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ONTOLOGY REPORT - ANNOTATIONS

Term:lactate metabolic process
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Accession:GO:0006089 term browser browse the term
Definition:The chemical reactions and pathways involving lactate, the anion of lactic acid.
Synonyms:exact_synonym: 2-hydroxypropanoate metabolic process;   2-hydroxypropanoate metabolism;   alpha-hydroxypropionate metabolic process;   alpha-hydroxypropionate metabolism;   lactate metabolism


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lactate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC098459.1 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 Ensembl chr 6:75,727,440...75,728,627 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2386679 (PMID:15328538)		 Ensembl
RGD		 PMID:15328538 GO_REF:0000107 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Ldha lactate dehydrogenase A involved_in IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:24816116), (PMID:34381247)
GO_REF:0000117		 GO_Central
RGD
UniProt		 PMID:24816116 PMID:34381247 PMID:17447164 PMID:6849973 GO_REF:0000033 GO_REF:0000117, RGD:1624966, RGD:1600284 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldhal1 lactate dehydrogenase A like 1 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 8:30,363,220...30,364,836 JBrowse link
G Ldhal6b lactate dehydrogenase A-like 6B involved_in ISO (PMID:18351441) RGD PMID:18351441 NCBI chr 1:45,997,845...45,999,268
Ensembl chr 1:45,991,991...45,999,272 		JBrowse link
G Ldhb lactate dehydrogenase B involved_in IDA
IBA
ISO		 GO_REF:0000033
(PMID:15117937)		 GO_Central
RGD		 PMID:15117937 PMID:17447164 GO_REF:0000033, RGD:1624966 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Ldhc lactate dehydrogenase C acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:18367675)
GO_REF:0000033		 RGD
GO_Central		 PMID:18367675 GO_REF:0000033 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
G Mrs2 magnesium transporter MRS2 IMP RGD PMID:21253565 RGD:12793070 NCBI chr17:40,063,924...40,087,073
Ensembl chr17:40,063,962...40,081,887 		JBrowse link
G Mtch2 mitochondrial carrier 2 acts_upstream_of_or_within ISO MGI:2449949|MGI:5566664 (PMID:26219591) RGD PMID:26219591 NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189 		JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 IDA RGD PMID:16980436 RGD:2304071 NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699 		JBrowse link
G Slc37a4 solute carrier family 37 member 4 acts_upstream_of_or_within ISO MGI:3046091 (PMID:16891306) RGD PMID:16891306 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301 		JBrowse link
glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldha lactate dehydrogenase A acts_upstream_of_or_within ISO MGI:2384559 (PMID:8224816) RGD PMID:8224816 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of ISO (PMID:20935145) RGD PMID:20935145 NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:20935145)		 Ensembl
RGD		 PMID:20935145 GO_REF:0000107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
lactate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gatd1 glutamine amidotransferase class 1 domain containing 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:196,504,533...196,512,561
Ensembl chr 1:196,504,833...196,512,551 		JBrowse link
G Ins2 insulin 2 involved_in ISO (PMID:8069456) RGD PMID:8069456 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO (PMID:22523093) RGD PMID:22523093 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Per2 period circadian regulator 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23977055)		 UniProt
RGD		 PMID:23977055 GO_REF:0000024 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
lactate biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htt huntingtin acts_upstream_of_or_within ISO (PMID:17708681) RGD PMID:17708681 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Ldhc lactate dehydrogenase C acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:18367675)
GO_REF:0000107		 RGD
Ensembl		 PMID:18367675 GO_REF:0000107 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
lactate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldhd lactate dehydrogenase D involved_in ISO
IBA		 (PMID:30931947)
GO_REF:0000033		 RGD
GO_Central		 PMID:30931947 GO_REF:0000033 NCBI chr19:39,583,529...39,588,397
Ensembl chr19:39,573,621...39,595,575 		JBrowse link
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gatd1 glutamine amidotransferase class 1 domain containing 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:196,504,533...196,512,561
Ensembl chr 1:196,504,833...196,512,551 		JBrowse link
G Hagh hydroxyacyl glutathione hydrolase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504 		JBrowse link
G Haghl hydroxyacylglutathione hydrolase-like involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:14,804,957...14,809,495
Ensembl chr10:14,804,997...14,807,665 		JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:75,868,620...75,937,126
Ensembl chr 9:75,867,468...75,937,124 		JBrowse link
methylglyoxal catabolic process to lactate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in ISO
ISS		 (PMID:28993701)
GO_REF:0000024		 RGD
UniProt		 PMID:28993701 GO_REF:0000024 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
negative regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc25a12 solute carrier family 25 member 12 IMP RGD PMID:19764902 RGD:13628741 NCBI chr 3:56,097,166...56,191,841
Ensembl chr 3:56,097,269...56,192,100 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within ISO (PMID:20935145) RGD PMID:20935145 NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:20935145)		 Ensembl
RGD		 PMID:20935145 GO_REF:0000107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
positive regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (PMID:17828264) RGD PMID:17828264 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012 		JBrowse link
G Mir210 microRNA 210 involved_in ISO (PMID:20436681) RGD PMID:20436681 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        organic hydroxy compound metabolic process 585
          lactate metabolic process 25
            L-threonine catabolic process to D-lactate 0
            glucose catabolic process to lactate + 6
            lactate biosynthetic process + 6
            lactate catabolic process + 1
            lactate racemization 0
            methylglyoxal catabolic process to lactate + 5
            mixed acid fermentation 0
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        small molecule metabolic process 1914
          organic acid metabolic process 1044
            oxoacid metabolic process 1031
              carboxylic acid metabolic process 1016
                monocarboxylic acid metabolic process 743
                  lactate metabolic process 25
                    L-threonine catabolic process to D-lactate 0
                    glucose catabolic process to lactate + 6
                    lactate biosynthetic process + 6
                    lactate catabolic process + 1
                    lactate racemization 0
                    methylglyoxal catabolic process to lactate + 5
                    mixed acid fermentation 0
paths to the root