11549596 GO_REF:0000107 NCBI chr 7:134,855,311...134,860,537
Ensembl chr 7:132,976,620...132,981,844 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000043
(PMID:18424734)
GO_REF:0000033
GO_REF:0000107
(PMID:17182967)		 UniProt
RGD
GO_Central
Ensembl		 PMID:17182967 PMID:18424734 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr11:90,839,081...90,909,922
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in ISO
IBA
IEA		 (PMID:17182967), (PMID:9087411)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:9087411 PMID:17182967 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:159,035,911...159,049,580 		JBrowse link
G Mbl1 mannose binding lectin 1 involved_in
acts_upstream_of_or_within		 IDA
IEA
ISO		 GO_REF:0000043
MGI:96924 (PMID:15148336)		 UniProt
RGD		 PMID:15148336 PMID:16272342 GO_REF:0000043, RGD:1582134 NCBI chr16:17,063,232...17,069,271
Ensembl chr16:17,029,118...17,035,174 		JBrowse link
G Mbl2 mannose binding lectin 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15148336)
GO_REF:0000107
GO_REF:0000043
MGI:3577339|MGI:96923 (PMID:15148336)
UniProtKB:P04264 (PMID:11549596), (PMID:22691502), (PMID:35102342)		 RGD
Ensembl
UniProt		 PMID:11549596 PMID:15148336 PMID:22691502 PMID:35102342 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:237,429,873...237,465,567 JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59b CD59b molecule acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA		 (PMID:10946279), (PMID:11471050)
GO_REF:0000033		 RGD
GO_Central		 PMID:10946279 PMID:11471050 PMID:15843577 GO_REF:0000033, RGD:1600482 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G LOC134480016 urinary protein 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:43,339,749...43,343,430 JBrowse link
G Rup2l2 urinary protein 2 like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:43,961,640...43,965,241
Ensembl chr 8:35,750,482...35,754,071 		JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in IDA
ISO		 (PMID:28657829), (PMID:6211481) RGD PMID:6211481 PMID:28657829 PMID:10929073 RGD:2326180 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd59b CD59b molecule acts_upstream_of_or_within ISO (PMID:10946279) RGD PMID:10946279 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within IMP
ISO		 MGI:2158683 (PMID:10642554) RGD PMID:10642554 PMID:11861390 RGD:625470 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) RGD PMID:11485744 NCBI chr11:90,839,081...90,909,922
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) RGD PMID:9029106 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) RGD PMID:23482636 NCBI chr13:96,982,867...97,109,419
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO
IBA		 UniProtKB:P01024 (PMID:17051150)
GO_REF:0000033		 RGD
GO_Central		 PMID:17051150 GO_REF:0000033 NCBI chr  X:65,154,422...65,179,708
Ensembl chr  X:61,144,928...61,170,212 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpa complement component 4 binding protein, alpha involved_in ISO
IEA
IBA		 (PMID:22333221)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:22333221 GO_REF:0000033 GO_REF:0000107 NCBI chr13:44,627,959...44,663,552
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C4bpb complement component 4 binding protein, beta involved_in ISO
IEA		 (PMID:22333221)
GO_REF:0000107		 RGD
Ensembl		 PMID:22333221 GO_REF:0000107 NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817 		JBrowse link
G Cd46 CD46 molecule involved_in ISO
IBA		 (PMID:9029106)
GO_REF:0000033		 RGD
GO_Central		 PMID:9029106 GO_REF:0000033 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cd46l1 CD46 molecule like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:34,538,996...34,539,997
Ensembl chr20:33,996,224...33,997,432 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:109,207,034...109,244,980
Ensembl chr13:106,685,413...106,716,235 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) RGD PMID:23482636 NCBI chr13:96,982,867...97,109,419
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
G Zp3r zona pellucida 3 receptor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:44,572,283...44,617,101
Ensembl chr13:42,020,018...42,064,812 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO (PMID:12538697) RGD PMID:12538697 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Serping1 serpin family G member 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:10946292)		 UniProt
Ensembl
RGD		 PMID:10946292 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15611275)		 Ensembl
RGD		 PMID:15611275 GO_REF:0000107 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta involved_in ISO RNAcentral:URS0000424278_9606 (PMID:29384235) RGD PMID:29384235 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mbl2 mannose binding lectin 2 IDA RGD PMID:9920905 RGD:4889148 NCBI chr 1:237,429,873...237,465,567 JBrowse link
G Phb1 prohibitin 1 involved_in ISO (PMID:17070910) RGD PMID:17070910 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:30548312) RGD PMID:30548312 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:8195709)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:8195709 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:25284781) RGD PMID:25284781 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd59b CD59b molecule acts_upstream_of_or_within NAS
ISO		 (PMID:25284781) RGD PMID:25284781 PMID:7528012 RGD:727654 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cd5l Cd5 molecule-like acts_upstream_of_or_within ISO
IEA		 MGI:2653296 (PMID:25284781)
GO_REF:0000107		 RGD
Ensembl		 PMID:25284781 GO_REF:0000107 NCBI chr 2:175,088,915...175,099,928
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within IDA
ISO		 MGI:2384179 (PMID:18947875)
(PMID:25284781)		 RGD PMID:18947875 PMID:25284781 PMID:12374811 RGD:628500 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO (PMID:25284781)
MGI:2158683 (PMID:18947875)		 RGD PMID:18947875 PMID:25284781 NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Phb2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) RGD PMID:17070910 NCBI chr 4:159,203,948...159,208,561
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IEA		 (PMID:23482636)
GO_REF:0000002		 RGD
InterPro		 PMID:23482636 GO_REF:0000002 NCBI chr13:96,982,867...97,109,419
Ensembl chr13:94,455,165...94,577,750 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) RGD PMID:20378178 PMID:28671664 NCBI chr13:54,063,079...54,164,523
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO MGI:2387405 (PMID:9892684) RGD PMID:9892684 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    immune system process 3132
      immune effector process 847
        complement activation 66
          activation of membrane attack complex + 5
          complement activation, alternative pathway + 14
          complement activation, classical pathway + 40
          complement activation, lectin pathway + 13
          negative regulation of complement activation + 16
          positive regulation of complement activation + 5
          regulation of complement activation + 25
Path 2
Term Annotations click to browse term
  biological_process 20567
    biological regulation 13841
      regulation of biological process 13403
        positive regulation of biological process 6770
          positive regulation of response to stimulus 2579
            positive regulation of immune response 834
              activation of immune response 599
                complement activation 66
                  activation of membrane attack complex + 5
                  complement activation, alternative pathway + 14
                  complement activation, classical pathway + 40
                  complement activation, lectin pathway + 13
                  negative regulation of complement activation + 16
                  positive regulation of complement activation + 5
                  regulation of complement activation + 25
paths to the root