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ONTOLOGY REPORT - ANNOTATIONS

Term:pyrimidine nucleobase metabolic process
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Accession:GO:0006206 term browser browse the term
Definition:The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
Synonyms:exact_synonym: pyrimidine base metabolic process;   pyrimidine base metabolism
 related_synonym: pyrimidine metabolic process;   pyrimidine metabolism


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pyrimidine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr21:26,595,838...26,631,476
Ensembl chr21:26,595,914...26,631,135 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr17:7,106,515...7,113,868
Ensembl chr17:7,104,961...7,122,939 		JBrowse link
G TYMS thymidylate synthetase ISO 5-fluorocytosine RGD PMID:9524100 RGD:5133447 NCBI chr 7:67,487,927...67,497,747
Ensembl chr 7:67,487,927...67,497,747 		JBrowse link
'de novo' pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase involved_in ISO
IBA
IEA 		RGD
GO_Central
Ensembl
InterPro		 PMID:1476792 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:5132591 NCBI chr17:21,198,839...21,221,897
Ensembl chr17:21,197,826...21,221,635 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr15:13,324,235...13,357,387
Ensembl chr15:13,326,185...13,358,152 		JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697 		JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) involved_in ISO
IBA
IEA 		RGD
GO_Central
InterPro		 PMID:1476792 GO_REF:0000002 GO_REF:0000033 RGD:5132591 NCBI chr 5:77,756,411...77,766,207
Ensembl chr 5:77,756,407...77,774,090 		JBrowse link
G LOC479668 haptoglobin-like involved_in IEA
IBA 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:77,795,183...77,800,034 JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114 		JBrowse link
G TRIM54 tripartite motif containing 54 involved_in IEA InterPro GO_REF:0000002 NCBI chr17:21,257,660...21,278,410
Ensembl chr17:21,257,706...21,278,274 		JBrowse link
G UMPS uridine monophosphate synthetase involved_in IEA InterPro GO_REF:0000002 NCBI chr33:27,754,592...27,782,517
Ensembl chr33:27,754,643...27,782,514 		JBrowse link
cytosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G TET2 tet methylcytosine dioxygenase 2 acts_upstream_of_or_within ISO (PMID:21803851) MGI PMID:21803851 NCBI chr32:26,021,745...26,145,109
Ensembl chr32:26,059,693...26,143,536 		JBrowse link
pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTPS1 CTP synthase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:2,067,767...2,093,014
Ensembl chr15:2,067,763...2,093,014 		JBrowse link
G CTPS2 CTP synthase 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:12,759,998...12,867,707
Ensembl chr  X:12,760,015...12,865,111 		JBrowse link
G UMPS uridine monophosphate synthetase involved_in IBA GO_Central GO_REF:0000033 NCBI chr33:27,754,592...27,782,517
Ensembl chr33:27,754,643...27,782,514 		JBrowse link
pyrimidine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRMP1 collapsin response mediator protein 1 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:71,009,382...71,077,814
Ensembl chr 3:71,010,299...71,082,216 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase acts_upstream_of_or_within
involved_in 		ISO
IEA 		RGD
Ensembl		 PMID:1629785 GO_REF:0000107 RGD:1599794 NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923 		JBrowse link
G DPYS dihydropyrimidinase involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:5,583,795...5,659,355
Ensembl chr13:5,583,801...5,659,463 		JBrowse link
G DPYSL2 dihydropyrimidinase like 2 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr25:30,900,347...31,038,256
Ensembl chr25:30,903,253...31,038,144 		JBrowse link
G DPYSL3 dihydropyrimidinase like 3 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:41,687,725...41,809,402
Ensembl chr 2:41,690,845...41,802,376 		JBrowse link
G DPYSL4 dihydropyrimidinase like 4 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr28:40,171,461...40,185,910
Ensembl chr28:40,171,239...40,185,481 		JBrowse link
G DPYSL5 dihydropyrimidinase like 5 NOT|involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:20,852,000...20,948,841
Ensembl chr17:20,895,134...20,946,055 		JBrowse link
thymine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 involved_in ISO
IBA
IEA 		RGD
GO_Central
Ensembl		 PMID:2768248 GO_REF:0000033 GO_REF:0000107 RGD:1599052 NCBI chr 8:47,280,872...47,304,460
Ensembl chr 8:47,282,235...47,304,283 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923 		JBrowse link
G DPYS dihydropyrimidinase involved_in ISO PMID:8307005 UniProt PMID:8307005 RGD:1624990 NCBI chr13:5,583,795...5,659,355
Ensembl chr13:5,583,801...5,659,463 		JBrowse link
thymine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 involved_in ISO PMID:2768248 UniProt PMID:2768248 RGD:1599052 NCBI chr 8:47,280,872...47,304,460
Ensembl chr 8:47,282,235...47,304,283 		JBrowse link
uracil catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923 		JBrowse link
G DPYS dihydropyrimidinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:5,583,795...5,659,355
Ensembl chr13:5,583,801...5,659,463 		JBrowse link
uracil metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase ISO RGD PMID:7626590 RGD:1624989 NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923 		JBrowse link
G DPYS dihydropyrimidinase ISO RGD PMID:7626590 PMID:8307005 RGD:1624989 RGD:1624990 NCBI chr13:5,583,795...5,659,355
Ensembl chr13:5,583,801...5,659,463 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:2043679 RGD:5133426 NCBI chr 7:67,487,927...67,497,747
Ensembl chr 7:67,487,927...67,497,747 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22130
    cellular process 21660
      metabolic process 15378
        pyrimidine-containing compound metabolic process 70
          pyrimidine nucleobase metabolic process 23
            cytosine metabolic process + 2
            negative regulation of pyrimidine nucleobase metabolic process 0
            positive regulation of pyrimidine nucleobase metabolic process 0
            pyrimidine nucleobase biosynthetic process + 10
            pyrimidine nucleobase catabolic process + 8
            regulation of pyrimidine nucleobase metabolic process + 0
            thymine metabolic process + 3
            uracil metabolic process + 3
Path 2
Term Annotations click to browse term
  biological_process 22130
    cellular process 21660
      metabolic process 15378
        primary metabolic process 13957
          nucleobase-containing compound metabolic process 9612
            nucleobase-containing small molecule metabolic process 706
              nucleobase metabolic process 44
                pyrimidine nucleobase metabolic process 23
                  cytosine metabolic process + 2
                  negative regulation of pyrimidine nucleobase metabolic process 0
                  positive regulation of pyrimidine nucleobase metabolic process 0
                  pyrimidine nucleobase biosynthetic process + 10
                  pyrimidine nucleobase catabolic process + 8
                  regulation of pyrimidine nucleobase metabolic process + 0
                  thymine metabolic process + 3
                  uracil metabolic process + 3
paths to the root