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ONTOLOGY REPORT - ANNOTATIONS

Term:sodium channel activity
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Accession:GO:0005272 term browser browse the term
Definition:Enables the energy-independent facilitated diffusion of a sodium ion through a transmembrane aqueous pore or channel.
Synonyms:xref: Reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol";   Reactome:R-HSA-9717374 "SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol";   Reactome:R-HSA-9717382 "SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol";   Reactome:R-HSA-9717395 "TRPM5 transports Na+ from the extracellular region to the cytosol";   Reactome:R-HSA-9717396 "SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol";   reactome:R-HSA-3295580 "TRPM4,5 transport extracellular Na+ to cytosol"


show annotations for term's descendants           Sort by:
sodium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic1 acid sensing ion channel subunit 1 enables IEA GO_REF:0000002
GO_REF:0000043		 InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 7:132,677,158...132,707,379
Ensembl chr 7:130,799,917...130,828,541 		JBrowse link
G Asic2 acid sensing ion channel subunit 2 enables IEA GO_REF:0000043
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr10:66,368,308...67,438,237
Ensembl chr10:65,870,594...66,940,424 		JBrowse link
G Asic3 acid sensing ion channel subunit 3 enables IEA GO_REF:0000043
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr 4:11,652,946...11,657,415
Ensembl chr 4:10,760,597...10,764,643 		JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 enables IEA GO_REF:0000043
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr 9:84,389,610...84,411,545
Ensembl chr 9:76,941,532...76,962,900 		JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 enables ISO
IEA		 (PMID:20656685)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000043		 RGD
InterPro
Ensembl
UniProt		 PMID:20656685 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chr 2:169,606,059...169,634,885
Ensembl chr 2:167,307,984...167,336,812 		JBrowse link
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:35,920,948...35,959,065
Ensembl chr14:35,567,125...35,605,065 		JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr19:9,732,646...9,798,864
Ensembl chr19:9,726,595...9,791,173 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:49,495,771...49,899,774 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 7:10,620,422...10,639,457
Ensembl chr 7:9,970,368...9,988,841 		JBrowse link
G Hcn3 hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:176,849,635...176,867,726
Ensembl chr 2:174,551,680...174,565,966 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:68,118,062...68,155,482
Ensembl chr 8:59,221,653...59,259,639 		JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 enables ISS
IEA
IDA
ISO		 GO_REF:0000024
GO_REF:0000107
PMID:22948150
(PMID:21653227)		 UniProt
Ensembl
RGD		 PMID:21653227 PMID:22948150 GO_REF:0000024 GO_REF:0000107, RGD:408345197 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:53,959,657...53,997,724 		JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 enables ISO
IEA		 (PMID:22948150)
GO_REF:0000043
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:22948150 GO_REF:0000043 GO_REF:0000107 NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:25,763,228...25,799,153 		JBrowse link
G Kcnk9 potassium two pore domain channel subfamily K member 9 enables ISO
IEA		 (PMID:22948150)
GO_REF:0000107
GO_REF:0000043		 RGD
Ensembl
UniProt		 PMID:22948150 GO_REF:0000043 GO_REF:0000107 NCBI chr 7:106,316,783...106,362,452
Ensembl chr 7:104,437,934...104,473,175 		JBrowse link
G Mcoln1 mucolipin TRP cation channel 1 enables ISO
IEA		 (PMID:17989217)
GO_REF:0000107		 RGD
Ensembl		 PMID:17989217 GO_REF:0000107 NCBI chr12:6,357,851...6,372,151
Ensembl chr12:1,560,359...1,574,252 		JBrowse link
G Mcoln3 mucolipin TRP cation channel 3 enables ISO
IEA		 (PMID:17989217)
GO_REF:0000107		 RGD
Ensembl		 PMID:17989217 GO_REF:0000107 NCBI chr 2:235,008,716...235,042,885
