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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity
 xref: Reactome:R-HSA-166658 "Complement cascade"

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complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1r complement C1r involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624860:3,675,926...3,684,598
Ensembl chrNW_004624860:3,676,252...3,684,406 		JBrowse link
G C1s complement C1s involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624860:3,658,272...3,667,717
Ensembl chrNW_004624860:3,659,341...3,671,142 		JBrowse link
G C2 complement C2 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624754:24,316,778...24,327,065
Ensembl chrNW_004624754:24,317,058...24,322,656 		JBrowse link
G C3 complement C3 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:25284781)
(PMID:18947875)		 RGD
TreeGrafter
MGI		 PMID:18947875 PMID:20712003 PMID:25284781 GO_REF:0000118 RGD:5129529 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
G C6 complement C6 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624759:13,775,339...13,842,415
Ensembl chrNW_004624759:13,775,358...13,842,648 		JBrowse link
G C7 complement C7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624759:13,991,104...14,114,271
Ensembl chrNW_004624759:13,992,681...14,114,411 		JBrowse link
G C8a complement C8 alpha chain acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12413696) MGI
TreeGrafter		 PMID:12413696 GO_REF:0000118 NCBI chrNW_004624862:3,234,826...3,288,574
Ensembl chrNW_004624862:3,232,463...3,288,640 		JBrowse link
G C8b complement C8 beta chain involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624862:3,187,573...3,224,895
Ensembl chrNW_004624862:3,187,120...3,225,751 		JBrowse link
G C8g complement C8 gamma chain involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624760:937,871...939,655
Ensembl chrNW_004624760:937,871...939,466 		JBrowse link
G C9 complement C9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624759:15,534,743...15,623,767
Ensembl chrNW_004624759:15,534,660...15,624,381 		JBrowse link
G Cd46 CD46 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624807:4,040,639...4,074,631 JBrowse link
G Cfb complement factor B involved_in ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:6906329 GO_REF:0000002 GO_REF:0000118 RGD:2311339 NCBI chrNW_004624754:24,310,344...24,316,482
Ensembl chrNW_004624754:24,310,247...24,317,366 		JBrowse link
G Cfh complement factor H involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:20702729)
(PMID:15574507), (PMID:17517971), (PMID:17921253), (PMID:19541934), (PMID:28057640)
(PMID:19411110), (PMID:20675597)		 RGD
TreeGrafter
MGI		 PMID:12911541 PMID:15574507 PMID:17517971 PMID:17921253 PMID:19411110 More... GO_REF:0000118 RGD:1599888 NCBI chrNW_004624798:3,332,549...3,414,435 JBrowse link
G Cfi complement factor I involved_in ISO (PMID:18202746) MGI PMID:18202746 NCBI chrNW_004624830:111,123...151,668
Ensembl chrNW_004624830:111,004...151,514 		JBrowse link
G Colec11 collectin subfamily member 11 involved_in ISO (PMID:23954398) UniProt PMID:23954398 NCBI chrNW_004624846:5,173,292...5,185,036
Ensembl chrNW_004624846:5,173,292...5,182,471 		JBrowse link
G Fcn3 ficolin 3 involved_in ISO (PMID:22851708) UniProt PMID:22851708 NCBI chrNW_004624764:11,265,740...11,269,588
Ensembl chrNW_004624764:11,265,505...11,269,650 		JBrowse link
G LOC101719002 complement C4-A involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624754:24,258,026...24,270,710 JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624730:69,569,046...69,632,401
Ensembl chrNW_004624730:69,568,915...69,632,470 		JBrowse link
activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H acts_upstream_of_or_within ISO (PMID:20813971) MGI PMID:20813971 NCBI chrNW_004624798:3,332,549...3,414,435 JBrowse link
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624862:3,234,826...3,288,574
Ensembl chrNW_004624862:3,232,463...3,288,640 		JBrowse link
G C8b complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624862:3,187,573...3,224,895
Ensembl chrNW_004624862:3,187,120...3,225,751 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624759:15,534,743...15,623,767
Ensembl chrNW_004624759:15,534,660...15,624,381 		JBrowse link
G Cfb complement factor B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9238044)
(PMID:27564415)		 UniProt
MGI		 PMID:9238044 PMID:27564415 GO_REF:0000043 NCBI chrNW_004624754:24,310,344...24,316,482
Ensembl chrNW_004624754:24,310,247...24,317,366 		JBrowse link
G Cfd complement factor D acts_upstream_of_or_within ISO (PMID:27564415) MGI PMID:27564415 NCBI chrNW_004624828:7,714,926...7,717,139
Ensembl chrNW_004624828:7,711,537...7,717,337 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within_negative_effect ISO (PMID:19828624)
