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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular iron ion homeostasis
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Accession:GO:0006879 term browser browse the term
Definition:A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.
Synonyms:exact_synonym: cellular iron ion homeostasis
 broad_synonym: iron homeostasis
 xref: Reactome:R-HSA-917937 "Iron uptake and transport"

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intracellular iron ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:64,633,989...64,748,638
Ensembl chr  X:64,634,079...64,701,938 		JBrowse link
G ACO1 aconitase 1 acts_upstream_of_or_within ISO
IEA 		RGD
Ensembl		 PMID:15086359 GO_REF:0000107 RGD:1642737 NCBI chr12:47,771,140...47,874,478
Ensembl chr12:47,806,436...47,874,227 		JBrowse link
G ACVR2B activin A receptor type 2B involved_in ISO (PMID:31800957) UniProt PMID:31800957 NCBI chr15:923,222...962,438 JBrowse link
G ACVR2B activin A receptor type 2B involved_in IEA Ensembl GO_REF:0000107 Ensembl chr15:933,070...939,419 JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:51,086,062...51,108,564
Ensembl chr  X:51,086,066...51,103,505 		JBrowse link
G ATP13A2 ATPase cation transporting 13A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:115,578,185...115,605,416
Ensembl chr20:115,578,261...115,605,647 		JBrowse link
G ATP6AP1 ATPase H+ transporting accessory protein 1 involved_in IEA Ensembl GO_REF:0000107
G ATP6V0A2 ATPase H+ transporting V0 subunit a2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:119,042,465...119,095,380
Ensembl chr11:119,042,525...119,097,450 		JBrowse link
G ATP6V0D1 ATPase H+ transporting V0 subunit d1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:59,976,118...60,018,414
Ensembl chr 5:60,002,544...60,017,894 		JBrowse link
G ATP6V1A ATPase H+ transporting V1 subunit A involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:67,049,745...67,112,971
Ensembl chr22:67,048,796...67,081,962 		JBrowse link
G ATP6V1G1 ATPase H+ transporting V1 subunit G1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:24,994,480...25,004,618
Ensembl chr12:24,994,051...25,004,668 		JBrowse link
G B2M beta-2-microglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:38,331,818...38,338,785
Ensembl chr26:38,331,442...38,338,809 		JBrowse link
G BMP6 bone morphogenetic protein 6 acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:19252488) Ensembl
BHF-UCL		 PMID:19252488 GO_REF:0000107 NCBI chr17:64,279,243...64,436,356
Ensembl chr17:64,280,609...64,435,382 		JBrowse link
G BOLA2B bolA family member 2B involved_in IEA TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000118 NCBI chr 5:26,478,391...26,479,775 JBrowse link
G CYB561 cytochrome b561 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:57,831,350...57,850,225
Ensembl chr16:57,839,614...57,844,989 		JBrowse link
G CYB561A3 cytochrome b561 family member A3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:12,480,222...12,493,219
Ensembl chr 1:12,484,551...12,491,755 		JBrowse link
G CYBRD1 cytochrome b reductase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:57,034,961...57,063,560
Ensembl chr10:57,035,238...57,063,682 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:68,624,754...68,685,961
Ensembl chr25:68,625,260...68,682,804 		JBrowse link
G ERFE erythroferrone involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:124,180,014...124,190,445
Ensembl chr10:124,180,126...124,188,669 		JBrowse link
G FBXL5 F-box and leucine rich repeat protein 5 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr27:34,575,889...34,682,308
Ensembl chr27:34,580,426...34,625,036 		JBrowse link
G FRRS1 ferric chelate reductase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:33,584,933...33,627,279
Ensembl chr20:33,586,115...33,625,997 		JBrowse link
G FTH1 ferritin heavy chain 1 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr 1:11,837,533...11,840,926 JBrowse link
G FTL ferritin light chain involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 6:42,196,682...42,198,575
Ensembl chr 6:42,196,538...42,199,614 		JBrowse link
G FTMT ferritin mitochondrial involved_in IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chr23:24,954,906...24,956,116
Ensembl chr23:24,955,238...24,955,969 		JBrowse link
G FXN frataxin involved_in
acts_upstream_of_or_within 		IEA UniProt
Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr12:80,133,899...80,173,950
Ensembl chr12:80,134,422...80,173,168 		JBrowse link
G GLRX3 glutaredoxin 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:122,737,101...122,780,001
Ensembl chr 9:122,737,379...122,781,391 		JBrowse link
G HAMP hepcidin antimicrobial peptide involved_in ISO
