membrane lipid metabolic process - Ontology Report

PMID:20643956

GO_REF:0000033

NCBI chr 7:15,117,223...15,562,015
Ensembl chr 7:15,200,317...15,562,017

B4GALT4

beta-1,4-galactosyltransferase 4

involved_in

TAS

(PMID:9792633)

PMID:9792633

NCBI chr 3:119,211,742...119,240,878
Ensembl chr 3:119,211,628...119,240,952

CNPY4

canopy FGF signaling regulator 4

acts_upstream_of_or_within

ISO

(PMID:35504891)

PMID:35504891

NCBI chr 7:100,119,634...100,125,508
Ensembl chr 7:100,119,634...100,125,508

prosaposin

acts_upstream_of_or_within

ISO

(PMID:14684827)

PMID:14684827

NCBI chr10:71,816,298...71,851,251
Ensembl chr10:71,816,289...71,851,330

3-keto-sphinganine metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

MGI
GO_Central
UniProt
InterPro

3-ketodihydrosphingosine reductase

acts_upstream_of_or_within
involved_in

IDA
IBA
IMP
IEA

(PMID:15364918)
(PMID:19141869)

PMID:15364918 PMID:19141869

GO_REF:0000002 GO_REF:0000033

NCBI chr18:63,327,726...63,367,206
Ensembl chr18:63,327,566...63,367,615

ceramide biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AGK

acylglycerol kinase

involved_in
acts_upstream_of_or_within

IBA
IEA

GO_REF:0000033 GO_REF:0000107

NCBI chr 7:141,551,410...141,655,244
Ensembl chr 7:141,551,278...141,655,244

ALOX12B

arachidonate 12-lipoxygenase, 12R type

involved_in

ISS
IEA

GO_REF:0000024 GO_REF:0000107

NCBI chr17:8,072,636...8,087,716
Ensembl chr17:8,072,636...8,087,716

ALOXE3

arachidonate epidermal lipoxygenase 3

involved_in
acts_upstream_of_or_within

IEA
ISO
ISS

(PMID:22832496)

Ensembl
MGI
UniProt

PMID:22832496

GO_REF:0000024 GO_REF:0000107

NCBI chr17:8,095,900...8,118,916
Ensembl chr17:8,095,900...8,119,047

N-acylsphingosine amidohydrolase 1

involved_in

IDA

(PMID:12764132), (PMID:12815059)

PMID:12764132 PMID:12815059

NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998

N-acylsphingosine amidohydrolase 2

involved_in

IMP
IEA
IDA

(PMID:11278489)
(PMID:17475390)

PMID:11278489 PMID:17475390

GO_REF:0000117

NCBI chr10:50,184,861...50,251,516
Ensembl chr10:50,182,778...50,279,720

ASAH2B

N-acylsphingosine amidohydrolase 2B

involved_in

IEA

GO_REF:0000117

NCBI chr10:50,739,936...50,759,255
Ensembl chr10:50,739,318...50,816,495

CASP7

caspase 7

acts_upstream_of_or_within

IEA

UniProt
Ensembl
GO_Central
HGNC-UCL
InterPro

GO_REF:0000107

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,731,290

CERS1

ceramide synthase 1

involved_in

IDA
IEA
IBA
ISS

(PMID:12105227), (PMID:12869556), (PMID:15823095), (PMID:17548428), (PMID:18541923), (PMID:22922758), (PMID:24782409)

PMID:12105227 PMID:12869556 PMID:15823095 PMID:17548428 PMID:18541923 More...

GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr19:18,868,545...18,896,982
Ensembl chr19:18,868,545...18,896,727

InterPro
UniProt
Ensembl
GO_Central

ceramide synthase 2

involved_in
acts_upstream_of_or_within

IEA
IDA
IBA

(PMID:17977534), (PMID:18165233), (PMID:29632068), (PMID:36170811)

PMID:17977534 PMID:18165233 PMID:29632068 PMID:36170811

GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr 1:150,965,186...150,974,835
Ensembl chr 1:150,960,583...150,977,396

CERS3

ceramide synthase 3

involved_in

IDA
IEA
IBA
IMP

(PMID:17977534), (PMID:22038835)
(PMID:23754960)

UniProt
Ensembl
GO_Central
InterPro

PMID:17977534 PMID:22038835 PMID:23754960

GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr15:100,400,395...100,544,683
Ensembl chr15:100,400,395...100,544,995

CERS4

ceramide synthase 4

involved_in
acts_upstream_of_or_within

IEA
IBA
IDA

(PMID:17977534), (PMID:29632068)

InterPro
Ensembl
GO_Central
UniProt

PMID:17977534 PMID:29632068

GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr19:8,209,370...8,262,421
Ensembl chr19:8,206,736...8,263,716

CERS5

ceramide synthase 5

involved_in

IDA
IBA
IEA

(PMID:16951403), (PMID:29632068)

UniProt
GO_Central
InterPro
Ensembl

PMID:16951403 PMID:29632068

GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr12:50,129,289...50,167,369
Ensembl chr12:50,129,289...50,167,533

CERS6

ceramide synthase 6

involved_in
acts_upstream_of_or_within

IEA
ISO
IBA
IDA

(PMID:15823095)
(PMID:17609214), (PMID:17977534)

InterPro
MGI
GO_Central
UniProt

PMID:15823095 PMID:17609214 PMID:17977534

GO_REF:0000002 GO_REF:0000033 GO_REF:0000117

NCBI chr 2:168,456,272...168,775,134
Ensembl chr 2:168,456,249...168,775,134

CLN8

CLN8 transmembrane ER and ERGIC protein

involved_in

NAS

(PMID:12151215)

PMID:12151215

NCBI chr 8:1,753,059...1,786,570
Ensembl chr 8:1,755,778...1,801,711

CYP4F22

cytochrome P450 family 4 subfamily F member 22

involved_in

IMP
IBA

(PMID:26056268)

PMID:16120614 PMID:22984457

PMID:26056268

GO_REF:0000033

NCBI chr19:15,508,525...15,552,317
Ensembl chr19:15,508,477...15,552,317

DEGS1

delta 4-desaturase, sphingolipid 1

involved_in
acts_upstream_of_or_within

IBA
IDA
ISO

(PMID:16120614)
(PMID:22984457)

GO_Central
UOS_MCB
MGI

GO_REF:0000033

NCBI chr 1:224,183,240...224,193,441
Ensembl chr 1:224,175,756...224,193,441

DEGS2

delta 4-desaturase, sphingolipid 2

involved_in
acts_upstream_of_or_within

IBA
ISO

(PMID:16571104)

GO_Central
MGI

PMID:16571104

GO_REF:0000033

NCBI chr14:100,143,957...100,166,886
Ensembl chr14:100,143,957...100,159,645

ELOVL1

ELOVL fatty acid elongase 1

involved_in

IEA

GO_REF:0000107

NCBI chr 1:43,363,401...43,368,011
Ensembl chr 1:43,363,396...43,368,075

fatty acid 2-hydroxylase

involved_in

IDA
IEA

(PMID:15337768)

PMID:15337768

GO_REF:0000107 GO_REF:0000117

NCBI chr16:74,712,969...74,774,820
Ensembl chr16:74,712,955...74,774,837

glucosylceramidase beta 1

involved_in

IMP

(PMID:19279011)

NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,447...155,245,178

GSDMD

gasdermin D

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062

3-ketodihydrosphingosine reductase

involved_in

IDA

(PMID:16120614)

PMID:16120614

NCBI chr18:63,327,726...63,367,206
Ensembl chr18:63,327,566...63,367,615

MECR

mitochondrial trans-2-enoyl-CoA reductase

acts_upstream_of

IMP

(PMID:37653044)

PMID:37653044

NCBI chr 1:29,167,696...29,230,934
Ensembl chr 1:29,192,657...29,230,945

P2RX1

purinergic receptor P2X 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr17:3,896,592...3,916,465
Ensembl chr17:3,896,592...3,916,500

P2RX7

purinergic receptor P2X 7

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032

PNPLA1

patatin like phospholipase domain containing 1

involved_in

IMP
IEA

(PMID:27751867)

PMID:27751867

GO_REF:0000107

NCBI chr 6:36,243,168...36,313,955
Ensembl chr 6:36,243,203...36,313,955

PRF1

perforin 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,596,401...70,602,759

PMID:19506037 PMID:25605874 PMID:25667419

sterile alpha motif domain containing 8

involved_in
acts_upstream_of_or_within

IDA
IEA
ISO
IBA

(PMID:19506037)
(PMID:25667419)
(PMID:25605874)
(PMID:25605874), (PMID:25667419)

UniProt
MGI
GO_Central

GO_REF:0000033 GO_REF:0000117

NCBI chr10:75,099,593...75,182,123
Ensembl chr10:75,099,586...75,182,127

sphingomyelin synthase 1

acts_upstream_of_or_within
involved_in

IDA
IEA
IBA

(PMID:25605874)

MGI
Ensembl
GO_Central

PMID:25605874

GO_REF:0000033 GO_REF:0000107

NCBI chr10:50,305,600...50,625,184
Ensembl chr10:50,305,586...50,625,187

sphingomyelin synthase 2

involved_in
acts_upstream_of_or_within

IBA
IEA

GO_REF:0000033 GO_REF:0000107

NCBI chr 4:107,824,563...107,915,047
Ensembl chr 4:107,824,563...107,915,047

sphingomyelin phosphodiesterase 1

involved_in

ISO
IBA
IEA
IDA
IMP

(PMID:17303575), (PMID:18815062), (PMID:20807762), (PMID:33163980)
(PMID:19279011), (PMID:8706124)

RGD
GO_Central
Ensembl
UniProt
BHF-UCL

PMID:8706124 PMID:17261082 PMID:17303575 PMID:18815062 PMID:19279011 More...

GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 RGD:1601344

NCBI chr11:6,390,474...6,394,996
Ensembl chr11:6,390,414...6,394,998

BHF-UCL
GO_Central
Ensembl

sphingomyelin phosphodiesterase 2

involved_in

ISO
IEA
IBA

RGD
Ensembl
GO_Central

PMID:12473648

GO_REF:0000033 GO_REF:0000107 RGD:1581395

NCBI chr 6:109,440,724...109,443,919
Ensembl chr 6:109,440,678...109,443,920

SMPD4

sphingomyelin phosphodiesterase 4

involved_in

IDA
IBA
IEA

(PMID:16517606), (PMID:25180167)

PMID:16517606 PMID:25180167

GO_REF:0000033 GO_REF:0000107

NCBI chr 2:130,151,392...130,181,757
Ensembl chr 2:130,151,392...130,183,901

SMPD5

sphingomyelin phosphodiesterase 5 (pseudogene)

involved_in

ISO

(PMID:21183079)

PMID:21183079

NCBI chr 8:144,049,398...144,050,059
Ensembl chr 8:144,049,079...144,051,203

serine palmitoyltransferase long chain base subunit 1

acts_upstream_of_or_within
involved_in

IDA
IEA
IBA

(PMID:25691431)

MGI
Ensembl
GO_Central

GO_REF:0000033 GO_REF:0000107

NCBI chr 9:92,031,147...92,115,413
Ensembl chr 9:92,000,087...92,115,433

serine palmitoyltransferase long chain base subunit 2

acts_upstream_of_or_within
involved_in

IDA
IEA
IBA

(PMID:25691431)

MGI
Ensembl
GO_Central

GO_REF:0000033 GO_REF:0000107

NCBI chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,672

serine palmitoyltransferase long chain base subunit 3

involved_in

IBA

GO_REF:0000033

NCBI chr20:13,008,972...13,169,103
Ensembl chr20:13,008,972...13,169,103

serine palmitoyltransferase small subunit A

acts_upstream_of_or_within
involved_in

IDA
IBA

(PMID:25691431)

MGI
GO_Central

GO_REF:0000033

NCBI chr14:34,432,788...34,462,240
Ensembl chr14:34,432,788...34,462,240

serine palmitoyltransferase small subunit B

acts_upstream_of_or_within
involved_in

ISS
IEA
IBA

GO_REF:0000024 GO_REF:0000033 GO_REF:0000107

NCBI chr 3:161,344,798...161,371,517
Ensembl chr 3:161,344,798...161,372,880

TLCD3B

TLC domain containing 3B

involved_in
acts_upstream_of_or_within

IBA
IEA

GO_REF:0000033 GO_REF:0000107

NCBI chr16:30,024,427...30,053,040
Ensembl chr16:30,024,426...30,052,978

ceramide catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BHF-UCL
Ensembl
GO_Central
UniProt

alkaline ceramidase 1

involved_in
acts_upstream_of_or_within

ISS
IEA
IBA
IMP

(PMID:20207939)

PMID:20207939

GO_REF:0000024 GO_REF:0000033 GO_REF:0000107

NCBI chr19:6,306,142...6,360,368
Ensembl chr19:6,306,142...6,333,612

alkaline ceramidase 2

involved_in

IMP
IBA

(PMID:16940153), (PMID:20207939)

PMID:16940153 PMID:20207939

GO_REF:0000033

NCBI chr 9:19,409,009...19,452,505
Ensembl chr 9:19,409,009...19,452,505

alkaline ceramidase 3

involved_in

IMP
IEA
IDA

(PMID:20207939), (PMID:26792856)
(PMID:30575723)

PMID:20207939 PMID:26792856 PMID:30575723

GO_REF:0000107

NCBI chr11:76,860,918...77,026,797
Ensembl chr11:76,860,859...77,026,797

N-acylsphingosine amidohydrolase 1

involved_in

IDA
IMP
IEA

(PMID:12815059)
(PMID:10610716)

PMID:10610716 PMID:12815059

GO_REF:0000107

NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998

InterPro
UniProt
GO_Central

N-acylsphingosine amidohydrolase 2

involved_in

IEA
IBA
IMP
IDA

(PMID:10781606), (PMID:15946935), (PMID:19345744), (PMID:30154232)
(PMID:16229686), (PMID:17475390)

PMID:10781606 PMID:15946935 PMID:16229686 PMID:17475390 PMID:19345744 More...