(PMID:27564415)		 MGI PMID:19828624 PMID:27564415 NCBI chrNW_004624798:3,332,549...3,414,435 JBrowse link
G Cfp complement factor properdin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624978:180,352...194,467
Ensembl chrNW_004624978:184,286...190,970 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect		 ISO (PMID:11981823)
(PMID:19828624)		 ARUK-UCL
MGI		 PMID:11981823 PMID:19828624 NCBI chrNW_004624807:4,149,472...4,179,269
Ensembl chrNW_004624807:4,152,230...4,179,211 		JBrowse link
G LOC101710080 complement C5-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:14,200,770...14,240,865 JBrowse link
G LOC101710435 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:14,296,904...14,396,585
Ensembl chrNW_004624760:14,296,967...14,396,188 		JBrowse link
G LOC101723821 complement C5-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:14,243,406...14,292,627 JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qa complement C1q A chain acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11901193) MGI
UniProt		 PMID:11901193 GO_REF:0000043 NCBI chrNW_004624764:7,363,615...7,366,408
Ensembl chrNW_004624764:7,363,567...7,366,617 		JBrowse link
G C1qb complement C1q B chain involved_in ISO (PMID:29449492) ComplexPortal PMID:29449492 NCBI chrNW_004624764:7,377,013...7,382,953
Ensembl chrNW_004624764:7,376,967...7,383,445 		JBrowse link
G C1qc complement C1q C chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:7,369,365...7,373,238
Ensembl chrNW_004624764:7,369,338...7,373,436 		JBrowse link
G C1r complement C1r involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624860:3,675,926...3,684,598
Ensembl chrNW_004624860:3,676,252...3,684,406 		JBrowse link
G C2 complement C2 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624754:24,316,778...24,327,065
Ensembl chrNW_004624754:24,317,058...24,322,656 		JBrowse link
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
G C6 complement C6 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624759:13,775,339...13,842,415
Ensembl chrNW_004624759:13,775,358...13,842,648 		JBrowse link
G C7 complement C7 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624759:13,991,104...14,114,271
Ensembl chrNW_004624759:13,992,681...14,114,411 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624862:3,234,826...3,288,574
Ensembl chrNW_004624862:3,232,463...3,288,640 		JBrowse link
G C8b complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624862:3,187,573...3,224,895
Ensembl chrNW_004624862:3,187,120...3,225,751 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624759:15,534,743...15,623,767
Ensembl chrNW_004624759:15,534,660...15,624,381 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624807:4,252,676...4,274,828 JBrowse link
G Crp C-reactive protein ISO RGD PMID:16367929 RGD:1580273 NCBI chrNW_004624794:1,531,555...1,533,804
Ensembl chrNW_004624794:1,531,571...1,533,804 		JBrowse link
G LOC101710080 complement C5-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:14,200,770...14,240,865 JBrowse link
G LOC101710435 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:14,296,904...14,396,585
Ensembl chrNW_004624760:14,296,967...14,396,188 		JBrowse link
G LOC101719002 complement C4-A involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624754:24,258,026...24,270,710 JBrowse link
G LOC101723821 complement C5-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624760:14,243,406...14,292,627 JBrowse link
G Mbl2 mannose binding lectin 2 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624791:10,881,319...10,886,294
Ensembl chrNW_004624791:10,881,268...10,886,297 		JBrowse link
complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Colec10 collectin subfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624763:17,302,075...17,350,682
Ensembl chrNW_004624763:17,301,993...17,352,559 		JBrowse link
G Colec11 collectin subfamily member 11 involved_in ISO (PMID:25912189)
(PMID:24174618)		 UniProt
ComplexPortal		 PMID:24174618 PMID:25912189 NCBI chrNW_004624846:5,173,292...5,185,036
Ensembl chrNW_004624846:5,173,292...5,182,471 		JBrowse link
G Fcn1 ficolin 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624760:2,743,996...2,751,116
Ensembl chrNW_004624760:2,743,996...2,751,110 		JBrowse link
G Fcn3 ficolin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624764:11,265,740...11,269,588
Ensembl chrNW_004624764:11,265,505...11,269,650 		JBrowse link
G Krt1 keratin 1 involved_in ISO (PMID:11549596) UniProt PMID:11549596 NCBI chrNW_004624904:801,979...816,463
Ensembl chrNW_004624904:802,460...807,469 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624730:69,569,046...69,632,401
Ensembl chrNW_004624730:69,568,915...69,632,470 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624818:1,745,401...1,759,051 JBrowse link
G Mbl2 mannose binding lectin 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15148336) MGI