IEA 		RGD
Ensembl
TreeGrafter
InterPro		 PMID:14592944 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1304454 NCBI chr 6:30,214,820...30,218,100
Ensembl chr 6:30,215,563...30,217,996 		JBrowse link
G HEPHL1 hephaestin like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:85,268,791...85,348,816
Ensembl chr 1:85,269,726...85,346,988 		JBrowse link
G HFE homeostatic iron regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:46,159,770...46,168,831
Ensembl chr17:46,156,685...46,164,649 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr24:38,873,830...38,927,657
Ensembl chr24:38,873,861...38,928,288 		JBrowse link
G HJV hemojuvelin BMP co-receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:12,730,106...12,735,230
Ensembl chr20:12,730,912...12,735,255 		JBrowse link
G HMOX1 heme oxygenase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971 		JBrowse link
G HPX hemopexin involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:58,385,860...58,396,269
Ensembl chr 1:58,386,190...58,396,298 		JBrowse link
G IREB2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within 		IEA Ensembl GO_REF:0000107 NCBI chr26:4,842,328...4,905,941
Ensembl chr26:4,842,122...4,905,964 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:103,753,175...103,760,168
Ensembl chr11:103,753,189...103,760,364 		JBrowse link
G LOC103231771 ferritin heavy polypeptide-like 17 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr  X:29,502,329...29,503,211
Ensembl chr  X:29,502,489...29,503,040 		JBrowse link
G LOC103241503 ceruloplasmin involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:41,488,795...41,547,526
Ensembl chr15:41,488,730...41,544,169 		JBrowse link
G LOC103241654 serotransferrin involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr15:56,586,311...56,618,304
Ensembl chr15:56,586,104...56,618,149 		JBrowse link
G MECR mitochondrial trans-2-enoyl-CoA reductase acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr20:103,591,944...103,630,253
Ensembl chr20:103,591,944...103,629,102 		JBrowse link
G MELTF melanotransferrin NOT|acts_upstream_of_or_within ISO (PMID:16291590) MGI PMID:16291590 NCBI chr15:90,225,699...90,254,893
Ensembl chr15:90,225,780...90,255,263 		JBrowse link
G MON1A MON1 homolog A, secretory trafficking associated acts_upstream_of_or_within ISO (PMID:17632513) MGI PMID:17632513 NCBI chr22:11,315,251...11,334,295
Ensembl chr22:11,315,396...11,333,991 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:122,282,989...122,288,392
Ensembl chr 8:122,282,630...122,288,384 		JBrowse link
G NCOA4 nuclear receptor coactivator 4 involved_in
acts_upstream_of_or_within 		IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 9:41,813,018...41,836,974
Ensembl chr 9:41,826,320...41,837,505 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:44,737,432...44,783,409
Ensembl chr23:44,737,422...44,775,657 		JBrowse link
G NEO1 neogenin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr26:10,173,707...10,427,732
Ensembl chr26:10,176,215...10,427,675 		JBrowse link
G NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,224,965...10,248,328
Ensembl chr 5:10,225,173...10,249,047 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:77,214,391...77,325,626
Ensembl chr 1:77,213,836...77,324,875 		JBrowse link
G SCARA5 scavenger receptor class A member 5 involved_in IEA Ensembl
UniProt		 GO_REF:0000104 GO_REF:0000107 NCBI chr 8:25,975,310...26,097,312
Ensembl chr 8:25,975,122...26,097,102 		JBrowse link
G SCO1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO (PMID:36301669) MGI PMID:36301669 NCBI chr16:10,021,480...10,036,920 JBrowse link
G SLC11A1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within 		ISO (PMID:16510578)
(PMID:11903051)
(PMID:18456389), (PMID:19321419) 		BHF-UCL
MGI		 PMID:11903051 PMID:16510578 PMID:18456389 PMID:19321419 NCBI chr10:104,276,553...104,288,466 JBrowse link
G SLC11A1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within 		IEA Ensembl GO_REF:0000107 Ensembl chr10:104,274,197...104,289,159 JBrowse link
G SLC40A1 solute carrier family 40 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:75,076,286...75,097,742
Ensembl chr10:75,075,971...75,096,271 		JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chr 1:66,375,924...66,430,804
Ensembl chr 1:66,376,299...66,433,055 		JBrowse link
G SMAD1 SMAD family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:92,047,273...92,123,451
Ensembl chr 7:92,079,914...92,123,429 		JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:29,894,157...29,951,445
Ensembl chr18:29,897,621...29,934,478 		JBrowse link
G SMAD5 SMAD family member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:38,877,294...38,926,208
