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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity
 xref: Reactome:R-HSA-166658 "Complement cascade"


show annotations for term's descendants           Sort by:
complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QA complement C1q A chain involved_in TAS (PMID:9461517) PINC PMID:9461517 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678 		JBrowse link
G C1QB complement C1q B chain involved_in TAS (PMID:1706597) PINC PMID:1706597 NCBI chr 1:22,653,236...22,661,637
Ensembl chr 1:22,652,762...22,661,637 		JBrowse link
G C1R complement C1r involved_in IEA InterPro GO_REF:0000002 NCBI chr12:7,080,219...7,092,445
Ensembl chr12:7,080,214...7,092,540 		JBrowse link
G C1S complement C1s involved_in IEA InterPro GO_REF:0000002 NCBI chr12:7,060,718...7,071,032
Ensembl chr12:6,988,259...7,071,032 		JBrowse link
G C2 complement C2 involved_in IEA
IBA
IMP		 (PMID:19302245) InterPro
GO_Central
Ensembl
BHF-UCL		 PMID:19302245 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:31,897,783...31,945,672
Ensembl chr 6:31,897,785...31,945,673 		JBrowse link
G C3 complement C3 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA
IMP		 (PMID:19302245) RGD
Ensembl
GO_Central
InterPro
BHF-UCL		 PMID:19302245 PMID:20712003 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:5129529 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G C4A complement C4A (Chido/Rodgers blood group) involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
IGI		 (PMID:1438267), (PMID:8133084)
(PMID:19302245)		 InterPro
MGI
GO_Central
BHF-UCL		 PMID:1438267 PMID:8133084 PMID:19302245 GO_REF:0000002 GO_REF:0000033 NCBI chr 6:31,982,057...32,002,681
Ensembl chr 6:31,982,057...32,002,681 		JBrowse link
G C4B complement C4B (Chido/Rodgers blood group) involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
IGI		 (PMID:12421924)
(PMID:19302245)		 InterPro
MGI
GO_Central
BHF-UCL		 PMID:12421924 PMID:19302245 GO_REF:0000002 GO_REF:0000033 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418 		JBrowse link
G C4B_2 complement component 4B (Chido/Rodgers blood group), copy 2 involved_in IEA
IBA
IGI		 (PMID:19302245) InterPro
GO_Central
BHF-UCL		 PMID:19302245 GO_REF:0000002 GO_REF:0000033
G C5 complement C5 involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195 		JBrowse link
G C6 complement C6 involved_in TAS
IBA
IDA		 (PMID:2808363) PINC
GO_Central
ComplexPortal		 PMID:2808363 GO_REF:0000033 NCBI chr 5:41,142,116...41,261,469
Ensembl chr 5:41,142,116...41,261,438 		JBrowse link
G C7 complement C7 involved_in TAS
IBA		 (PMID:3335508) PINC
GO_Central		 PMID:3335508 GO_REF:0000033 NCBI chr 5:40,909,497...40,984,643
Ensembl chr 5:40,909,492...41,020,216 		JBrowse link
G C8A complement C8 alpha chain acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:12413696) MGI
GO_Central		 PMID:12413696 GO_REF:0000033 NCBI chr 1:56,854,797...56,918,223
Ensembl chr 1:56,854,768...56,918,223 		JBrowse link
G C8B complement C8 beta chain involved_in TAS
IBA		 (PMID:8098723) PINC
GO_Central		 PMID:8098723 GO_REF:0000033 NCBI chr 1:56,929,207...56,966,015
Ensembl chr 1:56,929,207...56,974,383 		JBrowse link
G C8G complement C8 gamma chain involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:136,945,243...136,946,975
Ensembl chr 9:136,945,185...136,946,975 		JBrowse link
G C9 complement C9 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:39,284,140...39,364,495
Ensembl chr 5:39,284,140...39,371,324 		JBrowse link
G CFB complement factor B involved_in ISO
IBA
IEA		 RGD
GO_Central
InterPro		 PMID:6906329 GO_REF:0000002 GO_REF:0000033 RGD:2311339 NCBI chr 6:31,946,095...31,952,084
Ensembl chr 6:31,945,650...31,952,086 		JBrowse link
G CFD complement factor D involved_in TAS (PMID:1374388) PINC PMID:1374388 NCBI chr19:859,664...863,641
