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ONTOLOGY REPORT - ANNOTATIONS

Term:NADPH regeneration
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Accession:GO:0006740 term browser browse the term
Definition:A metabolic process that generates a pool of NADPH by the reduction of NADP+.
Synonyms:exact_synonym: reduced NADP regeneration;   reduced nicotinamide adenine dinucleotide phosphate regeneration
 xref: Reactome:R-HSA-389542 "NADPH regeneration"


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NADPH regeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 involved_in ISO (PMID:25550467) RGD PMID:25550467 NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 involved_in ISO
IEA
IDA		 (PMID:19933275)
GO_REF:0000107
PMID:1848231		 RGD
Ensembl		 PMID:19933275 PMID:1848231 GO_REF:0000107, RGD:632027 NCBI chr 4:124,617,182...124,663,674
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 involved_in ISO (PMID:21238436)
(PMID:33168096)		 RGD PMID:21238436 PMID:33168096 NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase involved_in ISO (PMID:17516514)
(PMID:21527585)		 RGD PMID:17516514 PMID:21527585 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 involved_in ISO (PMID:21527585) RGD PMID:21527585 NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase involved_in IMP
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:22198343 GO_REF:0000033, RGD:13513982 NCBI chr 2:53,144,157...53,237,857
Ensembl chr 2:51,411,413...51,504,823 		JBrowse link
G Pgd phosphogluconate dehydrogenase involved_in ISO (PMID:21527585) RGD PMID:21527585 NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
negative regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldob aldolase, fructose-bisphosphate B involved_in IEA
ISO		 GO_REF:0000107
(PMID:35122041)		 Ensembl
RGD		 PMID:35122041 GO_REF:0000107 NCBI chr 5:68,684,541...68,697,582
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO
IEA		 (PMID:21336310)
GO_REF:0000107		 RGD
Ensembl		 PMID:21336310 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-CoA carboxylase beta IMP RGD PMID:31709908 RGD:329901803 NCBI chr12:48,026,394...48,138,214
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase involved_in IDA
ISO		 (PMID:2297768) RGD PMID:2297768 PMID:2843500 RGD:1599574 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) acts_upstream_of_or_within ISO (PMID:12831846) RGD PMID:12831846 NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:160,438,697...160,470,171 		JBrowse link
G Kif1b kinesin family member 1B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:164,890,778...165,025,848
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Pgd phosphogluconate dehydrogenase involved_in IDA
IEA
ISS		 GO_REF:0000041
GO_REF:0000024		 UniProt
RGD		 PMID:2843500 GO_REF:0000024 GO_REF:0000041, RGD:1599574 NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Pgls 6-phosphogluconolactonase involved_in ISO
IEA		 (PMID:10518023)
GO_REF:0000041		 RGD
UniProt		 PMID:10518023 GO_REF:0000041 NCBI chr16:18,334,299...18,339,785
Ensembl chr16:18,300,317...18,305,803 		JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 involved_in ISO (PMID:24855946) RGD PMID:24855946 NCBI chr  X:108,920,663...108,942,713
Ensembl chr  X:104,132,141...104,154,187 		JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24855946)		 Ensembl
RGD		 PMID:24855946 GO_REF:0000107 NCBI chr  X:30,592,845...30,630,127
Ensembl chr  X:26,976,061...27,013,181 		JBrowse link
G Rbks ribokinase involved_in ISO (PMID:13405914) RGD PMID:13405914 NCBI chr 6:30,467,724...30,544,284
Ensembl chr 6:24,747,293...24,824,290 		JBrowse link
G Rpe ribulose-5-phosphate-3-epimerase involved_in IDA
ISO		 (PMID:5360673)
(PMID:20923965)		 RGD PMID:5360673 PMID:20923965 PMID:2843500 RGD:1599574 NCBI chr 9:75,640,867...75,661,009
Ensembl chr 9:68,191,292...68,211,591 		JBrowse link
G Rpia ribose 5-phosphate isomerase A involved_in IDA
ISO		 (PMID:5360673) RGD PMID:5360673 PMID:2843500 RGD:1599574 NCBI chr 4:104,282,081...104,307,732
Ensembl chr 4:102,723,712...102,749,355 		JBrowse link
G Taldo1 transaldolase 1 involved_in IDA
ISO
IEA		 (PMID:13405914), (PMID:19436114), (PMID:5360673)
GO_REF:0000041		 RGD
UniProt		 PMID:5360673 PMID:13405914 PMID:19436114 PMID:2843500 GO_REF:0000041, RGD:1599574 NCBI chr 1:205,923,196...205,933,526
Ensembl chr 1:196,493,589...196,503,974 		JBrowse link
G Tkt transketolase involved_in IDA