GO_REF:0000002 GO_REF:0000033 GO_REF:0000117

NCBI chr10:50,184,861...50,251,516
Ensembl chr10:50,182,778...50,279,720

ASAH2B

N-acylsphingosine amidohydrolase 2B

involved_in

IEA

GO_REF:0000002 GO_REF:0000117

NCBI chr10:50,739,936...50,759,255
Ensembl chr10:50,739,318...50,816,495

CEL

carboxyl ester lipase

involved_in
acts_upstream_of_or_within

IBA
IEA

GO_REF:0000033 GO_REF:0000107

NCBI chr 9:133,061,981...133,071,861
Ensembl chr 9:133,061,981...133,071,861

ceramide metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABCA12

ATP binding cassette subfamily A member 12

involved_in

ISS
IEA
IDA

(PMID:17927575)

PMID:17927575

GO_REF:0000024 GO_REF:0000107

NCBI chr 2:214,931,542...215,138,626
Ensembl chr 2:214,931,542...215,138,626

alkaline ceramidase 1

involved_in

IEA

GO_REF:0000002

NCBI chr19:6,306,142...6,360,368
Ensembl chr19:6,306,142...6,333,612

alkaline ceramidase 2

involved_in

IEA

GO_REF:0000002

NCBI chr 9:19,409,009...19,452,505
Ensembl chr 9:19,409,009...19,452,505

alkaline ceramidase 3

involved_in

IEA

GO_REF:0000002

NCBI chr11:76,860,918...77,026,797
Ensembl chr11:76,860,859...77,026,797

N-acylsphingosine amidohydrolase 2

involved_in

IDA

(PMID:26190575)

PMID:26190575

NCBI chr10:50,184,861...50,251,516
Ensembl chr10:50,182,778...50,279,720

CERK

ceramide kinase

involved_in

IDA
IBA
TAS

(PMID:19501188)
(PMID:11956206)

PMID:11956206 PMID:19501188

GO_REF:0000033

NCBI chr22:46,684,410...46,738,252
Ensembl chr22:46,684,410...46,738,267

CERT1

ceramide transporter 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 5:75,368,486...75,511,981
Ensembl chr 5:75,356,345...75,512,138

CLN8

CLN8 transmembrane ER and ERGIC protein

involved_in

IMP

(PMID:16086686)

PMID:16086686

NCBI chr 8:1,753,059...1,786,570
Ensembl chr 8:1,755,778...1,801,711

FUT3

fucosyltransferase 3 (Lewis blood group)

involved_in

IDA

(PMID:12668675), (PMID:7721776)

PMID:7721776 PMID:12668675

NCBI chr19:5,842,888...5,857,122
Ensembl chr19:5,842,888...5,851,471

FUT5

fucosyltransferase 5

involved_in

IDA

(PMID:17604274), (PMID:7721776), (PMID:9737988)

PMID:7721776 PMID:9737988 PMID:17604274

NCBI chr19:5,865,826...5,870,540
Ensembl chr19:5,865,826...5,870,540

FUT6

fucosyltransferase 6

involved_in

IDA

(PMID:17604274)

PMID:17604274

NCBI chr19:5,830,408...5,839,702
Ensembl chr19:5,830,361...5,839,722

FUT7

fucosyltransferase 7

involved_in

IDA

(PMID:9299472)

PMID:9299472

NCBI chr 9:137,030,174...137,032,088
Ensembl chr 9:137,030,174...137,032,825

HTRA2

HtrA serine peptidase 2

involved_in

IEA

GO_REF:0000107

NCBI chr 2:74,529,405...74,533,556
Ensembl chr 2:74,529,596...74,533,350

NSMAF

neutral sphingomyelinase activation associated factor

involved_in

TAS

(PMID:8808629)

PMID:8808629

NCBI chr 8:58,583,504...58,659,853
Ensembl chr 8:58,583,504...58,659,959

ORMDL sphingolipid biosynthesis regulator 1

involved_in

IMP
IEA
IBA

(PMID:20182505)

PMID:20182505

GO_REF:0000033 GO_REF:0000104

NCBI chr 2:189,763,859...189,784,339
Ensembl chr 2:189,766,012...189,784,382

ORMDL sphingolipid biosynthesis regulator 2

involved_in

IMP
IBA

(PMID:20182505)

PMID:20182505

GO_REF:0000033

NCBI chr12:55,818,041...55,821,879
Ensembl chr12:55,818,041...55,821,879

ORMDL sphingolipid biosynthesis regulator 3

involved_in

IMP
IBA

(PMID:20182505)

PMID:20182505

GO_REF:0000033

NCBI chr17:39,921,041...39,927,601
Ensembl chr17:39,921,037...39,929,328

PLA2G15

phospholipase A2 group XV

involved_in
acts_upstream_of_or_within

ISS
IEA
IBA
IDA

(PMID:20410020), (PMID:29724779)

PMID:20410020 PMID:29724779

GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr16:68,245,373...68,261,058
Ensembl chr16:68,245,304...68,261,063

PLPP1

phospholipid phosphatase 1

involved_in

IEA
IDA

(PMID:9305923), (PMID:9705349)

PMID:9305923 PMID:9705349

GO_REF:0000107

NCBI chr 5:55,424,854...55,534,964
Ensembl chr 5:55,424,849...55,535,035

PLPP2

phospholipid phosphatase 2

involved_in

IDA

(PMID:9705349)

PMID:9705349

NCBI chr19:281,043...291,403
Ensembl chr19:278,504...291,403

PLPP3

phospholipid phosphatase 3

involved_in

IDA

(PMID:9305923), (PMID:9705349)

PMID:9305923 PMID:9705349

NCBI chr 1:56,494,761...56,579,563
Ensembl chr 1:56,494,761...56,645,301

prosaposin

acts_upstream_of_or_within

ISO

(PMID:17353235)
(PMID:15345707)

PMID:15345707 PMID:17353235

NCBI chr10:71,816,298...71,851,251
Ensembl chr10:71,816,289...71,851,330

SGPL1

sphingosine-1-phosphate lyase 1

involved_in

IDA

(PMID:14570870)

PMID:14570870

NCBI chr10:70,815,948...70,881,184
Ensembl chr10:70,815,905...70,958,701

sphingomyelin phosphodiesterase 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr11:6,390,474...6,394,996
Ensembl chr11:6,390,414...6,394,998

sphingomyelin phosphodiesterase 2

involved_in

IEA

GO_REF:0000107

NCBI chr 6:109,440,724...109,443,919
Ensembl chr 6:109,440,678...109,443,920

sphingomyelin phosphodiesterase 3

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr16:68,358,327...68,448,508
Ensembl chr16:68,358,327...68,448,508

SMPD5

sphingomyelin phosphodiesterase 5 (pseudogene)

acts_upstream_of_or_within

ISO

(PMID:20378533)

PMID:20378533

NCBI chr 8:144,049,398...144,050,059
Ensembl chr 8:144,049,079...144,051,203

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

involved_in

IEA

GO_REF:0000117

NCBI chr 9:127,885,321...127,906,616
Ensembl chr 9:127,885,321...127,906,616

TM9SF2

transmembrane 9 superfamily member 2

involved_in

IMP

(PMID:30660999)

PMID:30660999

NCBI chr13:99,501,472...99,564,048
Ensembl chr13:99,446,311...99,564,048

ceramide phosphoethanolamine biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

sterile alpha motif domain containing 8

acts_upstream_of_or_within

ISO

(PMID:25667419)

PMID:25667419

NCBI chr10:75,099,593...75,182,123
Ensembl chr10:75,099,586...75,182,127

sphingomyelin synthase 2

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 4:107,824,563...107,915,047
Ensembl chr 4:107,824,563...107,915,047

ceramide phosphoethanolamine catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ETNPPL

ethanolamine-phosphate phospho-lyase

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 4:108,742,053...108,763,053
Ensembl chr 4:108,741,969...108,763,228

dolichol phosphate mannose biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DPM1

dolichyl-phosphate mannosyltransferase subunit 1, catalytic

involved_in

ISS
IDA

(PMID:10835346)

PMID:10835346

GO_REF:0000024

NCBI chr20:50,934,855...50,958,564
Ensembl chr20:50,934,852...50,959,140

DPM2

dolichyl-phosphate mannosyltransferase subunit 2, regulatory

involved_in

IEA
IDA

(PMID:10835346)

PMID:10835346

GO_REF:0000002

NCBI chr 9:127,935,099...127,937,854
Ensembl chr 9:127,935,090...127,937,866

DPM3

dolichyl-phosphate mannosyltransferase subunit 3, regulatory

involved_in

IDA

(PMID:10835346)

PMID:8765145 PMID:15287741 PMID:17401110 PMID:18702514 PMID:20083229

PMID:10835346

NCBI chr 1:155,139,891...155,140,531
Ensembl chr 1:155,139,886...155,140,595

galactolipid catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PNLIPRP2

pancreatic lipase related protein 2 (gene/pseudogene)

involved_in

ISO
IDA

(PMID:15287741), (PMID:17401110), (PMID:18702514), (PMID:20083229)

RGD
UniProt

RGD:2303162

NCBI chr10:116,620,953...116,645,143
Ensembl chr10:116,620,953...116,645,143

galactosylceramide biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

B4GALT3

beta-1,4-galactosyltransferase 3

involved_in

IBA

GO_REF:0000033

NCBI chr 1:161,171,310...161,177,968
Ensembl chr 1:161,171,306...161,178,652

fatty acid 2-hydroxylase

involved_in

IEA
ISS

GO_REF:0000024 GO_REF:0000041 GO_REF:0000107

NCBI chr16:74,712,969...74,774,820
Ensembl chr16:74,712,955...74,774,837

galactose-3-O-sulfotransferase 1

involved_in
acts_upstream_of_or_within

IBA
IEA

GO_REF:0000033 GO_REF:0000107

NCBI chr22:30,554,635...30,574,665
Ensembl chr22:30,554,632...30,576,210

Ensembl
GO_Central
UniProt

UDP glycosyltransferase 8

involved_in

IEA
IBA
ISS

GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107

NCBI chr 4:114,598,402...114,678,225
Ensembl chr 4:114,598,374...114,678,588

galactosylceramide catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

GALC

galactosylceramidase

involved_in
acts_upstream_of_or_within

IEA
IBA
ISS
IDA

(PMID:8399327)

InterPro
UniProt
Ensembl
GO_Central

PMID:8399327

GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr14:87,933,014...87,993,667
Ensembl chr14:87,837,820...87,993,665

glucosylceramidase beta 3 (gene/pseudogene)

involved_in

IDA

(PMID:17595169)

PMID:17595169

NCBI chr 4:22,692,937...22,819,569
Ensembl chr 4:22,692,914...22,819,575

prosaposin

acts_upstream_of_or_within

ISO

(PMID:11371512)

PMID:11371512

NCBI chr10:71,816,298...71,851,251
Ensembl chr10:71,816,289...71,851,330

galactosylceramide metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

galactose-3-O-sulfotransferase 1

involved_in

ISS
IEA

GO_REF:0000024 GO_REF:0000107

NCBI chr22:30,554,635...30,574,665
Ensembl chr22:30,554,632...30,576,210

ganglioside biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

B3GALT4

beta-1,3-galactosyltransferase 4

involved_in

IDA

(PMID:9582303)

PMID:9582303

NCBI chr 6:33,277,123...33,278,825
Ensembl chr 6:33,277,123...33,284,832

beta-1,4-N-acetyl-galactosaminyltransferase 1

involved_in
acts_upstream_of_or_within

IMP
IEA
IBA
IDA

(PMID:1601877)
(PMID:7487055), (PMID:7890749)

PMID:1601877 PMID:7487055 PMID:7890749

GO_REF:0000033 GO_REF:0000107

NCBI chr12:57,623,409...57,633,201
Ensembl chr12:57,623,409...57,633,239

B4GALT5

beta-1,4-galactosyltransferase 5

involved_in

ISS

GO_REF:0000024

NCBI chr20:49,632,945...49,713,878
Ensembl chr20:49,632,945...49,713,908

beta-1,4-galactosyltransferase 6

involved_in

ISS

GO_REF:0000024

NCBI chr18:31,622,246...31,724,641
Ensembl chr18:31,621,911...31,685,836

ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

involved_in

IDA

(PMID:8027041)

PMID:8027041

NCBI chr 8:133,454,848...133,571,887
Ensembl chr 8:133,454,848...133,572,518

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

involved_in

IDA

(PMID:8920913)

PMID:8920913

NCBI chr16:70,375,977...70,439,100
Ensembl chr16:70,375,977...70,439,263

ST3GAL3

ST3 beta-galactoside alpha-2,3-sialyltransferase 3

involved_in

ISO

(PMID:22735313)

PMID:22735313

NCBI chr 1:43,707,536...43,931,159
Ensembl chr 1:43,705,824...43,931,167

ST3GAL5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

involved_in

(PMID:9822625)

PMID:9822625

NCBI chr 2:85,837,120...85,889,034
Ensembl chr 2:85,837,120...85,905,199

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

involved_in

IBA

GO_REF:0000033

NCBI chr 1:76,074,746...76,637,339
Ensembl chr 1:76,074,746...76,634,603

ST6GALNAC4

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

involved_in

IBA

GO_REF:0000033

NCBI chr 9:127,907,886...127,917,041
Ensembl chr 9:127,907,876...127,917,055

ST6GALNAC5

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

involved_in

IBA

GO_REF:0000033

NCBI chr 1:76,867,480...77,067,546
Ensembl chr 1:76,867,447...77,067,546

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

involved_in
acts_upstream_of_or_within

ISS
ISO
IBA

(PMID:10702226)

BHF-UCL
MGI
GO_Central

PMID:10702226

GO_REF:0000024 GO_REF:0000033

NCBI chr 9:127,885,321...127,906,616
Ensembl chr 9:127,885,321...127,906,616

ST8SIA2

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

involved_in

IDA

(PMID:10766765)

