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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular iron ion homeostasis
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Accession:GO:0006879 term browser browse the term
Definition:A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell.
Synonyms:exact_synonym: cellular iron ion homeostasis
 broad_synonym: iron homeostasis
 xref: Reactome:R-HSA-917937 "Iron uptake and transport"

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intracellular iron ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 involved_in
acts_upstream_of_or_within 		ISO (PMID:30765471)
(PMID:16424901)
PMID:31511561 		UniProt
MGI		 PMID:16424901 PMID:30765471 PMID:31511561 RGD:126781736 NCBI chrNW_004955562:1,079,884...1,220,806
Ensembl chrNW_004955562:1,077,198...1,221,061 		JBrowse link
G Aco1 aconitase 1 acts_upstream_of_or_within ISO (PMID:14726953) RGD
MGI		 PMID:14726953 PMID:15086359 RGD:1642737 NCBI chrNW_004955472:3,141,473...3,170,959
Ensembl chrNW_004955472:3,141,257...3,170,959 		JBrowse link
G Acvr2b activin A receptor type 2B involved_in ISO (PMID:31800957) UniProt PMID:31800957 NCBI chrNW_004955427:25,438,652...25,467,360
Ensembl chrNW_004955427:25,438,652...25,467,360 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 acts_upstream_of_or_within ISO (PMID:10562540) MGI PMID:10562540 NCBI chrNW_004955475:2,362,368...2,382,680
Ensembl chrNW_004955475:2,362,118...2,377,864 		JBrowse link
G Atp13a2 ATPase cation transporting 13A2 involved_in ISO (PMID:26818499) ParkinsonsUK-UCL PMID:26818499 NCBI chrNW_004955527:1,805,854...1,823,623
Ensembl chrNW_004955527:1,806,009...1,823,344 		JBrowse link
G Atp6ap1 ATPase H+ transporting accessory protein 1 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004955580:927,546...934,633
Ensembl chrNW_004955580:927,114...934,734 		JBrowse link
G Atp6v0a2 ATPase H+ transporting V0 subunit a2 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004955482:5,311,434...5,337,684
Ensembl chrNW_004955482:5,311,434...5,337,697 		JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit d1 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004955484:9,167,439...9,206,193
Ensembl chrNW_004955484:9,167,439...9,206,193 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004955427:13,868,683...13,922,028
Ensembl chrNW_004955427:13,868,171...13,922,028 		JBrowse link
G Atp6v1g1 ATPase H+ transporting V1 subunit G1 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004955419:13,047,755...13,056,113
Ensembl chrNW_004955419:13,047,755...13,056,221 		JBrowse link
G B2m beta-2-microglobulin involved_in ISO (PMID:18353247) BHF-UCL PMID:18353247 NCBI chrNW_004955416:11,205,503...11,211,325
Ensembl chrNW_004955416:11,204,849...11,215,568 		JBrowse link
G Bmp6 bone morphogenetic protein 6 acts_upstream_of_or_within
involved_in 		ISO (PMID:21703414)
(PMID:19252488) 		MGI
BHF-UCL		 PMID:19252488 PMID:21703414 NCBI chrNW_004955465:6,053,600...6,201,254
Ensembl chrNW_004955465:6,054,931...6,200,377 		JBrowse link
G Bola2b bolA family member 2B involved_in ISO (PMID:27519415) ComplexPortal PMID:27519415 NCBI chrNW_004955493:6,812,208...6,812,932 JBrowse link
G Cp ceruloplasmin involved_in ISO (PMID:16150804), (PMID:29183916)
(PMID:14623105) 		UniProt PMID:14623105 PMID:16150804 PMID:29183916 NCBI chrNW_004955448:470,063...522,909
Ensembl chrNW_004955448:473,179...523,100 		JBrowse link
G Egln1 egl-9 family hypoxia inducible factor 1 involved_in ISO (PMID:26818499) ParkinsonsUK-UCL PMID:26818499 NCBI chrNW_004955492:7,407,800...7,454,851
Ensembl chrNW_004955492:7,407,800...7,454,842 		JBrowse link
G Erfe erythroferrone involved_in ISO (PMID:24880340) UniProt PMID:24880340 NCBI chrNW_004955542:2,408,504...2,415,522
Ensembl chrNW_004955542:2,409,988...2,415,522 		JBrowse link
