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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular iron ion homeostasis
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Accession:GO:0006879 term browser browse the term
Definition:A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.
Synonyms:exact_synonym: cellular iron ion homeostasis
 broad_synonym: iron homeostasis
 xref: Reactome:R-HSA-917937 "Iron uptake and transport"


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intracellular iron ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in
acts_upstream_of_or_within 		IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:60,186,559...60,313,098
Ensembl chr  X:60,186,814...60,313,064 		JBrowse link
G ACO1 aconitase 1 acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		RGD
Ensembl
GO_Central		 PMID:15086359 GO_REF:0000033 GO_REF:0000107 RGD:1642737 NCBI chr10:33,937,833...34,001,895
Ensembl chr10:33,937,833...34,001,900 		JBrowse link
G ACTL6B actin like 6B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:8,554,322...8,568,774
Ensembl chr 3:8,539,320...8,578,763 		JBrowse link
G ACVR2B activin A receptor type 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,237,699...23,276,086
Ensembl chr13:23,237,699...23,267,373 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:47,871,519...47,896,041
Ensembl chr  X:47,871,523...47,896,000 		JBrowse link
G ATP13A2 ATPase cation transporting 13A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:75,618,317...75,638,591
Ensembl chr 6:75,618,319...75,638,591 		JBrowse link
G ATP6AP1 ATPase H+ transporting accessory protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:124,952,532...124,960,344
Ensembl chr  X:124,952,500...124,960,343 		JBrowse link
G ATP6V0A2 ATPase H+ transporting V0 subunit a2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:29,250,400...29,297,697
Ensembl chr14:29,250,405...29,297,683 		JBrowse link
G ATP6V0D1 ATPase H+ transporting V0 subunit d1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:28,090,180...28,132,080
Ensembl chr 6:28,090,183...28,131,985 		JBrowse link
G ATP6V1A ATPase H+ transporting V1 subunit A involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:146,128,664...146,165,269
Ensembl chr13:146,121,759...146,192,442 		JBrowse link
G ATP6V1G1 ATPase H+ transporting V1 subunit G1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:255,151,909...255,159,299
Ensembl chr 1:255,151,863...255,159,509 		JBrowse link
G B2M beta-2-microglobulin involved_in ISO (PMID:18353247) BHF-UCL PMID:18353247 NCBI chr 1:126,837,721...126,844,043
Ensembl chr 1:126,835,143...126,981,582 		JBrowse link
G BMP6 bone morphogenetic protein 6 acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:19252488) Ensembl
BHF-UCL		 PMID:19252488 GO_REF:0000107 NCBI chr 7:5,058,817...5,208,868
Ensembl chr 7:5,058,817...5,210,270 		JBrowse link
G BOLA2B bolA family member 2B involved_in IBA
IEA 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 3:18,345,691...18,351,508 JBrowse link
G CCDC115 coiled-coil domain containing 115 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:31,974,715...31,979,062
Ensembl chr15:31,974,724...31,979,059 		JBrowse link
G CISD1 CDGSH iron sulfur domain 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:92,360,548...92,382,302 JBrowse link
G CP ceruloplasmin involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:89,396,713...89,463,540
Ensembl chr13:89,396,708...89,463,476 		JBrowse link
G CYB561 cytochrome b561 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:15,435,973...15,447,104
Ensembl chr12:15,436,803...15,447,100 		JBrowse link
G CYB561A3 cytochrome b561 family member A3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:10,142,102...10,159,160
Ensembl chr 2:10,142,960...10,157,001 		JBrowse link
G CYBRD1 cytochrome b reductase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:77,649,124...77,695,141
Ensembl chr15:77,649,040...77,695,138 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:59,113,527...59,168,421
Ensembl chr14:59,113,844...59,168,395 		JBrowse link
G ERFE erythroferrone involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:137,728,507...137,738,687
Ensembl chr15:137,728,478...137,738,676 		JBrowse link
G FBXL5 F-box and leucine rich repeat protein 5 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 8:10,915,526...10,987,374
Ensembl chr 8:10,913,106...10,961,306 		JBrowse link
G FRRS1 ferric chelate reductase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:118,269,141...118,383,647
Ensembl chr 4:118,269,156...118,370,773 		JBrowse link
G FTH1 ferritin heavy chain 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 2:9,535,051...9,537,979 JBrowse link
G FTHL17 ferritin heavy chain like 17 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr  X:26,955,098...26,956,111