PMID:10766765

NCBI chr15:92,393,881...92,468,728
Ensembl chr15:92,393,881...92,468,728

ST8SIA3

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

involved_in

IDA
IEA

(PMID:10766765)

BHF-UCL
Ensembl

PMID:10766765

GO_REF:0000107

NCBI chr18:57,352,557...57,368,931
Ensembl chr18:57,352,557...57,371,731

ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

involved_in

IDA

(PMID:10766765)

PMID:10766765

NCBI chr 5:100,806,933...100,903,282
Ensembl chr 5:100,806,933...100,903,285

ST8SIA6

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

involved_in

IEA
ISS

(PMID:11980897)

Ensembl
BHF-UCL

PMID:11980897

GO_REF:0000107

NCBI chr10:17,315,421...17,454,595
Ensembl chr10:17,315,421...17,454,595

ganglioside catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

GLB1

galactosidase beta 1

involved_in

IMP
IEA

(PMID:31720227)

FlyBase
UniProt
Ensembl

PMID:31720227

GO_REF:0000107 GO_REF:0000117

NCBI chr 3:32,961,108...33,097,146
Ensembl chr 3:32,996,609...33,097,202

InterPro
Ensembl
GO_Central

ganglioside GM2 activator

involved_in
acts_upstream_of_or_within

IEA
IBA

GO_REF:0000002 GO_REF:0000033 GO_REF:0000107

NCBI chr 5:151,253,185...151,270,440
Ensembl chr 5:151,212,150...151,270,440

HEXA

hexosaminidase subunit alpha

involved_in
acts_upstream_of_or_within

IDA
IEA
IBA

(PMID:8123671), (PMID:8672428), (PMID:9694901)

PMID:8123671 PMID:8672428 PMID:9694901

GO_REF:0000033 GO_REF:0000107

NCBI chr15:72,340,924...72,376,014
Ensembl chr15:72,340,924...72,376,420

HEXB

hexosaminidase subunit beta

involved_in
acts_upstream_of_or_within

IDA
IEA
IBA

(PMID:8123671), (PMID:8672428)

PMID:8123671 PMID:8672428

GO_REF:0000033 GO_REF:0000107

NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647

NEU1

neuraminidase 1

involved_in

IBA

GO_REF:0000033

NCBI chr 6:31,857,659...31,862,821
Ensembl chr 6:31,857,063...31,862,905

NEU2

neuraminidase 2

involved_in

IDA
IEA
IBA

(PMID:14613940), (PMID:22228546)

PMID:14613940 PMID:22228546

GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr 2:233,032,672...233,035,057
Ensembl chr 2:233,023,032...233,042,480

NEU3

neuraminidase 3

involved_in

IDA
IEA
IBA

(PMID:10861246), (PMID:11298736), (PMID:15847605), (PMID:17334392)

PMID:10861246 PMID:11298736 PMID:15847605 PMID:17334392

GO_REF:0000033 GO_REF:0000117

NCBI chr11:74,980,515...75,020,676
Ensembl chr11:74,984,361...75,018,893

NEU4

neuraminidase 4

involved_in

IEA
IBA
IDA

(PMID:15213228), (PMID:15847605)

Ensembl
UniProt
GO_Central

PMID:15213228 PMID:15847605

GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr 2:241,809,193...241,817,413
Ensembl chr 2:241,808,982...241,817,415

ganglioside metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATP binding cassette subfamily A member 2

involved_in

ISS

GO_REF:0000024

NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915

CLN6

CLN6 transmembrane ER protein

involved_in

IMP

(PMID:16857350)

PMID:16857350

NCBI chr15:68,206,992...68,257,211
Ensembl chr15:68,206,992...68,257,211

ganglioside GM2 activator

involved_in

ISO
IEA

RGD
Ensembl

PMID:9770472

GO_REF:0000107 RGD:1598995

NCBI chr 5:151,253,185...151,270,440
Ensembl chr 5:151,212,150...151,270,440

ITGB8

integrin subunit beta 8

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 7:20,329,766...20,415,754
Ensembl chr 7:20,330,609...20,415,754

NAGLU

N-acetyl-alpha-glucosaminidase

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr17:42,536,241...42,544,449
Ensembl chr17:42,536,241...42,544,449

globoside biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

A4GALT

alpha 1,4-galactosyltransferase (P1PK blood group)

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr22:42,692,121...42,721,301
Ensembl chr22:42,691,010...42,721,298

PLEKHA8

pleckstrin homology domain containing A8

involved_in

IDA

(PMID:23913272)

PMID:23913272

NCBI chr 7:30,028,412...30,130,483
Ensembl chr 7:30,027,404...30,130,483

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

involved_in

IDA

(PMID:12716912)

PMID:12716912

NCBI chr16:70,375,977...70,439,100
Ensembl chr16:70,375,977...70,439,263

globoside metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

GBGT1

globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)

involved_in

ISO

(PMID:8855242)

PMID:8855242

NCBI chr 9:133,152,948...133,163,914
Ensembl chr 9:133,152,938...133,164,245

glucosylceramide biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

fatty acid 2-hydroxylase

involved_in

IEA
ISS

Ensembl
GO_Central
UniProt

GO_REF:0000024 GO_REF:0000107

NCBI chr16:74,712,969...74,774,820
Ensembl chr16:74,712,955...74,774,837

UGCG

UDP-glucose ceramide glucosyltransferase

involved_in

IEA
IBA
IDA

(PMID:8643456)

PMID:8643456

GO_REF:0000033 GO_REF:0000107

NCBI chr 9:111,896,814...111,935,369
Ensembl chr 9:111,896,814...111,935,374

glucosylceramide catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

UniProt
GO_Central
ParkinsonsUK-UCL
Ensembl

glucosylceramidase beta 1

involved_in

IDA
IEA
IBA
IMP

(PMID:16293621), (PMID:24211208), (PMID:9201993)
(PMID:19279011), (PMID:21700325), (PMID:24022302), (PMID:25584808)

PMID:9201993 PMID:16293621 PMID:19279011 PMID:21700325 PMID:24022302 More...

GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,447...155,245,178

PMID:17080196 PMID:30308956

glucosylceramidase beta 2

involved_in

IMP
IEA
IDA

(PMID:30308956)
(PMID:17080196)

UniProt
InterPro
Ensembl

GO_REF:0000002 GO_REF:0000107 GO_REF:0000117

NCBI chr 9:35,736,866...35,749,228
Ensembl chr 9:35,736,864...35,749,986

glucosylceramidase beta 3 (gene/pseudogene)

NOT|involved_in

IDA
IMP

(PMID:20728381)
(PMID:26724485)
(PMID:17595169)

PMID:17595169 PMID:20728381 PMID:26724485

NCBI chr 4:22,692,937...22,819,569
Ensembl chr 4:22,692,914...22,819,575

glucosylceramide metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

B3GALT1

beta-1,3-galactosyltransferase 1

involved_in

IDA

(PMID:9582303)

PMID:9582303

NCBI chr 2:167,293,001...167,874,045
Ensembl chr 2:167,293,001...167,874,045

B3GALT2

beta-1,3-galactosyltransferase 2

involved_in

IDA

(PMID:9582303)

PMID:9582303

NCBI chr 1:193,178,730...193,186,613
Ensembl chr 1:193,178,730...193,186,613

B4GALT3

beta-1,4-galactosyltransferase 3

involved_in

IDA

(PMID:9405390)

PMID:9405390

NCBI chr 1:161,171,310...161,177,968
Ensembl chr 1:161,171,306...161,178,652

glucosylceramidase beta 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,447...155,245,178

prosaposin

acts_upstream_of_or_within

ISO

(PMID:17353235)

PMID:17353235

NCBI chr10:71,816,298...71,851,251
Ensembl chr10:71,816,289...71,851,330

glycolipid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

B3GNT5

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

involved_in

TAS

(PMID:11384981)

PMID:11384981

NCBI chr 3:183,253,253...183,273,385
Ensembl chr 3:183,249,324...183,298,504

galactose-3-O-sulfotransferase 1

involved_in

IEA

GO_REF:0000002

NCBI chr22:30,554,635...30,574,665
Ensembl chr22:30,554,632...30,576,210

GAL3ST2

galactose-3-O-sulfotransferase 2

involved_in

IEA

GO_REF:0000002

NCBI chr 2:241,776,822...241,804,287
Ensembl chr 2:241,776,822...241,804,287

GAL3ST3

galactose-3-O-sulfotransferase 3

involved_in

IEA

GO_REF:0000002

NCBI chr11:66,040,765...66,049,161
Ensembl chr11:66,040,748...66,049,502

GAL3ST4

galactose-3-O-sulfotransferase 4

involved_in

IEA

GO_REF:0000002

NCBI chr 7:100,159,244...100,168,617
Ensembl chr 7:100,159,244...100,168,953

glucosylceramidase beta 1

involved_in

IDA

(PMID:24211208), (PMID:26724485)

PMID:24211208 PMID:26724485

NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,447...155,245,178

glucosylceramidase beta 2

involved_in

ISS

GO_REF:0000024

NCBI chr 9:35,736,866...35,749,228
Ensembl chr 9:35,736,864...35,749,986

GBGT1

globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)

involved_in

TAS

(PMID:10506200)

PMID:10506200

NCBI chr 9:133,152,948...133,163,914
Ensembl chr 9:133,152,938...133,164,245

SCCPDH

saccharopine dehydrogenase (putative)

involved_in

IBA

GO_REF:0000033

NCBI chr 1:246,724,409...246,768,137
Ensembl chr 1:246,724,064...246,768,137

SLC35C1

solute carrier family 35 member C1

acts_upstream_of_or_within_negative_effect

ISO

(PMID:18308723)

PMID:18308723

NCBI chr11:45,804,079...45,813,016
Ensembl chr11:45,804,072...45,813,016

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

involved_in

IDA

(PMID:9266697)

PMID:9266697

NCBI chr16:70,375,977...70,439,100
Ensembl chr16:70,375,977...70,439,263

ST3GAL4

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

involved_in

IDA
IBA

(PMID:8288606)

BHF-UCL
GO_Central

PMID:8288606

GO_REF:0000033

NCBI chr11:126,355,686...126,414,638
Ensembl chr11:126,354,677...126,440,344

ST3GAL6

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

involved_in

IDA
IBA

(PMID:10206952)

PMID:10206952

GO_REF:0000033

NCBI chr 3:98,732,262...98,795,852
Ensembl chr 3:98,732,175...98,821,201

ST8SIA6

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

involved_in
acts_upstream_of_or_within

ISS
IEA

(PMID:11980897)

BHF-UCL
Ensembl

PMID:11980897

GO_REF:0000107

NCBI chr10:17,315,421...17,454,595
Ensembl chr10:17,315,421...17,454,595

UDP glycosyltransferase 8

involved_in

IEA

GO_REF:0000117

NCBI chr 4:114,598,402...114,678,225
Ensembl chr 4:114,598,374...114,678,588

glycolipid catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

FUCA1

alpha-L-fucosidase 1

involved_in

ISS

GO_REF:0000024

NCBI chr 1:23,845,077...23,868,290
Ensembl chr 1:23,845,077...23,868,356

GLA

galactosidase alpha

involved_in

IEA

GO_REF:0000117

NCBI chr X:101,397,803...101,407,925
Ensembl chr X:101,393,273...101,408,012

NAGA

alpha-N-acetylgalactosaminidase

involved_in

IMP
IEA

(PMID:9741689)

PMID:9741689

GO_REF:0000117

NCBI chr22:42,058,334...42,070,842
Ensembl chr22:42,058,334...42,071,198

glycolipid metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AHDC1

AT-hook DNA binding motif containing 1

acts_upstream_of_or_within

ISO

(PMID:37819197)

PMID:37819197

NCBI chr 1:27,534,245...27,604,227
Ensembl chr 1:27,534,035...27,604,431

FUT1

fucosyltransferase 1 (H blood group)

involved_in

ISO

(PMID:14967068)

PMID:14967068

NCBI chr19:48,748,011...48,755,358
Ensembl chr19:48,748,011...48,755,390

FUT2

fucosyltransferase 2 (H blood group)

involved_in

IEA

GO_REF:0000107

NCBI chr19:48,695,971...48,705,951
Ensembl chr19:48,695,957...48,705,951

MFSD8

major facilitator superfamily domain containing 8

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 4:127,917,732...127,965,963
Ensembl chr 4:127,917,799...127,966,034

prosaposin

acts_upstream_of_or_within

ISO

(PMID:12810822)

PMID:12810822

NCBI chr10:71,816,298...71,851,251
Ensembl chr10:71,816,289...71,851,330

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

involved_in

IEA

UniProt
GO_Central
Reactome

GO_REF:0000117

NCBI chr 1:76,074,746...76,637,339
Ensembl chr 1:76,074,746...76,634,603

ST6GALNAC4

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

involved_in

TAS
IEA

(PMID:10207017)

PINC
UniProt

PMID:10207017

GO_REF:0000117

NCBI chr 9:127,907,886...127,917,041
Ensembl chr 9:127,907,876...127,917,055

glycosphingolipid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

A3GALT2

alpha 1,3-galactosyltransferase 2

involved_in
acts_upstream_of_or_within

ISO
IBA
IEA

RGD
GO_Central
Ensembl

PMID:10854427

GO_REF:0000033 GO_REF:0000107 RGD:1299594

NCBI chr 1:33,306,766...33,321,098
Ensembl chr 1:33,306,766...33,321,098

A4GALT

alpha 1,4-galactosyltransferase (P1PK blood group)

involved_in

NAS
IBA
TAS

(PMID:10748143)

