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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity
 xref: Reactome:R-HSA-166658 "Complement cascade"


show annotations for term's descendants           Sort by:
complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1R complement C1r involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:63,644,097...63,655,149
Ensembl chr 5:63,643,374...63,655,143 		JBrowse link
G C1RL complement C1r subcomponent like involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:63,623,398...63,640,065
Ensembl chr 5:63,627,313...63,640,057 		JBrowse link
G C1S complement C1s involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:63,670,309...63,681,466
Ensembl chr 5:63,670,312...63,708,214 		JBrowse link
G C2 complement C2 involved_in IEA
IBA		 InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:24,020,590...24,034,042
Ensembl chr 7:24,020,290...24,034,039 		JBrowse link
G C3 complement C3 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 RGD
Ensembl
GO_Central
InterPro		 PMID:20712003 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:5129529 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G C4A complement C4A (Rodgers blood group) involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:12421924) GO_Central
MGI		 PMID:12421924 GO_REF:0000033 NCBI chr 7:24,068,019...24,083,060
Ensembl chr 7:24,068,013...24,083,065 		JBrowse link
G C5 complement C5 involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,668...261,133,483 		JBrowse link
G C6 complement C6 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr16:26,023,646...26,089,518
Ensembl chr16:26,020,628...26,084,652 		JBrowse link
G C7 complement C7 involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:25,846,860...25,902,707
Ensembl chr16:25,846,860...25,903,980 		JBrowse link
G C8A complement C8 alpha chain involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:155,464,855...155,530,473
Ensembl chr 6:155,464,852...155,530,472 		JBrowse link
G C8B complement C8 beta chain involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:155,411,982...155,453,034
Ensembl chr 6:155,387,145...155,453,438 		JBrowse link
G C8G complement C8 gamma chain involved_in IEA InterPro GO_REF:0000002
G C9 complement C9 involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:24,521,318...24,575,939
Ensembl chr16:24,520,634...24,590,338 		JBrowse link
G CFB complement factor B involved_in ISO
IBA
IEA		 RGD
GO_Central
InterPro		 PMID:6906329 GO_REF:0000002 GO_REF:0000033 RGD:2311339 NCBI chr 7:24,034,077...24,040,523
Ensembl chr 7:24,034,332...24,041,179 		JBrowse link
G CFH complement factor H acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:19411110), (PMID:20675597)
(PMID:20702729)
(PMID:15574507), (PMID:17517971), (PMID:17921253), (PMID:19541934), (PMID:28057640)		 RGD
MGI
GO_Central		 PMID:12911541 PMID:15574507 PMID:17517971 PMID:17921253 PMID:19411110 More... GO_REF:0000033 RGD:1599888
G CFI complement factor I involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:112,430,824...112,470,844
Ensembl chr 8:112,433,633...112,470,832 		JBrowse link
G COLEC11 collectin subfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:131,226,941...131,254,555
Ensembl chr 3:131,226,956...131,254,553 		JBrowse link
G MASP1 MBL associated serine protease 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr13:124,938,469...125,028,440
Ensembl chr13:124,955,030...125,054,463 		JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 6:71,224,637...71,243,041
Ensembl chr 6:71,224,637...71,243,874 		JBrowse link
G RGCC regulator of cell cycle involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:25,481,845...25,496,548
Ensembl chr11:25,478,879...25,496,519 		JBrowse link
activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H acts_upstream_of_or_within ISO (PMID:20813971) MGI PMID:20813971
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,668...261,133,483 		JBrowse link
G C7 complement C7 involved_in IEA UniProt GO_REF:0000043 NCBI chr16:25,846,860...25,902,707
Ensembl chr16:25,846,860...25,903,980 		JBrowse link
G C8A complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:155,464,855...155,530,473
Ensembl chr 6:155,464,852...155,530,472 		JBrowse link
G C8B complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:155,411,982...155,453,034
Ensembl chr 6:155,387,145...155,453,438 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chr16:24,521,318...24,575,939
Ensembl chr16:24,520,634...24,590,338 		JBrowse link
G CFB complement factor B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9238044)
(PMID:27564415)		 UniProt
MGI		 PMID:9238044 PMID:27564415 GO_REF:0000043 NCBI chr 7:24,034,077...24,040,523
Ensembl chr 7:24,034,332...24,041,179 		JBrowse link
G CFD complement factor D involved_in
acts_upstream_of_or_within		 IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr 2:77,509,792...77,511,988
Ensembl chr 2:77,509,795...77,511,974 		JBrowse link
G CFH complement factor H acts_upstream_of_or_within_negative_effect ISO (PMID:19828624)
(PMID:27564415)		 MGI PMID:19828624 PMID:27564415
G CFP complement factor properdin involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:42,145,754...42,152,879
Ensembl chr  X:42,143,697...42,152,868 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chr 9:68,025,673...68,132,162 JBrowse link
G LOC100517145 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:68,890,218...68,920,763 JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QA complement C1q A chain involved_in
