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ONTOLOGY REPORT - ANNOTATIONS

Term:pyrimidine nucleobase metabolic process
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Accession:GO:0006206 term browser browse the term
Definition:The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
Synonyms:exact_synonym: pyrimidine base metabolic process;   pyrimidine base metabolism
 related_synonym: pyrimidine metabolic process;   pyrimidine metabolism

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pyrimidine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rrm1 ribonucleotide reductase catalytic subunit M1 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chrNW_004624817:5,523,648...5,568,997
Ensembl chrNW_004624817:5,523,665...5,568,994 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chrNW_004624865:4,984,353...4,990,187
Ensembl chrNW_004624865:4,985,620...4,990,120 		JBrowse link
G Tymp thymidine phosphorylase involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624752:251,670...256,243
Ensembl chrNW_004624752:252,937...256,244 		JBrowse link
G Tyms thymidylate synthetase ISO 5-fluorocytosine RGD PMID:9524100 RGD:5133447 NCBI chrNW_004624770:11,138,673...11,149,600
Ensembl chrNW_004624770:11,138,652...11,149,600 		JBrowse link
'de novo' pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase involved_in ISO
IEA 		RGD
TreeGrafter
InterPro		 PMID:1476792 GO_REF:0000002 GO_REF:0000118 RGD:5132591 NCBI chrNW_004624738:9,318,213...9,340,765
Ensembl chrNW_004624738:9,318,232...9,340,925 		JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624859:5,452,694...5,495,840 JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624765:5,527,029...5,652,343
Ensembl chrNW_004624765:5,528,112...5,651,415 		JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) involved_in ISO
IEA 		RGD
TreeGrafter
InterPro		 PMID:1476792 GO_REF:0000002 GO_REF:0000118 RGD:5132591 NCBI chrNW_004624746:14,254,811...14,268,034
Ensembl chrNW_004624746:14,254,193...14,268,034 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO (PMID:23429704) CACAO PMID:23429704 NCBI chrNW_004624818:1,570,155...1,698,264
Ensembl chrNW_004624818:1,570,276...1,698,259 		JBrowse link
G Umps uridine monophosphate synthetase involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624731:761,235...780,355
Ensembl chrNW_004624731:761,210...779,321 		JBrowse link
cytosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen-activated protein kinase 1 acts_upstream_of_or_within ISO (PMID:15284227) MGI PMID:15284227 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 acts_upstream_of_or_within ISO (PMID:21803851) MGI PMID:21803851 NCBI chrNW_004624830:3,446,331...3,543,450
Ensembl chrNW_004624830:3,446,141...3,519,084 		JBrowse link
pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctps1 CTP synthase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624892:376,800...421,850 JBrowse link
G Ctps2 CTP synthase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624829:1,373,568...1,438,052
Ensembl chrNW_004624829:1,386,544...1,438,052 		JBrowse link
G Umps uridine monophosphate synthetase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:761,235...780,355
Ensembl chrNW_004624731:761,210...779,321 		JBrowse link
pyrimidine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpys dihydropyrimidinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624763:20,618,515...20,680,790
Ensembl chrNW_004624763:20,620,380...20,680,782 		JBrowse link
thymine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh6a1 aldehyde dehydrogenase 6 family member A1 involved_in ISO
IEA 		RGD
TreeGrafter		 PMID:2768248 GO_REF:0000118 RGD:1599052 NCBI chrNW_004624734:27,499,376...27,525,783
Ensembl chrNW_004624734:27,499,411...27,524,419 		JBrowse link
G Dpys dihydropyrimidinase involved_in ISO PMID:8307005 UniProt PMID:8307005 RGD:1624990 NCBI chrNW_004624763:20,618,515...20,680,790
Ensembl chrNW_004624763:20,620,380...20,680,782 		JBrowse link
G LOC101704452 dihydropyrimidine dehydrogenase [NADP(+)] involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624742:55,080...487,196 JBrowse link
G LOC106007540 dihydropyrimidine dehydrogenase [NADP(+)] involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624857:91,463...516,091 JBrowse link
thymine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh6a1 aldehyde dehydrogenase 6 family member A1 involved_in ISO PMID:2768248 UniProt PMID:2768248 RGD:1599052 NCBI chrNW_004624734:27,499,376...27,525,783
Ensembl chrNW_004624734:27,499,411...27,524,419 		JBrowse link
uracil catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpys dihydropyrimidinase involved_in ISO (PMID:10410956)
PMID:8307005
(PMID:18075467) 		UniProt PMID:8307005 PMID:10410956 PMID:18075467 RGD:1624990 NCBI chrNW_004624763:20,618,515...20,680,790
Ensembl chrNW_004624763:20,620,380...20,680,782 		JBrowse link
G LOC101704452 dihydropyrimidine dehydrogenase [NADP(+)] involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624742:55,080...487,196 JBrowse link
G LOC106007540 dihydropyrimidine dehydrogenase [NADP(+)] involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624857:91,463...516,091 JBrowse link
uracil metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpys dihydropyrimidinase ISO RGD PMID:7626590 PMID:8307005 RGD:1624989 RGD:1624990 NCBI chrNW_004624763:20,618,515...20,680,790
Ensembl chrNW_004624763:20,620,380...20,680,782 		JBrowse link
G Tyms thymidylate synthetase ISO RGD PMID:2043679 RGD:5133426 NCBI chrNW_004624770:11,138,673...11,149,600
Ensembl chrNW_004624770:11,138,652...11,149,600 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17647
    cellular process 17219
      metabolic process 10996
        pyrimidine-containing compound metabolic process 62
          pyrimidine nucleobase metabolic process 18
            cytosine metabolic process + 2
            negative regulation of pyrimidine nucleobase metabolic process 0
            positive regulation of pyrimidine nucleobase metabolic process 0
            pyrimidine nucleobase biosynthetic process + 8
            pyrimidine nucleobase catabolic process + 4
            regulation of pyrimidine nucleobase metabolic process + 0
            thymine metabolic process + 4
            uracil metabolic process + 4
Path 2
Term Annotations click to browse term
  biological_process 17647
    cellular process 17219
      metabolic process 10996
        primary metabolic process 9827
          nucleobase-containing compound metabolic process 5857
            nucleobase-containing small molecule metabolic process 608
              nucleobase metabolic process 39
                pyrimidine nucleobase metabolic process 18
                  cytosine metabolic process + 2
                  negative regulation of pyrimidine nucleobase metabolic process 0
                  positive regulation of pyrimidine nucleobase metabolic process 0
                  pyrimidine nucleobase biosynthetic process + 8
                  pyrimidine nucleobase catabolic process + 4
                  regulation of pyrimidine nucleobase metabolic process + 0
                  thymine metabolic process + 4
                  uracil metabolic process + 4
paths to the root