ONTOLOGY REPORT - ANNOTATIONS
Term: mitochondrial permeability transition pore complex
Accession: GO:0005757
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Definition: A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).
Synonyms: exact_synonym: MPTP complex; mitochondrial PT pore complex
broad_synonym: PTPC
G
Bax
BCL2 associated X, apoptosis regulator
part_of
ISO ISS
(PMID:9843949) GO_REF:0000024
RGD UniProt
PMID:9843949
GO_REF:0000024
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
G
Ppif
peptidylprolyl isomerase F
part_of
ISO ISS
(PMID:26387735) GO_REF:0000024 (PMID:31489369)
RGD UniProt
PMID:26387735 PMID:31489369
GO_REF:0000024
NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,257,106...1,263,913
G
Slc25a31
solute carrier family 25 member 31
part_of
ISO
(PMID:31489369)
RGD
PMID:31489369
NCBI chr 2:123,695,387...123,711,275
Ensembl chr 2:123,695,408...123,710,795
G
Slc25a4
solute carrier family 25 member 4
part_of
IEA ISS ISO
GO_REF:0000107 GO_REF:0000024 (PMID:31489369)
Ensembl UniProt RGD
PMID:31489369
GO_REF:0000024 GO_REF:0000107
NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733
G
Slc25a5
solute carrier family 25 member 5
part_of
ISS ISO
GO_REF:0000024 (PMID:31489369)
UniProt RGD
PMID:31489369
GO_REF:0000024
NCBI chr X:120,897,616...120,900,683
Ensembl chr X:116,031,803...116,034,967
G
Spg7
SPG7 matrix AAA peptidase subunit, paraplegin
part_of
IEA
GO_REF:0000107
Ensembl
GO_REF:0000107
NCBI chr19:68,025,619...68,059,754
Ensembl chr19:51,117,057...51,150,484
G
Vdac1
voltage-dependent anion channel 1
part_of
ISO ISS
(PMID:26387735) GO_REF:0000024
RGD UniProt
PMID:26387735
GO_REF:0000024
NCBI chr10:37,029,377...37,060,542
Ensembl chr10:36,532,244...36,559,640
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