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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity
 xref: Reactome:R-HSA-166658 "Complement cascade"


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complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C2 complement C2 involved_in ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr17:35,081,578...35,101,076
Ensembl chr17:35,081,580...35,117,241 		JBrowse link
G C3 complement component 3 involved_in
acts_upstream_of_or_within		 ISO
IBA
IDA
IMP		 (PMID:18947875)
(PMID:25284781)		 RGD
GO_Central
MGI		 PMID:18947875 PMID:20712003 PMID:25284781 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:5129529 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G C4a complement C4A (Rodgers blood group) involved_in
acts_upstream_of_or_within		 ISO
IDA		 (PMID:19302245)
(PMID:1438267), (PMID:8133084)		 BHF-UCL
MGI		 PMID:1438267 PMID:8133084 PMID:19302245 NCBI chr17:35,028,069...35,042,436
Ensembl chr17:35,028,069...35,042,440 		JBrowse link
G C4b complement C4B (Chido blood group) acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:12421924) MGI
GO_Central		 PMID:12421924 GO_REF:0000033 NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856 		JBrowse link
G C6 complement component 6 involved_in IBA
ISO		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449 		JBrowse link
G C7 complement component 7 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:5,017,232...5,093,230
Ensembl chr15:5,018,244...5,093,222 		JBrowse link
G C8a complement component 8, alpha polypeptide acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI
GO_Central		 GO_REF:0000008 GO_REF:0000033 NCBI chr 4:104,672,876...104,733,684
Ensembl chr 4:104,672,876...104,733,595 		JBrowse link
G C8b complement component 8, beta polypeptide involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:104,623,514...104,661,745
Ensembl chr 4:104,623,514...104,661,745 		JBrowse link
G C9 complement component 9 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:6,474,827...6,528,306
Ensembl chr15:6,474,808...6,528,232 		JBrowse link
G Cfb complement factor B involved_in ISO
IBA		 RGD
GO_Central		 PMID:6906329 GO_REF:0000033 RGD:2311339 NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494 		JBrowse link
G Cfh complement component factor h involved_in
acts_upstream_of_or_within		 ISO
IBA
IDA
IGI
IMP		 (PMID:19411110), (PMID:20675597)
(PMID:20702729)
(PMID:15574507), (PMID:17517971), (PMID:17921253), (PMID:19541934), (PMID:28057640)		 RGD
GO_Central
MGI		 PMID:12911541 PMID:15574507 PMID:17517971 PMID:17921253 PMID:19411110 More... GO_REF:0000033 GO_REF:0000119 RGD:1599888 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502 		JBrowse link
G Cfhr1 complement factor H-related 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:139,474,802...139,487,960
Ensembl chr 1:139,474,791...139,488,010 		JBrowse link
G Cfhr2 complement factor H-related 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:139,738,030...139,786,437
Ensembl chr 1:139,731,905...139,786,456 		JBrowse link
G Cfhr4 complement factor H-related 4 involved_in ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr 1:139,625,657...139,708,977
Ensembl chr 1:139,625,361...139,708,981 		JBrowse link
G Cfi complement component factor i involved_in IMP (PMID:18202746) MGI PMID:18202746 NCBI chr 3:129,630,432...129,668,978
Ensembl chr 3:129,629,533...129,668,981 		JBrowse link
G Cfp complement factor properdin involved_in NAS (PMID:23901101) ComplexPortal PMID:23901101 NCBI chr  X:20,791,693...20,797,794
Ensembl chr  X:20,791,693...20,797,794 		JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISO GO_Central GO_REF:0000119 NCBI chr12:28,644,171...28,673,458
Ensembl chr12:28,644,172...28,673,376 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within IMP (PMID:20675597) MGI PMID:20675597 NCBI chr 1:194,781,019...194,813,878
Ensembl chr 1:194,779,690...194,813,894 		JBrowse link
G Fcna ficolin A involved_in ISO (PMID:22851708) UniProt PMID:22851708 NCBI chr 2:25,514,677...25,525,448
Ensembl chr 2:25,514,678...25,518,042 		JBrowse link
G Rgcc regulator of cell cycle involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr14:79,526,190...79,539,075
Ensembl chr14:79,526,196...79,539,085 		JBrowse link
activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement component factor h acts_upstream_of_or_within IMP (PMID:20813971) MGI PMID:20813971 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502 		JBrowse link
