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ONTOLOGY REPORT - ANNOTATIONS

Term:mineralocorticoid biosynthetic process
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Accession:GO:0006705 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
Synonyms:exact_synonym: mineralocorticoid anabolism;   mineralocorticoid biosynthesis;   mineralocorticoid formation;   mineralocorticoid synthesis
 xref: Reactome:R-HSA-193993 "Mineralocorticoid biosynthesis"


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mineralocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 involved_in ISO GO_Central GO_REF:0000096 NCBI chr17:35,020,322...35,023,400
Ensembl chr17:35,020,322...35,023,535 		JBrowse link
aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit involved_in ISO GO_Central GO_REF:0000096 GO_REF:0000119 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000096 NCBI chr15:74,706,741...74,713,492
Ensembl chr15:74,705,974...74,713,492 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:1686470), (PMID:8645611) MGI
GO_Central		 PMID:1686470 PMID:8645611 GO_REF:0000033 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,467...74,728,167 		JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 9:75,682,647...75,807,598
Ensembl chr 9:75,682,646...75,807,592 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 7:111,715,226...111,758,689
Ensembl chr 7:111,715,224...111,758,264 		JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000096 GO_REF:0000119 NCBI chr 5:77,413,273...77,434,279
Ensembl chr 5:77,413,338...77,434,279 		JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278 		JBrowse link
G Dab2 disabled 2, mitogen-responsive phosphoprotein involved_in ISO RGD
GO_Central		 PMID:17303656 GO_REF:0000096 RGD:7243836 NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193 		JBrowse link
G Wnt4 wingless-type MMTV integration site family, member 4 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037 		JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride channel, voltage-sensitive 2 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr16:20,521,185...20,536,496
Ensembl chr16:20,521,714...20,536,496 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28636
    cellular process 18394
      metabolic process 11625
        hormone metabolic process 290
          hormone biosynthetic process 73
            mineralocorticoid biosynthetic process 12
              aldosterone biosynthetic process + 11
Path 2
Term Annotations click to browse term
  biological_process 28636
    cellular process 18394
      metabolic process 11625
        primary metabolic process 10233
          lipid metabolic process 1509
            lipid biosynthetic process 745
              steroid biosynthetic process 187
                steroid hormone biosynthetic process 48
                  mineralocorticoid biosynthetic process 12
                    aldosterone biosynthetic process + 11
paths to the root