Ensembl chr 2:234,966,010...235,043,047 		JBrowse link
G Nalcn sodium leak channel, non-selective enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:106,805,209...107,148,837
Ensembl chr15:100,398,615...100,741,001 		JBrowse link
G P2rx7 purinergic receptor P2X 7 enables ISO (PMID:17483156) RGD PMID:17483156 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel enables ISO (PMID:29443690) RGD PMID:29443690 NCBI chr14:5,541,821...5,585,140
Ensembl chr14:5,237,135...5,280,825 		JBrowse link
G Pkd2l1 polycystin 2 like 1, transient receptor potential cation channel enables ISO
IEA
IBA		 (PMID:10517637)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:10517637 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:252,982,096...253,019,235
Ensembl chr 1:243,032,913...243,070,031 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:128,374,441...128,444,718
Ensembl chr 8:119,496,769...119,567,044 		JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:71,360,840...71,479,870
Ensembl chr 3:50,952,791...51,071,699 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:70,710,862...70,845,569
Ensembl chr 3:50,302,877...50,437,214 		JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:70,554,496...70,666,198
Ensembl chr 3:50,148,139...50,258,119 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:49,527,529...49,550,019
Ensembl chr 8:40,630,455...40,652,868 		JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:91,745,459...91,796,452
Ensembl chr10:91,246,936...91,296,545 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 enables TAS
IEA
IBA
ISO
ISS		 GO_REF:0000107
GO_REF:0000033
(PMID:16223844), (PMID:17408578)
(PMID:26537257)
GO_REF:0000024		 Ensembl
GO_Central
RGD
UniProt		 PMID:16223844 PMID:17408578 PMID:26537257 PMID:1379737 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:634044 NCBI chr 3:71,743,873...71,846,454
Ensembl chr 3:51,335,841...51,438,256 		JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 7:133,860,901...134,034,809
Ensembl chr 7:131,982,480...132,151,292 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:71,553,185...71,701,377
Ensembl chr 3:51,145,146...51,293,516 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha contributes_to
enables		 ISO
IEA		 (PMID:24124190), (PMID:32729833)
GO_REF:0000043
GO_REF:0000107
GO_REF:0000002		 RGD
UniProt
Ensembl
InterPro		 PMID:24124190 PMID:32729833 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chr 4:159,809,187...159,832,409
Ensembl chr 4:158,122,962...158,146,181 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta contributes_to
enables		 ISO
IEA		 (PMID:24124190), (PMID:32729833)
GO_REF:0000002
GO_REF:0000043		 RGD
InterPro
UniProt		 PMID:24124190 PMID:32729833 GO_REF:0000002 GO_REF:0000043 NCBI chr 1:185,861,326...185,915,717
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma contributes_to
enables		 ISO
IEA		 (PMID:24124190), (PMID:32729833)
GO_REF:0000107
GO_REF:0000043
GO_REF:0000002		 RGD
Ensembl
UniProt
InterPro		 PMID:24124190 PMID:32729833 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chr 1:185,736,225...185,770,099
Ensembl chr 1:176,304,942...176,338,816 		JBrowse link
G Slc4a11 solute carrier family 4 member 11 enables ISO
IEA		 (PMID:15525507)
GO_REF:0000107		 RGD
Ensembl		 PMID:15525507 GO_REF:0000107 NCBI chr 3:138,353,305...138,365,983
Ensembl chr 3:117,900,223...117,912,674 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:10,703,190...10,752,795
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Trpm5 transient receptor potential cation channel, subfamily M, member 5 enables ISO
IEA		 (PMID:14634208)
GO_REF:0000107
(PMID:12842017), (PMID:14657398)		 RGD
Ensembl		 PMID:12842017 PMID:14634208 PMID:14657398 GO_REF:0000107 NCBI chr 1:207,684,811...207,707,380
Ensembl chr 1:198,255,723...198,277,654 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 enables ISO
IEA		 (PMID:37648856), (PMID:38691614)
GO_REF:0000107		 RGD
Ensembl		 PMID:37648856 PMID:38691614 GO_REF:0000107 NCBI chr10:58,382,054...58,413,657
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
