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ONTOLOGY REPORT - ANNOTATIONS

Term:smooth endoplasmic reticulum
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Accession:GO:0005790 term browser browse the term
Definition:The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
Synonyms:exact_synonym: SER;   smooth ER
 xref: NIF_Subcellular:sao710427438;   Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum


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smooth endoplasmic reticulum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g2 adaptor related protein complex 1 subunit gamma 2 located_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr15:32,541,528...32,549,392
Ensembl chr15:28,571,568...28,589,004 		JBrowse link
G App amyloid beta precursor protein located_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp8 aquaporin 8 located_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:14512882)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:14512882 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:187,424,314...187,430,243
Ensembl chr 1:177,993,305...177,999,158 		JBrowse link
G Calr calreticulin located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Canx calnexin located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr10:35,124,941...35,157,954
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Dmtn dematin actin binding protein located_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr15:52,087,667...52,111,956
Ensembl chr15:45,677,977...45,705,601 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr15:102,432,667...102,475,643
Ensembl chr15:96,025,624...96,065,181 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Gabarap GABA type A receptor-associated protein located_in ISO (PMID:11146101) RGD PMID:11146101 NCBI chr10:55,213,465...55,216,787
Ensembl chr10:54,714,198...54,717,765 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hyou1 hypoxia up-regulated 1 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Jph4 junctophilin 4 located_in ISO (PMID:17347645) RGD PMID:17347645 NCBI chr15:32,549,536...32,558,859
Ensembl chr15:28,571,568...28,587,573 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 located_in ISO (PMID:17347645) RGD PMID:17347645 NCBI chr18:40,004,693...40,445,043
Ensembl chr18:37,817,957...38,258,347 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 located_in IEA
ISO		 GO_REF:0000107
(PMID:16606357)		 Ensembl
RGD		 PMID:16606357 GO_REF:0000107 NCBI chr10:14,422,936...14,463,387
Ensembl chr10:13,918,400...13,958,273 		JBrowse link
G Myo5a myosin VA is_active_in ISO (PMID:21151132) RGD PMID:21151132 NCBI chr 8:84,692,524...84,860,564
Ensembl chr 8:75,812,412...75,975,918 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Plcb4 phospholipase C, beta 4 located_in
is_active_in		 IEA
ISO		 GO_REF:0000107
(PMID:15579147)		 Ensembl
RGD		 PMID:15579147 GO_REF:0000107 NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Ppib peptidylprolyl isomerase B located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:66,603,861...66,630,428 		JBrowse link
G Prdx4 peroxiredoxin 4 located_in IDA PMID:22665516 UniProt PMID:22665516 RGD:8553430 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066 		JBrowse link
G Psen1 presenilin 1 located_in ISO
IEA		 (PMID:10508860), (PMID:9632714)
GO_REF:0000107		 RGD
Ensembl		 PMID:9632714 PMID:10508860 GO_REF:0000107 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Rpl10 ribosomal protein L10 located_in ISO (PMID:10508860) RGD PMID:10508860 NCBI chr  X:157,205,850...157,208,057
Ensembl chr  X:152,054,452...152,056,761 		JBrowse link
G Rtn1 reticulon 1 located_in IDA PMID:23454728 MGI PMID:23454728 RGD:8693349 NCBI chr 6:90,763,212...90,983,436
Ensembl chr 6:90,763,216...90,983,436 		JBrowse link
G Ryr1 ryanodine receptor 1 is_active_in
located_in		 IBA
ISO		 GO_REF:0000033
(PMID:23454728)		 GO_Central
RGD		 PMID:23454728 GO_REF:0000033 NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Ryr2 ryanodine receptor 2 is_active_in
located_in		 IBA
ISO		 GO_REF:0000033
(PMID:23454728)		 GO_Central
RGD		 PMID:23454728 GO_REF:0000033 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Syvn1 synoviolin 1 located_in ISO
IEA		 (PMID:16186510)
GO_REF:0000107		 RGD
Ensembl		 PMID:16186510 GO_REF:0000107 NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Th tyrosine hydroxylase located_in ISO (PMID:12457228) RGD PMID:12457228 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
smooth endoplasmic reticulum membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldob aldolase, fructose-bisphosphate B IDA RGD PMID:234468 RGD:2313431 NCBI chr 5:68,684,541...68,697,582
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Aqp8 aquaporin 8 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 1:187,424,314...187,430,243
Ensembl chr 1:177,993,305...177,999,158 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase located_in ISO
IEA		 (PMID:14697341)
GO_REF:0000107		 RGD
Ensembl		 PMID:14697341 GO_REF:0000107 NCBI chr20:12,054,710...12,068,219
Ensembl chr20:12,055,208...12,068,735 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 is_active_in IDA PMID:1311032 SynGO PMID:1311032 RGD:13702190 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D is_active_in ISO (PMID:18234884) RGD PMID:18234884 NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:13,361,006...13,398,748 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr  X:120,698,610...120,706,805
Ensembl chr  X:115,832,884...115,888,682 		JBrowse link
G Stx17 syntaxin 17 located_in IDA
IEA		 PMID:10930465
GO_REF:0000044		 UniProt PMID:10930465 GO_REF:0000044, RGD:8553381 NCBI chr 5:67,241,673...67,302,228
Ensembl chr 5:62,446,187...62,504,451 		JBrowse link
G Svip small VCP interacting protein located_in IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 1:110,723,051...110,728,741
Ensembl chr 1:101,587,128...101,593,116 		JBrowse link
G Ttyh1 tweety family member 1 is_active_in
located_in		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:20568244)		 GO_Central
Ensembl
RGD		 PMID:20568244 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:79,125,564...79,144,137
Ensembl chr 1:70,053,324...70,071,845 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21364
    cellular anatomical structure 21069
      endomembrane system 4414
        endoplasmic reticulum 1911
          smooth endoplasmic reticulum 37
            smooth endoplasmic reticulum cisterna + 0
            smooth endoplasmic reticulum lumen 0
            smooth endoplasmic reticulum membrane + 9
Path 2
Term Annotations click to browse term
  cellular_component 21364
    cellular anatomical structure 21069
      intracellular anatomical structure 15590
        intracellular organelle 13880
          intracellular membrane-bounded organelle 12307
            endoplasmic reticulum 1911
              smooth endoplasmic reticulum 37
                smooth endoplasmic reticulum cisterna + 0
                smooth endoplasmic reticulum lumen 0
                smooth endoplasmic reticulum membrane + 9
paths to the root