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ONTOLOGY REPORT - ANNOTATIONS

Term:mineralocorticoid biosynthetic process
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Accession:GO:0006705 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
Synonyms:exact_synonym: mineralocorticoid anabolism;   mineralocorticoid biosynthesis;   mineralocorticoid formation;   mineralocorticoid synthesis
 xref: Reactome:R-HSA-193993 "Mineralocorticoid biosynthesis"

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aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004624913:1,926,405...1,952,426
Ensembl chrNW_004624913:1,891,156...1,949,633 		JBrowse link
G LOC101700701 cytochrome P450 11B1, mitochondrial acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:1686470), (PMID:8645611) MGI
TreeGrafter		 PMID:1686470 PMID:8645611 GO_REF:0000118 NCBI chrNW_004624735:13,701,382...13,708,750 JBrowse link
G LOC101701311 cytochrome P450 11B1, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624735:13,726,649...13,734,536 JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chrNW_004624741:7,706,205...7,717,677
Ensembl chrNW_004624741:7,706,236...7,719,484 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chrNW_004624850:3,324,553...3,481,439
Ensembl chrNW_004624850:3,322,782...3,481,512 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chrNW_004624766:4,042,307...4,085,613
Ensembl chrNW_004624766:4,041,816...4,085,209 		JBrowse link
G Rest RE1 silencing transcription factor involved_in ISO PMID:19342457
(PMID:19342457)		 UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004624761:12,464,243...12,495,294 JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in ISO (PMID:16527843) UniProt PMID:16527843 NCBI chrNW_004624756:17,742,822...17,894,931
Ensembl chrNW_004624756:17,743,834...17,894,753 		JBrowse link
G Dab2 DAB adaptor protein 2 ISO RGD PMID:17303656 RGD:7243836 NCBI chrNW_004624759:15,459,436...15,520,225
Ensembl chrNW_004624759:15,459,288...15,520,924 		JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chrNW_004624764:6,913,027...6,934,650
Ensembl chrNW_004624764:6,921,811...6,933,392 		JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in ISO (PMID:29403011) UniProt PMID:29403011 NCBI chrNW_004624730:72,228,912...72,242,636
Ensembl chrNW_004624730:72,228,189...72,244,332 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17640
    cellular process 17222
      metabolic process 11022
        hormone metabolic process 196
          hormone biosynthetic process 65
            mineralocorticoid biosynthetic process 11
              aldosterone biosynthetic process + 11
Path 2
Term Annotations click to browse term
  biological_process 17640
    cellular process 17222
      metabolic process 11022
        primary metabolic process 9867
          lipid metabolic process 1260
            lipid biosynthetic process 651
              steroid biosynthetic process 155
                steroid hormone biosynthetic process 39
                  mineralocorticoid biosynthetic process 11
                    aldosterone biosynthetic process + 11
paths to the root