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ONTOLOGY REPORT - ANNOTATIONS

Term:pyrimidine nucleobase metabolic process
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Accession:GO:0006206 term browser browse the term
Definition:The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
Synonyms:exact_synonym: pyrimidine base metabolic process;   pyrimidine base metabolism
 related_synonym: pyrimidine metabolic process;   pyrimidine metabolism


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pyrimidine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr11:3,956,528...3,999,205
Ensembl chr11:4,068,119...4,110,474 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr2A:10,119,508...10,128,318
Ensembl chr2A:10,275,598...10,284,640 		JBrowse link
G TYMS thymidylate synthetase ISO 5-fluorocytosine RGD PMID:9524100 RGD:5133447 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320 		JBrowse link
'de novo' pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase involved_in ISO
IEA 		RGD
TreeGrafter
Ensembl
InterPro		 PMID:1476792 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:5132591 NCBI chr2A:27,218,699...27,245,156
Ensembl chr2A:27,306,527...27,332,804 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:46,642,602...46,673,568 JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr2B:97,735,486...97,936,623
Ensembl chr2B:216,136,857...216,337,728 		JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) involved_in ISO
IEA 		RGD
TreeGrafter
InterPro		 PMID:1476792 GO_REF:0000002 GO_REF:0000118 RGD:5132591 NCBI chr16:52,977,879...52,994,496
Ensembl chr16:71,854,238...71,870,673 		JBrowse link
G LOC100977684 UMP-CMP kinase involved_in IEA InterPro GO_REF:0000002 NCBI chr19:31,871,009...31,873,992 JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841 		JBrowse link
G UMPS uridine monophosphate synthetase involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:121,832,758...121,851,707
Ensembl chr 3:128,731,355...128,745,029 		JBrowse link
cytosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335 		JBrowse link
G TET2 tet methylcytosine dioxygenase 2 acts_upstream_of_or_within ISO (PMID:21803851) MGI PMID:21803851 NCBI chr 4:97,612,439...97,745,544
Ensembl chr 4:108,269,082...108,358,400 		JBrowse link
pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTPS1 CTP synthase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:40,275,581...40,308,421
Ensembl chr 1:41,592,509...41,624,455 		JBrowse link
G CTPS2 CTP synthase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:9,209,727...9,332,641
Ensembl chr  X:16,579,409...16,693,184 		JBrowse link
G UMPS uridine monophosphate synthetase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:121,832,758...121,851,707
Ensembl chr 3:128,731,355...128,745,029 		JBrowse link
pyrimidine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase involved_in
acts_upstream_of_or_within 		ISO
IEA 		RGD
Ensembl		 PMID:1629785 GO_REF:0000107 RGD:1599794 NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100 		JBrowse link
G DPYS dihydropyrimidinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:101,008,090...101,096,234
Ensembl chr 8:103,160,922...103,248,303 		JBrowse link
thymine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 involved_in ISO
IEA 		RGD
TreeGrafter
Ensembl		 PMID:2768248 GO_REF:0000107 GO_REF:0000118 RGD:1599052 NCBI chr14:54,616,531...54,643,346
Ensembl chr14:73,472,255...73,495,734 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100 		JBrowse link
G DPYS dihydropyrimidinase involved_in ISO PMID:8307005 UniProt PMID:8307005 RGD:1624990 NCBI chr 8:101,008,090...101,096,234
Ensembl chr 8:103,160,922...103,248,303 		JBrowse link
thymine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 involved_in ISO PMID:2768248 UniProt PMID:2768248 RGD:1599052 NCBI chr14:54,616,531...54,643,346
Ensembl chr14:73,472,255...73,495,734 		JBrowse link
uracil catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100 		JBrowse link
G DPYS dihydropyrimidinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:101,008,090...101,096,234
Ensembl chr 8:103,160,922...103,248,303 		JBrowse link
uracil metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase ISO RGD PMID:7626590 RGD:1624989 NCBI chr 1:99,736,145...100,576,663
Ensembl chr 1:98,457,934...99,300,100 		JBrowse link
G DPYS dihydropyrimidinase ISO RGD PMID:7626590 PMID:8307005 RGD:1624989 RGD:1624990 NCBI chr 8:101,008,090...101,096,234
Ensembl chr 8:103,160,922...103,248,303 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:2043679 RGD:5133426 NCBI chr18:13,653,085...13,668,478
Ensembl chr18:17,295,182...17,310,320 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18868
      metabolic process 12795
        pyrimidine-containing compound metabolic process 65
          pyrimidine nucleobase metabolic process 17
            cytosine metabolic process + 2
            negative regulation of pyrimidine nucleobase metabolic process 0
            positive regulation of pyrimidine nucleobase metabolic process 0
            pyrimidine nucleobase biosynthetic process + 9
            pyrimidine nucleobase catabolic process + 3
            regulation of pyrimidine nucleobase metabolic process + 0
            thymine metabolic process + 3
            uracil metabolic process + 3
Path 2
Term Annotations click to browse term
  biological_process 19315
    cellular process 18868
      metabolic process 12795
        primary metabolic process 11190
          nucleobase-containing compound metabolic process 7097
            nucleobase-containing small molecule metabolic process 630
              nucleobase metabolic process 36
                pyrimidine nucleobase metabolic process 17
                  cytosine metabolic process + 2
                  negative regulation of pyrimidine nucleobase metabolic process 0
                  positive regulation of pyrimidine nucleobase metabolic process 0
                  pyrimidine nucleobase biosynthetic process + 9
                  pyrimidine nucleobase catabolic process + 3
                  regulation of pyrimidine nucleobase metabolic process + 0
                  thymine metabolic process + 3
                  uracil metabolic process + 3
paths to the root