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ONTOLOGY REPORT - ANNOTATIONS

Term:purine nucleobase metabolic process
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Accession:GO:0006144 term browser browse the term
Definition:The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
Synonyms:exact_synonym: purine base metabolic process;   purine base metabolism
 narrow_synonym: purine metabolic process;   purine metabolism


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purine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:18940592)		 Ensembl
RGD		 PMID:18940592 GO_REF:0000107 NCBI chr 8:113,784,372...113,833,033
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Adk adenosine kinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,863,244...3,246,510 		JBrowse link
G Gmpr guanosine monophosphate reductase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:19,357,992...19,395,807
Ensembl chr17:19,151,815...19,189,621 		JBrowse link
G Gmpr2 guanosine monophosphate reductase 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:33,135,455...33,144,923
Ensembl chr15:29,165,783...29,174,935 		JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 involved_in ISO (PMID:8253776) RGD PMID:8253776 NCBI chr  X:108,920,663...108,942,713
Ensembl chr  X:104,132,141...104,154,187 		JBrowse link
G Ttr transthyretin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:12,216,684...12,225,972
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Uox urate oxidase involved_in IEA GO_REF:0000043
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr 2:238,147,130...238,183,320
Ensembl chr 2:235,440,619...235,523,029 		JBrowse link
G Urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr12:12,745,388...12,755,034
Ensembl chr12:7,709,312...7,718,923 		JBrowse link
G Urah urate (5-hydroxyiso-) hydrolase involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000002
GO_REF:0000043		 GO_Central
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 NCBI chr 1:205,335,399...205,338,795
Ensembl chr 1:195,905,763...195,909,159 		JBrowse link
adenine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:44,351,841...44,377,086
Ensembl chr11:30,865,889...30,891,125 		JBrowse link
adenine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ak1 adenylate kinase 1 NAS RGD PMID:8468325 RGD:5490217 NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:15,912,485...15,923,041 		JBrowse link
G Ak2 adenylate kinase 2 TAS RGD PMID:8468325 RGD:5490217 NCBI chr 5:146,609,469...146,649,008
Ensembl chr 5:141,346,063...141,364,632 		JBrowse link
G Aprt adenine phosphoribosyl transferase acts_upstream_of_or_within ISO MGI:1857278|MGI:96217 (PMID:8643571), (PMID:8894695) RGD PMID:8643571 PMID:8894695 NCBI chr19:67,534,737...67,537,027
Ensembl chr19:50,626,202...50,628,431 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 acts_upstream_of_or_within ISO
IEA		 MGI:88061 (PMID:8894695)
GO_REF:0000107		 RGD
Ensembl		 PMID:8894695 GO_REF:0000107 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
adenine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aprt adenine phosphoribosyl transferase involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr19:67,534,737...67,537,027
Ensembl chr19:50,626,202...50,628,431 		JBrowse link
GMP catabolic process to guanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nt5c2 5'-nucleotidase, cytosolic II involved_in ISO
IEA		 (PMID:5560407)
GO_REF:0000107		 RGD
Ensembl		 PMID:5560407 GO_REF:0000107 NCBI chr 1:255,712,797...255,838,285
Ensembl chr 1:245,772,277...245,897,913 		JBrowse link
guanine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gda guanine deaminase involved_in IEA
ISO		 GO_REF:0000041
GO_REF:0000002
GO_REF:0000104
(PMID:8064675)		 UniProt
InterPro
RGD		 PMID:8064675 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:218,906,815...218,982,416 		JBrowse link
G Uox urate oxidase involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:238,147,130...238,183,320
Ensembl chr 2:235,440,619...235,523,029 		JBrowse link
G Urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in ISO (PMID:16462750) RGD PMID:16462750 NCBI chr12:12,745,388...12,755,034
Ensembl chr12:7,709,312...7,718,923 		JBrowse link
G Urah urate (5-hydroxyiso-) hydrolase involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:205,335,399...205,338,795
Ensembl chr 1:195,905,763...195,909,159 		JBrowse link
G Xdh xanthine dehydrogenase involved_in IEA
ISO
IDA		 GO_REF:0000107
(PMID:1590774)
PMID:3443108		 Ensembl
RGD		 PMID:1590774 PMID:3443108 GO_REF:0000107, RGD:42721989 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
guanine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gda guanine deaminase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:218,906,815...218,982,416 		JBrowse link
G Kdm1a lysine demethylase 1A IMP RGD PMID:20418916 RGD:9588315 NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
guanine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hprt1 hypoxanthine phosphoribosyltransferase 1 involved_in ISO
IBA
IEA
ISS		 (PMID:19527031)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:19527031 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Prtfdc1 phosphoribosyl transferase domain containing 1 NOT|involved_in ISO (PMID:21054786) RGD PMID:21054786 NCBI chr17:88,457,872...88,563,109
Ensembl chr17:83,548,803...83,655,179 		JBrowse link
hypoxanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO
IEA		 MGI:1857117|MGI:2683027 (PMID:10720488)
GO_REF:0000107		 RGD
Ensembl		 PMID:10720488 GO_REF:0000107 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 involved_in ISO (PMID:17701896) RGD PMID:17701896 NCBI chr  X:108,920,663...108,942,713