Ensembl chr19:859,453...867,884 		JBrowse link
G CFH complement factor H acts_upstream_of_or_within
involved_in		 ISO
IBA
TAS
IDA		 (PMID:15574507), (PMID:17517971), (PMID:17921253), (PMID:19541934), (PMID:28057640)
(PMID:20702729)
(PMID:19411110), (PMID:20675597)
(PMID:9312129)
(PMID:24835392)		 RGD
MGI
GO_Central
PINC
AgBase		 PMID:9312129 PMID:12911541 PMID:15574507 PMID:17517971 PMID:17921253 More... GO_REF:0000033 RGD:1599888 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476 		JBrowse link
G CFHR1 complement factor H related 1 involved_in TAS
IBA		 (PMID:1711047) PINC
GO_Central		 PMID:1711047 GO_REF:0000033 NCBI chr 1:196,819,731...196,832,189
Ensembl chr 1:196,819,731...196,837,159 		JBrowse link
G CFHR2 complement factor H related 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:196,943,738...196,959,622
Ensembl chr 1:196,943,738...196,959,622 		JBrowse link
G CFHR3 complement factor H related 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:196,774,840...196,795,407
Ensembl chr 1:196,774,813...196,795,407 		JBrowse link
G CFHR4 complement factor H related 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:196,888,052...196,918,633
Ensembl chr 1:196,888,014...196,918,795 		JBrowse link
G CFHR5 complement factor H related 5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:196,975,034...197,009,678
Ensembl chr 1:196,975,010...197,009,678 		JBrowse link
G CFI complement factor I involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:109,730,982...109,801,999
Ensembl chr 4:109,731,008...109,802,150 		JBrowse link
G CFP complement factor properdin involved_in NAS (PMID:23901101) ComplexPortal PMID:23901101 NCBI chr  X:47,623,282...47,630,305
Ensembl chr  X:47,623,172...47,630,305 		JBrowse link
G CLU clusterin involved_in TAS (PMID:1585460) PINC PMID:1585460 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700 		JBrowse link
G COLEC11 collectin subfamily member 11 involved_in IDA (PMID:23954398) UniProt PMID:23954398 NCBI chr 2:3,595,112...3,644,644
Ensembl chr 2:3,594,832...3,644,644 		JBrowse link
G CR1L complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO (PMID:20675597) MGI PMID:20675597 NCBI chr 1:207,645,133...207,723,703
Ensembl chr 1:207,645,113...207,738,416 		JBrowse link
G FCN3 ficolin 3 involved_in IDA (PMID:22851708) UniProt PMID:22851708 NCBI chr 1:27,369,110...27,374,824
Ensembl chr 1:27,369,110...27,374,824 		JBrowse link
G LOC110384692 complement C4A (Rodgers blood group)-like involved_in IEA InterPro GO_REF:0000002
G MASP1 MBL associated serine protease 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:187,217,282...187,291,737
Ensembl chr 3:187,217,282...187,291,980 		JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:11,026,523...11,047,239
Ensembl chr 1:11,022,009...11,047,239 		JBrowse link
activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H acts_upstream_of_or_within ISO (PMID:20813971) MGI PMID:20813971 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476 		JBrowse link
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AL645922.1 novel complement component 2 (C2) and complement factor B (CFB) protein involved_in IEA UniProt GO_REF:0000043 Ensembl chr 6:31,927,698...31,952,048 JBrowse link
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195 		JBrowse link
G C7 complement C7 involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:40,909,497...40,984,643
Ensembl chr 5:40,909,492...41,020,216 		JBrowse link
G C8A complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:56,854,797...56,918,223
Ensembl chr 1:56,854,768...56,918,223 		JBrowse link
G C8B complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:56,929,207...56,966,015
Ensembl chr 1:56,929,207...56,974,383 		JBrowse link
G C8G complement C8 gamma chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:136,945,243...136,946,975