ISO		 (PMID:13405914), (PMID:5360673)
(PMID:20667822)		 RGD PMID:5360673 PMID:13405914 PMID:20667822 PMID:2843500 RGD:1599574 NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,723,762...5,748,698 		JBrowse link
pentose-phosphate shunt, non-oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpe ribulose-5-phosphate-3-epimerase involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:3079759 GO_REF:0000033, RGD:1641816 NCBI chr 9:75,640,867...75,661,009
Ensembl chr 9:68,191,292...68,211,591 		JBrowse link
G Rpia ribose 5-phosphate isomerase A involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:3079759 GO_REF:0000033, RGD:1641816 NCBI chr 4:104,282,081...104,307,732
Ensembl chr 4:102,723,712...102,749,355 		JBrowse link
G Shpk sedoheptulokinase involved_in ISO (PMID:22682222) RGD PMID:22682222 NCBI chr10:58,316,065...58,340,489
Ensembl chr10:57,817,629...57,841,980 		JBrowse link
G Taldo1 transaldolase 1 involved_in IDA
IBA
ISO		 GO_REF:0000033
(PMID:18498245)		 GO_Central
RGD		 PMID:18498245 PMID:8477719 PMID:3079759 GO_REF:0000033, RGD:1641803, RGD:1641816 NCBI chr 1:205,923,196...205,933,526
Ensembl chr 1:196,493,589...196,503,974 		JBrowse link
G Tkt transketolase involved_in IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:32295803)
GO_REF:0000107		 GO_Central
RGD
Ensembl		 PMID:32295803 PMID:16116031 PMID:3079759 GO_REF:0000033 GO_REF:0000107, RGD:1580394, RGD:1641816 NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,723,762...5,748,698 		JBrowse link
pentose-phosphate shunt, oxidative branch term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pd glucose-6-phosphate dehydrogenase involved_in IMP
IBA
ISO		 GO_REF:0000033
MGI:2182739 (PMID:12466018), (PMID:22829586)
(PMID:2420826)		 GO_Central
RGD		 PMID:2420826 PMID:12466018 PMID:22829586 PMID:9794092 GO_REF:0000033, RGD:1641793 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) involved_in ISO
IBA		 (PMID:18628520), (PMID:23132696)
GO_REF:0000033		 RGD
GO_Central		 PMID:18628520 PMID:23132696 GO_REF:0000033 NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:160,438,697...160,470,171 		JBrowse link
G Pgd phosphogluconate dehydrogenase involved_in IMP
IBA
ISO		 GO_REF:0000033
(PMID:12466018), (PMID:5360673), (PMID:7496990)
(PMID:3858849)		 GO_Central
RGD		 PMID:3858849 PMID:5360673 PMID:7496990 PMID:12466018 PMID:9794092 GO_REF:0000033, RGD:1641793 NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Pgls 6-phosphogluconolactonase involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:971315 GO_REF:0000033, RGD:2311501 NCBI chr16:18,334,299...18,339,785
Ensembl chr16:18,300,317...18,305,803 		JBrowse link
positive regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tigar TP53 induced glycolysis regulatory phosphatase involved_in ISO (PMID:24872551) RGD PMID:24872551 NCBI chr 4:161,613,306...161,632,248
Ensembl chr 4:159,927,139...159,946,029
Ensembl chr 6:159,927,139...159,946,029 		JBrowse link
regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:16234247 RGD:1625062 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase involved_in ISO
IBA		 (PMID:25928429)
GO_REF:0000033		 RGD
GO_Central		 PMID:25928429 GO_REF:0000033 NCBI chr 4:161,613,306...161,632,248
Ensembl chr 4:159,927,139...159,946,029
Ensembl chr 6:159,927,139...159,946,029 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      metabolic process 12171
        generation of precursor metabolites and energy 558
          NADPH regeneration 23
            pentose-phosphate shunt + 18
            pentose-phosphate shunt, oxidative branch 4
            photosynthetic NADP+ reduction 0
Path 2
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      metabolic process 12171
        primary metabolic process 10746
          nucleobase-containing compound metabolic process 5951
            nucleobase-containing small molecule metabolic process 731
              nucleoside phosphate metabolic process 696
                nucleotide metabolic process 542
                  pyridine nucleotide metabolic process 236
                    nicotinamide nucleotide metabolic process 236
                      NADP metabolic process 47
                        NADPH regeneration 23
                          pentose-phosphate shunt + 18
                          pentose-phosphate shunt, oxidative branch 4
                          photosynthetic NADP+ reduction 0
paths to the root