PMID:10748143

GO_REF:0000033 Reactome:R-HSA-9840309

NCBI chr22:42,692,121...42,721,301
Ensembl chr22:42,691,010...42,721,298

B3GALNT1

beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group)

involved_in

TAS

Reactome:R-HSA-9840309

NCBI chr 3:161,083,883...161,105,349
Ensembl chr 3:161,083,612...161,105,445

B3GALT4

beta-1,3-galactosyltransferase 4

involved_in

TAS

Reactome:R-HSA-9840309

NCBI chr 6:33,277,123...33,278,825
Ensembl chr 6:33,277,123...33,284,832

B3GNT5

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

involved_in

TAS

Reactome:R-HSA-9840309

NCBI chr 3:183,253,253...183,273,385
Ensembl chr 3:183,249,324...183,298,504

beta-1,4-N-acetyl-galactosaminyltransferase 1

involved_in

ISO

PMID:1606358

PMID:1606358

RGD:21201272

NCBI chr12:57,623,409...57,633,201
Ensembl chr12:57,623,409...57,633,239

beta-1,4-galactosyltransferase 6

involved_in

ISO
IBA
IEA

RGD
GO_Central
Ensembl

PMID:9593693

GO_REF:0000033 GO_REF:0000107 RGD:70807

NCBI chr18:31,622,246...31,724,641
Ensembl chr18:31,621,911...31,685,836

CERK

ceramide kinase

involved_in

TAS

Reactome:R-HSA-9840309

NCBI chr22:46,684,410...46,738,252
Ensembl chr22:46,684,410...46,738,267

ceramide synthase 2

involved_in

EXP

(PMID:34080016)

NCBI chr 1:150,965,186...150,974,835
Ensembl chr 1:150,960,583...150,977,396

DEGS1

delta 4-desaturase, sphingolipid 1

involved_in

IDA

(PMID:34080016)

NCBI chr 1:224,183,240...224,193,441
Ensembl chr 1:224,175,756...224,193,441

FUT1

fucosyltransferase 1 (H blood group)

involved_in

TAS

Reactome:R-HSA-9840309

NCBI chr19:48,748,011...48,755,358
Ensembl chr19:48,748,011...48,755,390

FUT2

fucosyltransferase 2 (H blood group)

involved_in

TAS

Reactome:R-HSA-9840309

NCBI chr19:48,695,971...48,705,951
Ensembl chr19:48,695,957...48,705,951

FUT4

fucosyltransferase 4

involved_in

IDA

(PMID:29593094)

PMID:29593094

NCBI chr11:94,543,921...94,549,895
Ensembl chr11:94,543,921...94,549,895

FUT6

fucosyltransferase 6

involved_in

IDA

(PMID:29593094)

PMID:29593094

NCBI chr19:5,830,408...5,839,702
Ensembl chr19:5,830,361...5,839,722

FUT9

fucosyltransferase 9

involved_in

IDA

(PMID:29593094)

PMID:29593094

NCBI chr 6:96,015,974...96,215,612
Ensembl chr 6:96,015,436...96,215,612

galactose-3-O-sulfotransferase 1

involved_in

TAS

Reactome:R-HSA-9840309

NCBI chr22:30,554,635...30,574,665
Ensembl chr22:30,554,632...30,576,210

3-ketodihydrosphingosine reductase

involved_in

IDA

(PMID:34080016)

NCBI chr18:63,327,726...63,367,206
Ensembl chr18:63,327,566...63,367,615

LARGE1

LARGE xylosyl- and glucuronyltransferase 1

involved_in

TAS

(PMID:9892679)

PMID:9892679

NCBI chr22:33,066,663...33,922,824
Ensembl chr22:33,162,226...33,922,885

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

involved_in

TAS

Reactome:R-HSA-9840309

NCBI chr16:70,375,977...70,439,100
Ensembl chr16:70,375,977...70,439,263

ST3GAL3

ST3 beta-galactoside alpha-2,3-sialyltransferase 3

involved_in

TAS

Reactome:R-HSA-9840309

NCBI chr 1:43,707,536...43,931,159
Ensembl chr 1:43,705,824...43,931,167

ST3GAL5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

involved_in

TAS

(PMID:10092602)

PMID:10092602

Reactome:R-HSA-9840309

NCBI chr 2:85,837,120...85,889,034
Ensembl chr 2:85,837,120...85,905,199

ST6GALNAC5

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

involved_in

ISS
TAS

BHF-UCL
Reactome

GO_REF:0000024 Reactome:R-HSA-9840309

NCBI chr 1:76,867,480...77,067,546
Ensembl chr 1:76,867,447...77,067,546

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

involved_in

TAS
IEA

GO_REF:0000117 Reactome:R-HSA-9840309

NCBI chr 9:127,885,321...127,906,616
Ensembl chr 9:127,885,321...127,906,616

ST8SIA1

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

involved_in

TAS

(PMID:8195250)

PMID:8195250

NCBI chr12:22,193,391...22,334,707
Ensembl chr12:22,063,773...22,437,041

ST8SIA3

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

involved_in

TAS

(PMID:9073076)

PMID:9073076

NCBI chr18:57,352,557...57,368,931
Ensembl chr18:57,352,557...57,371,731

ST8SIA5

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

involved_in

ISS
TAS
IEA

(PMID:9199191)

UniProt
PINC
Ensembl

PMID:9199191

GO_REF:0000024 GO_REF:0000107 Reactome:R-HSA-9840309

NCBI chr18:46,667,821...46,757,053
Ensembl chr18:46,667,821...46,759,257

TM9SF2

transmembrane 9 superfamily member 2

involved_in

IMP

(PMID:30660999)

PMID:30660999

NCBI chr13:99,501,472...99,564,048
Ensembl chr13:99,446,311...99,564,048

UGCG

UDP-glucose ceramide glucosyltransferase

involved_in

TAS

Reactome:R-HSA-9840309

NCBI chr 9:111,896,814...111,935,369
Ensembl chr 9:111,896,814...111,935,374

UDP glycosyltransferase 8

involved_in

TAS
IDA

(PMID:34080016)

Reactome
UOS_MCB

Reactome:R-HSA-9840309

NCBI chr 4:114,598,402...114,678,225
Ensembl chr 4:114,598,374...114,678,588

glycosphingolipid catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ectonucleotide pyrophosphatase/phosphodiesterase 7

involved_in

TAS

Reactome:R-HSA-9840310

NCBI chr17:79,730,943...79,742,219
Ensembl chr17:79,728,809...79,742,930

GALC

galactosylceramidase

involved_in

TAS

Reactome:R-HSA-9840310

NCBI chr14:87,933,014...87,993,667
Ensembl chr14:87,837,820...87,993,665

glucosylceramidase beta 2

involved_in

TAS

Reactome:R-HSA-9840310

NCBI chr 9:35,736,866...35,749,228
Ensembl chr 9:35,736,864...35,749,986

glucosylceramidase beta 3 (gene/pseudogene)

involved_in

TAS

PMID:2160973 PMID:8804427 PMID:10838196 PMID:34320241

Reactome:R-HSA-9840310

NCBI chr 4:22,692,937...22,819,569
Ensembl chr 4:22,692,914...22,819,575

GLA

galactosidase alpha

involved_in

IMP
IEA
ISO
TAS
IDA

(PMID:10838196)
(PMID:2160973)
(PMID:8804427)

UniProt
RGD

GO_REF:0000117 RGD:401976418

NCBI chr X:101,397,803...101,407,925
Ensembl chr X:101,393,273...101,408,012

ganglioside GM2 activator

involved_in

TAS
IEA

GO_REF:0000117 Reactome:R-HSA-9840310

NCBI chr 5:151,253,185...151,270,440
Ensembl chr 5:151,212,150...151,270,440

M6PR

mannose-6-phosphate receptor, cation dependent

involved_in

TAS

Reactome:R-HSA-9840310

NCBI chr12:8,940,361...8,949,645
Ensembl chr12:8,940,358...8,951,856

NEU2

neuraminidase 2

involved_in

TAS

Reactome:R-HSA-9840310

NCBI chr 2:233,032,672...233,035,057
Ensembl chr 2:233,023,032...233,042,480

NEU3

neuraminidase 3

involved_in

TAS

Reactome:R-HSA-9840310

NCBI chr11:74,980,515...75,020,676
Ensembl chr11:74,984,361...75,018,893

sphingomyelin phosphodiesterase 1

involved_in

TAS

Reactome:R-HSA-9840310

NCBI chr11:6,390,474...6,394,996
Ensembl chr11:6,390,414...6,394,998

SUMF1

sulfatase modifying factor 1

involved_in

TAS

Reactome:R-HSA-9840310

NCBI chr 3:4,034,486...4,467,269
Ensembl chr 3:3,700,814...4,467,273

glycosphingolipid metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATP binding cassette subfamily A member 2

involved_in

ISS

GO_REF:0000024

NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915

beta-1,4-N-acetyl-galactosaminyltransferase 1

involved_in
acts_upstream_of_or_within

TAS
IEA

(PMID:1601877)

PINC
Ensembl

PMID:1601877

GO_REF:0000107

NCBI chr12:57,623,409...57,633,201
Ensembl chr12:57,623,409...57,633,239

BAX

BCL2 associated X, apoptosis regulator

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

CREM

cAMP responsive element modulator

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr10:35,126,846...35,212,958
Ensembl chr10:35,126,791...35,212,958

HEXB

hexosaminidase subunit beta

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647

KIT

KIT proto-oncogene, receptor tyrosine kinase

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783

MAP7

microtubule associated protein 7

acts_upstream_of_or_within

ISO

(PMID:18308723)

PMID:18308723

NCBI chr 6:136,342,734...136,550,422
Ensembl chr 6:136,342,281...136,550,819

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

involved_in

IDA

(PMID:17123352)

NCBI chr 1:76,074,746...76,637,339
Ensembl chr 1:76,074,746...76,634,603

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

involved_in

IDA

(PMID:17123352)

NCBI chr 9:127,885,321...127,906,616
Ensembl chr 9:127,885,321...127,906,616

glycosylceramide catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

glucosylceramidase beta 3 (gene/pseudogene)

involved_in

IBA

PMID:9122231 PMID:10840053 PMID:10841515 PMID:11752062 PMID:15629890

GO_REF:0000033

NCBI chr 4:22,692,937...22,819,569
Ensembl chr 4:22,692,914...22,819,575

GLA

galactosidase alpha

involved_in
acts_upstream_of_or_within

ISS
ISO

(PMID:10841515), (PMID:11752062), (PMID:9122231)
(PMID:10840053), (PMID:15629890)

UniProt
MGI

GO_REF:0000024

NCBI chr X:101,397,803...101,407,925
Ensembl chr X:101,393,273...101,408,012

LCT

lactase

involved_in

ISS

GO_REF:0000024

NCBI chr 2:135,787,850...135,837,184
Ensembl chr 2:135,787,850...135,837,184

glycosylceramide metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

involved_in

IDA

(PMID:17123352)

NCBI chr 1:76,074,746...76,637,339
Ensembl chr 1:76,074,746...76,634,603

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

involved_in

IDA

(PMID:17123352)

NCBI chr 9:127,885,321...127,906,616
Ensembl chr 9:127,885,321...127,906,616

GPI anchor biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CWH43

cell wall biogenesis 43 C-terminal homolog

involved_in

IEA
IBA

PMID:9535917 PMID:9724629 PMID:16280320

GO_REF:0000033 GO_REF:0000043

NCBI chr 4:48,986,275...49,062,079
Ensembl chr 4:48,986,162...49,062,093

DPM1

dolichyl-phosphate mannosyltransferase subunit 1, catalytic

acts_upstream_of_or_within
involved_in

IDA
IEA
IGI
IBA

(PMID:9535917), (PMID:9724629)
(PMID:16280320)

MGI
UniProt
HGNC-UCL
Ensembl
GO_Central

GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr20:50,934,855...50,958,564
Ensembl chr20:50,934,852...50,959,140

DPM2

dolichyl-phosphate mannosyltransferase subunit 2, regulatory

acts_upstream_of_or_within
involved_in

ISO
IDA

PMID:9724629
(PMID:16162815)

MGI
UniProt

PMID:9724629 PMID:16162815

RGD:69827

NCBI chr 9:127,935,099...127,937,854
Ensembl chr 9:127,935,090...127,937,866

GPAA1

glycosylphosphatidylinositol anchor attachment 1

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr 8:144,082,634...144,086,216
Ensembl chr 8:144,082,337...144,093,149

MPPE1

metallophosphoesterase 1

involved_in

ISS
IEA
IMP

(PMID:29374258)

UniProt
InterPro

PMID:29374258

GO_REF:0000002 GO_REF:0000024 GO_REF:0000043 GO_REF:0000117

NCBI chr18:11,882,622...11,908,317
Ensembl chr18:11,882,622...11,909,180

PGAP1

post-GPI attachment to proteins inositol deacylase 1

involved_in

ISO
IBA

RGD
GO_Central

PMID:14734546

GO_REF:0000033 RGD:1303970

NCBI chr 2:196,833,004...196,926,707
Ensembl chr 2:196,833,004...196,927,796

PGAP2

post-GPI attachment to proteins 2

involved_in

ISS
IDA
IBA
IEA
IMP

(PMID:23561846)
(PMID:29374258)

PMID:23561846 PMID:29374258

GO_REF:0000024 GO_REF:0000033 GO_REF:0000043

NCBI chr11:3,797,720...3,826,371
Ensembl chr11:3,797,724...3,826,371

PGAP3

post-GPI attachment to proteins phospholipase 3

involved_in

IMP
IBA
IEA

(PMID:29374258)

UniProt
GO_Central
InterPro

PMID:29374258

GO_REF:0000002 GO_REF:0000033 GO_REF:0000043

NCBI chr17:39,671,122...39,688,057
Ensembl chr17:39,671,122...39,696,797

PGAP4

post-GPI attachment to proteins GalNAc transferase 4

involved_in

IMP
IBA
IEA

(PMID:29374258)

UniProt
GO_Central
InterPro

PMID:29374258

GO_REF:0000002 GO_REF:0000033

NCBI chr 9:101,473,170...101,533,686
Ensembl chr 9:101,473,170...101,533,537

PIGA

phosphatidylinositol glycan anchor biosynthesis class A

involved_in
acts_upstream_of_or_within

IEA
TAS
IBA

UniProt
Ensembl
Reactome
GO_Central
InterPro

GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 Reactome:R-HSA-162710

NCBI chr X:15,319,451...15,335,554
Ensembl chr X:15,319,452...15,335,554

PIGB

phosphatidylinositol glycan anchor biosynthesis class B

involved_in

IDA
IBA
TAS
IEA

(PMID:8861954)