Ensembl chr 9:136,945,185...136,946,975 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:39,284,140...39,364,495
Ensembl chr 5:39,284,140...39,371,324 		JBrowse link
G CFB complement factor B involved_in
acts_upstream_of_or_within		 TAS
ISO
NAS
IEA		 (PMID:9238044)
(PMID:27564415)
(PMID:8225386)		 Reactome
MGI
UniProt		 PMID:8225386 PMID:9238044 PMID:27564415 GO_REF:0000043 Reactome:R-HSA-173736 NCBI chr 6:31,946,095...31,952,084
Ensembl chr 6:31,945,650...31,952,086 		JBrowse link
G CFD complement factor D involved_in
acts_upstream_of_or_within		 TAS
IEA		 Reactome
Ensembl
UniProt		 GO_REF:0000043 GO_REF:0000107 Reactome:R-HSA-173736 NCBI chr19:859,664...863,641
Ensembl chr19:859,453...867,884 		JBrowse link
G CFH complement factor H involved_in
acts_upstream_of_or_within_negative_effect		 IEA
ISO		 (PMID:19828624)
(PMID:27564415)		 UniProt
MGI		 PMID:19828624 PMID:27564415 GO_REF:0000043 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476 		JBrowse link
G CFHR5 complement factor H related 5 involved_in NAS (PMID:11058592) UniProt PMID:11058592 NCBI chr 1:196,975,034...197,009,678
Ensembl chr 1:196,975,010...197,009,678 		JBrowse link
G CFP complement factor properdin involved_in IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr  X:47,623,282...47,630,305
Ensembl chr  X:47,623,172...47,630,305 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IMP (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765 		JBrowse link
G CR2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect		 IMP
ISO		 (PMID:11981823)
(PMID:19828624)		 ARUK-UCL
MGI		 PMID:11981823 PMID:19828624 NCBI chr 1:207,454,328...207,489,892
Ensembl chr 1:207,453,024...207,489,895 		JBrowse link
G VSIG4 V-set and immunoglobulin domain containing 4 involved_in IEA UniProt GO_REF:0000043 NCBI chr  X:66,021,738...66,040,080
Ensembl chr  X:66,021,738...66,040,125 		JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QA complement C1q A chain involved_in
acts_upstream_of_or_within		 IDA
IEA
NAS		 (PMID:29449492)
(PMID:11527969)		 ComplexPortal
Ensembl
UniProt		 PMID:11527969 PMID:29449492 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678 		JBrowse link
G C1QB complement C1q B chain involved_in IEA
NAS
IDA		 (PMID:11527969)
(PMID:29449492)		 UniProt
ComplexPortal		 PMID:11527969 PMID:29449492 GO_REF:0000043 NCBI chr 1:22,653,236...22,661,637
Ensembl chr 1:22,652,762...22,661,637 		JBrowse link
G C1QBP complement C1q binding protein involved_in IEA UniProt GO_REF:0000043 NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830 		JBrowse link
G C1QC complement C1q C chain involved_in IEA
NAS
IDA		 (PMID:11527969)
(PMID:29449492)		 UniProt
ComplexPortal		 PMID:11527969 PMID:29449492 GO_REF:0000043 NCBI chr 1:22,643,633...22,648,108
Ensembl chr 1:22,643,014...22,648,110 		JBrowse link
G C1R complement C1r involved_in IEA
TAS		 UniProt
Reactome		 GO_REF:0000043 Reactome:R-HSA-173623 NCBI chr12:7,080,219...7,092,445
Ensembl chr12:7,080,214...7,092,540 		JBrowse link
G C1RL complement C1r subcomponent like involved_in IEA UniProt GO_REF:0000043 NCBI chr12:7,094,554...7,109,214
Ensembl chr12:7,089,587...7,109,238 		JBrowse link
G C1S complement C1s involved_in IEA UniProt GO_REF:0000043 NCBI chr12:7,060,718...7,071,032
Ensembl chr12:6,988,259...7,071,032 		JBrowse link
G C2 complement C2 involved_in TAS
IEA		 (PMID:8621452) PINC
UniProt		 PMID:8621452 GO_REF:0000043 NCBI chr 6:31,897,783...31,945,672
Ensembl chr 6:31,897,785...31,945,673 		JBrowse link
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G C4A complement C4A (Chido/Rodgers blood group) involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:31,982,057...32,002,681
Ensembl chr 6:31,982,057...32,002,681 		JBrowse link
