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ONTOLOGY REPORT - ANNOTATIONS

Term:mineralocorticoid biosynthetic process
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Accession:GO:0006705 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
Synonyms:exact_synonym: mineralocorticoid anabolism;   mineralocorticoid biosynthesis;   mineralocorticoid formation;   mineralocorticoid synthesis
 xref: Reactome:R-HSA-193993 "Mineralocorticoid biosynthesis"


show annotations for term's descendants           Sort by:
mineralocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in TAS Reactome Reactome:R-HSA-193993 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843 		JBrowse link
G CYP21A1P cytochrome P450 family 21 subfamily A member 1, pseudogene ISO 11-deoxycorticosterone RGD PMID:19665544 RGD:4891164 NCBI chr 6:32,005,636...32,008,909
Ensembl chr 6:32,005,689...32,008,399 		JBrowse link
G CYP21A2 cytochrome P450 family 21 subfamily A member 2 involved_in TAS Reactome Reactome:R-HSA-193993 NCBI chr 6:32,038,415...32,041,644
Ensembl chr 6:32,038,327...32,041,644 		JBrowse link
aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr16:1,153,106...1,221,768
Ensembl chr16:1,153,103...1,224,169 		JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in ISO
IBA
IDA
IMP		 (PMID:2256920)
(PMID:19342457)		 RGD
GO_Central
BHF-UCL
UniProt		 PMID:2256920 PMID:11832364 PMID:19342457 GO_REF:0000033 RGD:727991 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,356...142,879,846 		JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in
acts_upstream_of_or_within		 IMP
ISO
IBA
IDA		 (PMID:19342457)
(PMID:1686470), (PMID:8645611)
(PMID:1741400), (PMID:2256920), (PMID:23322723)		 UniProt
MGI
GO_Central
BHF-UCL		 PMID:1686470 PMID:1741400 PMID:2256920 PMID:8645611 PMID:19342457 More... GO_REF:0000033 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843 		JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246 		JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IDA (PMID:19584291) BHF-UCL PMID:19584291 NCBI chr 6:55,753,653...55,875,590
Ensembl chr 6:55,753,653...55,875,590 		JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr11:11,963,036...12,009,745
Ensembl chr11:11,956,207...12,009,769 		JBrowse link
G REST RE1 silencing transcription factor involved_in IMP (PMID:19342457) UniProt PMID:19342457 NCBI chr 4:56,907,900...56,935,844
Ensembl chr 4:56,907,876...56,966,808 		JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP6 bone morphogenetic protein 6 involved_in IDA (PMID:16527843) UniProt PMID:16527843 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728 		JBrowse link
G DAB2 DAB adaptor protein 2 involved_in IEA
ISO		 Ensembl
RGD		 PMID:17303656 GO_REF:0000107 RGD:7243836 NCBI chr 5:39,371,677...39,424,980
Ensembl chr 5:39,371,675...39,462,300 		JBrowse link
G WNT4 Wnt family member 4 involved_in IDA (PMID:16981135) UniProt PMID:16981135 NCBI chr 1:22,117,313...22,143,097
Ensembl chr 1:22,117,313...22,143,969 		JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in IMP (PMID:29403011) UniProt PMID:29403011 NCBI chr 3:184,346,185...184,361,605
Ensembl chr 3:184,346,185...184,361,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20486
    cellular process 19728
      metabolic process 13561
        hormone metabolic process 276
          hormone biosynthetic process 81
            mineralocorticoid biosynthetic process 13
              aldosterone biosynthetic process + 11
Path 2
Term Annotations click to browse term
  biological_process 20486
    cellular process 19728
      metabolic process 13561
        primary metabolic process 11774
          lipid metabolic process 1512
            lipid biosynthetic process 805
              steroid biosynthetic process 196
                steroid hormone biosynthetic process 55
                  mineralocorticoid biosynthetic process 13
                    aldosterone biosynthetic process + 11
paths to the root