UniProt
GO_Central
Reactome

PMID:8861954

GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 Reactome:R-HSA-162710

NCBI chr15:55,319,222...55,355,648
Ensembl chr15:55,318,960...55,355,648

PIGC

phosphatidylinositol glycan anchor biosynthesis class C

involved_in

IDA
IEA
TAS
IMP

(PMID:16162815)
(PMID:8806613)
(PMID:27694521)

UniProt
InterPro
PINC

PMID:8806613 PMID:16162815 PMID:27694521

GO_REF:0000002 GO_REF:0000041 GO_REF:0000043

NCBI chr 1:172,441,457...172,444,069
Ensembl chr 1:172,370,189...172,444,148

PIGF

phosphatidylinositol glycan anchor biosynthesis class F

involved_in

TAS
IBA
IEA
ISS
IMP

(PMID:8463218)
(PMID:33386993)

PINC
GO_Central
UniProt
InterPro
Ensembl

PMID:8463218 PMID:33386993

GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107

NCBI chr 2:46,580,937...46,617,041
Ensembl chr 2:46,580,937...46,617,055

PIGG

phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)

acts_upstream_of_or_within
involved_in

IDA
TAS
IBA
IEA

(PMID:15632136)

MGI
Reactome
GO_Central
InterPro
UniProt

PMID:15632136

GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 Reactome:R-HSA-162710

NCBI chr 4:499,210...540,200
Ensembl chr 4:499,210...540,200

PIGH

phosphatidylinositol glycan anchor biosynthesis class H

involved_in

TAS
IBA
IEA
IDA

(PMID:8900170)
(PMID:16162815)

PINC
GO_Central
UniProt
InterPro

PMID:8900170 PMID:16162815

GO_REF:0000002 GO_REF:0000033 GO_REF:0000041

NCBI chr14:67,589,311...67,600,268
Ensembl chr14:67,581,955...67,600,286

PIGK

phosphatidylinositol glycan anchor biosynthesis class K

involved_in

IEA

PMID:9188481 PMID:10085243

GO_REF:0000041 GO_REF:0000043

NCBI chr 1:77,088,989...77,219,430
Ensembl chr 1:77,088,987...77,219,508

PIGL

phosphatidylinositol glycan anchor biosynthesis class L

involved_in

ISO
IEA
IMP
TAS
NAS

(PMID:10085243)

RGD
UniProt
Reactome
Ensembl

GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 GO_REF:0000117 RGD:729509 Reactome:R-HSA-162710

NCBI chr17:16,217,210...16,326,411
Ensembl chr17:16,217,191...16,351,797

PIGM

phosphatidylinositol glycan anchor biosynthesis class M

involved_in

ISO
IBA
IDA
IEA

(PMID:11226175)

RGD
GO_Central
UniProt
InterPro

PMID:11226175

GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 RGD:70624

NCBI chr 1:160,024,953...160,031,990
Ensembl chr 1:160,024,953...160,031,990

PIGN

phosphatidylinositol glycan anchor biosynthesis class N

involved_in

IEA
IBA
ISS
TAS

InterPro
UniProt
GO_Central
Reactome

GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000117 Reactome:R-HSA-162710

NCBI chr18:62,017,615...62,187,056
Ensembl chr18:61,905,255...62,187,118

PIGO

phosphatidylinositol glycan anchor biosynthesis class O

involved_in

ISS
IEA
IBA
IMP

(PMID:24049131), (PMID:24417746), (PMID:28337824)

UniProt
GO_Central
InterPro

PMID:24049131 PMID:24417746 PMID:28337824

GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000117

NCBI chr 9:35,088,688...35,096,591
Ensembl chr 9:35,085,493...35,096,632

PIGP

phosphatidylinositol glycan anchor biosynthesis class P

involved_in
acts_upstream_of_or_within

IDA
ISO
IBA
IEA
IMP

(PMID:16162815)
(PMID:10944123)
(PMID:28334793)

UniProt
MGI
GO_Central
InterPro

PMID:10944123 PMID:16162815 PMID:28334793

GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043

NCBI chr21:37,065,364...37,073,071
Ensembl chr21:37,062,846...37,073,318

PIGQ

phosphatidylinositol glycan anchor biosynthesis class Q

involved_in
acts_upstream_of_or_within

IDA
IEA
IBA

(PMID:16162815)

UniProt
Ensembl
GO_Central
InterPro

PMID:16162815

GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107

NCBI chr16:569,968...584,109
Ensembl chr16:566,995...584,120

PIGS

phosphatidylinositol glycan anchor biosynthesis class S

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr17:28,553,387...28,571,524
Ensembl chr17:28,553,383...28,571,794

PIGT

phosphatidylinositol glycan anchor biosynthesis class T

involved_in

IEA

UniProt
Reactome
GO_Central
InterPro

GO_REF:0000041 GO_REF:0000043

NCBI chr20:45,416,141...45,426,241
Ensembl chr20:45,416,084...45,456,934

PIGU

phosphatidylinositol glycan anchor biosynthesis class U

involved_in

IDA
IEA

(PMID:15034568)

HGNC-UCL
UniProt

PMID:15034568

GO_REF:0000041 GO_REF:0000043

NCBI chr20:34,560,542...34,677,092
Ensembl chr20:34,560,542...34,698,790

PIGV

phosphatidylinositol glycan anchor biosynthesis class V

involved_in

IGI
TAS
IBA
IEA
IMP

(PMID:15623507), (PMID:15720390)

PMID:15623507 PMID:15720390

GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 Reactome:R-HSA-162710

NCBI chr 1:26,787,054...26,800,659
Ensembl chr 1:26,787,054...26,800,659

PIGW

phosphatidylinositol glycan anchor biosynthesis class W

involved_in

IEA
ISS
TAS
IBA

UniProt
Reactome
GO_Central
InterPro

GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 Reactome:R-HSA-162710

NCBI chr17:36,534,987...36,539,303
Ensembl chr17:36,534,987...36,539,310

PIGX

phosphatidylinositol glycan anchor biosynthesis class X

involved_in

IEA

UniProt
InterPro

GO_REF:0000002 GO_REF:0000041 GO_REF:0000043

NCBI chr 3:196,712,377...196,736,007
Ensembl chr 3:196,639,775...196,736,007

PIGY

phosphatidylinositol glycan anchor biosynthesis class Y

acts_upstream_of_or_within
involved_in

IDA
IBA
IEA

(PMID:16162815)

MGI
GO_Central
UniProt

PMID:16162815

GO_REF:0000033 GO_REF:0000041 GO_REF:0000043

NCBI chr 4:88,520,998...88,523,776
Ensembl chr 4:88,520,998...88,523,776

PIGZ

phosphatidylinositol glycan anchor biosynthesis class Z

involved_in

IGI
TAS
IBA
IEA
IMP

(PMID:15208306)

UniProt
Reactome
GO_Central

PMID:15208306

GO_REF:0000033 GO_REF:0000041 GO_REF:0000043 Reactome:R-HSA-162710

NCBI chr 3:196,946,356...196,968,833
Ensembl chr 3:196,946,356...196,969,060

SLC30A5

solute carrier family 30 member 5

acts_upstream_of_positive_effect

IMP

(PMID:35525268)

PMID:17021251 PMID:24439110

PMID:35525268

NCBI chr 5:69,094,014...69,131,069
Ensembl chr 5:69,093,991...69,131,069

GPI anchor metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PGAP3

post-GPI attachment to proteins phospholipase 3

involved_in

IEA
IMP

(PMID:17021251), (PMID:24439110)

UniProt
FlyBase

GO_REF:0000104

NCBI chr17:39,671,122...39,688,057
Ensembl chr17:39,671,122...39,696,797

PIGW

phosphatidylinositol glycan anchor biosynthesis class W

involved_in

IC
IEA

(PMID:24367057)

PMID:24367057

GO_REF:0000117

NCBI chr17:36,534,987...36,539,303
Ensembl chr17:36,534,987...36,539,310

PIGX

phosphatidylinositol glycan anchor biosynthesis class X

involved_in

IEA

GO_REF:0000104

NCBI chr 3:196,712,377...196,736,007
Ensembl chr 3:196,639,775...196,736,007

lactosylceramide biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

B4GALT4

beta-1,4-galactosyltransferase 4

involved_in

IDA

(PMID:9792633)

PMID:9792633

NCBI chr 3:119,211,742...119,240,878
Ensembl chr 3:119,211,628...119,240,952

beta-1,4-galactosyltransferase 6

involved_in

IDA

(PMID:10320813)

PMID:10320813

NCBI chr18:31,622,246...31,724,641
Ensembl chr18:31,621,911...31,685,836

membrane lipid catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BLVRB

biliverdin reductase B

acts_upstream_of_or_within

ISO

(PMID:33359909)

PMID:33359909

NCBI chr19:40,447,768...40,465,745
Ensembl chr19:40,447,765...40,465,826

CYP1B1

cytochrome P450 family 1 subfamily B member 1

involved_in

ISS
IEA

GO_REF:0000024 GO_REF:0000107

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

FABP1

fatty acid binding protein 1

acts_upstream_of_or_within

ISO

(PMID:23359610)

PMID:23359610

NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,115

MGST2

microsomal glutathione S-transferase 2

involved_in

IDA

(PMID:23409838)

PMID:23409838

NCBI chr 4:139,665,819...139,754,618
Ensembl chr 4:139,665,768...139,741,884

SMPDL3B

sphingomyelin phosphodiesterase acid like 3B

involved_in

ISS
IEA

GO_REF:0000024 GO_REF:0000107

NCBI chr 1:27,935,000...27,959,152
Ensembl chr 1:27,935,000...27,959,157

ZPBP2

zona pellucida binding protein 2

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr17:39,868,202...39,877,896
Ensembl chr17:39,868,202...39,877,896

negative regulation of ceramide biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ORMDL sphingolipid biosynthesis regulator 1

acts_upstream_of_or_within

IMP

(PMID:25691431)

NCBI chr 2:189,763,859...189,784,339
Ensembl chr 2:189,766,012...189,784,382

ORMDL sphingolipid biosynthesis regulator 2

acts_upstream_of_or_within

IMP

(PMID:25691431)

NCBI chr12:55,818,041...55,821,879
Ensembl chr12:55,818,041...55,821,879

ORMDL sphingolipid biosynthesis regulator 3

acts_upstream_of_or_within

IMP
IEA

(PMID:25691431)

MGI
Ensembl

GO_REF:0000107

NCBI chr17:39,921,041...39,927,601
Ensembl chr17:39,921,037...39,929,328

sphingosine kinase 1

involved_in

IEA
IDA

(PMID:16118219)

PMID:16118219

GO_REF:0000107

NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860

negative regulation of glucosylceramide biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PRKAA1

protein kinase AMP-activated catalytic subunit alpha 1

involved_in

NAS

(PMID:11165240)

PMID:11165240

NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374

negative regulation of sphingolipid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATP binding cassette subfamily A member 2

involved_in

IDA

(PMID:24201375)

PMID:24201375

NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915

ATG7

autophagy related 7

acts_upstream_of_or_within

ISO

(PMID:25332431)

PMID:25332431

NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665

omega-hydroxyceramide biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PNPLA1

patatin like phospholipase domain containing 1

involved_in

IEA
IMP

(PMID:28248318)

PMID:28248318

GO_REF:0000107 GO_REF:0000117

NCBI chr 6:36,243,168...36,313,955
Ensembl chr 6:36,243,203...36,313,955

phytosphingosine biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

alkaline ceramidase 3

involved_in

IDA
IBA

(PMID:11356846), (PMID:20068046)

PMID:11356846 PMID:20068046

GO_REF:0000033

NCBI chr11:76,860,918...77,026,797
Ensembl chr11:76,860,859...77,026,797

positive regulation of ceramide biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CCN1

cellular communication network factor 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,756...85,584,589

ectonucleotide pyrophosphatase/phosphodiesterase 7

involved_in

ISS

GO_REF:0000024

NCBI chr17:79,730,943...79,742,219
Ensembl chr17:79,728,809...79,742,930

PLA2G6

phospholipase A2 group VI

involved_in

ISO
IBA

RGD
GO_Central

PMID:18936091

GO_REF:0000033 RGD:6482750

NCBI chr22:38,111,495...38,181,830
Ensembl chr22:38,111,495...38,214,778

protein kinase C delta

involved_in

IMP

(PMID:19279011)

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

SIRT3

sirtuin 3

involved_in

ISS

GO_REF:0000024

NCBI chr11:215,030...236,931
Ensembl chr11:215,028...236,931

sphingomyelin phosphodiesterase 3

ISO

RGD

PMID:20096352

RGD:10041064

NCBI chr16:68,358,327...68,448,508
Ensembl chr16:68,358,327...68,448,508

sphingosine kinase 2

involved_in

IEA
IDA

(PMID:16118219)

PMID:16118219

GO_REF:0000107

NCBI chr19:48,619,506...48,630,405
Ensembl chr19:48,619,291...48,630,717

ZNF750

zinc finger protein 750

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr17:82,829,434...82,840,022
Ensembl chr17:82,829,434...82,840,022

positive regulation of glucosylceramide catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

protein kinase C delta

involved_in

IMP

(PMID:19279011)

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

positive regulation of sphingomyelin catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ectonucleotide pyrophosphatase/phosphodiesterase 7

involved_in

ISS

GO_REF:0000024

NCBI chr17:79,730,943...79,742,219
Ensembl chr17:79,728,809...79,742,930

protein kinase C delta

involved_in

IMP

(PMID:19279011)

