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ONTOLOGY REPORT - ANNOTATIONS

Term:estrogen biosynthetic process
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Accession:GO:0006703 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
Synonyms:exact_synonym: estrogen anabolism;   estrogen biosynthesis;   estrogen formation;   estrogen synthesis;   oestrogen biosynthesis;   oestrogen biosynthetic process
 xref: Reactome:R-HSA-193144 "Estrogen biosynthesis"


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estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IDA estrone RGD PMID:19665544 RGD:4891164 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 involved_in IDA
ISO
IEA
IBA		 estradiol
(PMID:8994190)
GO_REF:0000041
GO_REF:0000033
(PMID:9658408)		 RGD
UniProt
GO_Central		 PMID:8994190 PMID:9658408 PMID:8612487 GO_REF:0000033 GO_REF:0000041, RGD:728619 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 involved_in IDA
IEA
ISO		 estrone
GO_REF:0000107
(PMID:11940569)		 Ensembl
RGD		 PMID:11940569 PMID:8612487 GO_REF:0000107, RGD:728619 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 involved_in IDA
IEA
ISO		 PMID:9658408
GO_REF:0000041
GO_REF:0000107
(PMID:12732193)
(PMID:12732193), (PMID:9658408)		 UniProt
Ensembl
RGD		 PMID:9658408 PMID:12732193 PMID:9658408 GO_REF:0000041 GO_REF:0000107, RGD:30309934 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 involved_in IEA
IBA
ISO
ISS		 GO_REF:0000041
GO_REF:0000033
GO_REF:0000107
(PMID:17978863)
GO_REF:0000024		 UniProt
GO_Central
Ensembl
RGD		 PMID:17978863 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742 		JBrowse link
G Rdh8 retinol dehydrogenase 8 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:19,353,191...19,360,462
Ensembl chr 8:19,353,191...19,360,462 		JBrowse link
G Star steroidogenic acute regulatory protein IMP estradiol; positive regulation RGD PMID:16579833 RGD:1600078 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    cellular process 19526
      metabolic process 12168
        hormone metabolic process 267
          hormone biosynthetic process 70
            estrogen biosynthetic process 9
              negative regulation of estrogen biosynthetic process 1
              positive regulation of estrogen biosynthetic process 0
              regulation of estrogen biosynthetic process + 1
Path 2
Term Annotations click to browse term
  biological_process 20536
    cellular process 19526
      metabolic process 12168
        primary metabolic process 10755
          lipid metabolic process 1458
            lipid biosynthetic process 731
              steroid biosynthetic process 192
                steroid hormone biosynthetic process 46
                  estrogen biosynthetic process 9
                    negative regulation of estrogen biosynthetic process 1
                    positive regulation of estrogen biosynthetic process 0
                    regulation of estrogen biosynthetic process + 1
paths to the root