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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular iron ion homeostasis
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Accession:GO:0006879 term browser browse the term
Definition:A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.
Synonyms:exact_synonym: cellular iron ion homeostasis
 broad_synonym: iron homeostasis
 xref: Reactome:R-HSA-917937 "Iron uptake and transport"

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intracellular iron ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in
acts_upstream_of_or_within 		IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624836:5,605,901...5,769,488
Ensembl chrNW_004624836:5,605,831...5,766,275 		JBrowse link
G Aco1 aconitase 1 acts_upstream_of_or_within ISO
IEA 		RGD
Ensembl		 PMID:15086359 GO_REF:0000107 RGD:1642737 NCBI chrNW_004624736:37,063,540...37,127,772
Ensembl chrNW_004624736:37,063,246...37,126,702 		JBrowse link
G Acvr2b activin A receptor type 2B involved_in ISO (PMID:31800957) UniProt PMID:31800957 NCBI chrNW_004624731:2,557,993...2,600,250
Ensembl chrNW_004624731:2,566,063...2,600,035 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 acts_upstream_of_or_within ISO (PMID:10562540) MGI PMID:10562540 NCBI chrNW_004624910:426,273...726,778
Ensembl chrNW_004624910:426,032...448,325 		JBrowse link
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:26818499) ParkinsonsUK-UCL PMID:26818499 NCBI chrNW_004624764:2,614,541...2,631,972
Ensembl chrNW_004624764:2,614,827...2,631,793 		JBrowse link
G Atp6ap1 ATPase H+ transporting accessory protein 1 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004624946:885,400...902,082
Ensembl chrNW_004624946:884,685...902,365 		JBrowse link
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004624747:23,471,697...23,501,018
Ensembl chrNW_004624747:23,471,403...23,504,576 		JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit d1 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004624746:18,828,025...18,883,128
Ensembl chrNW_004624746:18,828,024...18,883,128 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004624731:34,721,142...34,780,632 JBrowse link
G Atp6v1g1 ATPase H+ transporting V1 subunit G1 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004624760:20,627,985...20,636,670
Ensembl chrNW_004624760:20,624,624...20,636,631 		JBrowse link
G B2m beta-2-microglobulin involved_in ISO (PMID:18353247) BHF-UCL PMID:18353247 NCBI chrNW_004624804:11,514,728...11,521,625 JBrowse link
G Bmp6 bone morphogenetic protein 6 acts_upstream_of_or_within
involved_in 		ISO (PMID:21703414)
(PMID:19252488) 		MGI
BHF-UCL		 PMID:19252488 PMID:21703414 NCBI chrNW_004624756:17,742,822...17,894,931
Ensembl chrNW_004624756:17,743,834...17,894,753 		JBrowse link
G Bola2b bolA family member 2B involved_in IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004624782:13,103,842...13,104,823 JBrowse link
G Cp ceruloplasmin involved_in ISO (PMID:16150804), (PMID:29183916)
(PMID:14623105) 		UniProt PMID:14623105 PMID:16150804 PMID:29183916 NCBI chrNW_004624730:26,458,554...26,510,796
Ensembl chrNW_004624730:26,462,550...26,511,078 		JBrowse link
G Egln1 egl-9 family hypoxia inducible factor 1 involved_in ISO (PMID:26818499) ParkinsonsUK-UCL PMID:26818499 NCBI chrNW_004624775:18,325,135...18,369,504 JBrowse link
G Erfe erythroferrone involved_in ISO (PMID:24880340) UniProt PMID:24880340 NCBI chrNW_004624847:3,313,214...3,319,050 JBrowse link
G Fbxl5 F-box and leucine rich repeat protein 5 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004624755:16,197,223...16,245,108
Ensembl chrNW_004624755:16,197,242...16,245,653 		JBrowse link
G Frrs1 ferric chelate reductase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624857:2,518,132...2,572,759
Ensembl chrNW_004624857:2,518,065...2,562,172 		JBrowse link
G Fth1 ferritin heavy chain 1 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624926:469,870...471,142 JBrowse link
G Ftl ferritin light chain involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624832:5,046,207...5,047,828