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

regulation of ceramide biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ORMDL sphingolipid biosynthesis regulator 1

involved_in
acts_upstream_of

IEA

GO_REF:0000104 GO_REF:0000107 GO_REF:0000117

NCBI chr 2:189,763,859...189,784,339
Ensembl chr 2:189,766,012...189,784,382

ORMDL sphingolipid biosynthesis regulator 2

involved_in

IEA

GO_REF:0000117

NCBI chr12:55,818,041...55,821,879
Ensembl chr12:55,818,041...55,821,879

ORMDL sphingolipid biosynthesis regulator 3

involved_in
acts_upstream_of

IEA

GO_REF:0000107 GO_REF:0000117

NCBI chr17:39,921,041...39,927,601
Ensembl chr17:39,921,037...39,929,328

PAQR4

progestin and adipoQ receptor family member 4

involved_in

IDA
IEA

(PMID:32291319), (PMID:38961186)

PMID:32291319 PMID:38961186

GO_REF:0000107

NCBI chr16:2,969,348...2,973,484
Ensembl chr16:2,969,242...2,973,484

protein kinase C delta

involved_in

IDA

(PMID:17303575)

PMID:17303575

NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717

sterile alpha motif domain containing 8

involved_in

IDA

(PMID:19506037)

PMID:19506037

NCBI chr10:75,099,593...75,182,123
Ensembl chr10:75,099,586...75,182,127

regulation of glucosylceramide catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

MIR127

microRNA 127

acts_upstream_of

IGI

(PMID:25584808)

NCBI chr14:100,882,979...100,883,075
Ensembl chr14:100,882,979...100,883,075

MIR16-1

microRNA 16-1

acts_upstream_of_or_within

IGI

(PMID:25584808)

NCBI chr13:50,048,973...50,049,061
Ensembl chr13:50,048,973...50,049,061

MIR16-2

microRNA 16-2

acts_upstream_of_or_within

IGI

(PMID:25584808)

NCBI chr 3:160,404,745...160,404,825
Ensembl chr 3:160,404,745...160,404,825

MIR195

microRNA 195

acts_upstream_of_or_within

IGI

(PMID:25584808)

NCBI chr17:7,017,615...7,017,701
Ensembl chr17:7,017,615...7,017,701

SCARB2

scavenger receptor class B member 2

involved_in

TAS

(PMID:25584808)

NCBI chr 4:76,158,737...76,234,532
Ensembl chr 4:76,158,737...76,234,536

regulation of membrane lipid metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NSMAF

neutral sphingomyelinase activation associated factor

involved_in

IEA

GO_REF:0000107

NCBI chr 8:58,583,504...58,659,853
Ensembl chr 8:58,583,504...58,659,959

TNF

tumor necrosis factor

involved_in

IEA

GO_REF:0000107

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

TNFRSF1A

TNF receptor superfamily member 1A

involved_in

IEA

GO_REF:0000107

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

regulation of sphingolipid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ORMDL sphingolipid biosynthesis regulator 1

acts_upstream_of

IEA

GO_REF:0000107

NCBI chr 2:189,763,859...189,784,339
Ensembl chr 2:189,766,012...189,784,382

ORMDL sphingolipid biosynthesis regulator 3

acts_upstream_of

IEA

GO_REF:0000107

NCBI chr17:39,921,041...39,927,601
Ensembl chr17:39,921,037...39,929,328

sphinganine biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

serine palmitoyltransferase long chain base subunit 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 9:92,031,147...92,115,413
Ensembl chr 9:92,000,087...92,115,433

serine palmitoyltransferase long chain base subunit 2

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,672

sphinganine metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DEGS2

delta 4-desaturase, sphingolipid 2

involved_in
acts_upstream_of_or_within

IBA
IEA

GO_REF:0000033 GO_REF:0000107

NCBI chr14:100,143,957...100,166,886
Ensembl chr14:100,143,957...100,159,645

sphinganine-1-phosphate biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ensembl
GO_Central
UniProt

sphingosine kinase 2

involved_in

IEA
IBA
IDA

(PMID:10751414), (PMID:19729656)

PMID:10751414 PMID:19729656

GO_REF:0000033 GO_REF:0000107

NCBI chr19:48,619,506...48,630,405
Ensembl chr19:48,619,291...48,630,717

sphinganine-1-phosphate metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

sphingosine-1-phosphate phosphatase 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr14:63,684,216...63,728,065
Ensembl chr14:63,684,216...63,728,065

sphingoid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

serine palmitoyltransferase long chain base subunit 3

acts_upstream_of_or_within

IDA

(PMID:19648650)

PMID:19648650

NCBI chr20:13,008,972...13,169,103
Ensembl chr20:13,008,972...13,169,103

sphingoid catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

sphingosine kinase 1

involved_in

NAS

(PMID:10863092)

PMID:10863092

NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860

sphingolipid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABCC1

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

involved_in

TAS

Reactome:R-HSA-1660661

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

ABCG2

ATP binding cassette subfamily G member 2 (JR blood group)

involved_in

TAS

Reactome:R-HSA-1660661

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,818

alkaline ceramidase 1

involved_in

IDA

(PMID:17713573)

PMID:17713573

NCBI chr19:6,306,142...6,360,368
Ensembl chr19:6,306,142...6,333,612

B3GNT5

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

involved_in

IEA

GO_REF:0000117

NCBI chr 3:183,253,253...183,273,385
Ensembl chr 3:183,249,324...183,298,504

CERKL

CERK like autophagy regulator

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr 2:181,536,672...181,657,105
Ensembl chr 2:181,535,041...181,680,665

CERS1

ceramide synthase 1

involved_in

TAS
IDA

(PMID:12105227)

PMID:12105227

Reactome:R-HSA-1660661

NCBI chr19:18,868,545...18,896,982
Ensembl chr19:18,868,545...18,896,727

ceramide synthase 2

involved_in
acts_upstream_of_or_within

TAS
IEA

GO_REF:0000107 Reactome:R-HSA-1660661

NCBI chr 1:150,965,186...150,974,835
Ensembl chr 1:150,960,583...150,977,396

CERS3

ceramide synthase 3

involved_in
acts_upstream_of_or_within

TAS
IEA

GO_REF:0000107 Reactome:R-HSA-1660661

NCBI chr15:100,400,395...100,544,683
Ensembl chr15:100,400,395...100,544,995

CERS4

ceramide synthase 4

involved_in
acts_upstream_of_or_within

TAS
IEA

GO_REF:0000107 Reactome:R-HSA-1660661

NCBI chr19:8,209,370...8,262,421
Ensembl chr19:8,206,736...8,263,716

CERS5

ceramide synthase 5

involved_in
acts_upstream_of_or_within

TAS
IEA

GO_REF:0000107 Reactome:R-HSA-1660661

NCBI chr12:50,129,289...50,167,369
Ensembl chr12:50,129,289...50,167,533

CERS6

ceramide synthase 6

involved_in
acts_upstream_of_or_within

TAS
ISO

(PMID:15823095)

Reactome
MGI

PMID:15823095

Reactome:R-HSA-1660661

NCBI chr 2:168,456,272...168,775,134
Ensembl chr 2:168,456,249...168,775,134

CSNK1G2

casein kinase 1 gamma 2

involved_in

TAS

Reactome
Ensembl
InterPro
UniProt

Reactome:R-HSA-1660661

NCBI chr19:1,941,172...1,981,338
Ensembl chr19:1,941,146...1,981,339

DEGS1

delta 4-desaturase, sphingolipid 1

involved_in

TAS
IEA

Reactome
InterPro

GO_REF:0000002 Reactome:R-HSA-1660661

NCBI chr 1:224,183,240...224,193,441
Ensembl chr 1:224,175,756...224,193,441

DEGS2

delta 4-desaturase, sphingolipid 2

involved_in
acts_upstream_of_or_within

TAS
IEA

GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 Reactome:R-HSA-1660661

NCBI chr14:100,143,957...100,166,886
Ensembl chr14:100,143,957...100,159,645

ELOVL1

ELOVL fatty acid elongase 1

involved_in

IMP
IBA
IEA

(PMID:20937905)

UniProt
GO_Central
Ensembl

PMID:20937905

GO_REF:0000033 GO_REF:0000107

NCBI chr 1:43,363,401...43,368,011
Ensembl chr 1:43,363,396...43,368,075

ELOVL2

ELOVL fatty acid elongase 2

involved_in

IBA

GO_REF:0000033

NCBI chr 6:10,980,759...11,044,305
Ensembl chr 6:10,980,759...11,044,399

ELOVL3

ELOVL fatty acid elongase 3

involved_in

IBA

GO_REF:0000033

NCBI chr10:102,224,767...102,229,589
Ensembl chr10:102,226,299...102,229,589

ELOVL4

ELOVL fatty acid elongase 4

involved_in

IBA

GO_REF:0000033

NCBI chr 6:79,914,814...79,947,553
Ensembl chr 6:79,914,814...79,947,553

ELOVL5

ELOVL fatty acid elongase 5

involved_in

IBA

GO_REF:0000033

NCBI chr 6:53,267,404...53,348,950
Ensembl chr 6:53,260,285...53,349,179

ELOVL6

ELOVL fatty acid elongase 6

involved_in

IBA

GO_REF:0000033

NCBI chr 4:110,045,846...110,199,202
Ensembl chr 4:110,045,846...110,199,199

ELOVL7

ELOVL fatty acid elongase 7

involved_in

IBA

GO_REF:0000033

NCBI chr 5:60,751,791...60,844,269
Ensembl chr 5:60,751,791...60,844,274

fatty acid 2-hydroxylase

involved_in

TAS

Reactome:R-HSA-1660661

NCBI chr16:74,712,969...74,774,820
Ensembl chr16:74,712,955...74,774,837

HACD1

3-hydroxyacyl-CoA dehydratase 1

involved_in

IGI
IBA

(PMID:18554506)

PMID:18554506

GO_REF:0000033

NCBI chr10:17,589,032...17,617,374
Ensembl chr10:17,588,316...17,617,430

HACD2

3-hydroxyacyl-CoA dehydratase 2

involved_in

IGI
IBA

(PMID:18554506)

PMID:18554506

GO_REF:0000033

NCBI chr 3:123,491,554...123,585,053
Ensembl chr 3:123,490,820...123,585,081

HACD3

3-hydroxyacyl-CoA dehydratase 3

involved_in

IBA

GO_REF:0000033

NCBI chr15:65,530,463...65,578,349
Ensembl chr15:65,530,418...65,578,349

HACD4

3-hydroxyacyl-CoA dehydratase 4

involved_in

IBA

GO_REF:0000033

NCBI chr 9:20,999,509...21,031,640
Ensembl chr 9:20,999,509...21,031,640

InterPro
Ensembl
GO_Central
UniProt
Reactome

3-ketodihydrosphingosine reductase

involved_in
acts_upstream_of_or_within

IEA
IBA
IMP
ISS
TAS

(PMID:19141869)

PMID:19141869

GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 Reactome:R-HSA-1660661

NCBI chr18:63,327,726...63,367,206
Ensembl chr18:63,327,566...63,367,615

MFSD2B

MFSD2 lysolipid transporter B, sphingolipid

involved_in

TAS

Reactome:R-HSA-1660661

NCBI chr 2:24,010,085...24,026,775
Ensembl chr 2:24,010,081...24,063,321

ORMDL sphingolipid biosynthesis regulator 1

involved_in

IBA

GO_REF:0000033

NCBI chr 2:189,763,859...189,784,339
Ensembl chr 2:189,766,012...189,784,382

ORMDL sphingolipid biosynthesis regulator 2

involved_in

IBA

GO_REF:0000033

NCBI chr12:55,818,041...55,821,879
Ensembl chr12:55,818,041...55,821,879

ORMDL sphingolipid biosynthesis regulator 3

involved_in

IBA

GO_REF:0000033

NCBI chr17:39,921,041...39,927,601
Ensembl chr17:39,921,037...39,929,328

PPM1L

protein phosphatase, Mg2+/Mn2+ dependent 1L

involved_in

TAS

Reactome:R-HSA-1660661

NCBI chr 3:160,756,231...161,078,902
Ensembl chr 3:160,755,602...161,078,902

PRKD1

protein kinase D1

involved_in

TAS
IEA

GO_REF:0000117 Reactome:R-HSA-1660661

NCBI chr14:29,576,479...29,927,847
Ensembl chr14:29,576,479...30,191,898

PRKD2

protein kinase D2

involved_in

TAS
IEA

GO_REF:0000117 Reactome:R-HSA-1660661

NCBI chr19:46,674,316...46,717,114
Ensembl chr19:46,674,275...46,717,127

PRKD3

protein kinase D3

involved_in

TAS
IEA

GO_REF:0000117 Reactome:R-HSA-1660661

NCBI chr 2:37,250,502...37,324,833
Ensembl chr 2:37,250,502...37,324,833

sphingomyelin synthase 1

involved_in

TAS

Reactome:R-HSA-1660661

NCBI chr10:50,305,600...50,625,184
Ensembl chr10:50,305,586...50,625,187

sphingomyelin synthase 2

involved_in

TAS

Reactome:R-HSA-1660661

NCBI chr 4:107,824,563...107,915,047
Ensembl chr 4:107,824,563...107,915,047

sphingosine kinase 1

involved_in

TAS

Reactome:R-HSA-1660661

NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860

sphingosine kinase 2

involved_in

TAS

Reactome:R-HSA-1660661

NCBI chr19:48,619,506...48,630,405
Ensembl chr19:48,619,291...48,630,717

SPNS2

SPNS lysolipid transporter 2, sphingosine-1-phosphate

involved_in

TAS

Reactome:R-HSA-1660661

NCBI chr17:4,498,881...4,539,035
Ensembl chr17:4,498,850...4,539,036

PMID:19416851 PMID:25332431

serine palmitoyltransferase long chain base subunit 1

involved_in
acts_upstream_of_or_within

TAS
IEA
IDA

(PMID:19416851)
(PMID:25332431)

UniProt
MGI

GO_REF:0000117

NCBI chr 9:92,031,147...92,115,413
Ensembl chr 9:92,000,087...92,115,433

PMID:19416851 PMID:25332431 PMID:26573920

serine palmitoyltransferase long chain base subunit 2

acts_upstream_of_or_within
involved_in

IDA
TAS
IEA

(PMID:25332431)
(PMID:19416851)
(PMID:26573920)

