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ONTOLOGY REPORT - ANNOTATIONS

Term:ubiquinone biosynthetic process
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Accession:GO:0006744 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
Synonyms:exact_synonym: coenzyme Q biosynthesis;   coenzyme Q biosynthetic process;   ubiquinone anabolism;   ubiquinone biosynthesis;   ubiquinone formation;   ubiquinone synthesis
 narrow_synonym: coenzyme Q10 biosynthesis;   coenzyme Q10 biosynthetic process;   coenzyme Q6 biosynthesis;   coenzyme Q6 biosynthetic process;   coenzyme Q8 biosynthesis;   coenzyme Q8 biosynthetic process;   coenzyme Q9 biosynthesis;   coenzyme Q9 biosynthetic process
 xref: MetaCyc:UBISYN-PWY;   Reactome:R-HSA-2142789 "Ubiquinol biosynthesis"


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ubiquinone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coq2 coenzyme Q2, polyprenyltransferase involved_in
acts_upstream_of_or_within 		IEA
ISO
ISS
IBA 		GO_REF:0000041
(PMID:15153069), (PMID:16400613), (PMID:17374725), (PMID:27493029)
GO_REF:0000024
SGD:S000005324 (PMID:15153069)
GO_REF:0000033
MGI:7628277 (PMID:38697100)
GO_REF:0000104
GO_REF:0000043 		UniProt
RGD
GO_Central		 PMID:15153069 PMID:16400613 PMID:17374725 PMID:27493029 PMID:38697100 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 NCBI chr14:8,941,429...8,961,418
Ensembl chr14:8,941,461...8,960,891 		JBrowse link
G Coq3 coenzyme Q3 methyltransferase involved_in IGI
IEA
ISS
ISO 		GO_REF:0000104
GO_REF:0000043
GO_REF:0000002
GO_REF:0000041
GO_REF:0000117
GO_REF:0000107
GO_REF:0000024
UniProtKB:P27680 (PMID:10777520), (PMID:38425362) 		UniProt
InterPro
Ensembl
RGD		 PMID:10777520 PMID:38425362 PMID:8125303 GO_REF:0000002 GO_REF:0000024 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117, RGD:69814 NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607 		JBrowse link
G Coq4 coenzyme Q4 involved_in IEA
ISS
ISO 		GO_REF:0000041
GO_REF:0000024
(PMID:30659264), (PMID:38014483), (PMID:38295803), (PMID:38425362)
GO_REF:0000104
GO_REF:0000002
GO_REF:0000043 		UniProt
RGD
InterPro		 PMID:30659264 PMID:38014483 PMID:38295803 PMID:38425362 GO_REF:0000002 GO_REF:0000024 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 NCBI chr 3:13,060,054...13,070,502
Ensembl chr 3:13,060,455...13,068,799 		JBrowse link
G Coq5 coenzyme Q5, methyltransferase involved_in IEA
ISO
ISS
IBA 		GO_REF:0000041
GO_REF:0000104
GO_REF:0000107
GO_REF:0000043
UniProtKB:P49017 (PMID:25152161), (PMID:38425362)
GO_REF:0000024
GO_REF:0000033 		UniProt
Ensembl
RGD
GO_Central		 PMID:25152161 PMID:38425362 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 NCBI chr12:41,316,922...41,333,855
Ensembl chr12:41,316,748...41,333,848 		JBrowse link
G Coq6 coenzyme Q6 monooxygenase involved_in IEA
ISO
ISS
IBA 		GO_REF:0000041
(PMID:38425362)
GO_REF:0000104
GO_REF:0000002
GO_REF:0000107
GO_REF:0000024
MGI:6451728 (PMID:30737270)
GO_REF:0000033
GO_REF:0000043 		UniProt
RGD
InterPro
Ensembl
GO_Central		 PMID:30737270 PMID:38425362 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657 		JBrowse link
G Coq7 coenzyme Q7, hydroxylase involved_in
NOT|acts_upstream_of_or_within 		IGI
IEA
ISS
ISO
IBA 		GO_REF:0000041
GO_REF:0000024
MGI:2157003 (PMID:19478076)
MGI:2157003|MGI:2158322 (PMID:11585841), (PMID:11716496)
GO_REF:0000033
(PMID:28409910), (PMID:38425362)
MGI:2158322 (PMID:11716496)
GO_REF:0000104
GO_REF:0000002
GO_REF:0000043
GO_REF:0000117
GO_REF:0000107 		UniProt
RGD
GO_Central
InterPro
Ensembl		 PMID:11585841 PMID:11716496 PMID:19478076 PMID:28409910 PMID:38425362 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117, RGD:69815 NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158 		JBrowse link
G Coq8a coenzyme Q8A involved_in IEA
ISS
IBA
ISO 		GO_REF:0000041
GO_REF:0000024
GO_REF:0000033
MGI:6359448 (PMID:27499294)
GO_REF:0000107
GO_REF:0000043
(PMID:25498144), (PMID:27499294), (PMID:38425362) 		UniProt
GO_Central
RGD
Ensembl		 PMID:25498144 PMID:27499294 PMID:38425362 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431 		JBrowse link
G Coq8b coenzyme Q8B involved_in ISS
ISO
IEA
IBA 		GO_REF:0000024
(PMID:27499294), (PMID:38425362)