bile acid-gated sodium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic5 acid sensing ion channel subunit family member 5 enables IDA
ISO
IEA		 PMID:22735174
(PMID:22735174)
GO_REF:0000107		 RGD
Ensembl		 PMID:22735174 PMID:22735174 GO_REF:0000107, RGD:596936192 NCBI chr 2:169,606,059...169,634,885
Ensembl chr 2:167,307,984...167,336,812 		JBrowse link
kainate selective glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 enables IDA PMID:21846932 UniProt PMID:21846932 RGD:8553303 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 enables IDA
ISO
IBA		 PMID:12873388
MGI:2176347|MGI:95815 (PMID:11985817), (PMID:12223554), (PMID:15483117), (PMID:15509753), (PMID:17174564)
GO_REF:0000033
(PMID:9335499)		 RGD
GO_Central		 PMID:9335499 PMID:11985817 PMID:12223554 PMID:15483117 PMID:15509753 More... GO_REF:0000033, RGD:1642466, RGD:405650399 NCBI chr11:40,655,974...41,056,966
Ensembl chr11:27,169,740...27,570,645 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 enables IDA
IEA
ISO
IBA		 GO_REF:0000107
MGI:1857979|MGI:95814|MGI:95818 (PMID:10704492), (PMID:11985817), (PMID:12151522), (PMID:12223554), (PMID:1310861), (PMID:15483117), (PMID:15509753), (PMID:7681676), (PMID:9580260), (PMID:9880586)
(PMID:1379666)
GO_REF:0000033
(PMID:15537878)		 Ensembl
RGD
GO_Central		 PMID:1310861 PMID:1379666 PMID:7681676 PMID:9580260 PMID:9880586 More... GO_REF:0000033 GO_REF:0000107, RGD:69852, RGD:405650269 NCBI chr20:53,717,564...54,415,283
Ensembl chr20:52,133,851...52,838,375 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 enables ISO
IBA
IEA		 (PMID:7719709)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:7719709 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:143,052,442...143,268,873
Ensembl chr 5:137,767,865...137,984,307 		JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 enables TAS
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:7527545 GO_REF:0000033, RGD:734533 NCBI chr 8:51,802,045...52,228,751
Ensembl chr 8:42,905,056...43,193,751 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 enables IDA
ISO
IBA
IEA		 MGI:95815 (PMID:1310861)
GO_REF:0000033
GO_REF:0000107
(PMID:1321949)		 RGD
GO_Central
Ensembl		 PMID:1310861 PMID:1321949 PMID:12080343 GO_REF:0000033 GO_REF:0000107, RGD:625595 NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:80,605,892...80,667,125 		JBrowse link
ligand-gated sodium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic1 acid sensing ion channel subunit 1 enables IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:132,677,158...132,707,379
Ensembl chr 7:130,799,917...130,828,541 		JBrowse link
G Asic2 acid sensing ion channel subunit 2 enables ISO
IEA
IBA		 (PMID:11306621), (PMID:9368048)
GO_REF:0000002
GO_REF:0000033		 RGD
InterPro
GO_Central		 PMID:9368048 PMID:11306621 GO_REF:0000002 GO_REF:0000033 NCBI chr10:66,368,308...67,438,237
Ensembl chr10:65,870,594...66,940,424 		JBrowse link
G Asic3 acid sensing ion channel subunit 3 enables IMP
IEA
IBA
IDA		 GO_REF:0000002
GO_REF:0000033
PMID:9261094		 InterPro
GO_Central
RGD		 PMID:9261094 PMID:9261094 GO_REF:0000002 GO_REF:0000033, RGD:1299543, RGD:1299543 NCBI chr 4:11,652,946...11,657,415
Ensembl chr 4:10,760,597...10,764,643 		JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:84,389,610...84,411,545
Ensembl chr 9:76,941,532...76,962,900 		JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 enables
NOT|enables		 IDA
IMP
IBA
ISO		 PMID:34549327
GO_REF:0000033
(PMID:20656685)		 GO_Central
RGD		 PMID:20656685 PMID:12050153 PMID:34549327 GO_REF:0000033, RGD:631861, RGD:596936204 NCBI chr 2:169,606,059...169,634,885
Ensembl chr 2:167,307,984...167,336,812 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 enables ISS
ISO		 GO_REF:0000024
(PMID:21376300)		 UniProt
RGD		 PMID:21376300 GO_REF:0000024 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha enables
contributes_to		 IDA
IEA
IBA
ISO		 GO_REF:0000002
GO_REF:0000033
(PMID:16941024)
MGI:104695|MGI:104696 (PMID:10409305), (PMID:17715136)
GO_REF:0000107		 InterPro
GO_Central
RGD
Ensembl		 PMID:10409305 PMID:16941024 PMID:17715136 PMID:16554417 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:1624119 NCBI chr 4:159,809,187...159,832,409
