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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity
 xref: Reactome:R-HSA-166658 "Complement cascade"


show annotations for term's descendants           Sort by:
complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1R complement C1r involved_in IEA InterPro GO_REF:0000002 NCBI chr27:37,951,137...37,960,687
Ensembl chr27:37,950,246...37,960,557 		JBrowse link
G C1RL complement C1r subcomponent like involved_in IEA InterPro GO_REF:0000002 NCBI chr27:37,934,946...37,947,579
Ensembl chr27:37,935,004...37,947,563 		JBrowse link
G C1S complement C1s involved_in IEA InterPro GO_REF:0000002 NCBI chr27:37,976,196...37,985,846
Ensembl chr27:37,976,197...37,989,575 		JBrowse link
G C2 complement C2 involved_in IEA
IBA		 InterPro
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr12:1,363,656...1,399,732
Ensembl chr12:1,363,803...1,399,728 		JBrowse link
G C3 complement C3 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 RGD
Ensembl
GO_Central		 PMID:20712003 GO_REF:0000033 GO_REF:0000107 RGD:5129529 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761 		JBrowse link
G C5 complement C5 involved_in IEA InterPro GO_REF:0000002 NCBI chr11:73,953,727...74,029,919
Ensembl chr11:73,953,727...74,029,851 		JBrowse link
G C6 complement C6 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:68,223,626...68,318,773
Ensembl chr 4:68,253,255...68,318,252 		JBrowse link
G C7 complement C7 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:68,450,660...68,502,753
Ensembl chr 4:68,451,578...68,513,386 		JBrowse link
G C8A complement C8 alpha chain involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:52,584,707...52,649,612
Ensembl chr 5:52,584,934...52,653,794 		JBrowse link
G C8B complement C8 beta chain involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:52,535,359...52,574,872
Ensembl chr 5:52,532,481...52,574,182 		JBrowse link
G C8G complement C8 gamma chain involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:48,672,332...48,674,190
Ensembl chr 9:48,672,333...48,673,854 		JBrowse link
G C9 complement C9 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:69,660,861...69,719,793
Ensembl chr 4:69,660,907...69,719,562 		JBrowse link
G CFB complement factor B involved_in ISO
IBA
IEA		 RGD
GO_Central
InterPro		 PMID:6906329 GO_REF:0000002 GO_REF:0000033 RGD:2311339 NCBI chr12:1,400,143...1,406,267 JBrowse link
G CFH complement factor H involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:19411110), (PMID:20675597)
(PMID:15574507), (PMID:17517971), (PMID:17921253), (PMID:19541934), (PMID:28057640)
(PMID:20702729)		 RGD
GO_Central
MGI		 PMID:12911541 PMID:15574507 PMID:17517971 PMID:17921253 PMID:19411110 More... GO_REF:0000033 RGD:1599888 NCBI chr38:2,878,677...2,956,226 JBrowse link
G CFHR5 complement factor H related 5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:5,723,819...5,752,881
Ensembl chr 7:5,724,129...5,752,816 		JBrowse link
G CFI complement factor I involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:29,936,447...29,986,755
Ensembl chr32:29,936,393...29,985,724 		JBrowse link
G COLEC11 collectin subfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:2,147,679...2,180,096
Ensembl chr17:2,147,882...2,180,098 		JBrowse link
G FCN3 ficolin 3 involved_in ISO (PMID:22851708) UniProt PMID:22851708
G LOC481722 complement C4-A acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:12421924) MGI
GO_Central		 PMID:12421924 GO_REF:0000033 NCBI chr12:1,433,185...1,448,056 JBrowse link
G MASP1 MBL associated serine protease 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr34:19,689,426...19,750,669
Ensembl chr34:19,691,630...19,750,587 		JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:84,976,366...84,987,376
Ensembl chr 2:84,976,456...84,989,797 		JBrowse link
G RGCC regulator of cell cycle involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:9,199,204...9,209,297 JBrowse link
G SKIC2 SKI2 subunit of superkiller complex involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:1,412,407...1,424,521
Ensembl chr12:1,412,540...1,424,526 		JBrowse link
activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H acts_upstream_of_or_within ISO (PMID:20813971) MGI PMID:20813971 NCBI chr38:2,878,677...2,956,226 JBrowse link
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761 		JBrowse link
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chr11:73,953,727...74,029,919
Ensembl chr11:73,953,727...74,029,851 		JBrowse link
G C8B complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:52,535,359...52,574,872
Ensembl chr 5:52,532,481...52,574,182 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:69,660,861...69,719,793
Ensembl chr 4:69,660,907...69,719,562 		JBrowse link
G CFB complement factor B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9238044)
(PMID:27564415)		 UniProt
MGI		 PMID:9238044 PMID:27564415 GO_REF:0000043 NCBI chr12:1,400,143...1,406,267 JBrowse link
G CFD complement factor D acts_upstream_of_or_within ISO (PMID:27564415) MGI PMID:27564415 NCBI chr20:57,785,297...57,787,773
Ensembl chr20:57,657,154...57,787,713 		JBrowse link
G CFH complement factor H acts_upstream_of_or_within_negative_effect ISO (PMID:19828624)
(PMID:27564415)		 MGI PMID:19828624 PMID:27564415 NCBI chr38:2,878,677...2,956,226 JBrowse link
G CFP complement factor properdin involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:41,245,868...41,252,194
Ensembl chr  X:41,245,905...41,251,623 		JBrowse link
G LOC484960 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:50,993,122...51,019,645 JBrowse link
G LOC490269 complement receptor type 2 involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chr 7:6,456,238...6,480,672 JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QA complement C1q A chain involved_in
acts_upstream_of_or_within		 IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr 2:76,668,086...76,671,082
Ensembl chr 2:76,668,217...76,670,977 		JBrowse link
G C1QB complement C1q B chain involved_in ISO (PMID:29449492) ComplexPortal PMID:29449492 NCBI chr 2:76,650,440...76,655,546
Ensembl chr 2:76,650,586...76,655,549 		JBrowse link
G C1QC complement C1q C chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:76,660,039...76,664,602
Ensembl chr 2:76,660,035...76,664,577 		JBrowse link
G C1R complement C1r involved_in IEA UniProt GO_REF:0000043 NCBI chr27:37,951,137...37,960,687
Ensembl chr27:37,950,246...37,960,557 		JBrowse link
G C1S complement C1s involved_in IEA UniProt GO_REF:0000043 NCBI chr27:37,976,196...37,985,846
Ensembl chr27:37,976,197...37,989,575 		JBrowse link
G C2 complement C2 involved_in IEA UniProt GO_REF:0000043 NCBI chr12:1,363,656...1,399,732
Ensembl chr12:1,363,803...1,399,728 		JBrowse link
G C3 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761 		JBrowse link
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chr11:73,953,727...74,029,919
Ensembl chr11:73,953,727...74,029,851 		JBrowse link
G C6 complement C6 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:68,223,626...68,318,773
Ensembl chr 4:68,253,255...68,318,252 		JBrowse link
G C7 complement C7 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:68,450,660...68,502,753
Ensembl chr 4:68,451,578...68,513,386 		JBrowse link
G C8A complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:52,584,707...52,649,612
Ensembl chr 5:52,584,934...52,653,794 		JBrowse link
G C8B complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chr 5:52,535,359...52,574,872
Ensembl chr 5:52,532,481...52,574,182 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:69,660,861...69,719,793
Ensembl chr 4:69,660,907...69,719,562 		JBrowse link
G CRP C-reactive protein ISO RGD PMID:16367929 RGD:1580273 NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166 		JBrowse link
G IGHE immunoglobulin heavy constant epsilon involved_in IBA GO_Central GO_REF:0000033
G LOC481722 complement C4-A involved_in IEA UniProt GO_REF:0000043 NCBI chr12:1,433,185...1,448,056 JBrowse link
G LOC484960 complement C3 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:50,993,122...51,019,645 JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:84,976,366...84,987,376