G Fbxl5 F-box and leucine rich repeat protein 5 involved_in ISO (PMID:19762596)
(PMID:19762597) 		UniProt PMID:19762596 PMID:19762597 NCBI chrNW_004955480:8,360,957...8,397,903
Ensembl chrNW_004955480:8,344,019...8,398,650 		JBrowse link
G Frrs1 ferric chelate reductase 1 involved_in ISO (PMID:14499595) ARUK-UCL PMID:14499595 NCBI chrNW_004955435:4,531,279...4,578,146
Ensembl chrNW_004955435:4,527,309...4,578,147 		JBrowse link
G Ftmt ferritin mitochondrial involved_in ISO (PMID:11323407), (PMID:18160053) BHF-UCL PMID:11323407 PMID:18160053 NCBI chrNW_004955521:76,591...77,470 JBrowse link
G Fxn frataxin involved_in
acts_upstream_of_or_within 		ISO (PMID:18160053)
(PMID:9405681) 		BHF-UCL
MGI		 PMID:9405681 PMID:18160053 NCBI chrNW_004955434:3,983,225...4,008,324
Ensembl chrNW_004955434:3,980,653...4,008,761 		JBrowse link
G Glrx3 glutaredoxin 3 involved_in ISO (PMID:27519415) ComplexPortal PMID:27519415 NCBI chrNW_004955477:7,715,257...7,748,913
Ensembl chrNW_004955477:7,715,257...7,752,818 		JBrowse link
G Hamp hepcidin antimicrobial peptide involved_in ISO (PMID:11447267)
(PMID:15514116) 		RGD
UniProt
CACAO		 PMID:11447267 PMID:14592944 PMID:15514116 RGD:1304454 NCBI chrNW_004955468:4,576,080...4,577,591
Ensembl chrNW_004955468:4,575,510...4,577,649 		JBrowse link
G Hephl1 hephaestin like 1 involved_in ISO (PMID:31125343) UniProt PMID:31125343 NCBI chrNW_004955414:461,212...551,323
Ensembl chrNW_004955414:461,212...551,323 		JBrowse link
G Hfe homeostatic iron regulator involved_in ISO (PMID:10085150), (PMID:18353247) UniProt PMID:10085150 PMID:18353247 NCBI chrNW_004955483:933,269...941,070
Ensembl chrNW_004955483:932,352...941,143 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within ISO (PMID:16787915) MGI PMID:16787915 NCBI chrNW_004955466:8,000,311...8,022,497
Ensembl chrNW_004955466:8,000,044...8,022,497 		JBrowse link
G Hjv hemojuvelin BMP co-receptor involved_in ISO (PMID:25860887) BHF-UCL PMID:25860887 NCBI chrNW_004955568:80,386...84,707
Ensembl chrNW_004955568:80,444...84,834 		JBrowse link
G Hmox1 heme oxygenase 1 involved_in ISO (PMID:22989377)
(PMID:17915953) 		CACAO
BHF-UCL		 PMID:17915953 PMID:22989377 NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979 		JBrowse link
G Ireb2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within 		ISO (PMID:30915432)
(PMID:14726953)
(PMID:14726953), (PMID:15831703)
(PMID:11175792) 		UniProt
MGI		 PMID:11175792 PMID:14726953 PMID:15831703 PMID:30915432 NCBI chrNW_004955450:852,554...898,908
Ensembl chrNW_004955450:852,554...900,011 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO (PMID:16517407), (PMID:23508953) UniProt PMID:16517407 PMID:23508953 NCBI chrNW_004955455:9,833,924...9,840,547
Ensembl chrNW_004955455:9,833,924...9,841,619 		JBrowse link
G LOC102016503 cytochrome b ascorbate-dependent protein 3 involved_in ISO (PMID:16911521) UniProt PMID:16911521 NCBI chrNW_004955511:6,191,644...6,200,099
Ensembl chrNW_004955511:6,191,645...6,200,099 		JBrowse link
G LOC102019452 cytochrome b reductase 1 involved_in ISO (PMID:14499595) ARUK-UCL PMID:14499595 NCBI chrNW_004955449:3,368,976...3,394,405
Ensembl chrNW_004955449:3,368,670...3,394,306 		JBrowse link
G LOC102027549 serotransferrin involved_in ISO (PMID:18353247) BHF-UCL PMID:18353247 NCBI chrNW_004955501:4,801,710...4,832,025
Ensembl chrNW_004955501:4,801,885...4,831,910 		JBrowse link
G LOC102028532 cytochrome b561 involved_in ISO (PMID:14499595) ARUK-UCL PMID:14499595 NCBI chrNW_004955478:8,362,190...8,366,947 JBrowse link
G LOC102030058 protein SCO1 homolog, mitochondrial acts_upstream_of_or_within ISO (PMID:36301669) MGI PMID:36301669 NCBI chrNW_004955467:6,519,873...6,535,321
Ensembl chrNW_004955467:6,519,873...6,537,753 		JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase acts_upstream_of ISO (PMID:37653044) UniProt PMID:37653044 NCBI chrNW_004955452:8,185,550...8,218,711
