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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity
 xref: Reactome:R-HSA-166658 "Complement cascade"

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complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C2 complement C2 involved_in ISO (PMID:19302245) BHF-UCL PMID:19302245 NCBI chrNW_004955437:449,171...460,898
Ensembl chrNW_004955437:448,672...460,519 		JBrowse link
G C3 complement C3 acts_upstream_of_or_within
involved_in		 ISO (PMID:18947875)
(PMID:25284781)
(PMID:19302245)		 RGD
MGI
BHF-UCL		 PMID:18947875 PMID:19302245 PMID:20712003 PMID:25284781 RGD:5129529 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697 		JBrowse link
G C8a complement C8 alpha chain acts_upstream_of_or_within ISO (PMID:12413696) MGI PMID:12413696 NCBI chrNW_004955464:2,806,859...2,874,444 JBrowse link
G Cfb complement factor B ISO RGD PMID:6906329 RGD:2311339 NCBI chrNW_004955437:461,235...466,908
Ensembl chrNW_004955437:461,235...470,464 		JBrowse link
G Cfi complement factor I involved_in ISO (PMID:18202746) MGI PMID:18202746 NCBI chrNW_004955496:492,217...553,398
Ensembl chrNW_004955496:492,167...553,217 		JBrowse link
G Colec11 collectin subfamily member 11 involved_in ISO (PMID:23954398) UniProt PMID:23954398 NCBI chrNW_004955487:3,778,901...3,789,852
Ensembl chrNW_004955487:3,778,858...3,790,080 		JBrowse link
G Fcn3 ficolin 3 involved_in ISO (PMID:22851708) UniProt PMID:22851708 NCBI chrNW_004955452:6,630,548...6,635,334
Ensembl chrNW_004955452:6,630,505...6,635,235 		JBrowse link
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfb complement factor B acts_upstream_of_or_within ISO (PMID:9238044)
(PMID:27564415)		 MGI PMID:9238044 PMID:27564415 NCBI chrNW_004955437:461,235...466,908
Ensembl chrNW_004955437:461,235...470,464 		JBrowse link
G Cfd complement factor D acts_upstream_of_or_within ISO (PMID:27564415) MGI PMID:27564415 NCBI chrNW_004955495:6,955,612...6,961,317 JBrowse link
G Cfp complement factor properdin involved_in ISO (PMID:18292556) MGI PMID:18292556 NCBI chrNW_004955516:449,993...455,897
Ensembl chrNW_004955516:449,993...456,492 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect		 ISO (PMID:11981823)
(PMID:19828624)		 ARUK-UCL
MGI		 PMID:11981823 PMID:19828624 NCBI chrNW_004955406:42,877,041...42,910,970
Ensembl chrNW_004955406:42,876,966...42,911,564 		JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qa complement C1q A chain involved_in
acts_upstream_of_or_within		 ISO (PMID:29449492)
(PMID:11901193)		 ComplexPortal
MGI		 PMID:11901193 PMID:29449492 NCBI chrNW_004955452:2,753,362...2,756,220
Ensembl chrNW_004955452:2,752,970...2,756,488 		JBrowse link
G C1qb complement C1q B chain involved_in ISO (PMID:29449492) ComplexPortal PMID:29449492 NCBI chrNW_004955452:2,765,844...2,771,695
Ensembl chrNW_004955452:2,769,752...2,772,534 		JBrowse link
G C1qc complement C1q C chain involved_in ISO (PMID:29449492) ComplexPortal PMID:29449492 NCBI chrNW_004955452:2,759,079...2,762,522
Ensembl chrNW_004955452:2,758,821...2,762,522 		JBrowse link
complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Colec10 collectin subfamily member 10 involved_in ISO (PMID:24174618) ComplexPortal PMID:24174618 NCBI chrNW_004955417:24,954,969...24,994,188
Ensembl chrNW_004955417:24,954,938...24,994,188 		JBrowse link
G Colec11 collectin subfamily member 11 involved_in ISO (PMID:25912189)
(PMID:24174618)		 UniProt
ComplexPortal		 PMID:24174618 PMID:25912189 NCBI chrNW_004955487:3,778,901...3,789,852
Ensembl chrNW_004955487:3,778,858...3,790,080 		JBrowse link
G Fcn1 ficolin 1 involved_in ISO (PMID:16116205) ComplexPortal PMID:16116205 NCBI chrNW_004955513:3,690,550...3,697,785
Ensembl chrNW_004955513:3,687,232...3,698,673 		JBrowse link
G Fcn3 ficolin 3 involved_in ISO (PMID:11907111) UniProt PMID:11907111 NCBI chrNW_004955452:6,630,548...6,635,334
Ensembl chrNW_004955452:6,630,505...6,635,235 		JBrowse link
G Krt1 keratin 1 involved_in ISO (PMID:11549596) UniProt PMID:11549596 NCBI chrNW_004955458:25,193...29,282
Ensembl chrNW_004955458:25,187...29,208 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:17182967)
(PMID:18424734)		 UniProt PMID:17182967 PMID:18424734 NCBI chrNW_004955420:20,540,266...20,605,830
Ensembl chrNW_004955420:20,540,016...20,605,854 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in ISO (PMID:17182967), (PMID:9087411) UniProt PMID:9087411 PMID:17182967 NCBI chrNW_004955486:2,641,730...2,655,125 JBrowse link
G Mbl2 mannose binding lectin 2 acts_upstream_of_or_within
involved_in		 ISO (PMID:15148336)
(PMID:22691502), (PMID:35102342)
(PMID:11549596)		 MGI
ComplexPortal
UniProt		 PMID:11549596 PMID:15148336 PMID:22691502 PMID:35102342 NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006 		JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (PMID:10946279), (PMID:11471050) RGD
MGI		 PMID:10946279 PMID:11471050 PMID:15843577 RGD:1600482 NCBI chrNW_004955422:12,500,572...12,528,738 JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in ISO (PMID:6211481)
