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ONTOLOGY REPORT - ANNOTATIONS

Term:pyrimidine nucleobase metabolic process
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Accession:GO:0006206 term browser browse the term
Definition:The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
Synonyms:exact_synonym: pyrimidine base metabolic process;   pyrimidine base metabolism
 related_synonym: pyrimidine metabolic process;   pyrimidine metabolism


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pyrimidine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr 9:6,026,151...6,065,211
Ensembl chr 9:6,025,073...6,065,143 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr 3:126,357,198...126,367,145
Ensembl chr 3:126,347,819...126,365,644 		JBrowse link
G TYMS thymidylate synthetase ISO 5-fluorocytosine RGD PMID:9524100 RGD:5133447 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
'de novo' pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase involved_in ISO
IBA
IEA 		RGD
GO_Central
Ensembl
InterPro		 PMID:1476792 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:5132591 NCBI chr 3:111,887,017...111,914,511
Ensembl chr 3:111,887,020...111,914,492 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 6:164,161,439...164,197,429
Ensembl chr 6:164,162,518...164,197,379 		JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr15:113,210,038...113,339,086
Ensembl chr15:113,150,157...113,339,078 		JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) involved_in ISO
IBA
IEA 		RGD
GO_Central
InterPro		 PMID:1476792 GO_REF:0000002 GO_REF:0000033 RGD:5132591 NCBI chr 6:14,942,898...14,956,000
Ensembl chr 6:14,942,933...14,955,997 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G UMPS uridine monophosphate synthetase involved_in IEA InterPro GO_REF:0000002 NCBI chr13:135,611,857...135,650,656
Ensembl chr13:135,610,058...135,650,603 		JBrowse link
cytosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 acts_upstream_of_or_within ISO (PMID:15284227) MGI PMID:15284227 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G TET2 tet methylcytosine dioxygenase 2 acts_upstream_of_or_within ISO (PMID:21803851) MGI PMID:21803851 NCBI chr 8:116,413,253...116,546,976
Ensembl chr 8:116,415,267...116,545,299 		JBrowse link
pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTPS1 CTP synthase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:170,201,749...170,233,105
Ensembl chr 6:170,201,751...170,233,016 		JBrowse link
G CTPS2 CTP synthase 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:13,050,740...13,181,131
Ensembl chr  X:13,049,941...13,174,568 		JBrowse link
G UMPS uridine monophosphate synthetase involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:135,611,857...135,650,656
Ensembl chr13:135,610,058...135,650,603 		JBrowse link
pyrimidine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRMP1 collapsin response mediator protein 1 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr 8:4,734,175...4,805,647
Ensembl chr 8:4,734,200...4,805,644 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase acts_upstream_of_or_within
involved_in 		ISO
IEA 		RGD
Ensembl		 PMID:1629785 GO_REF:0000107 RGD:1599794 NCBI chr 4:119,931,471...120,712,461
Ensembl chr 4:119,931,414...120,712,459 		JBrowse link
G DPYS dihydropyrimidinase involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:32,791,152...32,879,489
Ensembl chr 4:32,789,460...32,879,489 		JBrowse link
G DPYSL2 dihydropyrimidinase like 2 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:10,428,598...10,545,705
Ensembl chr14:10,427,957...10,545,704 		JBrowse link
G DPYSL3 dihydropyrimidinase like 3 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:148,663,563...148,777,055
Ensembl chr 2:148,662,051...148,776,619 		JBrowse link
G DPYSL4 dihydropyrimidinase like 4 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:140,497,457...140,511,740
Ensembl chr14:140,497,457...140,511,733 		JBrowse link
G DPYSL5 dihydropyrimidinase like 5 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:112,155,538...112,252,963
Ensembl chr 3:112,156,676...112,252,968 		JBrowse link
thymine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 involved_in ISO
IBA
IEA 		RGD
GO_Central
Ensembl		 PMID:2768248 GO_REF:0000033 GO_REF:0000107 RGD:1599052 NCBI chr 7:97,360,583...97,381,885
Ensembl chr 7:97,360,610...97,381,830 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:119,931,471...120,712,461
Ensembl chr 4:119,931,414...120,712,459 		JBrowse link
G DPYS dihydropyrimidinase involved_in ISO PMID:8307005 UniProt PMID:8307005 RGD:1624990 NCBI chr 4:32,791,152...32,879,489
Ensembl chr 4:32,789,460...32,879,489 		JBrowse link
thymine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 involved_in ISO PMID:2768248 UniProt PMID:2768248 RGD:1599052 NCBI chr 7:97,360,583...97,381,885
Ensembl chr 7:97,360,610...97,381,830 		JBrowse link
uracil catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase involved_in ISS
IBA
IEA 		UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:119,931,471...120,712,461
Ensembl chr 4:119,931,414...120,712,459 		JBrowse link
G DPYS dihydropyrimidinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:32,791,152...32,879,489
Ensembl chr 4:32,789,460...32,879,489 		JBrowse link
uracil metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase ISO RGD PMID:7626590 RGD:1624989 NCBI chr 4:119,931,471...120,712,461
Ensembl chr 4:119,931,414...120,712,459 		JBrowse link
G DPYS dihydropyrimidinase ISO RGD PMID:7626590 PMID:8307005 RGD:1624989 RGD:1624990 NCBI chr 4:32,791,152...32,879,489
Ensembl chr 4:32,789,460...32,879,489 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:2043679 RGD:5133426 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18945
    cellular process 18488
      metabolic process 11687
        pyrimidine-containing compound metabolic process 65
          pyrimidine nucleobase metabolic process 21
            cytosine metabolic process + 2
            negative regulation of pyrimidine nucleobase metabolic process 0
            positive regulation of pyrimidine nucleobase metabolic process 0
            pyrimidine nucleobase biosynthetic process + 8
            pyrimidine nucleobase catabolic process + 8
            regulation of pyrimidine nucleobase metabolic process + 0
            thymine metabolic process + 3
            uracil metabolic process + 3
Path 2
Term Annotations click to browse term
  biological_process 18945
    cellular process 18488
      metabolic process 11687
        primary metabolic process 10342
          nucleobase-containing compound metabolic process 6285
            nucleobase-containing small molecule metabolic process 625
              nucleobase metabolic process 42
                pyrimidine nucleobase metabolic process 21
                  cytosine metabolic process + 2
                  negative regulation of pyrimidine nucleobase metabolic process 0
                  positive regulation of pyrimidine nucleobase metabolic process 0
                  pyrimidine nucleobase biosynthetic process + 8
                  pyrimidine nucleobase catabolic process + 8
                  regulation of pyrimidine nucleobase metabolic process + 0
                  thymine metabolic process + 3
                  uracil metabolic process + 3
paths to the root