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement component 3 involved_in IEA UniProt GO_REF:0000043 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G C8a complement component 8, alpha polypeptide involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:104,672,876...104,733,684
Ensembl chr 4:104,672,876...104,733,595 		JBrowse link
G C8b complement component 8, beta polypeptide involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:104,623,514...104,661,745
Ensembl chr 4:104,623,514...104,661,745 		JBrowse link
G C8g complement component 8, gamma polypeptide involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:25,388,662...25,391,731
Ensembl chr 2:25,388,663...25,391,731 		JBrowse link
G C9 complement component 9 involved_in IEA UniProt GO_REF:0000043 NCBI chr15:6,474,827...6,528,306
Ensembl chr15:6,474,808...6,528,232 		JBrowse link
G Cfb complement factor B acts_upstream_of_or_within IGI
IMP
TAS		 (PMID:27564415)
(PMID:9238044)
(PMID:6550027)		 MGI PMID:6550027 PMID:9238044 PMID:27564415 NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494 		JBrowse link
G Cfd complement factor D acts_upstream_of_or_within IMP (PMID:27564415) MGI PMID:27564415 NCBI chr10:79,726,687...79,728,489
Ensembl chr10:79,726,687...79,728,489 		JBrowse link
G Cfh complement component factor h acts_upstream_of_or_within
acts_upstream_of_or_within_negative_effect		 IMP
IGI		 (PMID:27564415)
(PMID:19828624)		 MGI PMID:19828624 PMID:27564415 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502 		JBrowse link
G Cfp complement factor properdin involved_in IMP (PMID:18292556) MGI PMID:18292556 NCBI chr  X:20,791,693...20,797,794
Ensembl chr  X:20,791,693...20,797,794 		JBrowse link
G Cr2 complement receptor 2 acts_upstream_of_or_within_negative_effect
involved_in		 IGI
ISO		 (PMID:19828624) MGI
GO_Central		 PMID:19828624 GO_REF:0000119 NCBI chr 1:194,819,120...194,859,096
Ensembl chr 1:194,819,119...194,859,024 		JBrowse link
G Hc hemolytic complement involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450 		JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qa complement component 1, q subcomponent, alpha polypeptide acts_upstream_of_or_within
involved_in		 IMP
NAS
ISO		 (PMID:11901193)
(PMID:11527969)		 MGI
ComplexPortal
GO_Central		 PMID:11527969 PMID:11901193 GO_REF:0000114 GO_REF:0000119 NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114 		JBrowse link
G C1qb complement component 1, q subcomponent, beta polypeptide involved_in ISO
NAS		 (PMID:11527969) ComplexPortal
GO_Central		 PMID:11527969 GO_REF:0000114 GO_REF:0000119 NCBI chr 4:136,607,437...136,613,511
Ensembl chr 4:136,607,440...136,613,498 		JBrowse link
G C1qbp complement component 1, q subcomponent binding protein involved_in IEA UniProt GO_REF:0000043 NCBI chr11:70,868,672...70,873,852
Ensembl chr11:70,868,662...70,873,852 		JBrowse link
G C1qc complement component 1, q subcomponent, C chain involved_in NAS
ISO		 (PMID:11527969) ComplexPortal
GO_Central		 PMID:11527969 GO_REF:0000114 GO_REF:0000119 NCBI chr 4:136,617,115...136,620,225
Ensembl chr 4:136,617,115...136,620,376 		JBrowse link
G C1ra complement component 1, r subcomponent A involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:124,489,580...124,500,399
Ensembl chr 6:124,489,364...124,500,402 		JBrowse link
G C1rb complement component 1, r subcomponent B involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:124,547,389...124,558,003
Ensembl chr 6:124,547,253...124,558,130 		JBrowse link
G C1rl complement component 1, r subcomponent-like involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:124,470,072...124,487,602
Ensembl chr 6:124,470,072...124,487,602 		JBrowse link
G C1s1 complement component 1, s subcomponent 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:124,507,303...124,519,340
Ensembl chr 6:124,507,304...124,519,318 		JBrowse link
G C1s2 complement component 1, s subcomponent 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:124,601,584...124,613,044
Ensembl chr 6:124,601,584...124,613,044 		JBrowse link
G C2 complement C2 involved_in IEA UniProt GO_REF:0000043 NCBI chr17:35,081,578...35,101,076
Ensembl chr17:35,081,580...35,117,241 		JBrowse link
G C3 complement component 3 involved_in IEA UniProt GO_REF:0000043 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G C4b complement C4B (Chido blood group) involved_in IEA UniProt GO_REF:0000043 NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856 		JBrowse link