Ensembl chrNW_004624832:5,046,208...5,047,828 		JBrowse link
G Fxn frataxin involved_in
acts_upstream_of_or_within 		IEA
ISO 		(PMID:9405681) TreeGrafter
UniProt
InterPro
MGI		 PMID:9405681 GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 NCBI chrNW_004624736:4,027,054...4,047,881
Ensembl chrNW_004624736:4,027,354...4,047,854 		JBrowse link
G Glrx3 glutaredoxin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624737:16,906,135...16,938,089
Ensembl chrNW_004624737:16,905,964...16,938,048 		JBrowse link
G Hamp hepcidin antimicrobial peptide involved_in IEA
ISO 		TreeGrafter
InterPro
RGD		 PMID:14592944 GO_REF:0000002 GO_REF:0000118 RGD:1304454 NCBI chrNW_004624794:8,257,760...8,259,243
Ensembl chrNW_004624794:8,257,760...8,259,264 		JBrowse link
G Hephl1 hephaestin like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624735:38,687,298...38,757,256
Ensembl chrNW_004624735:38,687,298...38,755,523 		JBrowse link
G Hfe homeostatic iron regulator involved_in ISO (PMID:10085150), (PMID:18353247) UniProt PMID:10085150 PMID:18353247 NCBI chrNW_004624756:821,738...831,482
Ensembl chrNW_004624756:823,947...831,376 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within ISO (PMID:16787915) MGI PMID:16787915 NCBI chrNW_004624734:39,414,458...39,471,705
Ensembl chrNW_004624734:39,411,824...39,471,705 		JBrowse link
G Hjv hemojuvelin BMP co-receptor involved_in ISO (PMID:25860887) BHF-UCL PMID:25860887 NCBI chrNW_004624772:17,363,062...17,367,320
Ensembl chrNW_004624772:17,360,207...17,367,373 		JBrowse link
G Hmox1 heme oxygenase 1 involved_in ISO (PMID:17915953)
(PMID:22989377) 		BHF-UCL
CACAO		 PMID:17915953 PMID:22989377 NCBI chrNW_004624750:341,699...346,005
Ensembl chrNW_004624750:342,146...345,887 		JBrowse link
G Hpx hemopexin involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624817:7,947,554...7,957,553
Ensembl chrNW_004624817:7,947,639...7,957,462 		JBrowse link
G Ireb2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within 		ISO (PMID:30915432)
(PMID:14726953)
(PMID:14726953), (PMID:15831703)
(PMID:11175792) 		UniProt
MGI		 PMID:11175792 PMID:14726953 PMID:15831703 PMID:30915432 NCBI chrNW_004624894:2,446,014...2,498,650
Ensembl chrNW_004624894:2,445,704...2,499,009 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO (PMID:16517407), (PMID:23508953) UniProt PMID:16517407 PMID:23508953 NCBI chrNW_004624747:11,808,789...11,815,269
Ensembl chrNW_004624747:11,808,640...11,816,400 		JBrowse link
G LOC101699814 cytochrome b561 involved_in ISO (PMID:14499595) ARUK-UCL PMID:14499595 NCBI chrNW_004624849:950,275...961,946
Ensembl chrNW_004624849:949,533...962,404 		JBrowse link
G LOC101701182 cytochrome b reductase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624787:8,937,521...8,965,279
Ensembl chrNW_004624787:8,937,620...8,964,737 		JBrowse link
G LOC101701770 protein SCO1 homolog, mitochondrial acts_upstream_of_or_within ISO (PMID:36301669) MGI PMID:36301669 NCBI chrNW_004624786:13,038,384...13,053,250
Ensembl chrNW_004624786:13,036,426...13,053,210 		JBrowse link
G LOC101704033 ferritin light chain, oocyte isoform-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624789:11,521,839...11,525,535 JBrowse link
G LOC101706262 ferritin heavy chain-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624881:3,607,674...3,609,065 JBrowse link
G LOC101707112 ferritin heavy chain-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624768:5,084,439...5,085,820 JBrowse link
G LOC101708454 cytochrome b ascorbate-dependent protein 3 involved_in ISO (PMID:16911521) UniProt PMID:16911521 NCBI chrNW_004624926:835,341...861,866
Ensembl chrNW_004624926:853,055...861,123 		JBrowse link
G LOC101710208 ferritin light chain pseudogene involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624762:16,974,328...16,975,941 JBrowse link
G LOC101714978 ferritin light chain-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624759:11,348,458...11,348,920 JBrowse link
G LOC101719373 ferritin heavy chain pseudogene involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624762:24,893,993...24,894,799 JBrowse link
