Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:fructose 2,6-bisphosphate metabolic process
go back to main search page
Accession:GO:0006003 term browser browse the term
Definition:The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
Synonyms:exact_synonym: fructose 2,6-bisphosphate metabolism


show annotations for term's descendants           Sort by:
fructose 2,6-bisphosphate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gck glucokinase IDA Gck and Pfkfb3 act synergistically to increase cellular levels of fructose-2,6-bisphosphate RGD PMID:17553851 RGD:2301905 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 involved_in TAS
IEA
ISS
ISO
IBA		 GO_REF:0000002
GO_REF:0000024
(PMID:2837207)
GO_REF:0000033		 InterPro
UniProt
RGD
GO_Central		 PMID:2837207 PMID:2549541 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033, RGD:729562 NCBI chr  X:22,936,038...22,989,691
Ensembl chr  X:19,508,546...19,562,182 		JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 involved_in TAS
IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central
RGD		 PMID:1652483 GO_REF:0000002 GO_REF:0000033, RGD:1299004 NCBI chr13:44,683,499...44,727,135
Ensembl chr13:42,147,478...42,174,699 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 involved_in IDA
IEA
IBA		 Gck and Pfkfb3 act synergistically to increase cellular levels of fructose-2,6-bisphosphate
GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central
RGD		 PMID:17553851 GO_REF:0000002 GO_REF:0000033, RGD:2301905 NCBI chr17:71,893,320...71,974,526
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:109,643,937...109,685,634 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within ISO
IEA		 (PMID:20935145)
GO_REF:0000107		 RGD
Ensembl		 PMID:20935145 GO_REF:0000107 NCBI chr 4:161,613,306...161,632,248
Ensembl chr 4:159,927,139...159,946,029
Ensembl chr 6:159,927,139...159,946,029 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        carbohydrate derivative metabolic process 1052
          fructose 2,6-bisphosphate metabolic process 6
Path 2
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        phosphorus metabolic process 2299
          phosphate-containing compound metabolic process 2296
            fructose 2,6-bisphosphate metabolic process 6
paths to the root