G C4bp complement component 4 binding protein involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:130,562,510...130,589,365
Ensembl chr 1:130,562,510...130,589,369 		JBrowse link
G C8a complement component 8, alpha polypeptide involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:104,672,876...104,733,684
Ensembl chr 4:104,672,876...104,733,595 		JBrowse link
G C8b complement component 8, beta polypeptide involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:104,623,514...104,661,745
Ensembl chr 4:104,623,514...104,661,745 		JBrowse link
G C8g complement component 8, gamma polypeptide involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:25,388,662...25,391,731
Ensembl chr 2:25,388,663...25,391,731 		JBrowse link
G C9 complement component 9 involved_in IEA UniProt GO_REF:0000043 NCBI chr15:6,474,827...6,528,306
Ensembl chr15:6,474,808...6,528,232 		JBrowse link
G Cd55 CD55 molecule, decay accelerating factor for complement involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481 		JBrowse link
G Cd55b CD55 molecule, decay accelerating factor for complement B involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:130,316,263...130,350,831
Ensembl chr 1:130,316,274...130,350,746 		JBrowse link
G Cfi complement component factor i involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:129,630,432...129,668,978
Ensembl chr 3:129,629,533...129,668,981 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:194,781,019...194,813,878
Ensembl chr 1:194,779,690...194,813,894 		JBrowse link
G Cr2 complement receptor 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:194,819,120...194,859,096
Ensembl chr 1:194,819,119...194,859,024 		JBrowse link
G Crp C-reactive protein, pentraxin-related involved_in ISO RGD
GO_Central		 PMID:16367929 GO_REF:0000096 RGD:1580273 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Hc hemolytic complement involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450 		JBrowse link
G Igh-8 immunoglobulin heavy chain 8 (heavy chain of IgG3) acts_upstream_of_or_within IDA (PMID:11901193) MGI PMID:11901193
G Igha immunoglobulin heavy constant alpha involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:113,219,824...113,223,856
Ensembl chr12:113,218,450...113,223,856 		JBrowse link
G Ighe Immunoglobulin heavy constant epsilon involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:113,232,883...113,236,868
Ensembl chr12:113,232,880...113,236,868 		JBrowse link
G Ighg Immunoglobulin heavy chain (gamma polypeptide) involved_in IBA GO_Central GO_REF:0000033
G Ighg1 immunoglobulin heavy constant gamma 1 (G1m marker) acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:6952213) MGI
GO_Central		 PMID:6952213 GO_REF:0000033 NCBI chr12:113,290,161...113,294,143
Ensembl chr12:113,288,860...113,294,143 		JBrowse link
G Ighg2a immunoglobulin heavy constant gamma 2A acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:11901193), (PMID:6952213) MGI
GO_Central		 PMID:6952213 PMID:11901193 GO_REF:0000033
G Ighg2b immunoglobulin heavy constant gamma 2B acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:11901193), (PMID:6952213) MGI
GO_Central		 PMID:6952213 PMID:11901193 GO_REF:0000033 NCBI chr12:113,267,934...113,271,553
Ensembl chr12:113,266,585...113,271,553 		JBrowse link
G Ighg2c immunoglobulin heavy constant gamma 2C involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:113,251,009...113,252,552
Ensembl chr12:113,248,945...113,252,552 		JBrowse link
G Ighg3 Immunoglobulin heavy constant gamma 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:113,321,062...113,324,852
Ensembl chr12:113,319,844...113,324,852 		JBrowse link
G Ighm immunoglobulin heavy constant mu involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:113,382,446...113,386,350
Ensembl chr12:113,382,178...113,386,350 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:148,679,079...148,699,939
Ensembl chr 4:148,687,011...148,699,956 		JBrowse link
G Mbl1 mannose-binding lectin (protein A) 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr14:40,873,413...40,885,861
Ensembl chr14:40,873,415...40,881,558 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788 		JBrowse link
complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Colec10 collectin sub-family member 10 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr15:54,274,170...54,329,755
Ensembl chr15:54,274,170...54,329,754 		JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr12:28,644,171...28,673,458
Ensembl chr12:28,644,172...28,673,376 		JBrowse link