Ensembl chr23:38,877,315...38,921,202 		JBrowse link
G SMAD9 SMAD family member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:15,369,119...15,444,599
Ensembl chr 3:15,372,933...15,405,836 		JBrowse link
G SOD1 superoxide dismutase 1 acts_upstream_of_or_within ISO (PMID:16377630) MGI PMID:16377630 NCBI chr 2:60,461,219...60,472,999 JBrowse link
G TFR2 transferrin receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:12,570,604...12,592,269
Ensembl chr28:12,571,841...12,592,266 		JBrowse link
G TFRC transferrin receptor involved_in
acts_upstream_of_or_within 		IEA UniProt
Ensembl
TreeGrafter		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr15:91,102,153...91,134,994
Ensembl chr15:91,102,817...91,135,584 		JBrowse link
G TMPRSS6 transmembrane serine protease 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:19,771,303...19,811,751
Ensembl chr19:19,771,952...19,806,420 		JBrowse link
G TTC7A tetratricopeptide repeat domain 7A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:60,117,116...60,271,937
Ensembl chr14:60,118,750...60,250,167 		JBrowse link
G VMA12 vacuolar ATPase assembly factor VMA12 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:22,124,413...22,130,922 JBrowse link
G VMA22 vacuolar ATPase assembly factor VMA22 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:66,264...70,711
Ensembl chr10:66,429...70,877 		JBrowse link
cellular response to iron ion starvation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HFE homeostatic iron regulator ISO RGD PMID:16208485 RGD:1582698 NCBI chr17:46,159,770...46,168,831
Ensembl chr17:46,156,685...46,164,649 		JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chr 1:66,375,924...66,430,804
Ensembl chr 1:66,376,299...66,433,055 		JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TFR2 transferrin receptor 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr28:12,570,604...12,592,269
Ensembl chr28:12,571,841...12,592,266 		JBrowse link
heme import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO2B1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chr 1:66,375,924...66,430,804
Ensembl chr 1:66,376,299...66,433,055 		JBrowse link
iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC11A2 solute carrier family 11 member 2 acts_upstream_of_or_within
involved_in 		IEA
ISO 		(PMID:17109629) Ensembl
UniProt		 PMID:17109629 GO_REF:0000107 NCBI chr11:47,190,138...47,238,543
Ensembl chr11:47,197,168...47,235,130 		JBrowse link
G SLC39A14 solute carrier family 39 member 14 involved_in ISO (PMID:20682781) UniProt PMID:20682781 NCBI chr 8:20,446,756...20,502,585 JBrowse link
G SLC39A14 solute carrier family 39 member 14 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 8:20,491,284...20,502,626 JBrowse link
G STEAP3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chr10:11,055,446...11,097,131
Ensembl chr10:11,053,981...11,075,452 		JBrowse link
G STEAP4 STEAP4 metalloreductase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr21:60,653,504...60,680,414
Ensembl chr21:60,653,454...60,680,323 		JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC39A8 solute carrier family 39 member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:50,355,756...50,451,253
Ensembl chr 7:50,367,436...50,451,510 		JBrowse link
G STEAP2 STEAP2 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chr21:58,689,298...58,718,386 JBrowse link
G STEAP2 STEAP2 metalloreductase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 Ensembl chr21:58,701,578...58,718,290 JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ISCU iron-sulfur cluster assembly enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:103,753,175...103,760,168
Ensembl chr11:103,753,189...103,760,364 		JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma involved_in ISO (PMID:29061364) ARUK-UCL PMID:29061364 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G LCN2 lipocalin 2 ISO RGD PMID:25557118 RGD:126790477 NCBI chr12:9,976,278...9,981,087
Ensembl chr12:9,976,614...9,980,870 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19706
    homeostatic process 2002
      chemical homeostasis 1220
        inorganic ion homeostasis 603
          intracellular iron ion homeostasis 74
            cellular response to iron ion starvation + 2
            iron import into cell + 13
Path 2
Term Annotations click to browse term
  biological_process 19706
    homeostatic process 2002
      chemical homeostasis 1220
        monoatomic ion homeostasis 687
          intracellular monoatomic ion homeostasis 595
            intracellular monoatomic cation homeostasis 583
              intracellular iron ion homeostasis 74
                cellular response to iron ion starvation + 2
                iron import into cell + 13
paths to the root