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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphatidylinositol 3-kinase complex
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Accession:GO:0005942 term browser browse the term
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
Comment:For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Synonyms:exact_synonym: 1-phosphatidylinositol 3-kinase complex;   PI3K complex;   phosphoinositide 3-kinase complex
 narrow_synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex;   PIK3C3-PIK3R4 complex;   PIK3CA-PIK3R1 complex


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phosphatidylinositol 3-kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha part_of IDA
ISO		 PR:Q64143 (PMID:7542745) RGD PMID:7542745 PMID:12882977 RGD:4144086 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta part_of IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:12882977 GO_REF:0000033, RGD:4144086 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma IDA RGD PMID:12882977 RGD:4144086 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 TAS
IDA		 RGD PMID:8621382 PMID:20236230 PMID:12882977 RGD:68289, RGD:4107732, RGD:4144086 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 part_of IEA
ISO		 GO_REF:0000107
PR:P42337 (PMID:7542745)		 Ensembl
RGD		 PMID:7542745 GO_REF:0000107 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 part_of IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:12882977 GO_REF:0000033, RGD:4144086 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243 		JBrowse link
phosphatidylinositol 3-kinase complex, class IA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha part_of IBA
ISO		 GO_REF:0000033
(PMID:19805105), (PMID:22402981)		 GO_Central
RGD		 PMID:19805105 PMID:22402981 GO_REF:0000033 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta part_of ISO (PMID:20713702), (PMID:22402981) RGD PMID:20713702 PMID:22402981 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta part_of ISO (PMID:28108251) RGD PMID:28108251 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma part_of IBA
ISO		 GO_REF:0000033
(PMID:10358071)		 GO_Central
RGD		 PMID:10358071 GO_REF:0000033 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 part_of ISS
IBA
ISO
IEA		 GO_REF:0000024
GO_REF:0000033
(PMID:28108251)
(PMID:19805105), (PMID:20713702)
GO_REF:0000107		 UniProt
GO_Central
RGD
Ensembl		 PMID:19805105 PMID:20713702 PMID:28108251 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 part_of ISO
IEA
IBA		 (PMID:22402981)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:22402981 GO_REF:0000033 GO_REF:0000107 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 part_of ISO (PMID:10358071) RGD PMID:10358071 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 part_of ISO (PMID:10358071) RGD PMID:10358071 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243 		JBrowse link
phosphatidylinositol 3-kinase complex, class IB term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma part_of ISO
IBA		 (PMID:12507995)
GO_REF:0000033		 RGD
GO_Central		 PMID:12507995 GO_REF:0000033 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 part_of ISO
IEA		 (PMID:12507995)
GO_REF:0000002		 RGD
InterPro		 PMID:12507995 GO_REF:0000002 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 part_of ISO (PMID:15797027) RGD PMID:15797027 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243 		JBrowse link
phosphatidylinositol 3-kinase complex, class III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg14 autophagy related 14 part_of ISS
ISO
IBA		 GO_REF:0000024
(PMID:23332761)
(PMID:25490155)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:23332761 PMID:25490155 GO_REF:0000024 GO_REF:0000033 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113 		JBrowse link
G Becn1 beclin 1 part_of ISS
ISO		 GO_REF:0000024
(PMID:23332761)
(PMID:25490155)		 UniProt
RGD		 PMID:23332761 PMID:25490155 GO_REF:0000024 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Nrbf2 nuclear receptor binding factor 2 located_in
part_of		 ISO (PMID:24785657)
(PMID:24849286)		 RGD PMID:24785657 PMID:24849286 NCBI chr20:21,308,555...21,326,881
Ensembl chr20:21,308,576...21,326,818 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 part_of ISS
ISO
IEA		 GO_REF:0000024
(PMID:23332761)
(PMID:25490155)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23332761 PMID:25490155 GO_REF:0000024 GO_REF:0000107 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 part_of ISS
ISO		 GO_REF:0000024
(PMID:23332761)
(PMID:25490155)		 UniProt
RGD		 PMID:23332761 PMID:25490155 GO_REF:0000024 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584 		JBrowse link
G Uvrag UV radiation resistance associated part_of ISO (PMID:25490155) RGD PMID:25490155 NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136 		JBrowse link
phosphatidylinositol 3-kinase complex, class III, type I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Becn2 beclin 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:87,842,980...87,892,410
Ensembl chr13:87,844,531...87,845,787 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584 		JBrowse link
phosphatidylinositol 3-kinase complex, class III, type II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Becn2 beclin 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:87,842,980...87,892,410
Ensembl chr13:87,844,531...87,845,787 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20833
    cellular anatomical structure 20633
      extrinsic component of membrane 183
        phosphatidylinositol 3-kinase complex 16
          phosphatidylinositol 3-kinase complex, class I + 9
          phosphatidylinositol 3-kinase complex, class II 0
          phosphatidylinositol 3-kinase complex, class III + 7
Path 2
Term Annotations click to browse term
  cellular_component 20833
    protein-containing complex 6558
      catalytic complex 1863
        transferase complex 933
          transferase complex, transferring phosphorus-containing groups 274
            phosphatidylinositol 3-kinase complex 16
              phosphatidylinositol 3-kinase complex, class I + 9
              phosphatidylinositol 3-kinase complex, class II 0
              phosphatidylinositol 3-kinase complex, class III + 7
paths to the root