G Fcna ficolin A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:25,514,677...25,525,448
Ensembl chr 2:25,514,678...25,518,042 		JBrowse link
G Fcnb ficolin B involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:27,966,491...27,974,921
Ensembl chr 2:27,966,390...27,974,897 		JBrowse link
G Krt1 keratin 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr15:101,753,861...101,759,221
Ensembl chr15:101,753,861...101,759,229 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IBA
IMP
ISO		 (PMID:18424734) GO_Central
UniProt		 PMID:18424734 GO_REF:0000033 GO_REF:0000119 NCBI chr16:23,261,778...23,340,127
Ensembl chr16:23,268,167...23,339,565 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IBA
ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr 4:148,679,079...148,699,939
Ensembl chr 4:148,687,011...148,699,956 		JBrowse link
G Mbl1 mannose-binding lectin (protein A) 1 involved_in
acts_upstream_of_or_within		 ISO
IDA
IGI		 (PMID:15148336) RGD
GO_Central
MGI		 PMID:15148336 PMID:16272342 GO_REF:0000096 RGD:1582134 NCBI chr14:40,873,413...40,885,861
Ensembl chr14:40,873,415...40,881,558 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 acts_upstream_of_or_within
involved_in		 IMP
ISO
IDA
IGI		 (PMID:15148336) MGI
GO_Central		 PMID:15148336 GO_REF:0000008 GO_REF:0000119 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59a CD59a antigen acts_upstream_of_or_within
involved_in		 IDA
IBA
ISO
IMP		 (PMID:11471050)
(PMID:17237428)		 MGI
GO_Central
BHF-UCL		 PMID:11471050 PMID:17237428 GO_REF:0000033 GO_REF:0000096 NCBI chr 2:103,926,177...103,945,755
Ensembl chr 2:103,926,146...103,945,699 		JBrowse link
G Cd59b CD59b antigen involved_in
acts_upstream_of_or_within		 ISO
IBA
IDA		 (PMID:10946279), (PMID:11471050) RGD
GO_Central
MGI		 PMID:10946279 PMID:11471050 PMID:15843577 GO_REF:0000033 GO_REF:0000096 RGD:1600482 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534 		JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule, decay accelerating factor for complement involved_in ISO
ISS		 RGD
GO_Central
UniProt		 PMID:10929073 GO_REF:0000024 GO_REF:0000096 GO_REF:0000119 RGD:2326180 NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481 		JBrowse link
G Cd55b CD55 molecule, decay accelerating factor for complement B involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000096 GO_REF:0000119 NCBI chr 1:130,316,263...130,350,831
Ensembl chr 1:130,316,274...130,350,746 		JBrowse link
G Cd59a CD59a antigen involved_in IDA (PMID:17237428) BHF-UCL PMID:17237428 NCBI chr 2:103,926,177...103,945,755
Ensembl chr 2:103,926,146...103,945,699 		JBrowse link
G Cd59b CD59b antigen acts_upstream_of_or_within IDA (PMID:10946279) MGI PMID:10946279 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in
acts_upstream_of_or_within		 ISO
IMP		 (PMID:10642554) RGD
GO_Central
MGI		 PMID:10642554 PMID:11861390 GO_REF:0000096 RGD:625470 NCBI chr 1:194,781,019...194,813,878
Ensembl chr 1:194,779,690...194,813,894 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr16:23,261,778...23,340,127
Ensembl chr16:23,268,167...23,339,565 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 antigen, complement regulatory protein involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chr 1:194,721,279...194,781,149
Ensembl chr 1:194,719,134...194,774,557 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 1:182,591,609...182,724,161
Ensembl chr 1:182,591,425...182,724,156 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in IBA
ISO		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr  X:95,290,807...95,337,044
Ensembl chr  X:95,290,809...95,337,044 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bp complement component 4 binding protein involved_in ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr 1:130,562,510...130,589,365
Ensembl chr 1:130,562,510...130,589,369 		JBrowse link
G Cd46 CD46 antigen, complement regulatory protein involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:194,721,279...194,781,149
Ensembl chr 1:194,719,134...194,774,557 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:194,781,019...194,813,878
Ensembl chr 1:194,779,690...194,813,894 		JBrowse link
G Cr2 complement receptor 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:194,819,120...194,859,096
Ensembl chr 1:194,819,119...194,859,024 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 1:182,591,609...182,724,161
Ensembl chr 1:182,591,425...182,724,156 		JBrowse link