G C4B complement C4B (Chido/Rodgers blood group) involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418 		JBrowse link
G C4B_2 complement component 4B (Chido/Rodgers blood group), copy 2 involved_in IEA UniProt GO_REF:0000043
G C4BPA complement component 4 binding protein alpha involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:207,104,233...207,144,972
Ensembl chr 1:207,104,233...207,144,972 		JBrowse link
G C4BPB complement component 4 binding protein beta involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:207,088,860...207,099,993
Ensembl chr 1:207,088,860...207,099,993 		JBrowse link
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195 		JBrowse link
G C6 complement C6 involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:41,142,116...41,261,469
Ensembl chr 5:41,142,116...41,261,438 		JBrowse link
G C7 complement C7 involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:40,909,497...40,984,643
Ensembl chr 5:40,909,492...41,020,216 		JBrowse link
G C8A complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:56,854,797...56,918,223
Ensembl chr 1:56,854,768...56,918,223 		JBrowse link
G C8B complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:56,929,207...56,966,015
Ensembl chr 1:56,929,207...56,974,383 		JBrowse link
G C8G complement C8 gamma chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:136,945,243...136,946,975
Ensembl chr 9:136,945,185...136,946,975 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:39,284,140...39,364,495
Ensembl chr 5:39,284,140...39,371,324 		JBrowse link
G CD46 CD46 molecule involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:207,752,038...207,795,516
Ensembl chr 1:207,752,037...207,795,513 		JBrowse link
G CD55 CD55 molecule (Cromer blood group) involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:207,321,678...207,360,966
Ensembl chr 1:207,321,519...207,386,804 		JBrowse link
G CFI complement factor I involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:109,730,982...109,801,999
Ensembl chr 4:109,731,008...109,802,150 		JBrowse link
G CLU clusterin involved_in IEA UniProt GO_REF:0000043 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765 		JBrowse link
G CR2 complement C3d receptor 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:207,454,328...207,489,892
Ensembl chr 1:207,453,024...207,489,895 		JBrowse link
G CRP C-reactive protein ISO RGD PMID:16367929 RGD:1580273 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G IGHA1 immunoglobulin heavy constant alpha 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:105,707,168...105,708,664
Ensembl chr14:105,703,995...105,708,665 		JBrowse link
G IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker) involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:105,586,937...105,588,394
Ensembl chr14:105,583,731...105,588,395 		JBrowse link
G IGHD immunoglobulin heavy constant delta involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:105,838,401...105,845,677
Ensembl chr14:105,836,765...105,845,677 		JBrowse link
G IGHE immunoglobulin heavy constant epsilon involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:105,600,066...105,601,727
Ensembl chr14:105,597,691...105,601,728 		JBrowse link
G IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:6952213) GO_Central
MGI		 PMID:6952213 GO_REF:0000033 NCBI chr14:105,741,473...105,743,070
Ensembl chr14:105,736,343...105,743,071 		JBrowse link
G IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker) involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:105,643,203...105,644,789
Ensembl chr14:105,639,559...105,644,790 		JBrowse link
G IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker) involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:105,765,914...105,771,405
Ensembl chr14:105,764,503...105,771,405 		JBrowse link
G IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker) involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:105,624,476...105,626,065
Ensembl chr14:105,620,506...105,626,066 		JBrowse link
G LOC110384692 complement C4A (Rodgers blood group)-like involved_in IEA UniProt GO_REF:0000043
G MASP2 MBL associated serine protease 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:11,026,523...11,047,239
Ensembl chr 1:11,022,009...11,047,239 		JBrowse link
G MBL2 mannose binding lectin 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784 		JBrowse link
G SERPING1 serpin family G member 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr11:57,597,685...57,614,848
Ensembl chr11:57,597,387...57,619,171 		JBrowse link
G SUSD4 sushi domain containing 4 involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:223,220,831...223,365,235
Ensembl chr 1:223,220,819...223,364,233 		JBrowse link
complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COLEC10 collectin subfamily member 10 involved_in IDA (PMID:24174618) ComplexPortal PMID:24174618 NCBI chr 8:118,952,263...119,108,455
Ensembl chr 8:118,995,452...119,108,455 		JBrowse link
G COLEC11 collectin subfamily member 11 involved_in IDA
IMP		 (PMID:24174618)
(PMID:25912189)		 ComplexPortal
UniProt		 PMID:24174618 PMID:25912189 NCBI chr 2:3,595,112...3,644,644
Ensembl chr 2:3,594,832...3,644,644 		JBrowse link
G FCN1 ficolin 1 involved_in IDA
IBA		 (PMID:16116205) ComplexPortal
GO_Central		 PMID:16116205 GO_REF:0000033 NCBI chr 9:134,903,232...134,917,912
Ensembl chr 9:134,903,232...134,917,912 		JBrowse link
G FCN2 ficolin 2 involved_in IDA
IBA
IEA		 (PMID:10679061), (PMID:14707097), (PMID:15804047) UniProt
GO_Central		 PMID:10679061 PMID:14707097 PMID:15804047 GO_REF:0000033 GO_REF:0000043 NCBI chr 9:134,864,144...134,887,523
Ensembl chr 9:134,880,810...134,887,523 		JBrowse link
G FCN3 ficolin 3 involved_in IEA
IBA
IDA		 (PMID:11907111) UniProt
GO_Central
ComplexPortal		 PMID:11907111 GO_REF:0000033 GO_REF:0000043 NCBI chr 1:27,369,110...27,374,824
Ensembl chr 1:27,369,110...27,374,824 		JBrowse link
G KRT1 keratin 1 involved_in IPI (PMID:11549596) UniProt PMID:11549596 NCBI chr12:52,674,736...52,680,407
Ensembl chr12:52,674,736...52,680,407 		JBrowse link
G MASP1 MBL associated serine protease 1 involved_in IMP
IEA
IBA		 (PMID:17182967) UniProt
Ensembl
GO_Central		 PMID:17182967 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 3:187,217,282...187,291,737
Ensembl chr 3:187,217,282...187,291,980 		JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IDA
IBA		 (PMID:17182967), (PMID:9087411) UniProt
GO_Central		 PMID:9087411 PMID:17182967 GO_REF:0000033 NCBI chr 1:11,026,523...11,047,239
Ensembl chr 1:11,022,009...11,047,239 		JBrowse link
G MBL1P mannose binding lectin 1, pseudogene acts_upstream_of_or_within ISO (PMID:15148336) RGD
MGI		 PMID:15148336 PMID:16272342 RGD:1582134 NCBI chr10:79,920,178...79,923,119
Ensembl chr10:79,920,327...79,923,032
Ensembl chr10:79,920,327...79,923,032 		JBrowse link
G MBL2 mannose binding lectin 2 involved_in
acts_upstream_of_or_within		 IEA
IDA
IPI		 (PMID:22691502), (PMID:35102342)
(PMID:11549596)
(PMID:15148336)		 UniProt
Ensembl
ComplexPortal
MGI		 PMID:11549596 PMID:15148336 PMID:22691502 PMID:35102342 GO_REF:0000043 GO_REF:0000107 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784 		JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:10946279), (PMID:11471050) RGD
MGI
GO_Central		 PMID:10946279 PMID:11471050 PMID:15843577 GO_REF:0000033 RGD:1600482 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,479 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) acts_upstream_of IDA (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765 		JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD55 CD55 molecule (Cromer blood group) involved_in ISO
IDA
IMP		 (PMID:6211481)