(PMID:28657829)		 RGD
UniProt		 PMID:6211481 PMID:10929073 PMID:28657829 RGD:2326180 NCBI chrNW_004955406:42,773,368...42,796,205 JBrowse link
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (PMID:10946279) MGI PMID:10946279 NCBI chrNW_004955422:12,500,572...12,528,738 JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) UniProt PMID:11485744 NCBI chrNW_004955420:20,540,266...20,605,830
Ensembl chrNW_004955420:20,540,016...20,605,854 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) UniProt PMID:23482636 NCBI chrNW_004955520:1,444,618...1,523,214
Ensembl chrNW_004955520:1,444,618...1,523,260 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO (PMID:17051150) UniProt PMID:17051150 NCBI chrNW_004955475:5,461,512...5,481,552
Ensembl chrNW_004955475:5,461,064...5,481,564 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpa complement component 4 binding protein alpha involved_in ISO (PMID:22333221) BHF-UCL PMID:22333221 NCBI chrNW_004955406:42,613,659...42,641,918
Ensembl chrNW_004955406:42,613,607...42,641,670 		JBrowse link
G C4bpb complement component 4 binding protein beta involved_in ISO (PMID:22333221) BHF-UCL PMID:22333221 NCBI chrNW_004955406:42,601,164...42,608,912 JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) UniProt PMID:23482636 NCBI chrNW_004955520:1,444,618...1,523,214
Ensembl chrNW_004955520:1,444,618...1,523,260 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102021956 alpha-2-macroglobulin involved_in ISO (PMID:12538697) UniProt PMID:12538697 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529 		JBrowse link
G Serping1 serpin family G member 1 involved_in ISO (PMID:10946292) UniProt PMID:10946292 NCBI chrNW_004955511:2,545,337...2,557,850
Ensembl chrNW_004955511:2,545,285...2,557,982 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (PMID:15611275) BHF-UCL PMID:15611275 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697 		JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta involved_in ISO (PMID:29384235) ARUK-UCL PMID:29384235 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Mbl2 mannose binding lectin 2 ISO RGD PMID:9920905 RGD:4889148 NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006 		JBrowse link
G Phb1 prohibitin 1 involved_in ISO (PMID:17070910) UniProt PMID:17070910 NCBI chrNW_004955451:12,110,290...12,119,870
Ensembl chrNW_004955451:12,110,290...12,120,124 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:30548312) ARUK-UCL PMID:30548312 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697 		JBrowse link
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in ISO (PMID:8195709) UniProt PMID:8195709 NCBI chrNW_004955467:10,788,142...10,792,272
Ensembl chrNW_004955467:10,788,277...10,792,449 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chrNW_004955406:42,773,368...42,796,205 JBrowse link
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chrNW_004955422:12,500,572...12,528,738 JBrowse link
G Cd5l CD5 molecule like acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chrNW_004955468:9,670,958...9,690,331
Ensembl chrNW_004955468:9,667,514...9,689,150 		JBrowse link
G Phb2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) UniProt PMID:17070910 NCBI chrNW_004955413:4,557,969...4,563,697
Ensembl chrNW_004955413:4,558,259...4,563,582 		JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO (PMID:23482636) UniProt PMID:23482636 NCBI chrNW_004955520:1,444,618...1,523,214
Ensembl chrNW_004955520:1,444,618...1,523,260 		JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:9892684) MGI PMID:9892684 NCBI chrNW_004955406:42,773,368...42,796,205 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12619
    immune system process 2046
      immune effector process 559
        complement activation 34
          activation of membrane attack complex + 2
          complement activation, alternative pathway + 7
          complement activation, classical pathway + 9
          complement activation, lectin pathway + 10
          negative regulation of complement activation + 10
          positive regulation of complement activation + 5
          regulation of complement activation + 18
Path 2
Term Annotations click to browse term
  biological_process 12619
    biological regulation 9092
      regulation of biological process 8790
        positive regulation of biological process 5696
          positive regulation of response to stimulus 2173
            positive regulation of immune response 626
              activation of immune response 460
                complement activation 34
                  activation of membrane attack complex + 2
                  complement activation, alternative pathway + 7
                  complement activation, classical pathway + 9
                  complement activation, lectin pathway + 10
                  negative regulation of complement activation + 10
                  positive regulation of complement activation + 5
                  regulation of complement activation + 18
paths to the root