Ensembl chr 2:84,976,456...84,989,797 		JBrowse link
G SKIC2 SKI2 subunit of superkiller complex involved_in IEA UniProt GO_REF:0000043 NCBI chr12:1,412,407...1,424,521
Ensembl chr12:1,412,540...1,424,526 		JBrowse link
complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COLEC10 collectin subfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:18,291,168...18,331,918
Ensembl chr13:18,291,051...18,330,617 		JBrowse link
G COLEC11 collectin subfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:2,147,679...2,180,096
Ensembl chr17:2,147,882...2,180,098 		JBrowse link
G FCN2 ficolin 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:50,868,942...50,876,001
Ensembl chr 9:50,868,973...50,875,792 		JBrowse link
G FCN3 ficolin 3 involved_in ISO (PMID:11907111) UniProt PMID:11907111
G KRT1 keratin 1 involved_in ISO (PMID:11549596) UniProt PMID:11549596 NCBI chr27:2,422,150...2,427,160 JBrowse link
G MASP1 MBL associated serine protease 1 involved_in IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr34:19,689,426...19,750,669
Ensembl chr34:19,691,630...19,750,587 		JBrowse link
G MASP2 MBL associated serine protease 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:84,976,366...84,987,376
Ensembl chr 2:84,976,456...84,989,797 		JBrowse link
G MBL1 mannose binding lectin 1 acts_upstream_of_or_within
involved_in		 ISO (PMID:15148336)
(PMID:11549596)
(PMID:22691502), (PMID:35102342)		 MGI
UniProt
ComplexPortal		 PMID:11549596 PMID:15148336 PMID:22691502 PMID:35102342 NCBI chr 4:29,419,886...29,424,377 JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD59 CD59 molecule involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:10946279), (PMID:11471050) RGD
GO_Central
MGI		 PMID:10946279 PMID:11471050 PMID:15843577 GO_REF:0000033 RGD:1600482 NCBI chr18:33,977,433...33,999,145
Ensembl chr18:33,977,480...33,998,329 		JBrowse link
G LOC490269 complement receptor type 2 acts_upstream_of ISO (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chr 7:6,456,238...6,480,672 JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD55 CD55 molecule involved_in ISO (PMID:6211481)
(PMID:28657829)		 RGD
UniProt		 PMID:6211481 PMID:10929073 PMID:28657829 RGD:2326180 NCBI chr 7:6,361,037...6,396,063
Ensembl chr 7:6,360,964...6,386,226 		JBrowse link
G CD59 CD59 molecule acts_upstream_of_or_within ISO (PMID:10946279) MGI PMID:10946279 NCBI chr18:33,977,433...33,999,145
Ensembl chr18:33,977,480...33,998,329 		JBrowse link
G LOC490269 complement receptor type 2 involved_in ISO (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chr 7:6,456,238...6,480,672 JBrowse link
G MASP1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) UniProt PMID:11485744 NCBI chr34:19,689,426...19,750,669
Ensembl chr34:19,691,630...19,750,587 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC490269 complement receptor type 2 involved_in ISO (PMID:10531307) UniProt PMID:10531307 NCBI chr 7:6,456,238...6,480,672 JBrowse link
G LOC609365 CD46 molecule, complement regulatory protein-like involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chr 7:6,602,762...6,646,561 JBrowse link
G SUSD4 sushi domain containing 4 involved_in ISO (PMID:23482636) UniProt PMID:23482636 NCBI chr38:23,640,882...23,685,288
Ensembl chr38:23,639,616...23,685,304 		JBrowse link
G VSIG4 V-set and immunoglobulin domain containing 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:50,839,979...50,881,684
Ensembl chr  X:50,803,330...50,881,618 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4BPA complement component 4 binding protein alpha involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:6,239,036...6,268,934
Ensembl chr 7:6,241,102...6,268,910 		JBrowse link
G C4BPB complement component 4 binding protein beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:6,224,962...6,236,925
Ensembl chr 7:6,225,188...6,236,918 		JBrowse link
G LOC102156626 membrane cofactor protein-like involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:6,552,121...6,581,316 JBrowse link
G LOC490269 complement receptor type 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:6,456,238...6,480,672 JBrowse link
