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ONTOLOGY REPORT - ANNOTATIONS

Term:pyrimidine nucleobase metabolic process
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Accession:GO:0006206 term browser browse the term
Definition:The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
Synonyms:exact_synonym: pyrimidine base metabolic process;   pyrimidine base metabolism
 related_synonym: pyrimidine metabolic process;   pyrimidine metabolism


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pyrimidine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RRM1 ribonucleotide reductase catalytic subunit M1 involved_in ISO
IEA 		orotic acid RGD
Ensembl		 PMID:10204803 GO_REF:0000107 RGD:5133695 NCBI chr11:4,094,685...4,138,932
Ensembl chr11:4,094,707...4,138,932 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725 		JBrowse link
G TYMP thymidine phosphorylase involved_in IEA InterPro GO_REF:0000002 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032 		JBrowse link
G TYMS thymidylate synthetase ISO 5-fluorocytosine RGD PMID:9524100 RGD:5133447 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578 		JBrowse link
'de novo' pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase involved_in ISO
IBA
IEA
ISS
IDA 		(PMID:24332717) RGD
GO_Central
Ensembl
InterPro
BHF-UCL
UniProt		 PMID:1476792 PMID:24332717 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 RGD:5132591 NCBI chr 2:27,217,369...27,243,943
Ensembl chr 2:27,217,369...27,243,943 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:47,333,790...47,378,839
Ensembl chr 1:47,333,790...47,394,866 		JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:210,477,685...210,679,107
Ensembl chr 2:210,477,682...210,679,107 		JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) involved_in ISO
IBA
IEA 		RGD
GO_Central
InterPro		 PMID:1476792 GO_REF:0000002 GO_REF:0000033 RGD:5132591 NCBI chr16:72,008,744...72,027,659
Ensembl chr16:72,008,588...72,027,664 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G UMPS uridine monophosphate synthetase involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:124,730,452...124,749,273
Ensembl chr 3:124,730,433...124,749,273 		JBrowse link
cytosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDA cytidine deaminase involved_in TAS (PMID:7923172) UniProt PMID:7923172 NCBI chr 1:20,589,097...20,618,903
Ensembl chr 1:20,589,086...20,618,903 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G TET2 tet methylcytosine dioxygenase 2 acts_upstream_of_or_within ISO (PMID:21803851) MGI PMID:21803851 NCBI chr 4:105,145,875...105,279,803
Ensembl chr 4:105,145,875...105,279,816 		JBrowse link
pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTPS1 CTP synthase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:40,979,696...41,012,565
Ensembl chr 1:40,979,300...41,012,565 		JBrowse link
G CTPS2 CTP synthase 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:16,587,999...16,712,910
Ensembl chr  X:16,587,999...16,712,936 		JBrowse link
G UMPS uridine monophosphate synthetase involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:124,730,452...124,749,273
Ensembl chr 3:124,730,433...124,749,273 		JBrowse link
pyrimidine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRMP1 collapsin response mediator protein 1 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:5,820,764...5,893,086
Ensembl chr 4:5,748,084...5,893,086 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase acts_upstream_of_or_within
involved_in 		ISO
IEA
ISS
IMP 		(PMID:11988088) RGD
Ensembl
UniProt		 PMID:1629785 PMID:11988088 GO_REF:0000024 GO_REF:0000107 RGD:1599794 NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000 		JBrowse link
G DPYS dihydropyrimidinase involved_in IDA
IBA 		(PMID:9718352) UniProt
GO_Central		 PMID:9718352 GO_REF:0000033 NCBI chr 8:104,379,431...104,467,055
Ensembl chr 8:104,330,324...104,467,055 		JBrowse link
G DPYSL2 dihydropyrimidinase like 2 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178 		JBrowse link
G DPYSL3 dihydropyrimidinase like 3 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:147,390,808...147,510,068
Ensembl chr 5:147,390,808...147,510,068 		JBrowse link
G DPYSL4 dihydropyrimidinase like 4 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:132,186,948...132,205,759
Ensembl chr10:132,186,948...132,205,759 		JBrowse link
G DPYSL5 dihydropyrimidinase like 5 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:26,847,995...26,950,351
Ensembl chr 2:26,847,747...26,950,351 		JBrowse link
thymine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 involved_in ISO
IBA
IMP 		(PMID:23835272) RGD
GO_Central
BHF-UCL		 PMID:2768248 PMID:23835272 GO_REF:0000033 RGD:1599052 NCBI chr14:74,056,847...74,084,453
Ensembl chr14:74,056,847...74,084,492 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase involved_in IDA
IBA 		(PMID:10410956) UniProt
GO_Central		 PMID:10410956 GO_REF:0000033 NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000 		JBrowse link
G DPYS dihydropyrimidinase involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:104,379,431...104,467,055
Ensembl chr 8:104,330,324...104,467,055 		JBrowse link
thymine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 involved_in ISS UniProt GO_REF:0000024 NCBI chr14:74,056,847...74,084,453
Ensembl chr14:74,056,847...74,084,492 		JBrowse link
uracil catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase involved_in IDA
IBA 		(PMID:1512248), (PMID:18075467) UniProt
GO_Central		 PMID:1512248 PMID:18075467 GO_REF:0000033 NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000 		JBrowse link
G DPYS dihydropyrimidinase involved_in IMP
IDA 		(PMID:18075467)
(PMID:10410956) 		UniProt PMID:10410956 PMID:18075467 NCBI chr 8:104,379,431...104,467,055
Ensembl chr 8:104,330,324...104,467,055 		JBrowse link
uracil metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase ISO RGD PMID:7626590 RGD:1624989 NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000 		JBrowse link
G DPYS dihydropyrimidinase ISO RGD PMID:7626590 PMID:8307005 RGD:1624989 RGD:1624990 NCBI chr 8:104,379,431...104,467,055
Ensembl chr 8:104,330,324...104,467,055 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:2043679 RGD:5133426 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27207
    cellular process 19782
      metabolic process 13524
        pyrimidine-containing compound metabolic process 84
          pyrimidine nucleobase metabolic process 23
            cytosine metabolic process + 3
            negative regulation of pyrimidine nucleobase metabolic process 0
            positive regulation of pyrimidine nucleobase metabolic process 0
            pyrimidine nucleobase biosynthetic process + 8
            pyrimidine nucleobase catabolic process + 8
            regulation of pyrimidine nucleobase metabolic process + 0
            thymine metabolic process + 3
            uracil metabolic process + 3
Path 2
Term Annotations click to browse term
  biological_process 27207
    cellular process 19782
      metabolic process 13524
        primary metabolic process 11719
          nucleobase-containing compound metabolic process 7285
            nucleobase-containing small molecule metabolic process 754
              nucleobase metabolic process 45
                pyrimidine nucleobase metabolic process 23
                  cytosine metabolic process + 3
                  negative regulation of pyrimidine nucleobase metabolic process 0
                  positive regulation of pyrimidine nucleobase metabolic process 0
                  pyrimidine nucleobase biosynthetic process + 8
                  pyrimidine nucleobase catabolic process + 8
                  regulation of pyrimidine nucleobase metabolic process + 0
                  thymine metabolic process + 3
                  uracil metabolic process + 3
paths to the root