G LOC101719398 serotransferrin involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624730:10,078,165...10,109,349 JBrowse link
G LOC106009954 ferritin light chain 1-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624767:13,914,977...13,923,455 JBrowse link
G LOC110344516 ferritin, middle subunit-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624789:11,673,363...11,677,379 JBrowse link
G LOC110344519 ferritin, lower subunit-like involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chrNW_004624789:11,577,410...11,582,944 JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase acts_upstream_of ISO (PMID:37653044) UniProt PMID:37653044 NCBI chrNW_004624764:12,954,673...12,989,711
Ensembl chrNW_004624764:12,954,115...12,989,755 		JBrowse link
G Meltf melanotransferrin NOT|acts_upstream_of_or_within ISO (PMID:16291590) MGI PMID:16291590 NCBI chrNW_004624730:61,967,868...61,990,576
Ensembl chrNW_004624730:61,971,877...61,988,902 		JBrowse link
G Mon1a MON1 homolog A, secretory trafficking associated acts_upstream_of_or_within ISO (PMID:17632513) MGI PMID:17632513 NCBI chrNW_004624730:3,818,653...3,833,697
Ensembl chrNW_004624730:3,821,485...3,841,452 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO (PMID:9924025) UniProt PMID:9924025 NCBI chrNW_004624735:27,780,338...27,784,714
Ensembl chrNW_004624735:27,780,037...27,784,806 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 involved_in
acts_upstream_of_or_within 		IEA
ISO 		(PMID:25327288) InterPro
MGI		 PMID:25327288 GO_REF:0000002 NCBI chrNW_004624928:6,298...32,051
Ensembl chrNW_004624928:18,148...30,594 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in ISO (PMID:18776082) UniProt PMID:18776082 NCBI chrNW_004624774:1,245,587...1,353,253
Ensembl chrNW_004624774:1,303,773...1,353,253 		JBrowse link
G Neo1 neogenin 1 acts_upstream_of_or_within ISO (PMID:20065295) MGI PMID:20065295 NCBI chrNW_004624781:1,021,460...1,227,680
Ensembl chrNW_004624781:1,019,603...1,227,666 		JBrowse link
G Nubp1 NUBP iron-sulfur cluster assembly factor 1, cytosolic involved_in ISO (PMID:18573874) UniProt PMID:18573874 NCBI chrNW_004624824:8,024,459...8,040,353
Ensembl chrNW_004624824:8,024,575...8,040,364 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:22952941) ARUK-UCL PMID:22952941 NCBI chrNW_004624845:3,875,601...3,990,347
Ensembl chrNW_004624845:3,891,061...3,990,342 		JBrowse link
G Scara5 scavenger receptor class A member 5 involved_in IEA UniProt GO_REF:0000104 NCBI chrNW_004624758:22,661,136...22,757,578
Ensembl chrNW_004624758:22,663,129...22,753,776 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within 		IEA Ensembl GO_REF:0000107 NCBI chrNW_004624823:6,612,452...6,625,047
Ensembl chrNW_004624823:6,612,452...6,625,300 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624899:685,166...701,725
Ensembl chrNW_004624899:685,097...702,440 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chrNW_004624817:1,879,710...1,943,430
Ensembl chrNW_004624817:1,881,327...1,931,186 		JBrowse link
G Smad1 SMAD family member 1 involved_in ISO (PMID:31800957) UniProt PMID:31800957 NCBI chrNW_004624853:4,415,816...4,503,317
Ensembl chrNW_004624853:4,444,876...4,502,496 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624778:14,570,025...14,629,950
Ensembl chrNW_004624778:14,570,348...14,630,325 		JBrowse link
G Smad5 SMAD family member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624733:10,927,264...10,983,049
Ensembl chrNW_004624733:10,931,061...10,983,669 		JBrowse link
G Smad9 SMAD family member 9 involved_in ISO (PMID:31800957) UniProt PMID:31800957 NCBI chrNW_004624776:332,591...378,199 JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within ISO (PMID:16377630) MGI PMID:16377630 NCBI chrNW_004624745:20,032,003...20,037,958
Ensembl chrNW_004624745:20,032,011...20,037,958 		JBrowse link
G Tfr2 transferrin receptor 2 involved_in ISO (PMID:18353247) BHF-UCL PMID:18353247 NCBI chrNW_004624740:16,451,520...16,469,393
Ensembl chrNW_004624740:16,452,504...16,466,781 		JBrowse link