GO_REF:0000107
GO_REF:0000033 		UniProt
RGD
Ensembl
GO_Central		 PMID:27499294 PMID:38425362 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:82,525,578...82,549,182
Ensembl chr 1:82,526,568...82,549,180 		JBrowse link
G Coq9 coenzyme Q9 involved_in
acts_upstream_of_or_within 		IEA
ISO
ISS
IBA 		GO_REF:0000041
GO_REF:0000104
GO_REF:0000002
GO_REF:0000043
GO_REF:0000107
MGI:5473628 (PMID:23255162), (PMID:25339443)
(PMID:30661980), (PMID:38425362)
GO_REF:0000024
GO_REF:0000033 		UniProt
InterPro
Ensembl
RGD
GO_Central		 PMID:23255162 PMID:25339443 PMID:30661980 PMID:38425362 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000104 GO_REF:0000107 NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949 		JBrowse link
G Fdx2 ferredoxin 2 acts_upstream_of_positive_effect
involved_in 		IEA
ISO 		GO_REF:0000107
(PMID:38425362) 		Ensembl
RGD		 PMID:38425362 GO_REF:0000107 NCBI chr 8:27,881,091...27,886,230
Ensembl chr 8:19,604,916...19,609,849 		JBrowse link
G Fdxr ferredoxin reductase acts_upstream_of_positive_effect ISS
ISO 		GO_REF:0000024
(PMID:38425362) 		UniProt
RGD		 PMID:38425362 GO_REF:0000024 NCBI chr10:101,006,845...101,015,582
Ensembl chr10:100,507,865...100,516,658 		JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:161,345,398...161,374,188
Ensembl chr 4:159,659,242...159,688,018 		JBrowse link
G Pdss1 decaprenyl diphosphate synthase subunit 1 involved_in ISO
IEA
IBA 		(PMID:16262699)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:16262699 GO_REF:0000033 GO_REF:0000107 NCBI chr17:85,059,953...85,098,739
Ensembl chr17:85,060,106...85,098,730 		JBrowse link
G Pdss2 decaprenyl diphosphate synthase subunit 2 involved_in IEA
ISO
IBA 		GO_REF:0000041
GO_REF:0000043
(PMID:16262699)
GO_REF:0000033 		UniProt
RGD
GO_Central		 PMID:16262699 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 NCBI chr20:46,709,631...46,938,704
Ensembl chr20:46,709,649...46,938,708 		JBrowse link
G Rtn4ip1 reticulon 4 interacting protein 1 involved_in ISO (PMID:37884807) RGD PMID:37884807 NCBI chr20:47,382,251...47,422,747
Ensembl chr20:47,382,234...47,422,338 		JBrowse link
G Ubiad1 UbiA prenyltransferase domain containing 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:23374346)
GO_REF:0000107
GO_REF:0000041
GO_REF:0000043 		UniProt
RGD
Ensembl		 PMID:23374346 GO_REF:0000024 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 NCBI chr 5:164,139,714...164,167,777
Ensembl chr 5:158,868,672...158,880,271 		JBrowse link
positive regulation of ubiquinone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pptc7 protein phosphatase targeting COQ7 involved_in ISO
IEA 		(PMID:30267671)
GO_REF:0000107 		RGD
Ensembl		 PMID:30267671 GO_REF:0000107 NCBI chr12:34,249,963...34,288,339
Ensembl chr12:34,249,977...34,288,339 		JBrowse link
regulation of ubiquinone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adck2 aarF domain containing kinase 2 involved_in ISO
IEA 		(PMID:31480808)
GO_REF:0000107 		RGD
Ensembl		 PMID:31480808 GO_REF:0000107 NCBI chr 4:68,348,853...68,362,725
Ensembl chr 4:68,348,864...68,374,608 		JBrowse link
G Pptc7 protein phosphatase targeting COQ7 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:34,249,963...34,288,339
Ensembl chr12:34,249,977...34,288,339 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        ketone metabolic process 255
          quinone metabolic process 23
            ubiquinone metabolic process 21
              ubiquinone biosynthetic process 18
                negative regulation of ubiquinone biosynthetic process 0
                positive regulation of ubiquinone biosynthetic process 1
                regulation of ubiquinone biosynthetic process + 2
Path 2
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        biosynthetic process 8630
          small molecule biosynthetic process 669
            ketone biosynthetic process 58
              quinone biosynthetic process 18
                ubiquinone biosynthetic process 18
                  negative regulation of ubiquinone biosynthetic process 0
                  positive regulation of ubiquinone biosynthetic process 1
                  regulation of ubiquinone biosynthetic process + 2
paths to the root