Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial permeability transition pore complex
go back to main search page
Accession:GO:0005757 term browser browse the term
Definition:A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D).
Synonyms:exact_synonym: MPTP complex;   mitochondrial PT pore complex
 broad_synonym: PTPC



show annotations for term's descendants           Sort by:
mitochondrial permeability transition pore complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator part_of ISO
ISS
(PMID:9843949)
GO_REF:0000024
RGD
UniProt
PMID:9843949 GO_REF:0000024 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Ppif peptidylprolyl isomerase F part_of ISO
ISS
(PMID:26387735)
GO_REF:0000024
(PMID:31489369)
RGD
UniProt
PMID:26387735 PMID:31489369 GO_REF:0000024 NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Slc25a31 solute carrier family 25 member 31 part_of ISO (PMID:31489369) RGD PMID:31489369 NCBI chr 2:123,695,387...123,711,275
Ensembl chr 2:123,695,408...123,710,795
JBrowse link
G Slc25a4 solute carrier family 25 member 4 part_of IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:31489369)
Ensembl
UniProt
RGD
PMID:31489369 GO_REF:0000024 GO_REF:0000107 NCBI chr16:52,805,521...52,809,316
Ensembl chr16:46,072,939...46,076,733
JBrowse link
G Slc25a5 solute carrier family 25 member 5 part_of ISS
ISO
GO_REF:0000024
(PMID:31489369)
UniProt
RGD
PMID:31489369 GO_REF:0000024 NCBI chr  X:120,897,616...120,900,683
Ensembl chr  X:116,031,803...116,034,967
JBrowse link
G Spg7 SPG7 matrix AAA peptidase subunit, paraplegin part_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr19:68,025,619...68,059,754
Ensembl chr19:51,117,057...51,150,484
JBrowse link
G Vdac1 voltage-dependent anion channel 1 part_of ISO
ISS
(PMID:26387735)
GO_REF:0000024
RGD
UniProt
PMID:26387735 GO_REF:0000024 NCBI chr10:37,029,377...37,060,542
Ensembl chr10:36,532,244...36,559,640
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21327
    protein-containing complex 6790
      mitochondrial protein-containing complex 180
        mitochondrial permeability transition pore complex 7
Path 2
Term Annotations click to browse term
  cellular_component 21327
    cellular anatomical structure 21032
      intracellular anatomical structure 15552
        intracellular organelle 13830
          intracellular membrane-bounded organelle 12255
            mitochondrion 1991
              mitochondrial envelope 833
                mitochondrial permeability transition pore complex 7
paths to the root