UniProt		 PMID:15148336 GO_REF:0000043 NCBI chrNW_004624791:10,881,319...10,886,294
Ensembl chrNW_004624791:10,881,268...10,886,297 		JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in ISO (PMID:28657829)
(PMID:6211481)		 UniProt
RGD		 PMID:6211481 PMID:10929073 PMID:28657829 RGD:2326180 NCBI chrNW_004624807:4,252,676...4,274,828 JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) UniProt PMID:11485744 NCBI chrNW_004624730:69,569,046...69,632,401
Ensembl chrNW_004624730:69,568,915...69,632,470 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004624807:4,040,639...4,074,631 JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624835:5,531,507...5,600,181
Ensembl chrNW_004624835:5,531,472...5,599,922 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO (PMID:17051150) UniProt PMID:17051150 NCBI chrNW_004624898:1,268,998...1,288,756
Ensembl chrNW_004624898:1,268,886...1,289,180 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpb complement component 4 binding protein beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624807:4,407,008...4,416,313
Ensembl chrNW_004624807:4,406,766...4,415,248 		JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004624807:4,040,639...4,074,631 JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624835:5,531,507...5,600,181
Ensembl chrNW_004624835:5,531,472...5,599,922 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serping1 serpin family G member 1 involved_in ISO (PMID:10946292) UniProt PMID:10946292 NCBI chrNW_004624864:3,091,397...3,103,084
Ensembl chrNW_004624864:3,091,083...3,103,090 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (PMID:15611275) BHF-UCL PMID:15611275 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624749:12,852,128...12,858,478
Ensembl chrNW_004624749:12,852,021...12,858,760 		JBrowse link
G Mbl2 mannose binding lectin 2 ISO RGD PMID:9920905 RGD:4889148 NCBI chrNW_004624791:10,881,319...10,886,294
Ensembl chrNW_004624791:10,881,268...10,886,297 		JBrowse link
G Phb1 prohibitin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624795:5,556,728...5,565,969
Ensembl chrNW_004624795:5,556,450...5,565,988 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:30548312) ARUK-UCL PMID:30548312 NCBI chrNW_004624754:17,643,397...17,649,255
Ensembl chrNW_004624754:17,643,363...17,648,231 		JBrowse link
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624786:9,239,119...9,243,617
Ensembl chrNW_004624786:9,239,177...9,243,961 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chrNW_004624807:4,252,676...4,274,828 JBrowse link
G Cd5l CD5 molecule like acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chrNW_004624794:3,060,436...3,071,570
Ensembl chrNW_004624794:3,060,365...3,072,801 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within ISO (PMID:25284781)
(PMID:18947875)		 MGI
RGD		 PMID:12374811 PMID:18947875 PMID:25284781 RGD:628500 NCBI chrNW_004624798:3,332,549...3,414,435 JBrowse link
G Phb2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) UniProt PMID:17070910 NCBI chrNW_004624860:3,599,435...3,605,016
Ensembl chrNW_004624860:3,599,687...3,604,872 		JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624835:5,531,507...5,600,181
Ensembl chrNW_004624835:5,531,472...5,599,922 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) ComplexPortal PMID:20378178 PMID:28671664 NCBI chrNW_004624798:3,332,549...3,414,435 JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:9892684) MGI PMID:9892684 NCBI chrNW_004624807:4,252,676...4,274,828 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17650
    immune system process 2287
      immune effector process 587
        complement activation 44
          activation of membrane attack complex + 2
          complement activation, alternative pathway + 15
          complement activation, classical pathway + 22
          complement activation, lectin pathway + 9
          negative regulation of complement activation + 7
          positive regulation of complement activation + 5
          regulation of complement activation + 16
Path 2
Term Annotations click to browse term
  biological_process 17650
    biological regulation 11838
      regulation of biological process 11481
        positive regulation of biological process 6137
          positive regulation of response to stimulus 2296
            positive regulation of immune response 675
              activation of immune response 499
                complement activation 44
                  activation of membrane attack complex + 2
                  complement activation, alternative pathway + 15
                  complement activation, classical pathway + 22
                  complement activation, lectin pathway + 9
                  negative regulation of complement activation + 7
                  positive regulation of complement activation + 5
                  regulation of complement activation + 16
paths to the root