Ensembl chrNW_004955452:8,185,550...8,218,950 		JBrowse link
G Meltf melanotransferrin NOT|acts_upstream_of_or_within ISO (PMID:16291590) MGI PMID:16291590 NCBI chrNW_004955420:13,036,767...13,055,477
Ensembl chrNW_004955420:13,035,309...13,055,548 		JBrowse link
G Mon1a MON1 homolog A, secretory trafficking associated acts_upstream_of_or_within ISO (PMID:17632513) MGI PMID:17632513 NCBI chrNW_004955532:1,793,233...1,811,675
Ensembl chrNW_004955532:1,790,929...1,812,125 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO (PMID:9924025) UniProt PMID:9924025 NCBI chrNW_004955461:2,714,022...2,718,872
Ensembl chrNW_004955461:2,714,022...2,718,982 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 acts_upstream_of_or_within ISO (PMID:25327288) MGI PMID:25327288 NCBI chrNW_004955556:392,412...413,643
Ensembl chrNW_004955556:392,398...412,166 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 involved_in ISO (PMID:18776082) UniProt PMID:18776082 NCBI chrNW_004955415:11,643,846...11,666,131
Ensembl chrNW_004955415:11,643,846...11,666,131 		JBrowse link
G Neo1 neogenin 1 acts_upstream_of_or_within ISO (PMID:20065295) MGI PMID:20065295 NCBI chrNW_004955450:4,191,168...4,324,997
Ensembl chrNW_004955450:4,191,168...4,375,896 		JBrowse link
G Nubp1 NUBP iron-sulfur cluster assembly factor 1, cytosolic involved_in ISO (PMID:18573874) UniProt PMID:18573874 NCBI chrNW_004955442:7,717,422...7,732,496
Ensembl chrNW_004955442:7,717,422...7,732,496 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:22952941) ARUK-UCL PMID:22952941 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208 		JBrowse link
G Scara5 scavenger receptor class A member 5 involved_in ISO (PMID:19154717) UniProt PMID:19154717 NCBI chrNW_004955403:50,386,212...50,486,335
Ensembl chrNW_004955403:50,386,125...50,486,361 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within 		ISO (PMID:16510578)
(PMID:18456389), (PMID:19321419)
(PMID:11903051) 		BHF-UCL
MGI		 PMID:11903051 PMID:16510578 PMID:18456389 PMID:19321419 NCBI chrNW_004955453:14,980,562...14,995,118
Ensembl chrNW_004955453:14,980,562...14,995,608 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 involved_in ISO (PMID:12091367) BHF-UCL PMID:12091367 NCBI chrNW_004955403:9,253,734...9,271,732
Ensembl chrNW_004955403:9,253,734...9,271,916 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chrNW_004955414:16,615,012...16,664,784
Ensembl chrNW_004955414:16,614,155...16,664,485 		JBrowse link
G Smad1 SMAD family member 1 involved_in ISO (PMID:31800957) UniProt PMID:31800957 NCBI chrNW_004955428:1,357,398...1,429,521
Ensembl chrNW_004955428:1,361,085...1,429,948 		JBrowse link
G Smad4 SMAD family member 4 involved_in ISO (PMID:16330325) BHF-UCL PMID:16330325 NCBI chrNW_004955402:35,956,080...36,001,746
Ensembl chrNW_004955402:35,961,165...35,994,538 		JBrowse link
G Smad5 SMAD family member 5 involved_in ISO (PMID:31800957) UniProt PMID:31800957 NCBI chrNW_004955408:31,183,727...31,228,355
Ensembl chrNW_004955408:31,183,659...31,229,384 		JBrowse link
G Smad9 SMAD family member 9 involved_in ISO (PMID:31800957) UniProt PMID:31800957 NCBI chrNW_004955431:9,117,616...9,184,920 JBrowse link
G Sod1 superoxide dismutase 1 acts_upstream_of_or_within ISO (PMID:16377630) MGI PMID:16377630 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727 		JBrowse link
G Tfr2 transferrin receptor 2 involved_in ISO (PMID:18353247) BHF-UCL PMID:18353247 NCBI chrNW_004955573:272,315...289,227
Ensembl chrNW_004955573:272,289...291,668 		JBrowse link
G Tfrc transferrin receptor acts_upstream_of_or_within ISO (PMID:10192390) MGI PMID:10192390 NCBI chrNW_004955420:12,348,392...12,372,714
Ensembl chrNW_004955420:12,348,821...12,372,691 		JBrowse link
G Tmprss6 transmembrane serine protease 6 involved_in ISO (PMID:25860887) BHF-UCL PMID:25860887 NCBI chrNW_004955413:23,579,946...23,615,277