MGI
UniProt
Ensembl

GO_REF:0000107

NCBI chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,672

serine palmitoyltransferase long chain base subunit 3

involved_in

TAS

(PMID:19416851)

NCBI chr20:13,008,972...13,169,103
Ensembl chr20:13,008,972...13,169,103

serine palmitoyltransferase small subunit A

involved_in

TAS

(PMID:19416851)

NCBI chr14:34,432,788...34,462,240
Ensembl chr14:34,432,788...34,462,240

serine palmitoyltransferase small subunit B

involved_in
acts_upstream_of_or_within

TAS
IEA
ISS

(PMID:19416851)

GO_REF:0000024 GO_REF:0000107

NCBI chr 3:161,344,798...161,371,517
Ensembl chr 3:161,344,798...161,372,880

sphingolipid catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

alkaline ceramidase 1

involved_in

TAS

Reactome:R-HSA-9845614

NCBI chr19:6,306,142...6,360,368
Ensembl chr19:6,306,142...6,333,612

alkaline ceramidase 2

involved_in

TAS

Reactome:R-HSA-9845614

NCBI chr 9:19,409,009...19,452,505
Ensembl chr 9:19,409,009...19,452,505

ALDH3B1

aldehyde dehydrogenase 3 family member B1

involved_in

TAS

Reactome:R-HSA-9845614

NCBI chr11:68,008,547...68,029,276
Ensembl chr11:68,008,563...68,029,282

ALDH3B2

aldehyde dehydrogenase 3 family member B2

involved_in

TAS

Reactome:R-HSA-9845614

NCBI chr11:67,662,155...67,681,252
Ensembl chr11:67,662,155...67,681,224

ENPP2

ectonucleotide pyrophosphatase/phosphodiesterase 2

involved_in

IDA

(PMID:14500380)

PMID:14500380

NCBI chr 8:119,557,086...119,673,390
Ensembl chr 8:119,557,085...119,673,453

PLPP1

phospholipid phosphatase 1

involved_in

TAS

Reactome:R-HSA-9845614

NCBI chr 5:55,424,854...55,534,964
Ensembl chr 5:55,424,849...55,535,035

PLPP2

phospholipid phosphatase 2

involved_in

TAS

Reactome:R-HSA-9845614

NCBI chr19:281,043...291,403
Ensembl chr19:278,504...291,403

PLPP3

phospholipid phosphatase 3

involved_in

TAS

Reactome:R-HSA-9845614

NCBI chr 1:56,494,761...56,579,563
Ensembl chr 1:56,494,761...56,645,301

PPT1

palmitoyl-protein thioesterase 1

involved_in

TAS

(PMID:16542649)

UniProt
GO_Central
Reactome

PMID:16542649

NCBI chr 1:40,071,461...40,097,252
Ensembl chr 1:40,072,710...40,097,267

SGPL1

sphingosine-1-phosphate lyase 1

involved_in

IDA
IBA
TAS
IMP
NAS

(PMID:24809814)
(PMID:28165339)
(PMID:11018465)

PMID:11018465 PMID:24809814 PMID:28165339

GO_REF:0000033 Reactome:R-HSA-9845614

NCBI chr10:70,815,948...70,881,184
Ensembl chr10:70,815,905...70,958,701

sphingosine-1-phosphate phosphatase 1

involved_in

TAS
IEA

GO_REF:0000117 Reactome:R-HSA-9845614

NCBI chr14:63,684,216...63,728,065
Ensembl chr14:63,684,216...63,728,065

SGPP2

sphingosine-1-phosphate phosphatase 2

involved_in

TAS
IEA

GO_REF:0000117 Reactome:R-HSA-9845614

NCBI chr 2:222,423,988...222,562,621
Ensembl chr 2:222,424,511...222,562,621

sphingomyelin phosphodiesterase 2

involved_in

IBA

GO_REF:0000033

NCBI chr 6:109,440,724...109,443,919
Ensembl chr 6:109,440,678...109,443,920

VPS54

VPS54 subunit of GARP complex

involved_in

IEA

GO_REF:0000107

NCBI chr 2:63,892,150...64,019,428
Ensembl chr 2:63,892,146...64,019,476

sphingolipid metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

alkaline ceramidase 1

involved_in
acts_upstream_of_or_within

IEA
ISS

UniProt
Ensembl
BHF-UCL

GO_REF:0000024 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107

NCBI chr19:6,306,142...6,360,368
Ensembl chr19:6,306,142...6,333,612

alkaline ceramidase 2

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr 9:19,409,009...19,452,505
Ensembl chr 9:19,409,009...19,452,505

alkaline ceramidase 3

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr11:76,860,918...77,026,797
Ensembl chr11:76,860,859...77,026,797

ALOX12B

arachidonate 12-lipoxygenase, 12R type

involved_in

IEA
IDA

(PMID:21558561)

PMID:21558561

GO_REF:0000041

NCBI chr17:8,072,636...8,087,716
Ensembl chr17:8,072,636...8,087,716

ALOXE3

arachidonate epidermal lipoxygenase 3

involved_in

IDA
IEA

(PMID:21558561)

PMID:21558561

GO_REF:0000041

NCBI chr17:8,095,900...8,118,916
Ensembl chr17:8,095,900...8,119,047

ARV1

ARV1 homolog, fatty acid homeostasis modulator

involved_in

IBA

GO_REF:0000033

NCBI chr 1:230,979,094...231,000,733
Ensembl chr 1:230,978,981...231,000,733

N-acylsphingosine amidohydrolase 1

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998

N-acylsphingosine amidohydrolase 2

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr10:50,184,861...50,251,516
Ensembl chr10:50,182,778...50,279,720

beta-1,4-N-acetyl-galactosaminyltransferase 1

involved_in

IEA

GO_REF:0000043

NCBI chr12:57,623,409...57,633,201
Ensembl chr12:57,623,409...57,633,239

B4GALT5

beta-1,4-galactosyltransferase 5

involved_in

IEA

GO_REF:0000043

NCBI chr20:49,632,945...49,713,878
Ensembl chr20:49,632,945...49,713,908

beta-1,4-galactosyltransferase 6

involved_in

IEA

GO_REF:0000043

NCBI chr18:31,622,246...31,724,641
Ensembl chr18:31,621,911...31,685,836

CERKL

CERK like autophagy regulator

involved_in

IBA

GO_REF:0000033

NCBI chr 2:181,536,672...181,657,105
Ensembl chr 2:181,535,041...181,680,665

CERS1

ceramide synthase 1

involved_in

IEA

GO_REF:0000041

NCBI chr19:18,868,545...18,896,982
Ensembl chr19:18,868,545...18,896,727

ceramide synthase 2

involved_in

IEA

GO_REF:0000041

NCBI chr 1:150,965,186...150,974,835
Ensembl chr 1:150,960,583...150,977,396

CERS3

ceramide synthase 3

involved_in

IEA

GO_REF:0000041

NCBI chr15:100,400,395...100,544,683
Ensembl chr15:100,400,395...100,544,995

CERS4

ceramide synthase 4

involved_in

IEA

GO_REF:0000041

NCBI chr19:8,209,370...8,262,421
Ensembl chr19:8,206,736...8,263,716

CERS5

ceramide synthase 5

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr12:50,129,289...50,167,369
Ensembl chr12:50,129,289...50,167,533

CERS6

ceramide synthase 6

involved_in

IEA

GO_REF:0000041

NCBI chr 2:168,456,272...168,775,134
Ensembl chr 2:168,456,249...168,775,134

fatty acid 2-hydroxylase

involved_in

IEA

GO_REF:0000043

NCBI chr16:74,712,969...74,774,820
Ensembl chr16:74,712,955...74,774,837

FADS3

fatty acid desaturase 3

involved_in

IEA

GO_REF:0000041

NCBI chr11:61,873,526...61,892,224
Ensembl chr11:61,873,519...61,892,136

FUT3

fucosyltransferase 3 (Lewis blood group)

involved_in

IEA

GO_REF:0000117

NCBI chr19:5,842,888...5,857,122
Ensembl chr19:5,842,888...5,851,471

FUT4

fucosyltransferase 4

involved_in

IEA

GO_REF:0000117

NCBI chr11:94,543,921...94,549,895
Ensembl chr11:94,543,921...94,549,895

FUT5

fucosyltransferase 5

involved_in

IEA

GO_REF:0000117

NCBI chr19:5,865,826...5,870,540
Ensembl chr19:5,865,826...5,870,540

FUT6

fucosyltransferase 6

involved_in

IEA

GO_REF:0000117

NCBI chr19:5,830,408...5,839,702
Ensembl chr19:5,830,361...5,839,722

FUT7

fucosyltransferase 7

involved_in

IEA

GO_REF:0000117

NCBI chr 9:137,030,174...137,032,088
Ensembl chr 9:137,030,174...137,032,825

FUT9

fucosyltransferase 9

involved_in

IEA

GO_REF:0000117

NCBI chr 6:96,015,974...96,215,612
Ensembl chr 6:96,015,436...96,215,612

galactose-3-O-sulfotransferase 1

involved_in

IEA
IDA

(PMID:8830034)

PMID:8830034

GO_REF:0000041 GO_REF:0000043

NCBI chr22:30,554,635...30,574,665
Ensembl chr22:30,554,632...30,576,210

GALC

galactosylceramidase

involved_in

IEA

GO_REF:0000043

NCBI chr14:87,933,014...87,993,667
Ensembl chr14:87,837,820...87,993,665

glucosylceramidase beta 1

involved_in

IEA

GO_REF:0000002 GO_REF:0000043

NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,447...155,245,178

glucosylceramidase beta 2

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr 9:35,736,866...35,749,228
Ensembl chr 9:35,736,864...35,749,986

ganglioside GM2 activator

involved_in

IEA

GO_REF:0000043

NCBI chr 5:151,253,185...151,270,440
Ensembl chr 5:151,212,150...151,270,440

3-ketodihydrosphingosine reductase

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr18:63,327,726...63,367,206
Ensembl chr18:63,327,566...63,367,615

ORMDL sphingolipid biosynthesis regulator 1

involved_in

IEA

GO_REF:0000117

NCBI chr 2:189,763,859...189,784,339
Ensembl chr 2:189,766,012...189,784,382

ORMDL sphingolipid biosynthesis regulator 2

involved_in

IEA

GO_REF:0000117

NCBI chr12:55,818,041...55,821,879
Ensembl chr12:55,818,041...55,821,879

ORMDL sphingolipid biosynthesis regulator 3

involved_in

IEA

GO_REF:0000117

NCBI chr17:39,921,041...39,927,601
Ensembl chr17:39,921,037...39,929,328

prosaposin

involved_in
acts_upstream_of_or_within

IEA
ISO

(PMID:11371512)

UniProt
MGI
InterPro

PMID:11371512

GO_REF:0000002 GO_REF:0000043 GO_REF:0000104

NCBI chr10:71,816,298...71,851,251
Ensembl chr10:71,816,289...71,851,330

PSAPL1

prosaposin like 1

involved_in

IEA

GO_REF:0000002 GO_REF:0000043

NCBI chr 4:7,430,285...7,434,930
Ensembl chr 4:7,430,285...7,434,930

sterile alpha motif domain containing 8

involved_in

IEA

GO_REF:0000043

NCBI chr10:75,099,593...75,182,123
Ensembl chr10:75,099,586...75,182,127

SERINC1

serine incorporator 1

involved_in

ISS

HGNC-UCL

GO_REF:0000024

NCBI chr 6:122,443,351...122,471,807
Ensembl chr 6:122,443,348...122,471,854

SFTPB

surfactant protein B

involved_in

IEA

GO_REF:0000002

NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,655,154...85,668,741

sphingomyelin synthase 1

involved_in

IEA

GO_REF:0000043

NCBI chr10:50,305,600...50,625,184
Ensembl chr10:50,305,586...50,625,187

sphingomyelin synthase 2

involved_in

IEA

GO_REF:0000043

NCBI chr 4:107,824,563...107,915,047
Ensembl chr 4:107,824,563...107,915,047

SGPL1

sphingosine-1-phosphate lyase 1

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr10:70,815,948...70,881,184
Ensembl chr10:70,815,905...70,958,701

sphingosine-1-phosphate phosphatase 1

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr14:63,684,216...63,728,065
Ensembl chr14:63,684,216...63,728,065

sphingomyelin phosphodiesterase 2

involved_in

IEA

GO_REF:0000041 GO_REF:0000043 GO_REF:0000117

NCBI chr 6:109,440,724...109,443,919
Ensembl chr 6:109,440,678...109,443,920

sphingomyelin phosphodiesterase 3

involved_in
acts_upstream_of_or_within

IEA

GO_REF:0000041 GO_REF:0000043 GO_REF:0000107

NCBI chr16:68,358,327...68,448,508
Ensembl chr16:68,358,327...68,448,508

SPNS2

SPNS lysolipid transporter 2, sphingosine-1-phosphate

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr17:4,498,881...4,539,035
Ensembl chr17:4,498,850...4,539,036

serine palmitoyltransferase long chain base subunit 1

involved_in

IEA
TAS

(PMID:9363775)

UniProt
PINC
Ensembl

PMID:9363775

GO_REF:0000041 GO_REF:0000043 GO_REF:0000107

NCBI chr 9:92,031,147...92,115,413
Ensembl chr 9:92,000,087...92,115,433

serine palmitoyltransferase long chain base subunit 2

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,672

serine palmitoyltransferase long chain base subunit 3

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr20:13,008,972...13,169,103
Ensembl chr20:13,008,972...13,169,103

serine palmitoyltransferase small subunit A

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr14:34,432,788...34,462,240
Ensembl chr14:34,432,788...34,462,240

serine palmitoyltransferase small subunit B

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr 3:161,344,798...161,371,517
Ensembl chr 3:161,344,798...161,372,880

ST8SIA1

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr12:22,193,391...22,334,707
Ensembl chr12:22,063,773...22,437,041

TECR

trans-2,3-enoyl-CoA reductase

involved_in

IEA
IBA
IMP

(PMID:25049234)