(PMID:28657829)		 RGD
UniProt		 PMID:6211481 PMID:10929073 PMID:28657829 RGD:2326180 NCBI chr 1:207,321,678...207,360,966
Ensembl chr 1:207,321,519...207,386,804 		JBrowse link
G CD59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (PMID:10946279) MGI PMID:10946279 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,479 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IDA (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765 		JBrowse link
G CR1L complement C3b/C4b receptor 1 like acts_upstream_of_or_within ISO (PMID:10642554) RGD
MGI		 PMID:10642554 PMID:11861390 RGD:625470 NCBI chr 1:207,645,133...207,723,703
Ensembl chr 1:207,645,113...207,738,416 		JBrowse link
G MASP1 MBL associated serine protease 1 involved_in IDA (PMID:11485744) UniProt PMID:11485744 NCBI chr 3:187,217,282...187,291,737
Ensembl chr 3:187,217,282...187,291,980 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chr 1:207,752,038...207,795,516
Ensembl chr 1:207,752,037...207,795,513 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IDA (PMID:10531307) UniProt PMID:10531307 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765 		JBrowse link
G SUSD4 sushi domain containing 4 involved_in IDA (PMID:23482636) UniProt PMID:23482636 NCBI chr 1:223,220,831...223,365,235
Ensembl chr 1:223,220,819...223,364,233 		JBrowse link
G VSIG4 V-set and immunoglobulin domain containing 4 involved_in IPI
IBA		 (PMID:17051150) UniProt
GO_Central		 PMID:17051150 GO_REF:0000033 NCBI chr  X:66,021,738...66,040,080
Ensembl chr  X:66,021,738...66,040,125 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4BPA complement component 4 binding protein alpha involved_in IDA
IBA		 (PMID:22333221) BHF-UCL
GO_Central		 PMID:22333221 GO_REF:0000033 NCBI chr 1:207,104,233...207,144,972
Ensembl chr 1:207,104,233...207,144,972 		JBrowse link
G C4BPB complement component 4 binding protein beta involved_in IDA (PMID:22333221) BHF-UCL PMID:22333221 NCBI chr 1:207,088,860...207,099,993
Ensembl chr 1:207,088,860...207,099,993 		JBrowse link
G CD46 CD46 molecule involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:207,752,038...207,795,516
Ensembl chr 1:207,752,037...207,795,513 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IDA
IBA		 (PMID:10531307), (PMID:6910481) UniProt
GO_Central		 PMID:6910481 PMID:10531307 GO_REF:0000033 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765 		JBrowse link
G CR1L complement C3b/C4b receptor 1 like involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:207,645,133...207,723,703
Ensembl chr 1:207,645,113...207,738,416 		JBrowse link
G CR2 complement C3d receptor 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:207,454,328...207,489,892
Ensembl chr 1:207,453,024...207,489,895 		JBrowse link
G SUSD4 sushi domain containing 4 involved_in IDA (PMID:23482636) UniProt PMID:23482636 NCBI chr 1:223,220,831...223,365,235
Ensembl chr 1:223,220,819...223,364,233 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin involved_in IDA (PMID:12538697) UniProt PMID:12538697 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229 		JBrowse link
G SERPING1 serpin family G member 1 involved_in IDA (PMID:10946292) UniProt PMID:10946292 NCBI chr11:57,597,685...57,614,848
Ensembl chr11:57,597,387...57,619,171 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) involved_in IMP (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765 		JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1B interleukin 1 beta involved_in IGI (PMID:29384235) ARUK-UCL PMID:29384235 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G MBL2 mannose binding lectin 2 ISO RGD PMID:9920905 RGD:4889148 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784 		JBrowse link
G PHB1 prohibitin 1 involved_in IDA (PMID:17070910) UniProt PMID:17070910 NCBI chr17:49,404,052...49,414,882