Ensembl chrNW_004955413:23,580,530...23,612,276 		JBrowse link
G Ttc7a tetratricopeptide repeat domain 7A acts_upstream_of_or_within ISO (PMID:15155459) MGI PMID:15155459 NCBI chrNW_004955441:13,804,791...13,915,969
Ensembl chrNW_004955441:13,793,216...13,916,423 		JBrowse link
G Vma12 vacuolar ATPase assembly factor VMA12 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004955481:4,772,394...4,776,524
Ensembl chrNW_004955481:4,772,401...4,776,524 		JBrowse link
G Vma22 vacuolar ATPase assembly factor VMA22 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004955459:25,649...30,215
Ensembl chrNW_004955459:25,649...30,215 		JBrowse link
cellular response to iron ion starvation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hfe homeostatic iron regulator ISO RGD PMID:16208485 RGD:1582698 NCBI chrNW_004955483:933,269...941,070
Ensembl chrNW_004955483:932,352...941,143 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chrNW_004955414:16,615,012...16,664,784
Ensembl chrNW_004955414:16,614,155...16,664,485 		JBrowse link
endocytic iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tfr2 transferrin receptor 2 involved_in ISO (PMID:18353247) BHF-UCL PMID:18353247 NCBI chrNW_004955573:272,315...289,227
Ensembl chrNW_004955573:272,289...291,668 		JBrowse link
heme import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco2b1 solute carrier organic anion transporter family member 2B1 acts_upstream_of_or_within ISO (PMID:35714613) MGI PMID:35714613 NCBI chrNW_004955414:16,615,012...16,664,784
Ensembl chrNW_004955414:16,614,155...16,664,485 		JBrowse link
iron import into cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc39a14 solute carrier family 39 member 14 involved_in ISO (PMID:20682781) UniProt PMID:20682781 NCBI chrNW_004955403:45,828,247...45,867,309
Ensembl chrNW_004955403:45,827,942...45,867,309 		JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chrNW_004955459:10,441,906...10,485,235
Ensembl chrNW_004955459:10,441,752...10,485,269 		JBrowse link
G Steap4 STEAP4 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chrNW_004955432:5,618,086...5,641,372
Ensembl chrNW_004955432:5,618,086...5,641,565 		JBrowse link
iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc39a8 solute carrier family 39 member 8 involved_in ISO (PMID:22898811)
(PMID:30015240) 		UniProt PMID:22898811 PMID:30015240 RGD:15090842 NCBI chrNW_004955496:6,016,727...6,106,965
Ensembl chrNW_004955496:6,040,029...6,109,907 		JBrowse link
G Steap2 STEAP2 metalloreductase acts_upstream_of_or_within ISO (PMID:16609065) MGI PMID:16609065 NCBI chrNW_004955432:7,455,731...7,499,863
Ensembl chrNW_004955432:7,456,514...7,490,381 		JBrowse link
negative regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO (PMID:20436681) ARUK-UCL PMID:20436681 NCBI chrNW_004955455:9,833,924...9,840,547
Ensembl chrNW_004955455:9,833,924...9,841,619 		JBrowse link
positive regulation of iron ion import across plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:29061364) ARUK-UCL PMID:29061364 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12628
    homeostatic process 1721
      chemical homeostasis 1016
        inorganic ion homeostasis 483
          intracellular iron ion homeostasis 64
            cellular response to iron ion starvation + 2
            iron import into cell + 9
Path 2
Term Annotations click to browse term
  biological_process 12628
    homeostatic process 1721
      chemical homeostasis 1016
        monoatomic ion homeostasis 551
          intracellular monoatomic ion homeostasis 471
            intracellular monoatomic cation homeostasis 459
              intracellular iron ion homeostasis 64
                cellular response to iron ion starvation + 2
                iron import into cell + 9
paths to the root