acts_upstream_of_or_within		 IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr 6:80,586,259...80,589,213
Ensembl chr 6:80,586,280...80,589,204 		JBrowse link
G C1QB complement C1q B chain involved_in ISO (PMID:29449492) ComplexPortal PMID:29449492 NCBI chr 6:80,601,680...80,606,076
Ensembl chr 6:80,601,665...80,607,471 		JBrowse link
G C1QC complement C1q C chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:80,592,591...80,597,464
Ensembl chr 6:80,592,473...80,597,452 		JBrowse link
G C1R complement C1r involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:63,644,097...63,655,149
Ensembl chr 5:63,643,374...63,655,143 		JBrowse link
G C1RL complement C1r subcomponent like involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:63,623,398...63,640,065
Ensembl chr 5:63,627,313...63,640,057 		JBrowse link
G C1S complement C1s involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:63,670,309...63,681,466
Ensembl chr 5:63,670,312...63,708,214 		JBrowse link
G C2 complement C2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:24,020,590...24,034,042
Ensembl chr 7:24,020,290...24,034,039 		JBrowse link
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G C4A complement C4A (Rodgers blood group) involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:24,068,019...24,083,060
Ensembl chr 7:24,068,013...24,083,065 		JBrowse link
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,668...261,133,483 		JBrowse link
G C6 complement C6 involved_in IEA UniProt GO_REF:0000043 NCBI chr16:26,023,646...26,089,518
Ensembl chr16:26,020,628...26,084,652 		JBrowse link
G C7 complement C7 involved_in IEA UniProt GO_REF:0000043 NCBI chr16:25,846,860...25,902,707
Ensembl chr16:25,846,860...25,903,980 		JBrowse link
G C8A complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:155,464,855...155,530,473
Ensembl chr 6:155,464,852...155,530,472 		JBrowse link
G C8B complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:155,411,982...155,453,034
Ensembl chr 6:155,387,145...155,453,438 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chr16:24,521,318...24,575,939
Ensembl chr16:24,520,634...24,590,338 		JBrowse link
G CD46 CD46 molecule, complement regulatory protein involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:135,025,439...135,078,910 JBrowse link
G CRP C-reactive protein, pentraxin-related ISO RGD PMID:16367929 RGD:1580273 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218 		JBrowse link
G LOC100517145 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:68,890,218...68,920,763 JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:71,224,637...71,243,041
Ensembl chr 6:71,224,637...71,243,874 		JBrowse link
G MBL1 mannose binding lectin 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr14:82,080,232...82,085,174
Ensembl chr14:82,010,028...82,085,305 		JBrowse link
G MBL2 mannose binding lectin 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COLEC10 collectin subfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:19,692,990...20,143,740
Ensembl chr 4:19,692,830...19,744,135 		JBrowse link
G COLEC11 collectin subfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:131,226,941...131,254,555
Ensembl chr 3:131,226,956...131,254,553 		JBrowse link
G FCN1 ficolin (collagen/fibrinogen domain containing) 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:274,125,666...274,132,917 JBrowse link
G FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) involved_in IEA
IBA		 UniProt
GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:274,106,276...274,111,970
Ensembl chr 1:274,103,877...274,111,970 		JBrowse link
G KRT1 keratin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:18,012,922...18,018,582
Ensembl chr 5:18,012,925...18,018,582 		JBrowse link
G MASP1 MBL associated serine protease 1 involved_in IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:124,938,469...125,028,440
Ensembl chr13:124,955,030...125,054,463 		JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:71,224,637...71,243,041
Ensembl chr 6:71,224,637...71,243,874 		JBrowse link
G MBL1 mannose binding lectin 1 involved_in
acts_upstream_of_or_within		 IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr14:82,080,232...82,085,174
Ensembl chr14:82,010,028...82,085,305 		JBrowse link
G MBL2 mannose binding lectin 2 involved_in
acts_upstream_of_or_within		 IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD59 CD59 molecule acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:10946279), (PMID:11471050) RGD
MGI
GO_Central		 PMID:10946279 PMID:11471050 PMID:15843577 GO_REF:0000033 RGD:1600482 NCBI chr 2:27,186,587...27,207,303 JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) acts_upstream_of ISO (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chr 9:68,025,673...68,132,162 JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD55 CD55 molecule (Cromer blood group) involved_in ISO (PMID:28657829)
(PMID:6211481)		 RGD
UniProt		 PMID:6211481 PMID:10929073 PMID:28657829 RGD:2326180 NCBI chr 9:67,933,069...67,960,380 JBrowse link
G CD59 CD59 molecule acts_upstream_of_or_within ISO (PMID:10946279) MGI PMID:10946279 NCBI chr 2:27,186,587...27,207,303 JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in ISO (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chr 9:68,025,673...68,132,162 JBrowse link
G MASP1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) UniProt PMID:11485744 NCBI chr13:124,938,469...125,028,440