Ensembl chr17:49,404,049...49,414,905 		JBrowse link
positive regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR520B microRNA 520b involved_in IDA (PMID:20574151) ARUK-UCL PMID:20574151 NCBI chr19:53,701,227...53,701,287
Ensembl chr19:53,701,227...53,701,287 		JBrowse link
G MIR520E microRNA 520e involved_in IDA (PMID:20574151) ARUK-UCL PMID:20574151 NCBI chr19:53,675,711...53,675,797
Ensembl chr19:53,675,711...53,675,797 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186 		JBrowse link
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QBP complement C1q binding protein involved_in IDA
IBA		 (PMID:8195709) UniProt
GO_Central		 PMID:8195709 GO_REF:0000033 NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830 		JBrowse link
G CD55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within IDA (PMID:25284781) MGI PMID:25284781 NCBI chr 1:207,321,678...207,360,966
Ensembl chr 1:207,321,519...207,386,804 		JBrowse link
G CD59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within IDA (PMID:25284781) MGI PMID:25284781 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,479 		JBrowse link
G CD5L CD5 molecule like acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:157,827,068...157,841,808
Ensembl chr 1:157,830,911...157,898,256 		JBrowse link
G CFH complement factor H acts_upstream_of_or_within ISO
IDA		 (PMID:25284781) RGD
MGI		 PMID:12374811 PMID:25284781 RGD:628500 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476 		JBrowse link
G CR1L complement C3b/C4b receptor 1 like acts_upstream_of_or_within IDA (PMID:25284781) MGI PMID:25284781 NCBI chr 1:207,645,133...207,723,703
Ensembl chr 1:207,645,113...207,738,416 		JBrowse link
G PHB2 prohibitin 2 NOT|involved_in IDA (PMID:17070910) UniProt PMID:17070910 NCBI chr12:6,965,327...6,970,753
Ensembl chr12:6,965,327...6,970,780 		JBrowse link
G SUSD4 sushi domain containing 4 involved_in IEA
IDA		 (PMID:23482636) InterPro
UniProt		 PMID:23482636 GO_REF:0000002 NCBI chr 1:223,220,831...223,365,235
Ensembl chr 1:223,220,819...223,364,233 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H involved_in IDA (PMID:20378178), (PMID:28671664) ComplexPortal PMID:20378178 PMID:28671664 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476 		JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:9892684) MGI PMID:9892684 NCBI chr 1:207,321,678...207,360,966
Ensembl chr 1:207,321,519...207,386,804 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27210
    immune system process 3306
      immune effector process 841
        complement activation 70
          activation of membrane attack complex + 4
          complement activation, alternative pathway + 20
          complement activation, classical pathway + 43
          complement activation, lectin pathway + 12
          negative regulation of complement activation + 13
          positive regulation of complement activation + 8
          regulation of complement activation + 24
Path 2
Term Annotations click to browse term
  biological_process 27210
    biological regulation 13700
      regulation of biological process 13240
        positive regulation of biological process 7102
          positive regulation of response to stimulus 2691
            positive regulation of immune response 868
              activation of immune response 652
                complement activation 70
                  activation of membrane attack complex + 4
                  complement activation, alternative pathway + 20
                  complement activation, classical pathway + 43
                  complement activation, lectin pathway + 12
                  negative regulation of complement activation + 13
                  positive regulation of complement activation + 8
                  regulation of complement activation + 24
paths to the root