Ensembl chr 4:158,122,962...158,146,181 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta enables
contributes_to		 IMP
IEA
IBA
ISO
IDA		 GO_REF:0000002
GO_REF:0000033
(PMID:16941024)
MGI:101782|MGI:104695 (PMID:10409305), (PMID:17715136)
PMID:9118951		 InterPro
GO_Central
RGD		 PMID:10409305 PMID:16941024 PMID:17715136 PMID:11773057 PMID:9118951 More... GO_REF:0000002 GO_REF:0000033, RGD:729911, RGD:151356642, RGD:1624140 NCBI chr 1:185,861,326...185,915,717
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma enables
contributes_to		 IMP
IEA
IBA
ISO
IDA		 GO_REF:0000002
GO_REF:0000033
(PMID:16941024)
MGI:101782|MGI:104696 (PMID:10409305), (PMID:17715136)
PMID:9118951
GO_REF:0000107		 InterPro
GO_Central
RGD
Ensembl		 PMID:10409305 PMID:16941024 PMID:17715136 PMID:11773057 PMID:9118951 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:729911, RGD:151356642, RGD:1624119 NCBI chr 1:185,736,225...185,770,099
Ensembl chr 1:176,304,942...176,338,816 		JBrowse link
G Tpcn1 two pore segment channel 1 enables ISO
IEA
ISS		 (PMID:23063126), (PMID:24776928)
(PMID:24776928), (PMID:29562233)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23063126 PMID:24776928 PMID:29562233 GO_REF:0000024 GO_REF:0000107 NCBI chr12:41,633,399...41,690,200
Ensembl chr12:35,972,846...36,029,626 		JBrowse link
G Tpcn2 two pore segment channel 2 enables ISO
IEA
IBA		 (PMID:23063126), (PMID:30860481), (PMID:32167471)
GO_REF:0000107
(PMID:27231233)
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:23063126 PMID:27231233 PMID:30860481 PMID:32167471 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:209,845,827...209,875,561
Ensembl chr 1:200,416,540...200,446,236 		JBrowse link
pH-gated sodium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic2 acid sensing ion channel subunit 2 enables IDA
ISO
IEA		 PMID:10842183
(PMID:10842183)
(PMID:9368048)
GO_REF:0000107		 RGD
Ensembl		 PMID:9368048 PMID:10842183 PMID:10842183 GO_REF:0000107, RGD:596936210 NCBI chr10:66,368,308...67,438,237
Ensembl chr10:65,870,594...66,940,424 		JBrowse link
G Asic3 acid sensing ion channel subunit 3 enables IDA
ISO		 PMID:10842183
(PMID:10842183), (PMID:9744806), (PMID:9886053)
PMID:11120882		 RGD PMID:9744806 PMID:9886053 PMID:10842183 PMID:10842183 PMID:11120882 RGD:596936210, RGD:596936209 NCBI chr 4:11,652,946...11,657,415
Ensembl chr 4:10,760,597...10,764,643 		JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 NOT|enables IDA PMID:10852210
PMID:10923674		 UniProt PMID:10852210 PMID:10923674 RGD:632227, RGD:596936205 NCBI chr 9:84,389,610...84,411,545
Ensembl chr 9:76,941,532...76,962,900 		JBrowse link
voltage-gated sodium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:113,716,266...113,827,670
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 enables ISO
IEA		 (PMID:22748890)
GO_REF:0000107		 RGD
Ensembl		 PMID:22748890 GO_REF:0000107 NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:49,495,771...49,899,774 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 enables ISO
IEA		 (PMID:22748890)
GO_REF:0000107		 RGD
Ensembl		 PMID:22748890 GO_REF:0000107 NCBI chr 7:10,620,422...10,639,457
Ensembl chr 7:9,970,368...9,988,841 		JBrowse link
G Hcn3 hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 enables ISO (PMID:16043489), (PMID:22748890) RGD PMID:16043489 PMID:22748890 NCBI chr 2:176,849,635...176,867,726
Ensembl chr 2:174,551,680...174,565,966 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 enables ISO
IEA		 (PMID:22748890)
GO_REF:0000107		 RGD
Ensembl		 PMID:22748890 GO_REF:0000107 NCBI chr 8:68,118,062...68,155,482
Ensembl chr 8:59,221,653...59,259,639 		JBrowse link
G Nalcn sodium leak channel, non-selective enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:32494638), (PMID:32698188)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:32494638 PMID:32698188 GO_REF:0000024 GO_REF:0000107 NCBI chr15:106,805,209...107,148,837
Ensembl chr15:100,398,615...100,741,001 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel enables ISO
IBA		 (PMID:11252306), (PMID:27071085)
GO_REF:0000033		 RGD