Ensembl chr  X:104,132,141...104,154,187 		JBrowse link
hypoxanthine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Uox urate oxidase involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:238,147,130...238,183,320
Ensembl chr 2:235,440,619...235,523,029 		JBrowse link
G Urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in ISO (PMID:16462750) RGD PMID:16462750 NCBI chr12:12,745,388...12,755,034
Ensembl chr12:7,709,312...7,718,923 		JBrowse link
G Urah urate (5-hydroxyiso-) hydrolase involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:205,335,399...205,338,795
Ensembl chr 1:195,905,763...195,909,159 		JBrowse link
G Xdh xanthine dehydrogenase involved_in IDA
ISO
IEA		 (PMID:1590774), (PMID:30936145)
PMID:3443108
GO_REF:0000107
(PMID:1619276)		 RGD
Ensembl		 PMID:1590774 PMID:1619276 PMID:30936145 PMID:232638 PMID:3443108 GO_REF:0000107, RGD:13210503, RGD:42721989 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
hypoxanthine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hprt1 hypoxanthine phosphoribosyltransferase 1 acts_upstream_of_or_within
involved_in		 IDA
IEA
ISO
IBA		 GO_REF:0000107
MGI:1857297|MGI:1857299 (PMID:10037486), (PMID:3029599)
GO_REF:0000033
(PMID:9824441)		 Ensembl
RGD
GO_Central		 PMID:3029599 PMID:9824441 PMID:10037486 PMID:6206848 GO_REF:0000033 GO_REF:0000107, RGD:1580844 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
hypoxanthine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 involved_in ISO
IEA
ISS		 (PMID:19527031)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:19527031 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
purine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase involved_in IEA GO_REF:0000104
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr11:44,351,841...44,377,086
Ensembl chr11:30,865,889...30,891,125 		JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase involved_in ISS
ISO		 GO_REF:0000024
(PMID:31600779)		 UniProt
RGD		 PMID:31600779 GO_REF:0000024 NCBI chr14:31,553,355...31,586,843
Ensembl chr14:31,173,541...31,232,635 		JBrowse link
G Ppat phosphoribosyl pyrophosphate amidotransferase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:31,570,010...31,604,410
Ensembl chr14:31,216,165...31,250,144 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 involved_in ISO (PMID:11516159) RGD PMID:11516159 NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
purine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpyd dihydropyrimidine dehydrogenase involved_in ISO
IEA		 (PMID:11988088)
GO_REF:0000107		 RGD
Ensembl		 PMID:11988088 GO_REF:0000107 NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Uox urate oxidase involved_in TAS
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:3182808 GO_REF:0000033, RGD:730101 NCBI chr 2:238,147,130...238,183,320
Ensembl chr 2:235,440,619...235,523,029 		JBrowse link
xanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO
IEA		 MGI:1857117|MGI:2683027 (PMID:10720488)
GO_REF:0000107		 RGD
Ensembl		 PMID:10720488 GO_REF:0000107 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
xanthine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Uox urate oxidase involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:238,147,130...238,183,320
Ensembl chr 2:235,440,619...235,523,029 		JBrowse link
G Urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in ISO (PMID:16462750) RGD PMID:16462750 NCBI chr12:12,745,388...12,755,034
Ensembl chr12:7,709,312...7,718,923 		JBrowse link
G Urah urate (5-hydroxyiso-) hydrolase involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:205,335,399...205,338,795
Ensembl chr 1:195,905,763...195,909,159 		JBrowse link
G Xdh xanthine dehydrogenase involved_in ISO
IBA
IDA
ISS
IEA		 (PMID:17301077), (PMID:8670112)
(PMID:1590774)
GO_REF:0000033
PMID:3443108
PMID:15878860
GO_REF:0000024
GO_REF:0000107		 RGD
GO_Central
UniProt
Ensembl		 PMID:1590774 PMID:8670112 PMID:17301077 PMID:3443108 PMID:15878860 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:42721989, RGD:8553512 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        purine-containing compound metabolic process 610
          purine nucleobase metabolic process 24
            adenine metabolic process + 5
            guanine metabolic process + 9
            hypoxanthine metabolic process + 7
            negative regulation of purine nucleobase metabolic process 0
            positive regulation of purine nucleobase metabolic process 0
            purine nucleobase biosynthetic process + 9
            purine nucleobase catabolic process + 6
            regulation of purine nucleobase metabolic process + 0
            xanthine metabolic process + 5
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        primary metabolic process 10745
          nucleobase-containing compound metabolic process 5888
            nucleobase-containing small molecule metabolic process 723
              nucleobase metabolic process 45
                purine nucleobase metabolic process 24
                  adenine metabolic process + 5
                  guanine metabolic process + 9
                  hypoxanthine metabolic process + 7
                  negative regulation of purine nucleobase metabolic process 0
                  positive regulation of purine nucleobase metabolic process 0
                  purine nucleobase biosynthetic process + 9
                  purine nucleobase catabolic process + 6
                  regulation of purine nucleobase metabolic process + 0
                  xanthine metabolic process + 5
paths to the root