PMID:25049234

GO_REF:0000033 GO_REF:0000041 GO_REF:0000043

NCBI chr19:14,527,726...14,565,980
Ensembl chr19:14,517,085...14,565,988

TECRL

trans-2,3-enoyl-CoA reductase like

involved_in

IBA

GO_REF:0000033

NCBI chr 4:64,276,298...64,409,460
Ensembl chr 4:64,275,257...64,409,495

TEX2

testis expressed 2

involved_in

NAS

(PMID:16449791)

PMID:16449791

NCBI chr17:64,147,227...64,263,260
Ensembl chr17:64,147,227...64,263,291

tyrosine hydroxylase

ISO

sphingosine 1-phosphate

RGD

PMID:21076868

RGD:5128811

NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,968

UGCG

UDP-glucose ceramide glucosyltransferase

involved_in

IEA

GO_REF:0000041 GO_REF:0000043

NCBI chr 9:111,896,814...111,935,369
Ensembl chr 9:111,896,814...111,935,374

UDP glycosyltransferase 8

involved_in

IEA

GO_REF:0000043

NCBI chr 4:114,598,402...114,678,225
Ensembl chr 4:114,598,374...114,678,588

ZPBP2

zona pellucida binding protein 2

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr17:39,868,202...39,877,896
Ensembl chr17:39,868,202...39,877,896

sphingomyelin biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABCA8

ATP binding cassette subfamily A member 8

involved_in

IMP

(PMID:23560799)

PMID:23560799

NCBI chr17:68,867,289...68,955,392
Ensembl chr17:68,866,052...68,955,470

CERT1

ceramide transporter 1

involved_in

IDA

(PMID:39106189)

PMID:39106189

NCBI chr 5:75,368,486...75,511,981
Ensembl chr 5:75,356,345...75,512,138

ORMDL sphingolipid biosynthesis regulator 1

acts_upstream_of

IEA

GO_REF:0000107

NCBI chr 2:189,763,859...189,784,339
Ensembl chr 2:189,766,012...189,784,382

ORMDL sphingolipid biosynthesis regulator 3

acts_upstream_of

IEA

GO_REF:0000107

NCBI chr17:39,921,041...39,927,601
Ensembl chr17:39,921,037...39,929,328

OSBP

oxysterol binding protein

involved_in

IMP

(PMID:12023275)

PMID:12023275

NCBI chr11:59,574,398...59,615,774
Ensembl chr11:59,574,398...59,615,781

PEMT

phosphatidylethanolamine N-methyltransferase

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr17:17,505,563...17,592,142
Ensembl chr17:17,505,561...17,591,718

sterile alpha motif domain containing 8

involved_in

NAS

(PMID:14685263)

PMID:14685263

NCBI chr10:75,099,593...75,182,123
Ensembl chr10:75,099,586...75,182,127

Ensembl
GO_Central
HGNC-UCL

sphingomyelin synthase 1

involved_in

IEA
IBA
IDA

(PMID:14685263), (PMID:14976195), (PMID:17982138)

PMID:14685263 PMID:14976195 PMID:17982138

GO_REF:0000033 GO_REF:0000107

NCBI chr10:50,305,600...50,625,184
Ensembl chr10:50,305,586...50,625,187

sphingomyelin synthase 2

involved_in
acts_upstream_of_or_within

IDA
IEA
IBA

(PMID:14685263), (PMID:17982138)

PMID:14685263 PMID:17982138

GO_REF:0000033 GO_REF:0000107

NCBI chr 4:107,824,563...107,915,047
Ensembl chr 4:107,824,563...107,915,047

serine palmitoyltransferase long chain base subunit 1

involved_in
acts_upstream_of_or_within

IEA
ISO

(PMID:16216550)

Ensembl
MGI

PMID:16216550

GO_REF:0000107

NCBI chr 9:92,031,147...92,115,413
Ensembl chr 9:92,000,087...92,115,433

serine palmitoyltransferase long chain base subunit 2

acts_upstream_of_or_within

IEA

GO_REF:0000107

NCBI chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,672

VAPA

VAMP associated protein A

involved_in

IMP

(PMID:12023275)

PMID:12023275

NCBI chr18:9,914,016...9,960,021
Ensembl chr18:9,913,916...9,960,021

sphingomyelin catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

UniProt
Ensembl
GO_Central
InterPro

sphingomyelin phosphodiesterase 1

involved_in
acts_upstream_of_or_within

IDA
IEA
IBA

(PMID:18815062), (PMID:20807762), (PMID:22573858)

PMID:18815062 PMID:20807762 PMID:22573858

GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117

NCBI chr11:6,390,474...6,394,996
Ensembl chr11:6,390,414...6,394,998

PMID:10608884 PMID:14741383 PMID:23973266

sphingomyelin phosphodiesterase 2

involved_in
acts_upstream_of_or_within

IEA
ISO
IDA

(PMID:23973266)
(PMID:10608884), (PMID:14741383)

Ensembl
MGI
UniProt

GO_REF:0000107

NCBI chr 6:109,440,724...109,443,919
Ensembl chr 6:109,440,678...109,443,920

PMID:10823942 PMID:14741383

sphingomyelin phosphodiesterase 3

involved_in
acts_upstream_of_or_within

TAS
IEA
IDA

(PMID:10823942)
(PMID:14741383)

PINC
Ensembl
UniProt

GO_REF:0000107

NCBI chr16:68,358,327...68,448,508
Ensembl chr16:68,358,327...68,448,508

SMPD4

sphingomyelin phosphodiesterase 4

involved_in

IDA
IBA
IEA

(PMID:16517606), (PMID:25180167)

HGNC-UCL
GO_Central
Ensembl

PMID:16517606 PMID:25180167

GO_REF:0000033 GO_REF:0000107

NCBI chr 2:130,151,392...130,181,757
Ensembl chr 2:130,151,392...130,183,901

SMPD5

sphingomyelin phosphodiesterase 5 (pseudogene)

involved_in

ISO

(PMID:21183079)

PMID:21183079

NCBI chr 8:144,049,398...144,050,059
Ensembl chr 8:144,049,079...144,051,203

SMPDL3A

sphingomyelin phosphodiesterase acid like 3A

NOT|involved_in

IDA

(PMID:26783088)

PMID:26783088

NCBI chr 6:122,789,258...122,809,720
Ensembl chr 6:122,789,049...122,809,720

SMPDL3B

sphingomyelin phosphodiesterase acid like 3B

involved_in

IEA

GO_REF:0000002

NCBI chr 1:27,935,000...27,959,152
Ensembl chr 1:27,935,000...27,959,157

sphingomyelin metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATP binding cassette subfamily A member 2

involved_in

ISS

GO_REF:0000024

NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915

ectonucleotide pyrophosphatase/phosphodiesterase 7

involved_in

IDA

(PMID:12671034), (PMID:12885774), (PMID:28292932)

PMID:12671034 PMID:12885774 PMID:28292932

NCBI chr17:79,730,943...79,742,219
Ensembl chr17:79,728,809...79,742,930

PMID:1740330 PMID:7670466

sphingomyelin phosphodiesterase 1

involved_in

NAS
TAS

(PMID:1740330)
(PMID:7670466)

UniProt
PINC

NCBI chr11:6,390,474...6,394,996
Ensembl chr11:6,390,414...6,394,998

sphingomyelin phosphodiesterase 2

involved_in

IBA

GO_REF:0000033

NCBI chr 6:109,440,724...109,443,919
Ensembl chr 6:109,440,678...109,443,920

sphingomyelin phosphodiesterase 3

involved_in
acts_upstream_of_or_within

ISS
IEA
IBA

GO_REF:0000024 GO_REF:0000033 GO_REF:0000107

NCBI chr16:68,358,327...68,448,508
Ensembl chr16:68,358,327...68,448,508

sphingosine biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATP binding cassette subfamily A member 2

acts_upstream_of_positive_effect

IDA

(PMID:26510981)

PMID:26510981

NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915

UniProt
GO_Central
BHF-UCL
Ensembl

alkaline ceramidase 1

involved_in

IMP
IBA
IEA
IDA

(PMID:20207939)
(PMID:17713573), (PMID:20628055)

PMID:17713573 PMID:20207939 PMID:20628055

GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr19:6,306,142...6,360,368
Ensembl chr19:6,306,142...6,333,612

Ensembl
GO_Central
UniProt
BHF-UCL

alkaline ceramidase 2

involved_in

IEA
IBA
IDA
IMP

(PMID:16940153), (PMID:20089856), (PMID:20628055)
(PMID:20207939)

PMID:16940153 PMID:20089856 PMID:20207939 PMID:20628055

GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr 9:19,409,009...19,452,505
Ensembl chr 9:19,409,009...19,452,505

alkaline ceramidase 3

involved_in

IMP
IEA
IDA

(PMID:20207939), (PMID:26792856)
(PMID:20068046)

PMID:20068046 PMID:20207939 PMID:26792856

GO_REF:0000107 GO_REF:0000117

NCBI chr11:76,860,918...77,026,797
Ensembl chr11:76,860,859...77,026,797

AGK

acylglycerol kinase

involved_in

IBA

GO_REF:0000033

NCBI chr 7:141,551,410...141,655,244
Ensembl chr 7:141,551,278...141,655,244

N-acylsphingosine amidohydrolase 1

involved_in

IDA
IEA
IMP

(PMID:12815059)
(PMID:10610716)

PMID:10610716 PMID:12815059

GO_REF:0000107

NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998

N-acylsphingosine amidohydrolase 2

involved_in

IMP
IEA
IBA

(PMID:30154232)

PMID:30154232

GO_REF:0000033 GO_REF:0000117

NCBI chr10:50,184,861...50,251,516
Ensembl chr10:50,182,778...50,279,720

ASAH2B

N-acylsphingosine amidohydrolase 2B

involved_in

IEA

GO_REF:0000117

NCBI chr10:50,739,936...50,759,255
Ensembl chr10:50,739,318...50,816,495

glucosylceramidase beta 1

involved_in

IMP

(PMID:19279011)

NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,447...155,245,178

sphingosine kinase 1

involved_in

IGI
IEA
IBA
IMP

(PMID:23106337)

PMID:23106337

GO_REF:0000033 GO_REF:0000117

NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860

sphingosine kinase 2

involved_in

IGI
IEA
IBA
IMP

(PMID:23106337)

PMID:23106337

GO_REF:0000033 GO_REF:0000117

NCBI chr19:48,619,506...48,630,405
Ensembl chr19:48,619,291...48,630,717

ComplexPortal
Ensembl
GO_Central

serine palmitoyltransferase long chain base subunit 1

involved_in
acts_upstream_of_or_within

IDA
IEA
IBA

(PMID:19416851), (PMID:33558761)

PMID:19416851 PMID:33558761

GO_REF:0000033 GO_REF:0000107

NCBI chr 9:92,031,147...92,115,413
Ensembl chr 9:92,000,087...92,115,433

ComplexPortal
UniProt
Ensembl
GO_Central

serine palmitoyltransferase long chain base subunit 2

involved_in
acts_upstream_of_or_within

IDA
IEA
IBA

(PMID:19416851), (PMID:33558761)

PMID:19416851 PMID:33558761

GO_REF:0000033 GO_REF:0000107 GO_REF:0000117

NCBI chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,672

ComplexPortal
UniProt
GO_Central

serine palmitoyltransferase long chain base subunit 3

involved_in

IDA
IEA
IBA

(PMID:19416851)

GO_REF:0000033 GO_REF:0000117

NCBI chr20:13,008,972...13,169,103
Ensembl chr20:13,008,972...13,169,103

serine palmitoyltransferase small subunit A

involved_in

IDA

(PMID:19416851), (PMID:33558761)

PMID:19416851 PMID:33558761

NCBI chr14:34,432,788...34,462,240
Ensembl chr14:34,432,788...34,462,240

serine palmitoyltransferase small subunit B

involved_in

IDA

(PMID:19416851)

NCBI chr 3:161,344,798...161,371,517
Ensembl chr 3:161,344,798...161,372,880

sphingosine metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

N-acylsphingosine amidohydrolase 2

involved_in

IMP
IDA

(PMID:10781606), (PMID:15946935)
(PMID:16229686), (PMID:17475390), (PMID:26190575)

PMID:10781606 PMID:15946935 PMID:16229686 PMID:17475390 PMID:26190575

NCBI chr10:50,184,861...50,251,516
Ensembl chr10:50,182,778...50,279,720

NAAA

N-acylethanolamine acid amidase

involved_in

IDA

(PMID:15655246)

PMID:15655246

NCBI chr 4:75,910,655...75,941,013
Ensembl chr 4:75,910,655...75,941,013

PLPP1

phospholipid phosphatase 1

involved_in

IEA
IDA

(PMID:9705349)

PMID:9705349

GO_REF:0000107

NCBI chr 5:55,424,854...55,534,964
Ensembl chr 5:55,424,849...55,535,035

PLPP2

phospholipid phosphatase 2

involved_in

IDA

(PMID:9705349)

PMID:9705349

NCBI chr19:281,043...291,403
Ensembl chr19:278,504...291,403

PLPP3

phospholipid phosphatase 3

involved_in

IDA

(PMID:9305923), (PMID:9705349)

PMID:9305923 PMID:9705349

NCBI chr 1:56,494,761...56,579,563
Ensembl chr 1:56,494,761...56,645,301

sphingosine-1-phosphate phosphatase 1

involved_in
acts_upstream_of_or_within

IBA
IEA

GO_REF:0000033 GO_REF:0000107

NCBI chr14:63,684,216...63,728,065
Ensembl chr14:63,684,216...63,728,065

SGPP2

sphingosine-1-phosphate phosphatase 2

involved_in

IDA
IBA

(PMID:12411432)

PMID:12411432

GO_REF:0000033

NCBI chr 2:222,423,988...222,562,621
Ensembl chr 2:222,424,511...222,562,621

sphingosine kinase 1

involved_in

IDA

(PMID:20577214)

PMID:20577214

NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860

sphingosine kinase 2

involved_in
acts_upstream_of_or_within

ISS
IEA