GO_Central		 PMID:11252306 PMID:27071085 GO_REF:0000033 NCBI chr14:5,541,821...5,585,140
Ensembl chr14:5,237,135...5,280,825 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 enables IDA
IEA
ISO		 GO_REF:0000107
GO_REF:0000002
(PMID:16029194)
(PMID:23115331), (PMID:9839820)		 Ensembl
InterPro
RGD		 PMID:9839820 PMID:16029194 PMID:23115331 PMID:8538791 GO_REF:0000002 GO_REF:0000107, RGD:69979 NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 enables IEA
IBA
ISO
IDA		 GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:16029194), (PMID:24036948)
PMID:10196578
(PMID:12384689), (PMID:24036948), (PMID:24776970)		 Ensembl
InterPro
GO_Central
RGD		 PMID:12384689 PMID:16029194 PMID:24036948 PMID:24776970 PMID:10196578 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:69980 NCBI chr 8:128,374,441...128,444,718
Ensembl chr 8:119,496,769...119,567,044 		JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 enables TAS
IEA
IBA
ISO
IMP
IC		 GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
MGI:3665322 (PMID:16921370), (PMID:27281198)
(PMID:14672992)		 Ensembl
InterPro
GO_Central
RGD		 PMID:14672992 PMID:16921370 PMID:27281198 PMID:3754035 PMID:17273863 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:68844, RGD:2289022, RGD:2289019 NCBI chr 3:71,360,840...71,479,870
Ensembl chr 3:50,952,791...51,071,699 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 enables IDA
IEA
IBA
ISO
IC		 GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:10827969)
(PMID:1325650), (PMID:17021166), (PMID:28256214), (PMID:29844171)
PMID:24297919
PMID:28029095		 Ensembl
InterPro
GO_Central
RGD		 PMID:1325650 PMID:10827969 PMID:17021166 PMID:28256214 PMID:29844171 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:1299025, RGD:8554774, RGD:14390052, RGD:2289019 NCBI chr 3:70,710,862...70,845,569
Ensembl chr 3:50,302,877...50,437,214 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 IDA RGD PMID:8521473 RGD:729729 NCBI chr 8:54,322,383...54,334,519
Ensembl chr 8:45,425,629...45,437,765 		JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 enables TAS
IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
(PMID:35277491)		 Ensembl
InterPro
GO_Central
RGD		 PMID:35277491 PMID:14523090 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:734493 NCBI chr 3:70,554,496...70,666,198
Ensembl chr 3:50,148,139...50,258,119 		JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 enables TAS
IEA
IBA
ISO
ISS		 GO_REF:0000002
GO_REF:0000033
(PMID:11834499)
GO_REF:0000107
(PMID:12766226), (PMID:30190309)
GO_REF:0000024		 InterPro
GO_Central
RGD
Ensembl
UniProt		 PMID:11834499 PMID:12766226 PMID:30190309 PMID:9613589 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:634040 NCBI chr10:91,745,459...91,796,452
Ensembl chr10:91,246,936...91,296,545 		JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 enables ISO (PMID:12930796)
(PMID:20566860)		 RGD PMID:12930796 PMID:20566860 NCBI chr 8:54,343,873...54,359,046
Ensembl chr 8:45,446,215...45,462,292 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000002
GO_REF:0000107
(PMID:14500339), (PMID:17592081), (PMID:19074138), (PMID:19943616), (PMID:21895525), (PMID:22514276), (PMID:23085483), (PMID:26279430), (PMID:26392562)
(PMID:32175648)		 UniProt
InterPro
Ensembl
RGD		 PMID:14500339 PMID:17592081 PMID:19074138 PMID:19943616 PMID:21895525 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:71,743,873...71,846,454
Ensembl chr 3:51,335,841...51,438,256 		JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 enables IDA
IEA
IBA
ISO
IMP
IC		 GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
(PMID:21078353), (PMID:25239001), (PMID:25725044), (PMID:29726066), (PMID:36696443), (PMID:36823201)		 InterPro
Ensembl
GO_Central
RGD		 PMID:21078353 PMID:25239001 PMID:25725044 PMID:29726066 PMID:36696443 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:69984, RGD:2289022, RGD:2289019 NCBI chr 7:133,860,901...134,034,809
Ensembl chr 7:131,982,480...132,151,292 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 enables ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
(PMID:17145499), (PMID:7720699)		 UniProt