Ensembl chr13:124,955,030...125,054,463 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD46 CD46 molecule, complement regulatory protein involved_in IDA (PMID:9029106) AgBase PMID:9029106 NCBI chr 9:135,025,439...135,078,910 JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in ISO (PMID:10531307) UniProt PMID:10531307 NCBI chr 9:68,025,673...68,132,162 JBrowse link
G SUSD4 sushi domain containing 4 involved_in ISO (PMID:23482636) UniProt PMID:23482636 NCBI chr10:19,420,680...19,551,941
Ensembl chr10:19,421,565...19,551,840 		JBrowse link
G VSIG4 V-set and immunoglobulin domain containing 4 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:52,175,601...52,198,635
Ensembl chr  X:52,175,607...52,198,566 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4BPA complement component 4 binding protein alpha involved_in IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:67,726,159...67,774,369
Ensembl chr 9:67,731,179...67,776,115 		JBrowse link
G C4BPA complement component 4 binding protein, alpha involved_in IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:67,815,544...67,827,509
Ensembl chr 9:67,815,340...67,827,407 		JBrowse link
G C4BPB complement component 4 binding protein beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:67,716,205...67,725,785
Ensembl chr 9:67,716,283...67,725,783 		JBrowse link
G CD46 CD46 molecule, complement regulatory protein involved_in IDA
IBA		 (PMID:9029106) AgBase
GO_Central		 PMID:9029106 GO_REF:0000033 NCBI chr 9:135,025,439...135,078,910 JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in ISO (PMID:10531307), (PMID:6910481) UniProt PMID:6910481 PMID:10531307 NCBI chr 9:68,025,673...68,132,162 JBrowse link
G LOC100736569 membrane cofactor protein-like involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:68,136,576...68,186,756 JBrowse link
G SUSD4 sushi domain containing 4 involved_in ISO (PMID:23482636) UniProt PMID:23482636 NCBI chr10:19,420,680...19,551,941
Ensembl chr10:19,421,565...19,551,840 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:62,406,928...62,483,690
Ensembl chr 5:62,440,810...62,483,678 		JBrowse link
G SERPING1 serpin family G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:13,324,160...13,338,826
Ensembl chr 2:13,324,158...13,338,663 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chr 9:68,025,673...68,132,162 JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC110258578 interleukin-1 beta-like involved_in ISO (PMID:29384235) ARUK-UCL PMID:29384235
G MBL2 mannose binding lectin 2 ISO RGD PMID:9920905 RGD:4889148 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
G PHB1 prohibitin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:25,596,520...25,609,693
Ensembl chr12:25,596,523...25,609,706 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QBP complement C1q binding protein involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr12:51,548,361...51,553,076
Ensembl chr12:51,548,415...51,555,689 		JBrowse link
G CD55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chr 9:67,933,069...67,960,380 JBrowse link
G CD59 CD59 molecule acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chr 2:27,186,587...27,207,303 JBrowse link
G CD5L CD5 molecule like acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chr 4:92,394,535...92,412,146 JBrowse link
G CFH complement factor H acts_upstream_of_or_within ISO (PMID:18947875)
(PMID:25284781)		 RGD
MGI		 PMID:12374811 PMID:18947875 PMID:25284781 RGD:628500
G PHB2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) UniProt PMID:17070910 NCBI chr 5:63,751,566...63,756,480
Ensembl chr 5:63,751,558...63,756,478 		JBrowse link
G SUSD4 sushi domain containing 4 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr10:19,420,680...19,551,941
Ensembl chr10:19,421,565...19,551,840 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) ComplexPortal PMID:20378178 PMID:28671664
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:9892684) MGI PMID:9892684 NCBI chr 9:67,933,069...67,960,380 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18944
    immune system process 2587
      immune effector process 689
        complement activation 51
          activation of membrane attack complex + 4
          complement activation, alternative pathway + 15
          complement activation, classical pathway + 29
          complement activation, lectin pathway + 11
          negative regulation of complement activation + 13
          positive regulation of complement activation + 6
          regulation of complement activation + 22
Path 2
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  biological_process 18944
    biological regulation 13003
      regulation of biological process 12621
        positive regulation of biological process 6474
          positive regulation of response to stimulus 2443
            positive regulation of immune response 738
              activation of immune response 539
                complement activation 51
                  activation of membrane attack complex + 4
                  complement activation, alternative pathway + 15
                  complement activation, classical pathway + 29
                  complement activation, lectin pathway + 11
                  negative regulation of complement activation + 13
                  positive regulation of complement activation + 6
                  regulation of complement activation + 22
paths to the root