Ensembl chr  X:26,955,098...26,955,649 		JBrowse link
G FTL ferritin light chain involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr 6:54,231,121...54,232,756
Ensembl chr 6:54,231,172...54,232,750 		JBrowse link
G FTMT ferritin mitochondrial involved_in IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chr 2:125,391,524...125,395,066
Ensembl chr 2:125,392,394...125,393,122 		JBrowse link
G FXN frataxin involved_in
acts_upstream_of_or_within 		IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:222,412,485...222,433,224
Ensembl chr 1:222,412,509...222,434,702 		JBrowse link
G GLRX3 glutaredoxin 3 involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr14:139,072,554...139,108,063
Ensembl chr14:139,072,575...139,111,249 		JBrowse link
G HAMP hepcidin antimicrobial peptide involved_in ISO
IEA
IBA 		RGD
Ensembl
GO_Central
InterPro		 PMID:14592944 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:1304454 NCBI chr 6:44,785,863...44,787,303
Ensembl chr 6:44,784,160...44,787,305 		JBrowse link
G HEPHL1 hephaestin like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:26,356,159...26,438,315
Ensembl chr 9:26,355,996...26,437,442 		JBrowse link
G HFE homeostatic iron regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:20,758,604...20,767,004
Ensembl chr 7:20,758,741...20,767,000 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G HJV hemojuvelin BMP co-receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:99,327,989...99,332,647
Ensembl chr 4:99,328,053...99,332,645 		JBrowse link
G HMOX1 heme oxygenase 1 involved_in ISS
IEA 		AgBase
Ensembl		 GO_REF:0000024 GO_REF:0000107
G HPX hemopexin involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:3,288,288...3,297,051
Ensembl chr 9:3,288,172...3,297,047 		JBrowse link
G IREB2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within 		ISS
IEA
IBA 		UniProt
Ensembl
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:47,481,539...47,529,199
Ensembl chr 7:47,478,706...47,529,242 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr14:42,216,103...42,222,570
Ensembl chr14:42,216,111...42,222,711 		JBrowse link
G LOC100625618 ferritin heavy chain pseudogene involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr  X:33,369,020...33,369,929 JBrowse link
G LOC102162930 ferritin, heavy subunit-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr13:160,308,093...160,311,832 JBrowse link
G LOC102165256 V-type proton ATPase subunit G 1 pseudogene involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chr 7:19,272,032...19,272,926 JBrowse link
G MECR mitochondrial trans-2-enoyl-CoA reductase acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 6:86,094,383...86,131,691
Ensembl chr 6:86,094,423...86,131,682 		JBrowse link
G MELTF melanotransferrin NOT|acts_upstream_of_or_within ISO (PMID:16291590) MGI PMID:16291590 NCBI chr13:133,094,869...133,122,092
Ensembl chr13:133,094,863...133,122,065 		JBrowse link
G MON1A MON1 homolog A, secretory trafficking associated acts_upstream_of_or_within ISO (PMID:17632513) MGI PMID:17632513 NCBI chr13:32,426,733...32,437,735
Ensembl chr13:32,426,736...32,437,862 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078 		JBrowse link
G NCOA4 nuclear receptor coactivator 4 involved_in
acts_upstream_of_or_within 		IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr14:90,505,614...90,531,302
Ensembl chr14:90,505,110...90,531,118 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:143,688,946...143,734,523
Ensembl chr 2:143,629,783...143,734,520 		JBrowse link
G NEO1 neogenin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:60,064,984...60,299,892
Ensembl chr 7:60,064,994...60,300,562 		JBrowse link
G NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:32,311,774...32,340,120
Ensembl chr 3:32,311,779...32,340,034 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:19,835,934...19,947,239
Ensembl chr 9:19,835,938...20,123,566 		JBrowse link
G SCARA5 scavenger receptor class A member 5 involved_in IEA UniProt GO_REF:0000104 NCBI chr14:11,615,629...11,747,336 JBrowse link
G SCO1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO (PMID:36301669) MGI PMID:36301669 NCBI chr12:55,406,730...55,424,120
Ensembl chr12:55,405,483...55,424,118 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within 		IEA Ensembl GO_REF:0000107 NCBI chr15:120,434,100...120,446,396
Ensembl chr15:120,433,952...120,446,396 		JBrowse link
G SLC40A1 solute carrier family 40 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:94,140,635...94,161,793
Ensembl chr15:94,141,988...94,167,408 		JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chr 9:9,433,978...9,474,248
Ensembl chr 9:9,427,121...9,474,230 		JBrowse link
G SMAD1 SMAD family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:82,907,557...82,987,909
Ensembl chr 8:82,908,527...82,968,994 		JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029 		JBrowse link