InterPro
Ensembl
GO_Central
RGD		 PMID:7720699 PMID:17145499 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:71,553,185...71,701,377
Ensembl chr 3:51,145,146...51,293,516 		JBrowse link
G Tpcn1 two pore segment channel 1 enables ISO
IEA
ISS		 (PMID:24776928)
(PMID:24776928), (PMID:29562233)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:24776928 PMID:29562233 GO_REF:0000024 GO_REF:0000107 NCBI chr12:41,633,399...41,690,200
Ensembl chr12:35,972,846...36,029,626 		JBrowse link
G Tpcn2 two pore segment channel 2 NOT|enables ISO (PMID:24776928) RGD PMID:24776928 NCBI chr 1:209,845,827...209,875,561
Ensembl chr 1:200,416,540...200,446,236 		JBrowse link
voltage-gated sodium channel activity involved in AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18616619)		 BHF-UCL
Ensembl
RGD		 PMID:18616619 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
voltage-gated sodium channel activity involved in bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISO
IEA
ISS		 (PMID:18065446)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
BHF-UCL		 PMID:18065446 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
voltage-gated sodium channel activity involved in cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn10a sodium voltage-gated channel alpha subunit 10 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 enables ISO
IEA		 MGI:2451362 (PMID:27932425)
GO_REF:0000107		 RGD
Ensembl		 PMID:27932425 GO_REF:0000107 NCBI chr 8:54,322,383...54,334,519
Ensembl chr 8:45,425,629...45,437,765 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 enables ISO
IEA		 MGI:5294639 (PMID:19351516)
GO_REF:0000107		 RGD
Ensembl		 PMID:19351516 GO_REF:0000107 NCBI chr 8:49,527,529...49,550,019
Ensembl chr 8:40,630,455...40,652,868 		JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 enables ISO (PMID:17592081) RGD PMID:17592081 NCBI chr 8:54,343,873...54,359,046
Ensembl chr 8:45,446,215...45,462,292 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISS
IEA
ISO
IBA
IMP		 GO_REF:0000024
GO_REF:0000107
(PMID:18065446), (PMID:18616619), (PMID:19808477), (PMID:21895525), (PMID:22529811)
MGI:2179753 (PMID:11972032)
GO_REF:0000033
PMID:29457789		 BHF-UCL
Ensembl
RGD
GO_Central		 PMID:11972032 PMID:18065446 PMID:18616619 PMID:19808477 PMID:21895525 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:126781740 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
voltage-gated sodium channel activity involved in Purkinje myocyte action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISO
IEA
ISS		 (PMID:22766342)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
BHF-UCL		 PMID:22766342 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
voltage-gated sodium channel activity involved in SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISO
IEA
ISS		 (PMID:18616619)
MGI:2179753 (PMID:15932895)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
BHF-UCL		 PMID:15932895 PMID:18616619 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21100
    transporter activity 1274
      transmembrane transporter activity 1165
        monoatomic ion transmembrane transporter activity 771
          monoatomic ion channel activity 457
            monoatomic cation channel activity 347
              sodium channel activity 52
                bile acid-gated sodium channel activity 1
                ligand-gated sodium channel activity + 17
                voltage-gated sodium channel activity + 24
Path 2
Term Annotations click to browse term
  molecular_function 21100
    transporter activity 1274
      transmembrane transporter activity 1165
        monoatomic ion transmembrane transporter activity 771
          monoatomic cation transmembrane transporter activity 652
            metal ion transmembrane transporter activity 464
              sodium ion transmembrane transporter activity 175
                sodium channel activity 52
                  bile acid-gated sodium channel activity 1
                  ligand-gated sodium channel activity + 17
                  voltage-gated sodium channel activity + 24
paths to the root