G Zp3r zona pellucida 3 receptor involved_in ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr 1:130,474,847...130,557,371
Ensembl chr 1:130,504,450...130,557,358 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement component 3 involved_in IMP (PMID:15611275) BHF-UCL PMID:15611275 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 involved_in ISO RGD
GO_Central		 PMID:9920905 GO_REF:0000096 RGD:4889148 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Phb1 prohibitin 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr11:95,557,783...95,571,599
Ensembl chr11:95,557,783...95,571,599 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IMP (PMID:30548312) ARUK-UCL PMID:30548312 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175 		JBrowse link
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement component 1, q subcomponent binding protein involved_in IBA
ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr11:70,868,672...70,873,852
Ensembl chr11:70,868,662...70,873,852 		JBrowse link
G Cd55 CD55 molecule, decay accelerating factor for complement acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481 		JBrowse link
G Cd59a CD59a antigen acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chr 2:103,926,177...103,945,755
Ensembl chr 2:103,926,146...103,945,699 		JBrowse link
G Cd59b CD59b antigen acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534 		JBrowse link
G Cd5l CD5 antigen-like acts_upstream_of_or_within IMP (PMID:25284781) MGI PMID:25284781 NCBI chr 3:87,265,188...87,278,381
Ensembl chr 3:87,265,188...87,278,380 		JBrowse link
G Cfh complement component factor h involved_in
acts_upstream_of_or_within		 ISO
IMP		 (PMID:25284781)
(PMID:18947875)		 RGD
GO_Central
MGI		 PMID:12374811 PMID:18947875 PMID:25284781 GO_REF:0000096 RGD:628500 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502 		JBrowse link
G Cfhr4 complement factor H-related 4 involved_in ISO GO_Central GO_REF:0000096 NCBI chr 1:139,625,657...139,708,977
Ensembl chr 1:139,625,361...139,708,981 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like acts_upstream_of_or_within IMP
ISO
TAS		 (PMID:18947875)
(PMID:25284781)
(PMID:11698469)		 MGI PMID:11698469 PMID:18947875 PMID:25284781 NCBI chr 1:194,781,019...194,813,878
Ensembl chr 1:194,779,690...194,813,894 		JBrowse link
G Phb2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) UniProt PMID:17070910 NCBI chr 6:124,689,252...124,693,908
Ensembl chr 6:124,689,299...124,693,913 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 1:182,591,609...182,724,161
Ensembl chr 1:182,591,425...182,724,156 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement component factor h involved_in ISO GO_Central GO_REF:0000119 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502 		JBrowse link
G Cfhr4 complement factor H-related 4 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 1:139,625,657...139,708,977
Ensembl chr 1:139,625,361...139,708,981 		JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule, decay accelerating factor for complement acts_upstream_of_or_within IMP (PMID:9892684) MGI PMID:9892684 NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28640
    immune system process 3186
      immune effector process 881
        complement activation 67
          activation of membrane attack complex + 4
          complement activation, alternative pathway + 15
          complement activation, classical pathway + 42
          complement activation, lectin pathway + 11
          negative regulation of complement activation + 14
          positive regulation of complement activation + 5
          regulation of complement activation + 24
Path 2
Term Annotations click to browse term
  biological_process 28640
    biological regulation 13474
      regulation of biological process 13033
        positive regulation of biological process 6994
          positive regulation of response to stimulus 2700
            positive regulation of immune response 876
              activation of immune response 639
                complement activation 67
                  activation of membrane attack complex + 4
                  complement activation, alternative pathway + 15
                  complement activation, classical pathway + 42
                  complement activation, lectin pathway + 11
                  negative regulation of complement activation + 14
                  positive regulation of complement activation + 5
                  regulation of complement activation + 24
paths to the root