G SMAD5 SMAD family member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:138,287,635...138,344,092
Ensembl chr 2:138,287,710...138,344,762 		JBrowse link
G SMAD9 SMAD family member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:12,705,652...12,727,981
Ensembl chr11:12,705,368...12,763,008 		JBrowse link
G SOD1 superoxide dismutase 1 involved_in
acts_upstream_of_or_within 		ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G TF transferrin involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr13:74,930,655...74,970,599
Ensembl chr13:74,930,655...74,972,763 		JBrowse link
G TFR2 transferrin receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:8,539,316...8,553,993
Ensembl chr 3:8,539,320...8,578,763 		JBrowse link
G TFRC transferrin receptor involved_in
acts_upstream_of_or_within 		IEA
IBA 		UniProt
Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr13:133,976,765...133,997,554
Ensembl chr13:133,970,985...134,000,276 		JBrowse link
G TMEM199 transmembrane protein 199 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:44,636,379...44,641,536
Ensembl chr12:44,636,379...44,641,527 		JBrowse link
G TMPRSS6 transmembrane serine protease 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,663,491...10,704,583
Ensembl chr 5:10,663,635...10,705,471 		JBrowse link
G TTC7A tetratricopeptide repeat domain 7A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:93,457,623...93,591,982
Ensembl chr 3:93,457,625...93,591,941 		JBrowse link
cellular response to iron ion starvation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HFE homeostatic iron regulator ISO RGD PMID:16208485 RGD:1582698 NCBI chr 7:20,758,604...20,767,004
Ensembl chr 7:20,758,741...20,767,000 		JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chr 9:9,433,978...9,474,248
Ensembl chr 9:9,427,121...9,474,230 		JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTL6B actin like 6B involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:8,554,322...8,568,774
Ensembl chr 3:8,539,320...8,578,763 		JBrowse link
G TFR2 transferrin receptor 2 involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:8,539,316...8,553,993
Ensembl chr 3:8,539,320...8,578,763 		JBrowse link
heme import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO2B1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chr 9:9,433,978...9,474,248
Ensembl chr 9:9,427,121...9,474,230 		JBrowse link
iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP3CC protein phosphatase 3 catalytic subunit gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:6,711,789...6,799,318
Ensembl chr14:6,711,442...6,794,667 		JBrowse link
G SLC11A2 solute carrier family 11 member 2 acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:17109629) Ensembl
UniProt		 PMID:17109629 GO_REF:0000107
G SLC39A14 solute carrier family 39 member 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:6,639,485...6,687,929
Ensembl chr14:6,639,206...6,687,924 		JBrowse link
G STEAP3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chr15:24,736,556...24,785,376
Ensembl chr15:24,736,594...24,787,865 		JBrowse link
G STEAP4 STEAP4 metalloreductase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:68,549,142...68,570,350
Ensembl chr 9:68,546,465...68,570,424 		JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC39A8 solute carrier family 39 member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:118,604,852...118,678,115
Ensembl chr 8:118,605,402...118,678,107 		JBrowse link
G STEAP2 STEAP2 metalloreductase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:70,334,785...70,365,687
Ensembl chr 9:70,349,362...70,366,767 		JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ISCU iron-sulfur cluster assembly enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:42,216,103...42,222,570
Ensembl chr14:42,216,111...42,222,711 		JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in ISO (PMID:29061364) ARUK-UCL PMID:29061364 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G LCN2 lipocalin 2 ISO RGD PMID:25557118 RGD:126790477 NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18944
    homeostatic process 1938
      chemical homeostasis 1178
        inorganic ion homeostasis 565
          intracellular iron ion homeostasis 76
            cellular response to iron ion starvation + 2
            iron import into cell + 13
Path 2
Term Annotations click to browse term
  biological_process 18944
    homeostatic process 1938
      chemical homeostasis 1178
        monoatomic ion homeostasis 644
          intracellular monoatomic ion homeostasis 556
            intracellular monoatomic cation homeostasis 544
              intracellular iron ion homeostasis 76
                cellular response to iron ion starvation + 2
                iron import into cell + 13
paths to the root