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ONTOLOGY REPORT - ANNOTATIONS

Term:pyrimidine nucleobase metabolic process
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Accession:GO:0006206 term browser browse the term
Definition:The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
Synonyms:exact_synonym: pyrimidine base metabolic process;   pyrimidine base metabolism
 related_synonym: pyrimidine metabolic process;   pyrimidine metabolism


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pyrimidine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rrm1 ribonucleotide reductase catalytic subunit M1 IEP orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:156,823,960...156,848,261 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 IEP orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Tymp thymidine phosphorylase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Tyms thymidylate synthetase IEP 5-fluorocytosine RGD PMID:9524100 RGD:5133447 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
'de novo' pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase involved_in IDA
IBA
ISO		 GO_REF:0000033
(PMID:24332717)		 GO_Central
RGD		 PMID:24332717 PMID:1476792 GO_REF:0000033, RGD:5132591 NCBI chr 6:31,012,091...31,035,098
Ensembl chr 6:25,292,133...25,319,861 		JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:133,717,073...133,744,623
Ensembl chr 5:128,480,301...128,507,830 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:68,614,153...68,737,033 		JBrowse link
G Dhodh dihydroorotate dehydrogenase involved_in IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro
RGD		 PMID:1476792 GO_REF:0000002 GO_REF:0000033, RGD:5132591 NCBI chr19:54,460,636...54,483,049
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IEA
ISO		 GO_REF:0000107
(PMID:23429704)		 Ensembl
RGD		 PMID:23429704 GO_REF:0000107 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Umps uridine monophosphate synthetase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:80,311,269...80,321,678
Ensembl chr11:66,806,045...66,821,903 		JBrowse link
cytosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:15284227)		 Ensembl
RGD		 PMID:15284227 GO_REF:0000107 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 acts_upstream_of_or_within ISO MGI:5301343 (PMID:21803851) RGD PMID:21803851 NCBI chr 2:224,662,654...224,746,819
Ensembl chr 2:221,988,645...222,072,534 		JBrowse link
pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctps1 CTP synthase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:139,372,349...139,440,441
Ensembl chr 5:134,125,025...134,154,180 		JBrowse link
G Ctps2 CTP synthase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:35,277,658...35,418,505
Ensembl chr  X:31,645,873...31,786,733 		JBrowse link
pyrimidine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crmp1 collapsin response mediator protein 1 NOT|involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:77,734,675...77,780,916
Ensembl chr14:73,509,933...73,556,177 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase acts_upstream_of_or_within
involved_in		 IDA
ISO		 (PMID:12651209)
(PMID:11988088)		 RGD PMID:11988088 PMID:12651209 PMID:1629785 RGD:1599794 NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Dpys dihydropyrimidinase involved_in ISO
IBA		 (PMID:9718352)
GO_REF:0000033		 RGD
GO_Central		 PMID:9718352 GO_REF:0000033 NCBI chr 7:72,707,566...72,814,183
Ensembl chr 7:70,835,789...70,929,231 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 NOT|involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:45,181,041...45,287,065
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 NOT|involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,377,181...35,480,157 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 NOT|involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:193,883,106...193,898,914 		JBrowse link
G Dpysl5 dihydropyrimidinase-like 5 NOT|involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:31,295,035...31,379,348
Ensembl chr 6:25,575,104...25,659,422 		JBrowse link
thymine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 involved_in IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:23835272)		 GO_Central
Ensembl
RGD		 PMID:23835272 PMID:2768248 GO_REF:0000033 GO_REF:0000107, RGD:1599052 NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:104,077,979...104,098,656 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase involved_in ISO
IBA
IEA		 (PMID:10410956)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:10410956 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Dpys dihydropyrimidinase involved_in IDA PMID:8307005 UniProt PMID:8307005 RGD:1624990 NCBI chr 7:72,707,566...72,814,183
Ensembl chr 7:70,835,789...70,929,231 		JBrowse link
thymine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 involved_in IDA PMID:2768248 UniProt PMID:2768248 RGD:1599052 NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:104,077,979...104,098,656 		JBrowse link
uracil catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpyd dihydropyrimidine dehydrogenase involved_in ISO
IBA
ISS
IEA		 (PMID:1512248), (PMID:18075467)
GO_REF:0000033
GO_REF:0000024
GO_REF:0000107		 RGD
GO_Central
UniProt
Ensembl		 PMID:1512248 PMID:18075467 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Dpys dihydropyrimidinase involved_in ISO
IEA
IDA		 (PMID:10410956), (PMID:18075467)
GO_REF:0000107
PMID:8307005		 RGD
Ensembl		 PMID:10410956 PMID:18075467 PMID:8307005 GO_REF:0000107, RGD:1624990 NCBI chr 7:72,707,566...72,814,183
Ensembl chr 7:70,835,789...70,929,231 		JBrowse link
uracil metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpyd dihydropyrimidine dehydrogenase IDA RGD PMID:7626590 RGD:1624989 NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Dpys dihydropyrimidinase IDA RGD PMID:7626590 PMID:8307005 RGD:1624989, RGD:1624990 NCBI chr 7:72,707,566...72,814,183
Ensembl chr 7:70,835,789...70,929,231 		JBrowse link
G Tyms thymidylate synthetase IEP RGD PMID:2043679 RGD:5133426 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      metabolic process 12171
        pyrimidine-containing compound metabolic process 73
          pyrimidine nucleobase metabolic process 22
            cytosine metabolic process + 2
            negative regulation of pyrimidine nucleobase metabolic process 0
            positive regulation of pyrimidine nucleobase metabolic process 0
            pyrimidine nucleobase biosynthetic process + 8
            pyrimidine nucleobase catabolic process + 8
            regulation of pyrimidine nucleobase metabolic process + 0
            thymine metabolic process + 3
            uracil metabolic process + 3
Path 2
Term Annotations click to browse term
  biological_process 20546
    cellular process 19536
      metabolic process 12171
        primary metabolic process 10746
          nucleobase-containing compound metabolic process 5951
            nucleobase-containing small molecule metabolic process 731
              nucleobase metabolic process 45
                pyrimidine nucleobase metabolic process 22
                  cytosine metabolic process + 2
                  negative regulation of pyrimidine nucleobase metabolic process 0
                  positive regulation of pyrimidine nucleobase metabolic process 0
                  pyrimidine nucleobase biosynthetic process + 8
                  pyrimidine nucleobase catabolic process + 8
                  regulation of pyrimidine nucleobase metabolic process + 0
                  thymine metabolic process + 3
                  uracil metabolic process + 3
paths to the root