G Tfrc transferrin receptor involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624730:61,282,650...61,313,487
Ensembl chrNW_004624730:61,285,334...61,313,550 		JBrowse link
G Tmprss6 transmembrane serine protease 6 involved_in ISO (PMID:25860887) BHF-UCL PMID:25860887 NCBI chrNW_004624752:10,693,895...10,727,269
Ensembl chrNW_004624752:10,693,634...10,727,269 		JBrowse link
G Ttc7a tetratricopeptide repeat domain 7A acts_upstream_of_or_within ISO (PMID:15155459) MGI PMID:15155459 NCBI chrNW_004624738:28,355,161...28,472,733
Ensembl chrNW_004624738:28,355,121...28,472,733 		JBrowse link
G Vma12 vacuolar ATPase assembly factor VMA12 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624786:961,888...965,911
Ensembl chrNW_004624786:961,890...966,430 		JBrowse link
G Vma22 vacuolar ATPase assembly factor VMA22 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004624732:14,469,377...14,474,540
Ensembl chrNW_004624732:14,466,079...14,474,561 		JBrowse link
cellular response to iron ion starvation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hfe homeostatic iron regulator ISO RGD PMID:16208485 RGD:1582698 NCBI chrNW_004624756:821,738...831,482
Ensembl chrNW_004624756:823,947...831,376 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chrNW_004624817:1,879,710...1,943,430
Ensembl chrNW_004624817:1,881,327...1,931,186 		JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tfr2 transferrin receptor 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624740:16,451,520...16,469,393
Ensembl chrNW_004624740:16,452,504...16,466,781 		JBrowse link
heme import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco2b1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chrNW_004624817:1,879,710...1,943,430
Ensembl chrNW_004624817:1,881,327...1,931,186 		JBrowse link
iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a2 solute carrier family 11 member 2 acts_upstream_of_or_within
involved_in 		ISO (PMID:11739192)
(PMID:17109629) 		MGI
UniProt		 PMID:11739192 PMID:17109629 NCBI chrNW_004624816:1,345,020...1,389,615
Ensembl chrNW_004624816:1,345,006...1,384,299 		JBrowse link
G Slc39a14 solute carrier family 39 member 14 involved_in ISO (PMID:20682781) UniProt PMID:20682781 NCBI chrNW_004624758:17,911,889...17,954,870
Ensembl chrNW_004624758:17,912,827...17,953,294 		JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chrNW_004624732:25,913,034...25,958,537
Ensembl chrNW_004624732:25,913,736...25,958,582 		JBrowse link
G Steap4 STEAP4 metalloreductase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624809:5,084,992...5,103,765
Ensembl chrNW_004624809:5,084,814...5,103,980 		JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc39a8 solute carrier family 39 member 8 involved_in ISO (PMID:22898811)
(PMID:30015240) 		UniProt PMID:22898811 PMID:30015240 RGD:15090842 NCBI chrNW_004624830:5,514,595...5,573,250
Ensembl chrNW_004624830:5,514,780...5,574,894 		JBrowse link
G Steap2 STEAP2 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chrNW_004624809:2,989,360...3,016,283
Ensembl chrNW_004624809:2,993,366...3,016,233 		JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO (PMID:20436681) ARUK-UCL PMID:20436681 NCBI chrNW_004624747:11,808,789...11,815,269
Ensembl chrNW_004624747:11,808,640...11,816,400 		JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:29061364) ARUK-UCL PMID:29061364 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17647
    homeostatic process 1836
      chemical homeostasis 1118
        inorganic ion homeostasis 545
          intracellular iron ion homeostasis 76
            cellular response to iron ion starvation + 2
            iron import into cell + 10
Path 2
Term Annotations click to browse term
  biological_process 17647
    homeostatic process 1836
      chemical homeostasis 1118
        monoatomic ion homeostasis 621
          intracellular monoatomic ion homeostasis 538
            intracellular monoatomic cation homeostasis 526
              intracellular iron ion homeostasis 76
                cellular response to iron ion starvation + 2
                iron import into cell + 10
paths to the root