G LOC609365 CD46 molecule, complement regulatory protein-like involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:6,602,762...6,646,561 JBrowse link
G SUSD4 sushi domain containing 4 involved_in ISO (PMID:23482636) UniProt PMID:23482636 NCBI chr38:23,640,882...23,685,288
Ensembl chr38:23,639,616...23,685,304 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:36,654,328...36,695,775 JBrowse link
G SERPING1 serpin family G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:38,570,354...38,580,751
Ensembl chr18:38,570,607...38,581,665 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761 		JBrowse link
G LOC490269 complement receptor type 2 involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chr 7:6,456,238...6,480,672 JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1B interleukin 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G MBL1 mannose binding lectin 1 ISO RGD PMID:9920905 RGD:4889148 NCBI chr 4:29,419,886...29,424,377 JBrowse link
G PHB1 prohibitin 1 involved_in ISO (PMID:17070910) UniProt PMID:17070910 NCBI chr 9:25,525,711...25,536,722
Ensembl chr 9:25,526,649...25,536,722 		JBrowse link
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QBP complement C1q binding protein involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:31,354,665...31,359,672
Ensembl chr 5:31,354,723...31,359,469 		JBrowse link
G CD55 CD55 molecule acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chr 7:6,361,037...6,396,063
Ensembl chr 7:6,360,964...6,386,226 		JBrowse link
G CD59 CD59 molecule acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chr18:33,977,433...33,999,145
Ensembl chr18:33,977,480...33,998,329 		JBrowse link
G CD5L CD5 molecule like acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chr 7:40,516,190...40,526,528
Ensembl chr 7:40,516,190...40,526,528 		JBrowse link
G CFH complement factor H acts_upstream_of_or_within ISO (PMID:18947875)
(PMID:25284781)		 RGD
MGI		 PMID:12374811 PMID:18947875 PMID:25284781 RGD:628500 NCBI chr38:2,878,677...2,956,226 JBrowse link
G PHB2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) UniProt PMID:17070910 NCBI chr27:38,075,769...38,080,440
Ensembl chr27:38,075,652...38,080,109 		JBrowse link
G SUSD4 sushi domain containing 4 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr38:23,640,882...23,685,288
Ensembl chr38:23,639,616...23,685,304 		JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) ComplexPortal PMID:20378178 PMID:28671664 NCBI chr38:2,878,677...2,956,226 JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD55 CD55 molecule acts_upstream_of_or_within ISO (PMID:9892684) MGI PMID:9892684 NCBI chr 7:6,361,037...6,396,063
Ensembl chr 7:6,360,964...6,386,226 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22141
    immune system process 2645
      immune effector process 681
        complement activation 51
          activation of membrane attack complex + 4
          complement activation, alternative pathway + 13
          complement activation, classical pathway + 26
          complement activation, lectin pathway + 10
          negative regulation of complement activation + 12
          positive regulation of complement activation + 5
          regulation of complement activation + 20
Path 2
Term Annotations click to browse term
  biological_process 22141
    biological regulation 12559
      regulation of biological process 12176
        positive regulation of biological process 6621
          positive regulation of response to stimulus 2497
            positive regulation of immune response 754
              activation of immune response 555
                complement activation 51
                  activation of membrane attack complex + 4
                  complement activation, alternative pathway + 13
                  complement activation, classical pathway + 26
                  complement activation, lectin pathway + 10
                  negative regulation of complement activation + 12
                  positive regulation of complement activation + 5
                  regulation of complement activation + 20
paths to the root